• Gestational diabetes mellitus (GDM), a common pregnancy complication, continues to be a significant public health and clinical problem. (springer.com)
  • Gestational diabetes mellitus (GDM), defined as glucose intolerance with onset or first recognition in pregnancy, is a common complication of pregnancy [ 1 ]. (springer.com)
  • There were 18 independent genetic loci significantly associated with hypertensive disorders of pregnancy (HDPs) -- 12 of them new (i.e. (medpagetoday.com)
  • For example, CVS is generally done earlier in pregnancy than amniocentesis and is particularly advantageous for detecting certain genetic conditions. (cdc.gov)
  • There is limited evidence on how the classification of maternal metabolic syndrome during pregnancy affects children's developmental outcomes and the possible mediators of this association. (biomedcentral.com)
  • The results support the hypothesis that maternal metabolic syndrome classification during pregnancy is associated with some child developmental outcomes at age 5. (biomedcentral.com)
  • After adjusting for maternal, child, and environmental covariates, maternal metabolic syndrome classification during pregnancy was associated with children's LIT domain through direct effects of maternal metabolic health and indirect effects of cord blood markers (total effects), and COM and PSE domains via changes only in a child's cord blood markers (total indirect effects). (biomedcentral.com)
  • There is limited evidence from human studies on how maternal cardiometabolic health during pregnancy affects a child's cognitive and behavioural development. (biomedcentral.com)
  • The rates of gestational diabetes -- high blood sugar that starts, or is first diagnosed, during pregnancy -- were investigated by researchers in British Columbia. (scienceboard.net)
  • Although gestational diabetes is manageable during pregnancy, a diagnosis affects both patients and the health system, requiring lifestyle changes, additional healthcare appointments, and monitoring during and after pregnancy. (scienceboard.net)
  • The emphasis of the report Nutrition During Pregnancy (IOM, 1990) was on the short-term consequences of gestational weight gain (GWG). (nationalacademies.org)
  • Maternal smoking during pregnancy is an established risk factor for low infant birth weight, but evidence on critical exposure windows and timing of fetal growth restriction is limited. (plos.org)
  • Here we investigate the associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth by triangulating evidence from 3 analytical approaches to strengthen causal inference. (plos.org)
  • We analysed data from 8,621 European liveborn singletons in 2 population-based pregnancy cohorts (the Generation R Study, the Netherlands 2002-2006 [ n = 4,682]) and the Born in Bradford study, United Kingdom 2007-2010 [ n = 3,939]) with fetal ultrasound and birth anthropometric measures, parental smoking during pregnancy, and maternal genetic data. (plos.org)
  • A consistent linear dose-dependent association of maternal smoking with fetal growth was observed from the early second trimester onwards, while no major growth deficit was found in women who quit smoking early in pregnancy except for a shorter FL during late gestation. (plos.org)
  • Maternal smoking during pregnancy is an established risk factor for low infant birth weight. (plos.org)
  • The importance of smoking cessation in early pregnancy and the extent to which fetal growth restriction can be prevented or minimised by lowering cigarette consumption in women who find quitting difficult is also uncertain. (plos.org)
  • We analysed data from 8,621 white European liveborn singletons from 2 population-based pregnancy cohorts to assess the associations of maternal quitting, reducing, and continuing smoking during pregnancy with the longitudinal growth of different fetal parameters (weight, head circumference, femur length, and abdominal circumference). (plos.org)
  • Additionally, no link was found between antipsychotic drugs in pregnancy and the development of attention deficit hyperactivity disorder ( ADHD ) or autism spectrum disorder ( ASD ) in the kids. (sciencealert.com)
  • Our study found no evidence to support an association between antipsychotic medication use during pregnancy and an increased risk of neurodevelopmental disorders in children" such as ADHD or autism , Wang and colleagues write . (sciencealert.com)
  • With two lives are intertwined, decisions about using antipsychotic drugs in pregnancy are not straightforward, explains Simone Vigod, a psychiatric epidemiologist at the University of Toronto who co-authored a 2015 study that also found no evidence of an increased risk of pregnancy complications , including early births, for women on antipsychotic drugs. (sciencealert.com)
  • What are potential maternal complications of AT deficiency in pregnancy? (blogspot.com)
  • An ISB-led study examined the electronic health records of more than 18,000 people with SARS-CoV-2 tests during pregnancy, and found that those who contracted COVID-19 while pregnant were more likely to have poor birth outcomes including preterm birth, small for gestational age, low birth weight, and stillbirth. (isbscience.org)
  • The Brazil Ministry of Health (MoH) established a task force to investigate the possible association of microcephaly with Zika virus infection during pregnancy and a registry for incident microcephaly cases (head circumference ≥2 standard deviations [SD] below the mean for sex and gestational age at birth) and pregnancy outcomes among women suspected to have had Zika virus infection during pregnancy. (cdc.gov)
  • Further studies are needed to confirm the association of microcephaly with Zika virus infection during pregnancy and to understand any other adverse pregnancy outcomes associated with Zika virus infection. (cdc.gov)
  • Maternal weight and height, food frequency intake during pregnancy and haemoglobin levels were recorded for 594, 234 and 246 of the mothers respectively. (who.int)
  • The association between exposure to secondhand smoke (SHS) during pregnancy and a child's neurodevelopment has not been established yet. (biomedcentral.com)
  • We quantified urine cotinine concentrations in mothers once from 12th to 20th gestational weeks and excluded those whose urine cotinine levels exceeded 42.7 ng/ml to represent SHS exposure in early pregnancy. (biomedcentral.com)
  • Maternal exposure to SHS during pregnancy may result in delayed MDI in early childhood. (biomedcentral.com)
  • However, additional work needs to be done before using maternal cardiovascular health as a metric to predict child outcomes -- specifically in defining optimal cardiovascular health during pregnancy, he added. (medpagetoday.com)
  • While single factors during pregnancy such as obesity, diabetes, hypertension, and dyslipidemia are all known to pose cardiovascular risks to offspring, the relevance of gestational cardiovascular health as an indicator is not well defined. (medpagetoday.com)
  • The maternal outcome was studied in terms of type of labour, outcome of pregnancy, mode of delivery, indication of cesarean section, and maternal mortality. (hindawi.com)
  • Main outcome measures Risk ratio of spontaneous abortion and stillbirth after use of antiepileptic drugs during pregnancy, estimated by using binomial regression adjusting for potential confounders of maternal age, cohabitation, income, education, history of severe mental disorder, and history of drug misuse. (bmj.com)
  • Conclusion Among women with epilepsy and when analysing the risk in antiepileptic drug discordant pregnancies in the same woman, we found no overall association between the use of antiepileptic drugs during pregnancy and spontaneous abortions. (bmj.com)
  • We found no association between antiepileptic drug use during pregnancy and stillbirth, but the statistical precision was low. (bmj.com)
  • A recent study from the United States found that antiepileptic drug use during pregnancy is increasing, especially for the newer drugs. (bmj.com)
  • 2017), and this association was mediated by maternal anxiety assessed during pregnancy (Van den Heuvel et al. (researchgate.net)
  • In line with the hypotheses, better non-reacting skills in mothers during pregnancy were associated with more socialemotional capacities in children at 2 years of age. (researchgate.net)
  • 2017). The association between non-reacting and child social-emotional behavior in the current study was, against expectation, not mediated by pregnancy distress or postnatal symptoms of anxiety or depression. (researchgate.net)
  • The current study examined associations of mindfulness facets during pregnancy with toddler's social-emotional development and behavior problems, as well as potentially mediating effects of maternal mental health. (researchgate.net)
  • Pregnancy distress mediated the association between maternal non-judging skills during pregnancy and child externalizing problem behavior, but no other mediating effects were found. (researchgate.net)
  • There is an association between low levels of B12 in the bloodstream during pregnancy and an increased risk for preeclampsia, though research suggests that it is likely due to shared metabolic pathways rather than a direct relationship. (preeclampsia.org)
  • 3, 4 This finding is difficult to explain by the Barker hypothesis and points to a possible common genetic predisposition to both ischaemic heart disease and pregnancy complications. (bmj.com)
  • INTRODUCTION - Use of tobacco products, including cigarette smoking, smokeless tobacco, and electronic cigarettes (e-cigarettes), during pregnancy is one of the most important modifiable risk factors associated with adverse maternal, fetal, and neonatal outcomes. (medilib.ir)
  • The scope of the problem, the pathophysiology of tobacco use in pregnancy, and clinical effects of cigarette smoking on maternal, fetal, and neonatal outcomes will be reviewed here. (medilib.ir)
  • To evaluate the influence of genetic variants and clinical characteristics on the risk of gestational diabetes mellitus (GDM) and to construct and verify a prediction model of GDM in early pregnancy. (biomedcentral.com)
  • Therefore, these four genetic susceptible single nucleotide polymorphisms (SNPs) and six clinical characteristics were included in the construction of the GDM early pregnancy prediction model. (biomedcentral.com)
  • Based on the genetic variants and clinical characteristics, this study developed and verified the early pregnancy prediction model of GDM. (biomedcentral.com)
  • Therefore, we intended to find GDM-associated SNPs in Chinese population and hypothesized that an early pregnancy prediction model for GDM can be constructed using genetic risk variants and clinical factors. (biomedcentral.com)
  • 11), altered liver structure and function (12), altered naire data from 8,765 children aged 5 to 7 years, smoking gene expression (13), and possibly type 2 diabetes mel- after pregnancy was not associated with childhood obesity litus (10). (cdc.gov)
  • Another study found pregnancy has been associated with low birth weight, a that smoking during the 12 months before birth of a child marker of risk for obesity and other metabolic disorders was associated with adolescent overweight (21). (cdc.gov)
  • For example, they analyzed use of maternal vitamin supplementation before but not during pregnancy, during but not before pregnancy, and before and during pregnancy. (medscape.com)
  • They also examined exposure during the period from 4 weeks before pregnancy to 8 weeks into pregnancy, and maternal vitamin supplementation 2 years before pregnancy, during pregnancy, and 2 years before and during pregnancy. (medscape.com)
  • The variables studied were: presence of caries in pregnancy (DMFT) and the child (deft), visit to the dentist, oral hygiene habits, diet, socioeconomic and behavioral factors, and were related to two study outcomes: presence of caries during the examination and experience of caries (deft≥1) in children of 4 years of age. (bvsalud.org)
  • Association between UBE2E2 variant rs7612463 and type 2 diabetes mellitus in a Chinese Han population. (nih.gov)
  • Lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population. (nih.gov)
  • Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus. (nih.gov)
  • Multivariate logistic regression analysis was performed to adjust for the potential confounding effects of cigarette and alcohol consumption, body mass index, socioeconomic status, maternal age, parity, infant's sex, pre-eclampsia, and diabetes mellitus. (bmj.com)
  • Gestational diabetes mellitus (GDM) is a common obstetric disease that affects nearly 7% of pregnant women and their offspring [ 1 ]. (biomedcentral.com)
  • A health statistics review uses existing health data from data sources like birth certificates and health registries to determine whether health outcomes in a particular community are occurring at a higher, lower, or about the same level compared to statewide or national levels after taking into account factors such as gender and age of individuals within the community. (cdc.gov)
  • OBJECTIVE: To compare the incidence of GBS EOS in term neonates born to mothers who receive first, second-line or no intrapartum antibiotics, and describe the short term and survival outcomes of neonates who developed GBS EOS stratified by maternal antepartum prophylaxis. (bvsalud.org)
  • This study uses a cohort sample of 12,644 to 13,832 mother-child pairs from the UK Born in Bradford Study to examine the associations between maternal metabolic syndrome classification (MetS) and child development outcomes at age 5, using cord blood markers as candidate mediators. (biomedcentral.com)
  • It is possible that associations of GWG with outcomes do not result from GWG itself, but rather to underlying factors that influence both weight gain and the outcomes (e.g., maternal diet composition or physical activity level). (nationalacademies.org)
  • Previous studies indicated a range of risk factors associated with these poor outcomes, including maternal psychosocial and economic wellbeing. (springer.com)
  • We aimed to determine whether infants with intrauterine preeclampsia exposure, compared to infants born from normotensive pregnancies, have differing anthropometric growth outcomes and psychomotor developmental outcomes from birth to 2 years of age. (biomedcentral.com)
  • Our study results suggest that if pregnant women have a clinical need for antipsychotics, clinicians should not stop administering regular treatment because of a fear of birth outcomes with ADHD, ASD, preterm birth, and small for gestational age," write pharmaco-epidemiologist Zixuan Wang from the University College London and colleagues in their published paper . (sciencealert.com)
  • But as the researchers note, birth outcomes and childhood developmental disorders could still be influenced by a mother's genetic factors - or the very conditions that need medical treatment - so let's take a look at what the study shows. (sciencealert.com)
  • ISB researchers and their collaborators looked at the electronic health records of nearly 630,000 patients who were tested for SARS-CoV-2, and found stark disparities in COVID-19 outcomes - odds of infection, hospitalization, and in-hospital mortality - between White and non-White minority racial and ethnic groups. (isbscience.org)
  • Multiple logistic regression analyzed the association between CEEG use and these outcomes, controlling for age and underlying neurologic diagnosis. (stanford.edu)
  • This age range is associated with the best outcomes for both you and your baby. (healthline.com)
  • As the evolving literature examining birth outcomes increasingly recognizes their multifactorial nature, Dr. Keiser seeks to understand the complex interactions between genetics, environmental context, maternal age and racial/ethnic background that drive both outcomes and disparities. (hopkinsmedicine.org)
  • Previous research suggests that the mechanisms responsible for the associations between offspring adjustment and early maternal age at childbearing (MAC) are dependent on the outcomes being explored. (nlsinfo.org)
  • Multiple linear regression models were used to estimate the associations of benzene exposure and genetic susceptibility with gestational age, adjusting for maternal age, education, parity, stress, passive smoking, prepregnancy weight and height, and infant's sex. (cdc.gov)
  • Women bearing the FNDC5 rs726344 GG genotype had 2.18 fold ([CI] 1.193-4.008, p = 0.01) higher chance to deliver at term compared to both AG and AA genotypes (adjusting to age, gravidity, parity, weight percentile per gestational age and gender of newborn). (bgu.ac.il)
  • Neonates carrying the FNDC5 rs726344 GG genotype had 2.24 fold ([CI] 0.979-5.134, p = 0.05) higher chance to be born at term compared to either AG or AA genotypes (adjusting to parity, previous abortions and weight percentile per gestational age). (bgu.ac.il)
  • The researchers also assessed covariates including parity, maternal demographics, maternal alcohol use, and child demographics. (medpagetoday.com)
  • Without consideration of genotype, benzene exposure was associated with a decrease in mean gestational age of 0.29 (standard error (SE), 0.12) week. (cdc.gov)
  • Melchiorre et al found that there is a significant relationship between first-trimester uterine artery Doppler resistance indices (RI) and the subsequent delivery of neonates who are small for gestational age (SGA) or have intrauterine growth restriction. (medscape.com)
  • Children born small for gestational age (SGA) are a well-known group at a risk of obesity. (e-apem.org)
  • Studies show an increasing association between the risk of obesity and metabolic disease in adulthood, influenced by the intrauterine environment experienced in the foetal period and in the postpartum period 9-11 . (bvsalud.org)
  • epidemic towards decreased physical activity in 2013, 23.8% (95% uncertainty levels - because of the increasing- interval [UI], 22.9-24.7%) of boys Obesity is a result of a positive en- ly sedentary nature of recreational and 22.6% (95% UI, 21.7-23.6%) ergy balance (i.e. energy intake that activities, changing modes of trans- of girls were overweight or obese. (who.int)
  • abilities are intensified to specific maternal and environ- mental exposures that can lead to obesity (2). (cdc.gov)
  • Although a person is at risk for During gestation, risk factors for obesity include maternal obesity throughout his life, we focus on specific develop- diet, overweight, and smoking. (cdc.gov)
  • Gestational Period become focal points for obesity prevention or intervention. (cdc.gov)
  • glucocorticoids, protein restrictions, and maternal diet and obesity. (cdc.gov)
  • Increased use of prenatal care was found to decrease the rates of birth-weight-related mortality and other preventable medical ailments such as post-partum depression and infant injuries. (wikipedia.org)
  • Chorionic villus sampling (CVS) and amniocentesis are prenatal diagnostic procedures used to detect certain fetal genetic abnormalities. (cdc.gov)
  • By September, reports of an increase in the number of infants born with microcephaly in Zika virus-affected areas began to emerge, and Zika virus RNA was identified in the amniotic fluid of two women whose fetuses had been found to have microcephaly by prenatal ultrasound. (cdc.gov)
  • We explored the association between prenatal exposure to SHS and neurodevelopment at 24 months of age considering genetic polymorphism and breastfeeding in 720 mothers and their offspring enrolled in the Korean multicenter birth cohort study (Mothers and Children Environmental Health, MOCEH). (biomedcentral.com)
  • This underscores the potential of gestational cardiovascular health as a prenatal target to lower risk of cardiovascular disease among offspring, they stated. (medpagetoday.com)
  • In addition, she is using the Boston Birth Cohort to explore associations between maternal prenatal and perinatal exposures and the risk of infant necrotizing enterocolitis, and understand the extent to which these associations vary by race/ethnicity. (hopkinsmedicine.org)
  • We used logistic regression to examine the adjusted association between having the recommended visits and school readiness, controlling for characteristics of mothers, infants, prenatal care and delivery, and residence area. (cdc.gov)
  • Incidence of GBS EOS among all neonates with maternal GBS carriage was 0.22% (231/104,196). (bvsalud.org)
  • CONCLUSION: Neonates exposed to second-line maternal GBS prophylaxis had increased risk of GBS EOS compared to those exposed to first-line maternal GBS prophylaxis. (bvsalud.org)
  • Multivariable logistic regression analyses assessed the association between cEEG approach and successful seizure treatment.RESULTS: Among 514 neonates included, 161 (31%) had screening cEEG and 353 (69%) had confirmatory cEEG. (stanford.edu)
  • Although, full-term neonates may have lower lamellar body counts, suggesting diminished surfactant function and association with prolonged tachypnea of newborns. (medscape.com)
  • Studies of neonates (from birth to 28 days of age) born to mothers who smoke have reported increased signs of stress, irritability, and hypertonicity compared with those of mothers who do not smoke. (medilib.ir)
  • Growth Parameters in Neonates Growth parameters and gestational age help identify the risk of neonatal pathology. (msdmanuals.com)
  • Because the herniated bowel is bathed by amniotic fluid, alpha-fetoprotein (AFP) levels in both maternal serum and amniotic fluid are elevated, more so than in exomphalos. (medscape.com)
  • A recent meta-analysis of research (which included 19 individual studies for a total of 3211 cases) found that women with preeclampsia had significantly lower serum vitamin B12 levels compared with pregnant women without preeclampsia (Mardali 2020). (preeclampsia.org)
  • The authors of the meta-analysis examined if maternal serum homocysteine levels, folic acid supplementation, or gestational age could explain the variation in the results, but none significantly explained the difference between studies. (preeclampsia.org)
  • Folate is found naturally in foods such as leafy green vegetables, eggs, and citrus fruits, while folic acid is the synthetic version used in fortified foods and supplements. (preeclampsia.org)
  • A health statistics review can take risk factors such as age, race and sex that are commonly found on health records into account. (cdc.gov)
  • Risk factors for gestational diabetes: is prevention possible? (springer.com)
  • For example, it was observed that exposure to perfluorooctanoic acid (PFOA), an endocrine disruptor often found in some carpet cleaning liquids, microwave popcorn bags and some cooking ware was positively related to GDM risk [ 10 ]. (springer.com)
  • With new genetic variants identified for preeclampsia and gestational hypertension, researchers created polygenic risk scores (PRS) that may better identify candidates for prophylactic low-dose aspirin among pregnant mothers. (medpagetoday.com)
  • The PRS predicted HDP risk among nulliparous female individuals independent of first-trimester risk factors, with the top 10% highest scorers confirmed to be at significantly higher risk of preeclampsia and gestational hypertension. (medpagetoday.com)
  • This may have implications for improving upon the "modest" predictive ability of clinical risk factors for HDPs, the investigators suggested, citing existing first-trimester screening algorithms such as the U.K. Fetal Medicine Foundation preeclampsia model based on maternal history and biomarkers. (medpagetoday.com)
  • OBJECTIVE: To describe the epidemiology, risk factors, and timing of spontaneous intestinal perforation (SIP) among infants born at 22-24 weeks' gestational age (GA). STUDY DESIGN: Observational cohort study among infants born at 22-24 weeks' GA in 446 neonatal intensive care units. (bvsalud.org)
  • The counselor should also discuss both the mother's and father's risk(s) for transmitting genetic abnormalities to the fetus. (cdc.gov)
  • In the United States, the current standard of care in obstetrical practice is to offer either CVS or amniocentesis to women who will be greater than or equal to 35 years of age when they give birth, because these women are at increased risk for giving birth to infants with Down syndrome and certain other types of aneuploidy. (cdc.gov)
  • The aim of this study was to investigate maternal and neonatal risk factors for type 1 diabetes in children under 15 years old in Grampian, Scotland. (biomedcentral.com)
  • Conditional logistic regression was used to evaluate the association between various maternal and neonatal factors and the risk of type 1 diabetes. (biomedcentral.com)
  • This case-control study found limited evidence of a reduced risk of the development of type 1 diabetes in children whose mothers smoked, compared to children whose mothers did not. (biomedcentral.com)
  • Many investigators have focussed on the relationship between maternal and neonatal factors and the subsequent risk of type 1 diabetes. (biomedcentral.com)
  • Unadjusted models estimated a 2.04 increased risk of gestational diabetes in 2019 compared with 2005. (scienceboard.net)
  • Despite concerns that a higher proportion of pregnant women with high body mass index, older maternal age, or greater obstetric risk were leading to higher rates of gestational diabetes, these factors did not significantly contribute to the yearly increase in gestational diabetes in British Columbia across the 15-year study period. (scienceboard.net)
  • Thus, we determined FNDC5 polymorphisms frequencies in the Israeli population and demonstrated that maternal and neonatal FNDC5 rs726344 polymorphism is significantly associated with increased risk for PTB. (bgu.ac.il)
  • A number of risk factors have been identified for small for gestational age and preterm birth. (springer.com)
  • This paper finds an association between maternal financial strain and risk of preterm birth that is as high as that for smoking. (springer.com)
  • Gestational exposure to antipsychotic drugs is [also] unlikely to pose a significant risk of preterm birth and small for gestational age in children. (sciencealert.com)
  • Medication aside, underlying maternal psychiatric disorders may well be associated with the risk of ADHD and ASD in children, the Hong Kong study found. (sciencealert.com)
  • In research published in the journal Proceedings of the National Academy of Sciences (PNAS), ISB researchers have shown how an individual's genetic risk for disease is often reflected in their blood. (isbscience.org)
  • Additionally, two poor maternal cardiovascular health metrics were associated with double the risk of having a child with one poor CVH metric (RR 2.02, 95% CI 1.55-2.64), researchers found. (medpagetoday.com)
  • Additionally, we found that increasing number of non-chromosomal anomalies was associated with a stronger risk of cancer. (plos.org)
  • A 2012 study suggested that women who gave birth to their last or only child at age 40 or older had a lower risk for uterine cancer. (healthline.com)
  • An older mother has a higher risk of gestational diabetes, pre-eclampsia and other complications, including passing on genetic defects. (healthday.com)
  • Overall, the risk for death among people with diabetes is about twice that of people without diabetes of similar age. (diabetesnv.org)
  • Such complications include low birth weight, higher rates of neonatal mortality, placental malaria infection, reduced transfer of maternal antibodies and increased risk of mother-child transmission of HIV. (biomedcentral.com)
  • Information on the impact of maternal, gestational or neonatal characteristics on milk macronutrient composition could help identify mother-infant pairs at higher risk of extrauterine growth restriction and move towards a more individualized nutritional support [ 24 ]. (nature.com)
  • Many genetic variants have been shown to be associated with an increased risk of ischaemic heart disease and many more are likely to exist which remain to be discovered. (bmj.com)
  • In the present study we used family history of premature death from ischaemic heart disease as a proxy measure of overall genetic predisposition, and predicted that women with a positive family history would be at increased risk of a low birth weight baby. (bmj.com)
  • Each increasing year of maternal childbearing was associated with a 14% reduction (OR = 0.86, p\0.001) in the risk of early sexual intercourse (before the age of 14). (nlsinfo.org)
  • Due to advances in recent decades in maternal-foetal and neonatal medicine, a greater survival of preterm infants with progressively smaller birth weight and gestational age is observed, increasing the risk of future morbidities on those infants. (bvsalud.org)
  • A two- to fivefold increased risk of preterm premature rupture of membranes (risk varies by gestational age). (medilib.ir)
  • The risk of GDM is determined by both genetic susceptibility and environmental factors. (biomedcentral.com)
  • Genetics contributes to mental health risks in adoptees Genetics and early life stress both important factors for mental health problems in adults adopted as children, says large genetic risk study in Biological Psychiatry Philadelphia, January 29, 2020 - The adoption of children is a fundamental method of building families. (marketposters.com)
  • We found small differences in favor of the non-adopted peers ( N = 2021), while a minority of male domestic adoptees were at risk of anxiety/depression problems. (marketposters.com)
  • Thus, while children put up for adoption were at increased genetic risk for developing symptoms of mental illness, the adoption process did not appear to increase the impact of this genetic risk. (marketposters.com)
  • We found adopted individuals on average had a somewhat higher genetic risk for mental health problems, but the effects are quite small," said lead author Kelli Lehto, PhD, a postdoctoral researcher at Karolinska Institute in Stockholm. (marketposters.com)
  • Therefore, both from an aetiological and a public health perspective, there is a growing need to understand the role of non-genetic factors on the risk of T1D. (lu.se)
  • A social epidemiological approach would appear very relevant in this scenario as many of the non-genetic/environmental factors, known to be associated with T1D risk, are conditioned by socioeconomic circumstances at different. (lu.se)
  • It also revisits previously described associations between, on the one hand, socioeconomic and perinatal factors and, on the other, T1D risk. (lu.se)
  • Concretely, this thesis investigates geographical variation in cumulative incidence of T1D, the association between maternal smoking habits and T1D risk, and seasonal trends in cord blood islet autoantibodies (Abs). (lu.se)
  • To investigate the association between maternal smoking habits and T1D risk, we applied a propensity score matching analysis and investigated T1D risk in siblings from the same mother. (lu.se)
  • For children born in the summer, HLA-DQ genetic risk and gestational infections were independently associated with the presence of islet Abs in the cord blood. (lu.se)
  • Taking zinc by mouth, especially with antioxidant vitamins, might help slow vision loss and prevent age-related vision loss from becoming advanced in people at high risk. (medlineplus.gov)
  • When both CYP1A1 and GSTT1 were considered, the greatest decrease was found among exposed mothers with the CYP1A1 AA-GSTT1 absent group (0.79 (SE, 0.25) week) and the CYP1A1 AA-GSTT1 present group (0.50 (SE, 0.22) week). (cdc.gov)
  • data on gestational age have been available since 1988 for the offspring of white mothers and black mothers and since 1997 for Hispanic mothers. (cdc.gov)
  • No association was evident in children whose mothers had cotinine levels ≤1.90 ng/ml. (biomedcentral.com)
  • Mothers were around 30 years old on average, and the average age among children was 11. (medpagetoday.com)
  • Compared with mothers who had all ideal metrics, those in poorer maternal cardiovascular health categories were more likely to have kids with one or two poor cardiovascular metrics as well. (medpagetoday.com)
  • From 2000 to 2014, the age of first-time mothers increased 1.4 years -- from 24.9 years old on average to 26.3 years, according to a new report from the U.S. Centers for Disease Control and Prevention. (healthday.com)
  • Results There was a positive association between maternal non-reacting mindfulness skills and child social-emotional development at 2 years of age, regardless of mothers' perinatal mental health, whereas other mindfulness facets were unrelated. (researchgate.net)
  • For instance, offspring born to teenage mothers were 2.46 times more likely to have sex before the age of 14 than offspring born to non-teenage mothers. (nlsinfo.org)
  • Sociodemographic variables and maternal biochemical profile without statistical differences in the comparison of the mothers of the initial sample with those who completed the follow-up. (bvsalud.org)
  • The etiology of these anomalies is not ples haemolysed and some control mothers completely understood and has often been did not agree to enter the study, the final considered multifactorial, with genetic and sample for the control group was 36. (who.int)
  • Currently, it is difficult to define when these metrics should be measured to indicate cardiovascular health as well as the ideal gestational age to ascertain health status, he said. (medpagetoday.com)
  • Maternal cardiovascular health was assessed via the five CVH metrics of BMI, blood pressure, cholesterol levels, glucose levels, and history of smoking. (medpagetoday.com)
  • When children reached 10 to 14 years of age, they were assessed for all of the same metrics, with the exception of smoking. (medpagetoday.com)
  • The association remained when controlling for maternal covariates and when comparing siblings differentially exposed (b = -0.04 SD/year at childbearing, p\0.001). (nlsinfo.org)
  • Comparison of unrelated individuals in the sample indicated a robust inverse association, with the relation being larger at higher levels of income and for male offspring, even when statistical covariates were included to account for measured confounds that distinguish different families. (nlsinfo.org)
  • This study investigated whether the association between low level benzene exposure and shortened gestation is modified by two susceptibility genes, CYP1A1 and GSTT1. (cdc.gov)
  • MTHFR-CLCN6 , WNT3A , NPR3 , PGR , and RGL3 ) -- based on an expanded multi-ancestry genome-wide association study (GWAS) meta-analysis for preeclampsia/eclampsia and a separate GWAS for gestational hypertension alone. (medpagetoday.com)
  • A finding of preeclampsia can only be treated by delivery, timed according to gestational age and whether severe features of preeclampsia are present. (medpagetoday.com)
  • Included in the study were 20,064 preeclampsia/eclampsia cases with 703,117 control individuals, and 11,027 gestational hypertension cases accompanied by 412,788 control individuals. (medpagetoday.com)
  • It is additionally unknown whether any impacts of preeclampsia are independent of confounders including shared genetic factors that predispose to both preeclampsia and childhood morbidity, perinatal factors including small for gestational age or preterm birth and their sequelae, and postnatal environmental factors such childhood nutrition. (biomedcentral.com)
  • They found, however, that the sensitivity of first-trimester uterine artery Doppler is greater for SGA with preeclampsia than it is for IUGR alone and noted that this difference could be the result of different underlying placental abnormalities that are detected variably on first-trimester uterine artery Doppler evaluation. (medscape.com)
  • A realization in recent years of its association with severe diseases such as carditis, low birth weight babies, and preeclampsia has instigated dedicated research in this area. (encyclopedia.pub)
  • To investigate association between maternofoetal complications and the amount of proteinuria measured by spot urine protein creatinine ratio in patients with preeclampsia. (hindawi.com)
  • Preeclampsia is a major health problem in maternal health with the prevalence ranging from 1.8% to 16.7% in developing countries [ 1 ]. (hindawi.com)
  • Recently, great interest has been shown by investigators all around the world to find out predictors/markers that can predict the maternofoetal outcome in patients with preeclampsia [ 6 - 8 ]. (hindawi.com)
  • A couple of studies have also been done to find out association between the amount of proteinuria and maternofoetal outcome in patients with preeclampsia but the results have been variable [ 9 - 11 ]. (hindawi.com)
  • At our centre, we have found relatively high prevalence of maternofoetal complications in patients with preeclampsia. (hindawi.com)
  • This study was carried out in patients with preeclampsia to estimate the prevalence of maternal and foetal morbidity and to investigate the association between the amount of proteinuria measured by spot UPCR and maternofoetal outcome. (hindawi.com)
  • Question: Is there an association between low Vitamin B12 levels and preeclampsia? (preeclampsia.org)
  • That makes this finding hard to interpret beyond the knowledge that women with preeclampsia have lower B12 levels because it is not clear why different studies got different results. (preeclampsia.org)
  • Gestational diabetes occurs when a hormone made by the placenta prevents the body from using insulin properly. (scienceboard.net)
  • Passive and active transport of bone-minerals occurs across the placenta to achieve higher fetal concentration of calcium, phosphate, and magnesium compared to maternal levels. (frontiersin.org)
  • Fetal blood calcium concentrations are maintained ~0.3-0.5 mmol/L higher than in maternal circulation, with the placenta transporting 100-150 mg/kg/day of calcium during the third trimester ( 4 - 6 ). (frontiersin.org)
  • Models were adjusted for potential maternal, socioeconomic, and child confounders such as maternal education, deprivation, and gestational age. (biomedcentral.com)
  • This multisystem disorder affects millions of women worldwide and is recognized as an important direct cause of maternal and foetal morbidity and mortality [ 2 ]. (hindawi.com)
  • As there were differences in morbidity and mortality depending on the birth weight for gestational age, International Societies of Pediatric Endocrinology and the Growth Hormone Research Society (2007) suggested the criteria according to the birth weight for gestational age. (e-apem.org)
  • Approximately 48% of infants with gastroschisis are small for gestational age. (medscape.com)
  • We found that the infants of Group 1 showed advanced stages of ROP in comparison to Group 2. (hindawi.com)
  • The infants were divided into two groups based on their gestational age. (hindawi.com)
  • In 1991, concerns about the relative safety of these procedures arose after reports were published that described a possible association between CVS and birth defects in infants. (cdc.gov)
  • Hokken-Koelega and coauthors describe an international consensus guideline on treatment of infants and older children small for gestational age, including discussion of newly identified genetic and epigenetic causes. (endocrine.org)
  • It found women on antipsychotics are no more likely to give birth early or to underweight infants, than healthy pregnant women are. (sciencealert.com)
  • Growth of preterm infants, although linear, was lower than expected for age. (bvsalud.org)
  • The severity of ROP was associated with earlier gestational age, lower birth weight, and oxygen supplementation. (hindawi.com)
  • Dr Levine noted that the rates of vitamin supplementation in the current study were largely similar to those found in previous registry-based research. (medscape.com)
  • For the period 1978--2005, CDC assessed the overall prevalence of major birth defects and their frequency relative to selected maternal and infant characteristics. (cdc.gov)
  • In this context, we aimed to measure macronutrient content of very preterm milk and to identify changes associated with time and maternal, gestational and neonatal characteristics. (nature.com)
  • The association between MAC and early sexual activity remained when controlling for maternal characteristics, such as race/ethnicity, adolescent delinquency, depression, and educational level, and when comparing differentially exposed siblings (OR = .93, p\0.05). (nlsinfo.org)
  • Material and Methods: Linking the Swedish Medical Birth Registry with the Hospital Discharge Registry and other population databases with socioeconomic information, all newborns born between 1987 and 1993 (n = 811,599) were followed for development of T1D until the age of 14. (lu.se)
  • However, genome-wide association studies (GWAS) on genetic factors for GDM are very limited [ 8 ]. (springer.com)
  • However, the researchers found that the increase was largely due to changes in gestational diabetes screening practices, from a two-step screening process to a more sensitive one-step screening process. (scienceboard.net)
  • The researchers say their study highlights the importance of having accurate data on screening methods and completion to better understand the rising incidence of gestational diabetes observed elsewhere. (scienceboard.net)
  • Researchers from Rady Children's Institute for Genomic Medicine have found that the genetic disease contribution to infant deaths is higher than expected. (scienceboard.net)
  • What did the researchers do and find? (plos.org)
  • ISB researchers and their collaborators have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn predict survival in a population of older individuals. (isbscience.org)
  • Washington, D.C., saw the highest increase -- 3.4 years -- followed by Oregon where the average age rose 2.1 years, the researchers found. (healthday.com)
  • Adoptees reported more symptoms of depression, attention-deficit/hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD) and perfectionism than non-adopted adolescents, but there were no differences regarding … The researchers found a … We examined the mental health problems of Dutch young adult domestic adoptees (N = 75) relative to Dutch non-adopted peers and Dutch international adoptees. (marketposters.com)
  • An interaction between genetic susceptibility and environmental factors is thought to be involved in the aetiology of type 1 diabetes. (biomedcentral.com)
  • No evidence was found of a significant association between other maternal and neonatal factors and childhood type 1 diabetes. (biomedcentral.com)
  • However, the evidence on the role of many maternal and neonatal factors in the development of childhood type 1 diabetes is inconclusive and only one study has presented data on the Scottish population [ 5 ]. (biomedcentral.com)
  • This was used to account for genetic and environmental factors that could be shared among kids born to the same mum. (sciencealert.com)
  • Also, significant discoveries including new embryological molecular genetic transcription factors, the role of active placental mineral transport, and hormone regulation factors have changed the understanding of calcium and phosphate homeostasis in the fetus and the newborn. (frontiersin.org)
  • This study in Egypt investigated the influence of selected maternal factors on neonatal birth size. (who.int)
  • Because of these factors, your fertility begins to gradually decline at around age 32. (healthline.com)
  • The fertility treatment your doctor recommends depends on factors like the cause of your fertility issues, your age, and your preferences. (healthline.com)
  • The SMR2 database provided information on birth weight and gestational age at delivery, and SMR2 and WOSCOPS provided data on potential confounding factors. (bmj.com)
  • Offspring also were compared to their siblings and cousins who were exposed to different levels of family income in childhood to rule out unmeasured environmental and genetic factors confounded with family income as explanations for the association. (nlsinfo.org)
  • Among them are those that affect growth, which is a continuous process resulting from the interaction of genetic, hormonal, environmental and nutritional factors 2 . (bvsalud.org)
  • Background and Aims: While the development of type 1 diabetes (T1D) in childhood is in part genetically conditioned, non-genetic/environmental factors seem to play a decisive role in its aetiology. (lu.se)
  • Growth is influenced by genetic and nutritional factors as well as intrauterine conditions. (msdmanuals.com)
  • This was conducted among Korean women and demonstrated a potentially shared genetic basis between GDM and type 2 diabetes [ 9 ]. (springer.com)
  • OBJECTIVE: To examine the association between diabetes stigma and HbA1c, treatment plan and acute and chronic complications in adolescents and young adults (AYAs) with type 1 or type 2 diabetes. (cdc.gov)
  • In addition, the incidence of type 2 diabetes (T2DM) for GDM women is as high as 50% to 70% during postpartum follow-up [ 5 ], making GDM a main source of T2DM in middle-aged women. (biomedcentral.com)
  • Associations between changes in the maternal gut microbiome and differentially methylated regions of diabetes-associated genes in fetuses: A pilot study from a birth cohort study. (nih.gov)
  • Associations with trajectories of estimated fetal weight (EFW) and individual fetal parameters (head circumference, femur length [FL], and abdominal circumference [AC]) from 12-16 to 40 weeks' gestation were analysed using multilevel fractional polynomial models. (plos.org)
  • The Brazil Ministry of Health developed a case definition for Zika virus-related microcephaly (head circumference ≥2 standard deviations [SD] below the mean for sex and gestational age at birth). (cdc.gov)
  • A significant positive correlation between maternal anthropometric variables with neonatal birth dimensions was observed and the effect was more evident in girls than boys for BMI and head circumference. (who.int)
  • When stratified by the maternal CYP1A1 genotype, the estimated decrease was 0.54 (SE, 0.12) week for the AA group, which was significantly greater (p = 0.003) than that for the Aa/aa group, which showed no decrease in gestational age. (cdc.gov)
  • Genotype-phenotype associations were analyzed using SPSS program. (bgu.ac.il)
  • We found significant FNCD5 rs726344 genotype frequencies control and PTB groups. (bgu.ac.il)
  • We compared results from (1) confounder-adjusted multivariable analyses, (2) a Mendelian randomization (MR) analysis using maternal rs1051730 genotype as an instrument for smoking quantity and ease of quitting, and (3) a negative control analysis comparing maternal and mother's partner's smoking associations. (plos.org)
  • A general linear model was used to assess the relationship between maternal urinary cotinine level and neurodevelopment. (biomedcentral.com)
  • A detailed history included the gender, the gestational age, the birth weight, the need for intubation and blood transfusion, and the appearance of sepsis. (hindawi.com)
  • She has been examining trends at the population level through analyses using a statewide database from California, focusing first on preterm birth, and with plans to extend the analyses to examine both low birth weight and small for gestational age births. (hopkinsmedicine.org)
  • High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer's disease (AD), and neurological damage associated with epilepsy, fetal alcohol syndrome, and inherited conditions such as Down and Rett syndromes. (mdpi.com)
  • The MACDP results indicated that the prevalence of major birth defects in metropolitan Atlanta, Georgia, remained stable during 1978--2005 but varied by maternal age and race/ethnicity, birthweight, and gestational age. (cdc.gov)
  • The global prevalence of diabetes* among adults over 18 years of age rose from 4.7% in 1980 to 8.5% in 2014 (1). (diabetesnv.org)
  • The prevalence of HIV infection and malaria-HIV coinfection was too low to allow meaningful analysis of their association with anemia or hemoglobin concentration. (biomedcentral.com)
  • Statistically significant negative correlations were found between maternal haemoglobin levels and birth size. (who.int)
  • Statistically significant association was found between the frequencies of various complications in mother and newborn and spot UPCR. (hindawi.com)
  • Cordero M. Scerif G. Mahedy L. Evans J. Abioye A. Stein A. Maternal perinatal mental health and offspring academic achievement at age 16: the mediating role of childhood executive function . (bristol.ac.uk)
  • The frequency of various maternal and foetal complications was between 14-53% and 22-92%, respectively. (hindawi.com)
  • Enzyme-linked immunosorbent assays were used to investigate maternal plasma iNOS levels. (medscimonit.com)
  • March 20, 2023 -- A study published Monday in the Canadian Medical Association Journal found that although gestational diabetes is reportedly on the rise, changes in screening practices may largely explain the increase. (scienceboard.net)
  • Contrary to expectation, maternal distress in Pakistani women was negatively associated with SGA (OR 0.65: CI 0.48-0.88). (springer.com)
  • Scientists at the NIH's National Human Genome Research Institute (NHGRI) have found a set of small RNA molecules, called microRNAs, in human pancreatic. (scienceboard.net)
  • Objectives Preterm birth (PTB) and small for gestational age (SGA) are major causes of perinatal mortality and morbidity. (springer.com)
  • With this definition, IUGR and "small for gestational age" are synonymous terms. (medscape.com)
  • Children born small for gestational age (SGA) have several life-long consequences. (e-apem.org)
  • Major structural or genetic birth defects affect approximately 3% of births in the United States, are a major contributor to infant mortality ( 1,2 ), and result in billions of dollars in costs for care ( 3 ). (cdc.gov)
  • Information about identified defects among live births is updated until age 6 years. (cdc.gov)
  • Also, first births to women aged 30 to 34 rose 28 percent, while first births among women 35 and older increased 23 percent. (healthday.com)
  • In Scotland, between 1984 and 2003 the incidence of childhood type 1 diabetes increased by 2.6% per year, and this rise has been greater in children aged under 5 years [ 2 ]. (biomedcentral.com)
  • Because growth-restricted fetuses have a high incidence of structural and genetic abnormalities, an ultrasonographic examination of fetal anatomy also is recommended. (medscape.com)
  • Mechanism-based insights into the disease pathogenesis and association are highly relevant and shall be useful in avoiding any systemic complications. (encyclopedia.pub)
  • Recognize maternal and fetal complications of AT deficiency. (blogspot.com)
  • Maternofoetal complications and outcome correlate with maternal spot UPCR. (hindawi.com)
  • For those found to have growth restriction, the ACR notes that duplex Doppler velocimetry of the umbilical artery and a biophysical profile are usually appropropriate. (medscape.com)
  • The most frequently studied vessel in Doppler velocimetry is the umbilical artery because of its accessibility and association with fetal outcome. (medscape.com)
  • Parathyroid hormone related peptide (PTHrP) was first described in 1985 as a new compound with parathyroid hormone (PTH)-like bioactivity that accounted for the discrepancy between human umbilical cord and maternal PTH levels ( 1 ). (frontiersin.org)
  • It then rapidly begins to develop the physiologic changes that establish maternal-placental exchange. (medscape.com)
  • Systematic case-finding by the abstractors at each hospital includes review of labor and delivery logs, nursery and intensive-care logs (including neonatal intensive-care logs), stillbirth and pathology logs, and disease indices. (cdc.gov)
  • The primary exclusion criteria were cases where ROP developed in newborns of more than 30 weeks of gestational age and the cases where medical notes were unavailable or incomplete. (hindawi.com)
  • Less is known about associations with presence of non-chromosomal anomalies. (plos.org)
  • Genotypes of maternal and neonatal FNDC5 polymorphisms (rs726344 and rs1746661) were determined by restriction fragment length polymorphism analysis. (bgu.ac.il)
  • There was no significant association of the rs1746661 polymorphism with PTB. (bgu.ac.il)
  • This effect might be modified by genetic polymorphism and breastfeeding behavior. (biomedcentral.com)
  • Mediation models were used to examine the associations between the classification of maternal metabolic syndrome and child developmental milestones. (biomedcentral.com)
  • Additionally, we made use of a population based genetic study (Diabetes Prediction in Skåne (DiPiS)) to examine for seasonal trends in cord blood islet Abs. (lu.se)