Genetic among asian continental ancestry group. Medical search. Frequent questions

Human genetic clustering refers to patterns of relative genetic similarity among human individuals and populations, as well as the wide range of scientific and statistical methods used to study this aspect of human genetic variation. (wikipedia.org)
Clustering studies are thought to be valuable for characterizing the general structure of genetic variation among human populations, to contribute to the study of ancestral origins, evolutionary history, and precision medicine. (wikipedia.org)
A wide range of methods have been developed to assess the structure of human populations with the use of genetic data. (wikipedia.org)
In other words, algorithms like STRUCTURE generate results that assume the existence of discrete ancestral populations, operationalized through unique genetic markers, which have combined over time to form the admixed populations of the modern day. (wikipedia.org)
For example, many clustering studies use data derived from populations that are geographically distinct and far apart from one another, which may present an illusion of discrete clusters where, in reality, populations are much more blended with one another when intermediary groups are included. (wikipedia.org)
The population frequency of the indel (rs66698963) is remarkably different among human populations with the insertion being far more frequent in South Asians, Africans and some East Asian populations, and far less common in European and other East Asian populations. (fatsoflife.com)
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. (ox.ac.uk)
In order to determine a new subject's genetic ancestry, Parabon Snapshot analyzes tens of thousands of SNPs from a DNA sample to determine a person's percent membership in each of these global populations. (parabon-nanolabs.com)
Most other forensic ancestry systems use only a small number of SNPs and thus are limited to very coarse populations and cannot detect admixture between populations. (parabon-nanolabs.com)
Parabon's scientists have collected data from many published scientific articles, totalling more than 9,000 individuals with clearly defined ancestry from more than 150 populations around the world, as shown in the map below. (parabon-nanolabs.com)
Academic research using hundreds of thousands of SNPs from across the genome has shown that human groups generally divide into seven continental populations, which have been established over the past 50,000 years during the migration out of Africa. (parabon-nanolabs.com)
The 150 populations collected as the ancestry background can thus be divided into these seven continental groups according to their origin. (parabon-nanolabs.com)
Snapshot takes a similar approach to identifying within-continental (regional) ancestry, although the local populations were identified through empirical analysis performed by our bioinformatics team. (parabon-nanolabs.com)
In an ancestry analysis, Snapshot will determine an individual's precise genetic origins, as well as whether there is any evidence of admixture (contribution from multiple populations). (parabon-nanolabs.com)
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. (ox.ac.uk)
The assessment of cattle diversity reported here contributes an unbiased global view to genetic differentiation and structure of taurine and zebu cattle populations, which is essential for an effective conservation of the bovine genetic resources. (biomedcentral.com)
Several research initiatives have combined molecular marker datasets with historic and archaeological records in order to investigate the origin, history, genetic diversity, and differentiation of cattle populations (see Groeneveld et al . (biomedcentral.com)
Interethnic analyses of blood pressure loci in populations of East Asian and European descent. (ox.ac.uk)
We classified those articles on the basis of their samples into high-risk and low-risk populations and white and Asian ethnic groups. (ox.ac.uk)
TMB-high was significantly associated with improved outcomes only in European ancestries and merits validation in non-European ancestry populations. (bvsalud.org)
For example, the incidence rate of liver cancer has been shown with substantial disparity between Hispanic, Asian and non-Hispanic white populations. (omicsdi.org)
RESULTS:In this study we designed an unique AIM panel that infers 3-way genetic admixture from three distinct and selective continental populations (African (AFR), European (EUR), and East Asian (EAS)) within evolutionarily conserved exonic regions. (omicsdi.org)
Obviously individuals and populations exhibit genetic relationships to each other contingent upon the patterns of the variation of base pairs (A, C, G, and T) across the genomes of individuals, but there's no reasonable way to comprehend this 'by eye' when you're talking about hundreds of thousands of markers. (discovermagazine.com)
Genetic analyses show that this pre-Neolithic forager, who is associated with the 'Toalean' technocomplex3,4, shares most genetic drift and morphological similarities with present-day Papuan and Indigenous Australian groups, yet represents a previously unknown divergent human lineage that branched off around the time of the split between these populations approximately 37,000 years ago5. (anthropogeny.org)
These migrations resulted in gene flow across vast areas, ultimately linking pastoralist populations in Scandinavia with groups that expanded into Siberia. (mpg.de)
The 93 SNP AIM subset had substantially larger intercontinental paired Fst values than the random SNPs for any of the pairs of population groups from the sub-Saharan African, Amerindian, East Asian, Oceana and European (excluding the South Asian populations) continental groups (Table 1). (familytreedna.com)
A new effort to catalog genetic diversity among people in Mexico--who along with other Latin Americans have a unique ancestry--could shed light on diseases that affect these groups disproportionately, and on why some drugs may work more or less effectively in these populations. (acm.org)
Glioma incidence is highest in non-Hispanic Whites, and to date, glioma genome-wide association studies (GWAS) to date have only included European ancestry (EA) populations. (elsevierpure.com)
We estimated global and local ancestry using fastStructure and RFMix, respectively, using 1,000 genomes project reference populations. (elsevierpure.com)
While the Argentinean and Brazilian national populations have roughly the same degree of pre-1500 European ancestry, Argentine has a White European national image while Brazil has a multiracial one. (humanvarieties.org)
Across the Americas, Amerindian and African (versus European) ancestry was found to be negatively correlated in admixed populations (e.g. (humanvarieties.org)
At the Tokyo meeting, for example, it was noted that even among the Japanese researchers, there was no unitary understanding of what populations should be considered "Asian. (mixedracestudies.org)
Human genetic research, race, ethnicity and the labeling of populations: recommendations based on an interdisciplinary workshop in Japan ," BMC Medical Ethics , (Volume 15, Issue 1, December 2014). (mixedracestudies.org)
Because of extensive admixture among these various groups, the Brazilian population shows great variability in terms of Populations on different continents vary considerably in their skin pigmentation, phenotypic features, and genomic structure [2]. (cdc.gov)

We present age-specific incidence rates of MS from two ongoing prospective cohort studies of US women-the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHS II)-and compare them by ancestry and geographic region. (neurology.org)

There are caveats and limitations to genetic clustering methods of any type, given the degree of admixture and relative similarity within the human population. (wikipedia.org)
This analysis is robust to admixture, such that each piece of continental ancestry can be precisely localized within that continent. (parabon-nanolabs.com)
Therefore, the genetic admixture may cause biased genetic association study with cancer susceptibility variants specifically in Hispanics. (omicsdi.org)
Currently, ancestry informative marker (AIM) panels have been widely utilized with up to a few hundred ancestry-informative single nucleotide polymorphisms (SNPs) to infer ancestry admixture. (omicsdi.org)
If your family is Puerto Rican it is not at all unusual to have African ancestry, African ancestry on numerous lines, no family phenotypes that seem African in appearance, and no records identifying admixture events. (familytreedna.com)
AncestryDNA, 23andMe, FamilyTreeDNA Family Finder and Genographic2.0 all offer much more reliable ancestry admixture assays than AbDNA. (familytreedna.com)
These data provide additional support for using the 93 AIM set to efficiently identify continental subject groups for genetic studies, to identify study population outliers, and to control for admixture in association studies. (familytreedna.com)
And even as fun experiments with ADMIXTURE go, it's now horribly outdated, and probably useless for anyone with less than 15-20% Ashkenazi ancestry. (blogspot.com)
However since claiming Cherokee roots is so controversial I decided to preface my client's analysis with brief genealogical records of his claim but this blog focuses more on genetic admixture. (rootsandrecombinantdna.com)
Previously, a literature review was conducted regarding continental racial admixture and educational attainment and/or socioeconomic status. (humanvarieties.org)
Some of these predict that the ancestry-outcome association will generalize spatially, such that admixture will be correlated with outcomes across regions and nations. (humanvarieties.org)
The association between regional ancestral and cognitive related outcome variation in Mexico will first be explored, since for this county reliable regional admixture estimates, at least with regards to European and Amerindian ancestry, and outcome measures are available and also since there is a good deal of spatial variation in admixture (and outcomes). (humanvarieties.org)

This study reports a 22-bp nucleotide insertion-deletion (indel) genetic polymorphism that may be causally related to the control of gene expression of the fatty acid desaturases, enzymes that control the biosynthesis of long-chain polyunsaturated fatty acids (LCPUFA) from 18-carbon PUFA. (fatsoflife.com)
The polymorphism was present as an insertion in cells derived from a group of Japanese individuals, but was completely absent (a deletion) in others, albeit with a lower frequency (hence called the minor allele). (fatsoflife.com)
Studies that assessed the relationship between treatment response and genetic polymorphism of the serotonin transporter gene were eligible for inclusion. (york.ac.uk)
After attributing a regional and/or continental ancestry to each individual using genome-wide polymorphism data, we are able to capture the effect of different environmental exposures on gene expression and health-related traits, while simultaneously controlling for genetic relatedness and migration. (nature.com)

Genetic predisposition to risk for or protection from type 1 diabetes (T1D) is highly polygenic, with the total possible set of disease-associated variants yet to be fully defined 1 . (nature.com)

We developed a framework for inference of germline variants from tumor panel sequencing, including imputation, quality control, inference of genetic ancestry, germline polygenic risk scores, and HLA alleles. (biomedcentral.com)
Inspection of specific genes related to AJ genetic disorders identified known disease mutations as well as dozens of additional risk alleles. (blogspot.com)

Although cluster analyses invariably organize humans (or groups of humans) into subgroups, debate is ongoing on how to interpret these genetic clusters with respect to race and its social and phenotypic features. (wikipedia.org)
Studies on polymorphisms found in one cluster of closely-located genes coding for fatty acid desaturases (FADS), enzymes that play an important role in the biosynthesis of both omega-6 and omega-3 LCPUFA, are providing an interesting perspective on the interaction between traditional diets and the population genetic history of humans. (fatsoflife.com)
According to Nicholas Wade, "Humans cluster into five continental groups or races, and within each race there are further subclusters. (thisviewoflife.com)
Much of his assertion that biological races exist within humans is contingent upon both his uncritical acceptance and misrepresentation of the significance of STRUCTURE type analyses of human genetic diversity. (thisviewoflife.com)

Complementary methods for detecting genetic variants associated with T1D. (nature.com)
We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. (ox.ac.uk)
At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. (ox.ac.uk)
Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. (ox.ac.uk)
otherwise the genetic architecture was similar between PCOS diagnosed by self-report and PCOS diagnosed by NIH or non-NIH Rotterdam criteria across common variants at 13 loci. (ox.ac.uk)
Publicly available genetic summary data have high utility in research and the clinic, including prioritizing putative causal variants, polygenic scoring, and leveraging common controls. (omicsdi.org)
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. (wakehealth.edu)
They looked at 450,000 genetic variants (SNPs) per person (there are somewhat more than 10 million SNPs in the human genome). (discovermagazine.com)
Prior nDNA researchers who analyzed the DNA of individuals from many different countries found genetic variants that are associated with particular groups. (anthrohealth.net)
For ease of analysis, these variants were lumped into three continental groups: Asian, European, and African. (anthrohealth.net)
Our findings demonstrate how the local environment directly affects disease risk phenotypes and that genetic variation, including less common variants, can modulate individual's response to environmental challenges. (nature.com)
Over the last few years, scientists have discovered hundreds of genetic variants linked to disease. (acm.org)
The research might also help uncover rare genetic variants responsible for a significant portion of the genetic risk of disease. (acm.org)
[6] [13] About half of these genetic cases are due to disease-causing variants in one of four specific genes . (wikipedia.org)

Early studies of within and between-group genetic variation used physical phenotypes and blood groups, with modern genetic studies using genetic markers such as Alu sequences, short tandem repeat polymorphisms, and single nucleotide polymorphisms (SNPs), among others. (wikipedia.org)
By processing a large number of SNPs (or other genetic marker data) in different ways, both approaches to genetic clustering tend to converge on similar patterns by identifying similarities among SNPs and/or haplotype tracts to reveal ancestral genetic similarities. (wikipedia.org)
Where EuroDNA 1.0 used just 320 SNPs to delineate people of European ancestry into four groups â€" Northern European, Southeastern European, Middle Eastern, and South Asian â€" EuroDNA 2.0 uses 1,349 SNPs. (thegeneticgenealogist.com)
2007 paper, looking for the SNPs that provided most of the European Ancestry Information. (thegeneticgenealogist.com)
Snapshot uses tens of thousands of SNPs across the genome to obtain very precise estimates of ancestry, even for admixed individuals. (parabon-nanolabs.com)
We report a meta-analysis of four large genome-wide association studies of CAD, with ∼575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. (ox.ac.uk)

Latino ancestry is a mixture of European and Native American ancestry, so these groups are shown as well. (parabon-nanolabs.com)
For the purposes of analysis in the US, Asian is a proxy for Native American since genetic research has shown that these groups have a common origin. (anthrohealth.net)
Hispanics are a relatively young--about 500-year-old--amalgam of three major continental groups--European, Native American, and African--and make up about 15 percent of the world's population. (acm.org)
African Americans and Hispanics in the US have varying proportions of EA, African (AA) and Native American ancestries (NAA). (elsevierpure.com)

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. (ox.ac.uk)

Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. (ox.ac.uk)
BACKGROUND:Europeans and American Indians were major genetic ancestry of Hispanics in the U.S. These ancestral groups have markedly different incidence rates and outcomes in many types of cancers. (omicsdi.org)
We also inferred the split between the ancestral Middle-Eastern population and contemporary Europeans to be as recent as ≈11,000±500ya, suggesting the genetic origin of modern-day Europeans is predominantly Neolithic, and much later than the first dated Homo sapiens migration into Europe. (blogspot.com)

In addition to constituting fascinating signatures of the population genetic history, diverse types of genetic variance are also of importance to human health and chronic disease susceptibility. (fatsoflife.com)

Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). (ox.ac.uk)
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. (ox.ac.uk)
The data thus demonstrate 3 novel loci associated with PCOS and similar genetic architecture for all diagnostic criteria. (ox.ac.uk)

Linkage disequilibrium score regression analysis revealed genetic correlations with obesity, fasting insulin, type 2 diabetes, lipid levels and coronary artery disease, indicating shared genetic architecture between metabolic traits and PCOS. (ox.ac.uk)

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (ox.ac.uk)
Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. (ox.ac.uk)
We apply Summix to gnomAD v.2.1 exome and genome groups and subgroups, finding heterogeneous continental ancestry for several groups, including African/African American (∼84% AFR, ∼14% EUR) and American/Latinx (∼4% AFR, ∼5% EAS, ∼43% EUR, ∼46% IAM). (omicsdi.org)
We used an integrative approach to comprehensively assess the interactions between 1.6 million data points, encompassing a range of environmental exposures, health, and gene expression levels, coupled with whole-genome genetic variation. (nature.com)
Here we report, to our knowledge, the first ancient human genome from Wallacea, the oceanic island zone between the Sunda Shelf (comprising mainland southeast Asia and the continental islands of western Indonesia) and Pleistocene Sahul (Australia-New Guinea). (anthropogeny.org)
We also describe Denisovan and deep Asian-related ancestries in the Leang Panninge genome, and infer their large-scale displacement from the region today. (anthropogeny.org)
BTW my AbDNA accorded me about 10% African ancestry that has never been confirmed by on four sibling genome-wide scans. (familytreedna.com)
Within groups with ≥40% AA (AFR ≥0.4 ), and ≥15% NAA (AMR ≥0.15 ), genome-wide association between local EA and glioma was evaluated using logistic regression conditioned on global EA for all gliomas. (elsevierpure.com)

DNAPrint(R)'s EuroDNA(TM) 2.0 clarifies European sub-ancestry by using 1,349 European Ancestry Informative Markers (AIMs). (thegeneticgenealogist.com)
Global ancestry map showing mostly East Asian and Native/South American ancestry, with some European ancestry as well. (parabon-nanolabs.com)
For example, the admixed East Asian and Latino example from the global map above was determined to have specifically Japanese, Central American, and Southwest European ancestry, as shown in the map below. (parabon-nanolabs.com)
Regional ancestry map showing mostly Japanese, Southwest European, and Central American ancestry. (parabon-nanolabs.com)
Each piece of continental ancestry is partitioned according to its regional ancestry (e.g., if an individual is 50% European and 50% East Asian, the precise origin of each of those pieces will be determined). (parabon-nanolabs.com)
We report a fixed-effect, inverse-weighted-variance meta-analysis from 10,074 PCOS cases and 103,164 controls of European ancestry and characterisation of PCOS related traits. (ox.ac.uk)
Using continental reference ancestry, African (AFR), non-Finnish European (EUR), East Asian (EAS), Indigenous American (IAM), South Asian (SAS), we obtain accurate and precise estimates (within 0.1%) for all simulation scenarios. (omicsdi.org)
The above plot is from Characterizing the admixed African ancestry of African Americans , a 2009 paper with 94 Africans of diverse geographic origins, 136 African Americans, and 38 European Americans. (discovermagazine.com)
1) "In accordance with historical records, recent studies showed that AJ are genetically homogeneous with mixed European and Middle-Eastern ancestry and that the AJ population had undergone a severe bottleneck around 800ya followed by an extremely rapid expansion. (blogspot.com)
By this they mean that the 93 AIM SNP panel was able to accurately separate the samples by continent - sub-Saharan African, Amerindian, East Asian, Oceana and European. (familytreedna.com)
But the vast majority of that research has focused on people of European, Asian, and African descent. (acm.org)
On a somewhat related note, it seems that I was right when I hypothesized that some Sub-Saharan Africans had rather recent European ancestry. (blogspot.com)
2014) found a correlation of 0.48 between self-identified European and Amerindian racial identity and genomic ancestry in a five country sample. (humanvarieties.org)
2014) found that, on the individual level, White identity was associated with wealth (but not educational attainment) net of European ancestry (see note 1). (humanvarieties.org)
White European, Black African, and Amerindian - plus an "Other" group. (humanvarieties.org)
Another example of the challenges associated with the use of population descriptors can be found in the frequent use of the terms European, African, and Asian. (mixedracestudies.org)
When the actual samples in the name of "European", "African", and "Asian" are taken from certain limited groups, without taking into account significant diversity within each region, it is unlikely that such broad terms have any scientific meaning, at least from the perspective of genetics on the global level. (mixedracestudies.org)
Conclusions: Our results indicate that European ancestry is a risk factor for cutaneous melanoma. (cdc.gov)

STRUCTURE is an algorithm designed to infer population structure (cluster individuals into ancestry groups) within a species (Pritchard, Stephens, and Donnelly 2000. (thisviewoflife.com)

We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. (ox.ac.uk)
STRUCTURE produces for individuals an estimate of the probability that a randomly chosen genetic marker (e.g. single tandem repeats, STR, or single nucleotide polymorphisms, SNP) from that individual originated from one of a set of ancestral groups. (thisviewoflife.com)

Sykes is a geneticist who uses mtDNA (passed through the maternal line) and Y chromosome (passed through the paternal line) to tie genetic information to the past. (anthrohealth.net)
Not to mention that the actual amount of genetic information in mtDNA and the Y chromosome is extremely tiny compared to nDNA. (anthrohealth.net)
If solid-color chromosomes were the ones in the egg and sperm, all genetic information for that chromosome from one paternal and one maternal grandparent would be lost in the child. (anthrohealth.net)
The Jtest folder contains files that can be used to make an Ashkenazi ancestry test/chromosome painting with 14 Eurasian and African clusters. (blogspot.com)

Using all of this information, Snapshot builds a precise profile of an individual's ethnic ancestry using only his or her DNA. (parabon-nanolabs.com)
The number of ancestral groups, K, is chosen to produce a best estimate of these probabilities, which are averaged over all genetic markers to assign a membership coefficient, namely a fraction of each individual's ancestry to one of the ancestral groups (Feldman 2010. (thisviewoflife.com)

Subjects identified themselves as belonging to one of four major racial/ethnic groups (white, African American, East Asian, and Hispanic) and were recruited from 15 different geographic locales within the United States and Taiwan. (blogspot.com)
An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data. (omicsdi.org)

Characterizing the admixed African ancestry of African Americans My own inclination has been to not get bogged down in the latest race and IQ controversy because I don't have that much time, and the core readership here is probably not going to get any new information from me, since this is not an area of hot novel research. (discovermagazine.com)

The data also provide the first genetic evidence for a male phenotype for PCOS and a causal link to depression, a previously hypothesized comorbid disease. (ox.ac.uk)
http://www.partnershipfortomorrow.ca ) is a cohort comprising over 315,000 Canadians, and captures over 700 variables, ranging from longitudinal health information to environmental exposures, to determine genetic and environmental factors contributing to chronic disease. (nature.com)
For example, if a certain disease is much more common in one ancestral group, scientists need only screen the DNA inherited from that group in a person of mixed ancestry. (acm.org)
[12] The remaining 5% to 10% of cases have a genetic cause, often linked to a history of the disease in the family , and these are known as familial ALS (hereditary). (wikipedia.org)
ALS is a motor neuron disease , which is a group of neurological disorders that selectively affect motor neurons , the cells that control voluntary muscles of the body. (wikipedia.org)
9 Although a differential ascertainment of the disease does not seem to contribute to the observed differences within the United States, it has been argued that the latitude gradient reflects primarily genetic variation within the population. (neurology.org)

Parabon has built a powerful system for determining ethnic ancestry from DNA. (parabon-nanolabs.com)
Ethnic ancestry is one of the most informative traits that can be predicted from DNA. (parabon-nanolabs.com)
The overall results were concordant in both ethnic groups. (ox.ac.uk)
The lack of the letter 'F' in the pre-1987 Tagalog alphabet (Abakada) caused the letter 'P' to be substituted for 'F' , though the alphabets and/or writing scripts of some non-Tagalog ethnic groups included the letter 'F'. Upon official adoption of the modern, 28-letter Filipino alphabet in 1987, the term Filipino was preferred over Pilipino . (everipedia.org)
They were an ethnic group who took over regions (they replaced 90% of previous population of Britain). (blogspot.com)

although individual genetic markers can be used to produce smaller groups, there are no models that produce completely distinct subgroups when larger numbers of genetic markers are used. (wikipedia.org)
And, because there is such a small fraction of genetic variation between human genotypes overall, genetic clustering approaches are highly dependent on the sampled data, genetic markers, and statistical methods applied to their construction. (wikipedia.org)
The most common multidimensional statistical method used for genetic clustering is principal component analysis (PCA), which plots individuals by two or more axes (their "principal components") that represent aggregations of genetic markers that account for the highest variance. (wikipedia.org)
In order to obtain unbiased assessments of genetic differentiation and structure in taurine and zebu cattle, we analyzed a dataset of 135 AFLP markers in 1,593 samples from 13 zebu and 58 taurine breeds, representing nine continental areas. (biomedcentral.com)
Model-based clustering and ancestry informative markers analyses suggested that this is due to taurine introgression. (biomedcentral.com)
Molecular markers have been essential to the investigation of the history and genetic differentiation of domestic cattle. (biomedcentral.com)
We have analyzed genetic data for 326 microsatellite markers that were typed uniformly in a large multiethnic population-based sample of individuals as part of a study of the genetics of hypertension (Family Blood Pressure Program). (blogspot.com)
Genetic cluster analysis of the microsatellite markers produced four major clusters, which showed near-perfect correspondence with the four self-reported race/ethnicity categories. (blogspot.com)

Individual Genetic Variation Might Predict Acute Skin Reactions in Women Undergoing Adjuvant Breast Cancer Radiotherapy. (cancerindex.org)
The aim of this study was to explore whether genetic variation might be linked to acute radiation skin reactions (ARSR). (cancerindex.org)
Drawing from this founding population of individuals with largely French ancestry, we selected 1007 individuals to determine mechanisms by which genomes, the environment, and their interactions contribute to phenotypic variation. (nature.com)

The relationship between treatment response and genotype was assessed separately for Caucasians and Asians. (york.ac.uk)

Although several methods exist to estimate ancestry in individual-level data, methods to estimate ancestry proportions in summary data are lacking. (omicsdi.org)
Also, some users are doing weird stuff with the Jtest output in an attempt to estimate their supposedly "true" Ashkenazi ancestry proportions, like multiplying their Ashkenazi coefficient by three, because Ashkenazi Jews "only" score around 30% Ashkenazi in this test. (blogspot.com)

TMB estimates from tumor-only panels substantially overclassified individuals into the clinically important TMB-high group due to germline contamination, and this bias was particularly pronounced in patients with Asian/African ancestry. (bvsalud.org)

Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. (nature.com)

The appearance of genetic polymorphisms, i.e. differences in the DNA nucleotide sequence between individuals, contributes to the opportunity for functional adaptation to specific environments that organisms may encounter. (fatsoflife.com)
Over many generations, the selection of beneficial traits associated with particular polymorphisms can lead to gradual changes in the frequency of specific genetic polymorphisms in a genetically-isolated population. (fatsoflife.com)
In contrast with the positive selection of favorable adaptive polymorphisms, a genetic variant may also gradually disappear from a population if there is no survival advantage in having it. (fatsoflife.com)
This review examined the relationship between clinical response to selective serotonin re-uptake inhibitors in patients with depression and genetic polymorphisms (SERTPR and STin2) in the serotonin transporter gene. (york.ac.uk)

Using two clinical cohorts, we investigated the interplay between genetic ancestry, TMB, and tumor-only versus tumor-normal paired sequencing in solid tumors. (bvsalud.org)

For example: To what degree are differences in national racial identification related to such and such outcomes independent of genomic ancestry? (humanvarieties.org)

Human genetic clusters tend to be organized by geographic ancestry, with divisions between clusters aligning largely with geographic barriers such as oceans or mountain ranges. (wikipedia.org)
Many studies of human genetic clustering have been implicated in discussions of race, ethnicity, and scientific racism, as some have controversially suggested that genetically derived clusters may be understood as proof of genetically determined races. (wikipedia.org)
These algorithms operate by finding the best fit for genetic data among an arbitrary or mathematically derived number of clusters, such that differences within clusters are minimized and differences between clusters are maximized. (wikipedia.org)

Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancestry. (nature.com)

In his posts on this topic Ta-Nehisi repeatedly points to the real diversity in physical type and ancestry among African Americans, despite acknowledging implicitly the shared preponderant history. (discovermagazine.com)
I was expecting to read a major genetic analysis of population diversity in the US. (anthrohealth.net)
Within that area is so much environmental and genetic variability that you can really leverage the intrinsic diversity to your scientific advantage,' says Esteban Burchard , a physician and scientist at the University of California, San Francisco. (acm.org)
When considering the contribution of environmental as well as genetic factors to diversity within each continental region, the scientific validity of the use of such broad terms to describe samples becomes even more questionable. (mixedracestudies.org)

The old descriptor ANIMALS will be changed to ANIMAL POPULATION GROUPS. (bvsalud.org)

The Genetic Genealogist examines the intersection of traditional genealogical techniques and modern genetic research. (thegeneticgenealogist.com)
Editor's Note: Nicholas Wade's A Troublesome Inheritance: Genes, Race, and Human History attempts to report on the concept of race from a modern genetic and evolutionary perspective. (thisviewoflife.com)

This genetic variant, termed an indel (insertion/deletion mutation), was found to influence the regulation of the expression levels of both FADS-1 and FADS-2 in a cellular system, with the minor allele in Japanese people being associated with lower expression of the FADS-1 and FADS-2 genes. (fatsoflife.com)
The population frequency of the allele corresponding to the rs66698963 insertion (allele named I) or deletion (allele named D) was determined from genomic DNA extracted from human samples (blood, breast milk, and placenta) obtained from several participating institutions in the US and Canada (n=211, nearly all from Kansas City), as well as from a group of Asian Indians (n=76). (fatsoflife.com)
Here, we present Summix, a method to efficiently deconvolute ancestry and provide ancestry-adjusted allele frequencies (AFs) from summary data. (omicsdi.org)
Population-genetic comparison of the AJ genomes to 26 Flemish genomes sequenced using the same technology revealed increased heterozygosity and less allele sharing in AJ, in accordance with the AJ admixed nature and partial Middle-Eastern origin. (blogspot.com)

Our findings provide further evidence of genetic heterogeneity for ET. (nel.edu)
Recent genetic research indicates that the degree of genetic heterogeneity within groups and homogeneity across groups make race per se a less compelling predictor. (bvsalud.org)

These findings offer the first insights into ancestry-specific differences in the prostate cancer AR cistrome. (bvsalud.org)
and 4) patients who did not parasite genetic factors or differences in exposure rate ( 5 , 6 ). (cdc.gov)
The celebration of Tiger Woods' mixed descent and his widespread popularity would seem to support David Hollinger's argument that the history of the United States has been a successful (albeit episodic) history of "amalgamation" overcoming group differences. (historycooperative.org)

After global ancestry is determined, Snapshot's ancestry algorithm investigates which subpopulations (e.g. (parabon-nanolabs.com)

I wonder if some of the reason for these results is the quality of the marker/s they are using for African ancestry? (familytreedna.com)

This information can be used to help identify remains or to significantly focus an investigation by excluding a wide range of possible suspects or even pointing to a very small group. (parabon-nanolabs.com)

If you really want to confirm your Jewish ancestry, either or both Ashkenazi and Sephardi, then you need to look at much more powerful and sophisticated options. (blogspot.com)
One of these options is the Global25 analysis (see HERE ), which can pick up minor Jewish ancestry of just a few per cent. (blogspot.com)
But I can help you get started and even quickly check if you have any hope at all of confirming Jewish ancestry. (blogspot.com)

Of 3,636 subjects of varying race/ethnicity, only 5 (0.14%) showed genetic cluster membership different from their self-identified race/ethnicity. (blogspot.com)
On the other hand, we detected only modest genetic differentiation between different current geographic locales within each race/ethnicity group. (blogspot.com)
Thus, ancient geographic ancestry, which is highly correlated with self-identified race/ethnicity-as opposed to current residence-is the major determinant of genetic structure in the U.S. population. (blogspot.com)

The genetic similarities between cases diagnosed based on the two criteria have been largely unknown. (ox.ac.uk)

From ∼ 1000 individuals of a founder population in Quebec, we reveal a substantial impact of the environment on the transcriptome and clinical endophenotypes, overpowering that of genetic ancestry. (nature.com)
The ancestral groups are not specified in advance, and the population membership of individuals is removed prior to analysis. (thisviewoflife.com)

Some of the ancestry-specific association signals are also influenced by a selective sweep. (ox.ac.uk)
Implications of this genetic structure for case-control association studies are discussed. (blogspot.com)
To ascertain the association with ETM2, we performed a genetic analysis of three polymorphic loci, etm1231, etm1234, and etm1240, located within the ETM2 candidate region in 61 Czech patients with a family history of ET and 68 healthy controls. (nel.edu)
The identifications of novel association with EA suggest regions to target for future genetic association studies. (elsevierpure.com)

We showcase the feasibility and utility of our framework by analyzing 25,889 tumors and identifying the relationships between genetic ancestry, polygenic risk, and tumor characteristics that could not be studied with conventional on-target tumor data. (biomedcentral.com)

Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia. (ox.ac.uk)
Ancestry-aware tumor-only TMB calibration and ancestry-diverse biomarker studies are critical to ensure that existing disparities are not exacerbated in precision medicine. (bvsalud.org)

Evidence indicates that the CYP19 gene is a positional and functional candidate for genetic study in polycystic ovarian syndrome (PCOS). (nel.edu)

All genetic cluster findings are biased by the sampling process used to gather data, and by the quality and quantity of that data. (wikipedia.org)
These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D. (ox.ac.uk)
Findings from this analysis expand our knowledge of the genetic basis of obesity. (ox.ac.uk)

These characteristics make the AJ population highly attractive for genetic studies. (blogspot.com)

These genetic divisions stem simply from the fact that these groups were isolated from one another for many generations, and thus each group has a unique genetic signature that can be used for identification. (parabon-nanolabs.com)

Diseases1

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes11

Disciplines and Occupations1

Humanities1

Information Science1

Named Groups10

Health Care2

Geographicals4

Populations34

Cohort Studies1

Admixture12

Polymorphism4

Predisposition1

Alleles2

Humans4

Variants14

SNPs6

Native American4

South Asians1

Europeans3

Susceptibility1

Loci associated3

Coronary artery1

Genome8

European18

Infer1

Single Nucleotide2

Chromosome4

Individual's2

Hispanic2

Admixed African ancestry1

Disease6

Ethnic5

Markers8

Variation3

Genotype1

Proportions2

Germline1

Relatedness1

Polymorphisms4

Interplay1

Outcomes1

Clusters3

Traits1

Diversity4

Population Groups1

Modern genetic2

Allele4

Heterogeneity2

Differences3

Algorithm1

Marker1

Significantly1

Jewish3

Ethnicity3

Similarities1

Individuals2

Association4

Risk1

Tumor2

Gene1

Findings3

Studies1

Unique genetic1