Mu-derived plasmids transferred from pAV2 − strains of EBF65/65 back to E. coli K12 were found to carry defective prophages which had lost the abilityto produce detectable phage particles. (microbiologyresearch.org)
The 4th Bacteriophage Therapy Summit , February 14-16, 2022 (online) is the definitive gathering for global phage experts. (phagedirectory.com)
Focusing on human health and disease, the 4th Bacteriophage Therapy Summit is returning to help you advance your phage-based therapies through clinical development and commercialization beyond compassionate use. (phagedirectory.com)
The production of phage chromosome fragments and their capacity for genetic transfer. (wikidata.org)
Bacteriophage (phage) are ubiquitous viruses that infect and kill bacteria in a species-, sometimes even strain-, specific manner. (diabetesonthenet.com)
Genome3
Mobile genetic elements (MGEs) sometimes called selfish genetic elements are a type of genetic material that can move around within a genome, or that can be transferred from one species or replicon to another. (wikipedia.org)
Among them, the large family of transposons first described by Barbara McClintock in maize [ 5 ] have the ability to move their genetic information within the genome. (encyclopedia.pub)
For genome correction by introducing target-specific genetic scissors in various organisms, it is necessary to harness the endogenous cellular DNA repair system. (molcells.org)
Plasmids5
Plasmids that use other genetic element MFPs in the cell are mobilizable. (wikipedia.org)
Mu plasmids from Escherichia coli K12 to Acinetobacter calcoaceticus EBF65/65 was very inefficient compared with RP4 and was only detectable to strains of EBF65/65 lacking pAV2, a cryptic plasmid thought to code for a restriction/modification system. (microbiologyresearch.org)
Re-transfer of these defective plasmids from hsm k + and hsm k strains of E. coli K12 back to EBF65/65, when compared with the transfer of RP4, provided evidence for a second restriction/modification system in EBF65/65 which affected mainly Mu DNA. (microbiologyresearch.org)
No lytic bacteriophages were detected, but S. aureus was isolated from the surroundings of all patients. (mdpi.com)
artificial active i. acquired i.. artificial passive i. acquired i.. bacteriophage i. the state induced in a bacterium by lysogenization, the lysogenic bacterium being insusceptible to further lysogenization or to a lytic cycle by a superinfecting bacteriophage, in contradistinction to bacteriophage resistance. (theodora.com)
Transposons2
Plasmid insertion mutagenesis and lac gene fusion with mini-Mu bacteriophage transposons. (microbiologyresearch.org)
Transposons can contain any DNA (e.g. selectable markers or other genetic elements), between MuA binding sites at both ends. (domusbiotechnologies.com)
Target-specific genetic modification technology is expected to have a leading position in future gene therapy development, and has a ripple effect on various basic and applied studies. (molcells.org)
Recently, viruses have been explored as nano-containers for specific targeting applications, however these systems typically require modification of the virus surface using chemical or genetic means to achieve tumor-specific delivery. (biomedcentral.com)
Comprehensive identification of polymorphisms among individuals within a species is essential both for studying the genetic basis of phenotypic differences and for elucidating the evolutionary history of the species. (shengsci.com)
Tolerance can occur because of phenotypic, not genetic, changes in the state of the bacteria. (diabetesonthenet.com)
Phages3
Millard A, Clokie MRJ, Shub DA, Mann NH: Genetic organization Adriamycin of the psbAD region in phages infecting marine Synechococcus strains. (bcl-2protein.com)
This week, University of Vienna MSc student Jessica Neubauer explains why you should spend your Valentine's day cultivating your love of phages at the upcoming (virtual) Bacteriophage Therapy Summit! (phagedirectory.com)
Join the MICALIS Institute in Jouy-en-Josas, a south-east suburb of Paris, to explore the origin of spontaneous mutations in phages and bacteria. (phagedirectory.com)
Bacteria3
An example of MGEs in evolutionary context are that virulence factors and antibiotic resistance genes of MGEs can be transported to share genetic code with neighboring bacteria. (wikipedia.org)
Bacteria may develop a synergistic relationship with bacteriophages and more effectively resist various stresses, enabling them to persist despite disinfection and antimicrobial treatment. (mdpi.com)
Plasmid suicide by Mu' may enable the development of a method for directed chromosome mobilization in A. calcoaceticus. (microbiologyresearch.org)
Chromosome mobilization and integration of F factors in the chromosome of recA strains of E. coli under the influence of bacteriophage Mu-1. (microbiologyresearch.org)
Gene2
Data from the analysis of mutants that are impaired in this transport activity are consistent with the presence of the structural gene for the transport system at the same genetic locus. (microbiologyresearch.org)
Review: How do interactions between mobile genetic elements affect horizontal gene transfer? (antimicrobialresistance.eu)
Interactions1
General and enviromental microbiology researcher and PI with independent research programme in microbial ecology, metagenomics, host-microbial interactions and bacteriophage-related technologies. (massey.ac.nz)
Biol1
Duda RL, Hendrix RW, Huang WM, Conway JF: Shared architecture of bacteriophage SPO1 and herpesvirus capsids [erratum appears in Curr Biol. (bcl-2protein.com)
Locus1
From an analysis of mutants able to grow on glutamate we have identified a genetic locus that when mutated elevates the expression of the GltII glutamate/aspartate transport system. (microbiologyresearch.org)
Resistance1
March digest features a review of novel methods to quantifying the physical linkage between specific antimicrobial resistance genes and mobile genetic elements, how traveling affects AMR, and more. (antimicrobialresistance.eu)
Evolution2
Further isolation and genomic comparison of leptophages should reveal their role in the genetic evolution of Leptospira. (hal.science)
But by far the most active form of transposition is performed by retroviruses, such as HIV, that multiply by inserting themselves into the DNA, and then forcing the cell to make many new copies of their genetic information. (rcsb.org)
Assessment of the microbiome during bacteriophage therapy in combination with systemic antibiotics to treat a case of staphylococcal device infection, by Andre Mu et al. (phagedirectory.com)
Variants2
These efforts cumulatively allowed the development of novel variants of SB that offer advanced possibilities for genetic engineering due to their hyperactivity, integration deficiency, or targeting capacity. (encyclopedia.pub)
Limited Genetic Diversity Detected in Middle East Respiratory Syndrome-Related Coronavirus Variants Circulating in Dromedary Camels in Jordan. (cdc.gov)
however, expression of Mu in EBF65/65 was very poor and plaques were only detected on a restrictionless strain of E. coli K12. (microbiologyresearch.org)
Also, cep and orfU are the other two CTX-associated virulence genetic elements of importance that are found in V. cholerae [ 19 ]. (biomedcentral.com)
Types1
There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). (embl.de)
Cell2
It is (almost boringly) obvious that cell-to-cell com-mu-ni-ca-tion is vital in multicellular organisms. (asmblog.org)
CC (Carbon Copy), the first cat produced from a clone, was created from an ovarian cell taken from her genetic donor, Rainbow, a calico cat. (quizlet.com)