• certain genes
  • The work also suggested that certain genes are acquired through horizontal gene transfers, such as the genes for aerobic respiration. (wikipedia.org)
  • Bare lymphocyte syndrome is a condition caused by mutations in certain genes of the major histocompatibility complex or involved with the processing and presentation of MHC molecules. (wikipedia.org)
  • For example, it has been uncovered that the DNA of certain genes is often damaged in melanoma cells, most likely as a result of damage from UV radiation, and in turn increases the likelihood of developing melanoma. (wikipedia.org)
  • Inherent in sociobiological reasoning is the idea that certain genes or gene combinations that influence particular behavioral traits can be inherited from generation to generation For example, newly dominant male lions often kill cubs in the pride that they did not sire. (wikipedia.org)
  • sequences
  • The EFSA is endorsing 'retrospective risk assessment' of CaMV promoter and its Gene VI sequences - in an attempt to give it a clean bill of health. (slashdot.org)
  • Sequences at the 9p21.3 risk locus disrupt TEAD factor binding and TEAD3-dependent TGF-beta induction of p16 in HAoSMCs. (nih.gov)
  • MITF recognizes E-box (CAYRTG) and M-box (TCAYRTG or CAYRTGA) sequences in the promoter regions of target genes. (wikipedia.org)
  • WormBase offers many ways of searching and retrieving data from the database: WormMart, Wiki - was a tool for retrieving varied information on many genes (or the sequences of those genes). (wikipedia.org)
  • pathway
  • Understanding the molecular basis of genetic interactions is crucial in deciphering pathway organization and understanding the relationship between genotype, phenotype and disease. (beds.ac.uk)
  • In addition, the study provides general insight into the complex nature of epistasis and proposes mechanistic models for genetic interactions, the majority of which do not fall into easily recognizable within- or between-pathway relationships. (beds.ac.uk)
  • Transcription factor (TF) activation and signalling pathway in cancer. (els.net)
  • Known target genes (confirmed by at least two independent sources) of this transcription factor include, Additional genes identified by a microarray study (which confirmed the above targets) include the following, The LysRS-Ap4A-MITF signaling pathway was first discovered in mast cells, in which, the MAPK pathway is activated upon allergen stimulation. (wikipedia.org)
  • Upregulation of PHACTR1 by transforming growth factor (TGF)-β has been described in breast cancer cell lines, potentially pointing to a connection with the TGF-β signaling pathway, which is also implicated in genetic predisposition to migraine9 and has a key role in Marfan and Loeys-Dietz syndromes, two inherited connective tissue disorders causing aortic dissection. (wikipedia.org)
  • traits
  • 4 These include over 100 genetic traits (autosomal dominant, autosomal recessive, and sex linked) and deletions or translocations of virtually all the chromosomes 1 (Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/OMIM/ ). (bmj.com)
  • The term "lineage-specific", since it relates to MITF, means genes or traits that are only found in a certain cell type. (wikipedia.org)
  • Critics, led by Richard Lewontin and Stephen Jay Gould, argued that genes played a role in human behavior, but that traits such as aggressiveness could be explained by social environment rather than by biology. (wikipedia.org)
  • hepatic
  • Insulin-regulated glycolytic genes-Gck, Aldob, Pgk1, and Pklr, hepatic glucose transporter gene - SLC2A2, and gluconeogenic genes - Fbp1 and Pck1 were repressed in livers of Nfe2l1 transgenic mice. (wikipedia.org)
  • Genomic
  • 8 The transgene contained the complete gene with 1.6 kb of 5′-flanking and 0.35 kb of 3′-flanking genomic sequence, permitting the regulation of the transgene by its natural promoter. (ahajournals.org)
  • Genome Browser - browse the genes of C. elegans (and other species) in their genomic context Textpresso - a search tool that queries published C. elegans literature (including meeting abstracts) and a subset of nematode literature. (wikipedia.org)
  • Sequence curation at WormBase refers to the maintenance and annotation of the primary genomic sequence and a consensus gene set. (wikipedia.org)
  • promoter
  • This activation was dependent on intact binding sites for both factors in the TRAP promoter. (edu.au)
  • Three SNPs within the TOMM40 gene, one APOE promoter SNP and two SNPs within distal APOE enhancer elements (ME1 and BCR) predict CSF apoE levels. (iospress.com)
  • maternal
  • Not all cases of microphthalmia are genetic and both maternal virus infections (for example, rubella and cytomegalovirus) and drug use (for example, alcohol, thalidomide, and retinoic acid) have been implicated in the development of microphthalmia in some patients. (bmj.com)
  • microphthalmia
  • Other families with defects in the microphthalmia gene located on 14q32 may have a similar ocular phenotype aiding their identification. (bmj.com)
  • replication
  • The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. The region surrounding the FOXE1 gene has shown association in the pathogenesis of cleft lip and palate with genome-wide levels of significance in linkage analysis studies with additional fine-mapping and replication. (wikipedia.org)
  • targets
  • Metallothioenein-1 and Metallothioenein-2 genes, which protect cells against cytotoxicity induced by toxic metals, are also direct targets of Nfe2l1. (wikipedia.org)
  • oncogenes
  • An elevated percentage of oncogenes and tumour suppressor genes encode TFs. (els.net)
  • Abnormal amounts of gene product can be correlated with disease-causing alleles, such as the overactivity of oncogenes which can cause cancer. (wikipedia.org)
  • human
  • We've shown that this genetic profile is safe in the lab, safe in the field, and safe in the human body. (slashdot.org)
  • Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer. (nih.gov)
  • Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. (nih.gov)
  • 9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells. (nih.gov)
  • Transcription factor hStaf/ZNF143 is required for expression of the human TFAM gene. (nih.gov)
  • Grass et al 8 previously reported the development of lines of transgenic mice expressing the entire human group IIa sPLA 2 gene. (ahajournals.org)
  • The sPLA 2 transgenic mice were produced by microinjection of a 6.2-kb Hin dIII restriction fragment containing the human secretory PLA 2 gene into (B6×SJL)F2 hybrid embryos, which were transferred to strain ICR recipients and developed to term according to standard protocols. (ahajournals.org)
  • In May 2018, Houghton Mifflin Harcourt will publish his second book, "Human Errors: A Panorama of Our Glitches, from Pointless Bones to Broken Genes. (wikipedia.org)
  • prostate cancer
  • 2009) Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration‐resistant prostate cancer. (els.net)
  • 2015) Improvements in radiographic progression‐free survival stratified by ERG gene status in metastatic castration‐resistant prostate cancer patients treated with abiraterone acetate. (els.net)
  • 2007) Reduced PDEF expression increases invasion and expression of mesenchymal genes in prostate cancer cells. (els.net)
  • genome sequence
  • In the 1990's, he organized and led the team that deciphered the first genome sequence and genetic code for a salt-loving microbe, Halobacterium sp. (wikipedia.org)
  • molecules work
  • These siRNA molecules work in RNA-induced silencing complex (RISC) during RNA interference by binding to a target DNA sequence to prevent transcription of a specific mRNA. (wikipedia.org)
  • corticosteroids
  • The modifiable risk factors that contribute to PTDM include obesity, some viral infections (eg, hepatitis C virus, cytomegalovirus) and especially immunosuppressive drugs including corticosteroids, tacrolimus, cyclosporine and sirolimus. (dovepress.com)
  • Patients' response to inhaled corticosteroids has some basis in genetic variations. (wikipedia.org)
  • phenotype
  • The dun allele is a simple dominant, so the phenotype of a horse with either one copy or two copies of the gene is dun. (wikipedia.org)
  • commonly
  • One of the most commonly studied model organisms in regards to homeotic genes is the fruit fly Drosophila melanogaster. (wikipedia.org)
  • Primitive markings include: Dorsal stripe (stripe down the center of the back, along the spine), seen almost universally on all duns Horizontal striping on the back of forelegs, common on most duns, although at times, rather faint Shoulder blade stripe, the least commonly seen of the primitive markings Dorsal striping does not guarantee the horse carries the dun gene. (wikipedia.org)
  • cells
  • Re-establishment of Nfe2l1 function in Nfe2l1 null cells rescued proteasome expression and function, indicating Nfe2l1 was necessary for induction of proteasome genes (bounce-back response) in response to proteasome inhibition. (wikipedia.org)
  • loci
  • Additionally, a multi-locus genetic risk score study based on a combination of 27 loci, including the PHACTR1 gene, identified individuals at increased risk for both incident and recurrent coronary artery disease events, as well as an enhanced clinical benefit from statin therapy. (wikipedia.org)
  • species
  • These T3SSs are similar as a result of divergent evolution and phylogenetic analysis supports a model in which gram-negative bacteria can transfer the T3SS gene cassette horizontally to other species. (wikipedia.org)
  • To aid these comparisons, a coordinate re-mapping program and data are available from: http://wiki.wormbase.org/index.php/Converting_Coordinates_between_releases All the gene-sets of the WormBase species were initially generated by gene prediction programs. (wikipedia.org)
  • When genes are conserved between the available nematode species, comparative analysis can also be very informative. (wikipedia.org)
  • occur
  • Its homeotic genes occur in either the Antennapedia complex (ANT-C) or the Bithorax complex (BX-C) discovered by Edward B. Lewis. (wikipedia.org)