Loading...


  • infection
  • There are many stages in the development of a new drug for viral infection and such processes are even further complicated for adenovirus by the fact that there are at least 51 serotypes, forming six distinct groups (A-F), with different degree of infectivity. (mdpi.com)
  • We discuss these results and speculate on the consequences of viral morphology during influenza virus infection of the human respiratory tract. (springer.com)
  • Viral protein R (Vpr) is an accessory protein of HIV-1, which is potentially involved in the infection of macrophages and the induction of the ataxia-telangiectasia and Rad3-related protein (ATR)-mediated DNA damage response (DDR). (pubfacts.com)
  • The findings of this study indicate that Vpr-induced structural alteration of DNA is a primary event that triggers both DDR and DSB, which ultimately contributes to HIV-1 infection. (pubfacts.com)
  • Late genes are expressed from 140 min to 48 hours post-infection, producing all viral structural proteins. (wikipedia.org)
  • Viral Interactions with the Cell Surface and Cell Entry Viral infection is initiated by adsorption of the virus to the cell surface. (gkhub.info)
  • HCMV infection is more widespread in developing countries and in communities with lower socioeconomic status and represents the most significant viral cause of birth defects in industrialized countries. (wikipedia.org)
  • It is one of the two important viral causes of respiratory infection in cats, the other being feline herpesvirus. (wikipedia.org)
  • Usually 100 minutes post-infection Late Phase: Between 140 minutes and 48 hours post-infection, late genes are expressed. (wikipedia.org)
  • Vpu induces the degradation of the CD4 viral receptor and therefore participates in the general downregulation of CD4 expression during the course of HIV infection. (wikipedia.org)
  • virions
  • The concatameric intermediates produced earlier are now resolved into double strand DNA and packaged in the late viral proteins to produce and immature virions (IV). (wikipedia.org)
  • The first function is known to induce degradation of the viral receptor molecule CD4, and the second function is to enhance the release of newly formed virions from the cell surface. (wikipedia.org)
  • mRNA
  • Mutations at the complex interface impair mRNA deadenylation in mammalian cell extracts, suggesting that the GW182-PABC interaction contributes to microRNA-mediated gene silencing. (genes2cognition.org)
  • Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression. (genes2cognition.org)
  • These cis-acting elements also conferred miRNA susceptibility to target mRNAs translating under the control of viral- and eukaryotic mRNA-derived 5' UTR structures that enable cap-independent translation. (genes2cognition.org)
  • In HIV-1, the gag ORF that encodes the 55 kDa Gag protein, the major viral structural protein, is located at the 5' end of the full-length viral mRNA. (wikipedia.org)
  • Additionally, because the HIV-1 ribosomal frameshift signal relies on interactions between the viral mRNA and the host translational machinery, it is likely a more stable therapeutic target, because any selective pressure caused by a therapeutic compound would have to occur on the evolutionary time scale of the host instead of the rapidly evolving HIV-1 virus. (wikipedia.org)
  • The transcript is spliced and the viral mRNA is transported to the cytoplasm where it is then translated. (wikipedia.org)
  • Viral protein "u" (Vpu) is an oligomeric, 81-amino acid type I membrane protein (16 kDa) that is translated from vpu-env bicistronic mRNA. (wikipedia.org)
  • viruses
  • Being obligate intracellular parasites, viruses heavily depend on host cell structures and functions to complete their life cycle, and they also use the translational apparatus of the infected cell to express their proteins. (pubmedcentralcanada.ca)
  • DNA viruses such as poxviruses and adenoviruses commonly use another type of proteolysis, called morphogenic proteolysis where precursor proteins are first synthesized and then cleaved by viral proteinases to produce the mature form of the protein. (biomedcentral.com)
  • I7L is an essential late gene, as shown through temperature sensitive mutant viruses [ 7 , 8 ] and conditional lethal mutant viruses [ 9 , 10 ] where under non-permissive conditions, viral morphogenesis is blocked prior to the formation of IMV. (biomedcentral.com)
  • Viruses consist of a nucleic acid surrounded by one or more proteins. (gkhub.info)
  • Viruses have from a few to several hundred genes.These genes may be in a single-strand or double-strand DNA genome or in a single-strand sense, a single-strand or segmented antisense, or a double-strand segmented RNA genome. (gkhub.info)
  • Human cytomegalovirus is a species of the Cytomegalovirus genus of viruses, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. (wikipedia.org)
  • Of all herpes viruses, HCMV harbors the most genes dedicated to altering (evading) innate and adaptive immunity in the host and represents a lifelong burden of antigenic T cell surveillance and immune dysfunction. (wikipedia.org)
  • FAST proteins are coded for by members of the nonenveloped reoviridae family of viruses. (wikipedia.org)
  • However, a shift in the ORF is not universally deleterious, as many viruses capitalize on this phenomenon by using a programmed ribosomal frameshift (PRF) to translate several proteins from the same sequence, thereby maximizing the storage capacity of their genome. (wikipedia.org)
  • Thus, many viruses (including HIV-1) are categorized as having a polycistronic genome, meaning they employ multiple active ORF's in a single gene. (wikipedia.org)
  • The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods). (wikipedia.org)
  • retroviral
  • In addition, the retroviral proteins themselves have been co-opted to serve novel host functions, particularly in reproduction and development. (wikipedia.org)
  • Furthermore, in the instance of potentially antagonistic effects of retroviral sequences, repressor genes have co-evolved to combat them. (wikipedia.org)
  • Solo LTRs and LTRs associated with complete retroviral sequences have been shown to act as transcriptional elements on host genes. (wikipedia.org)
  • The genome contains the usual retroviral structural genes including gag, pol, and env. (wikipedia.org)
  • Gene therapy trials using retroviral vectors to treat X-linked severe combined immunodeficiency (X-SCID) represent the most successful application of gene therapy to date. (wikipedia.org)
  • particle
  • The viral nucleic acid is usually associated with one or more virus-encoded nucleoproteins in the core of the viral particle. (gkhub.info)
  • Mutation
  • De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus. (nih.gov)
  • The question of how far the NP gene can cross the species barrier by reassortment and become adapted by mutation to the new host has been discussed. (wikipedia.org)
  • regulation
  • The HIV-1 virus requires a programmed -1 ribosomal frameshift signal (the HIV-1 Ribosomal Frameshift Signal) for the expression of the Pol gene, which is an example of a cis-acting element of gene regulation. (wikipedia.org)
  • The HIV-1 ribosomal frameshift signal has emerged as a potential therapeutic target for the HIV-1 virus due to the requirement of the programmed ribosomal frameshift for the regulation of the Gag/Gag-Pol protein ratio and the relatively conserved structure. (wikipedia.org)
  • ERVs are a subclass of a type of gene called a transposon, which can be packaged and moved within the genome to serve a vital role in gene expression and in regulation. (wikipedia.org)
  • nucleocapsid
  • citation needed] Teguments are rarely[citation needed] haphazardly placed and usually involve scaffolding proteins in their formation around the nucleocapsid. (wikipedia.org)
  • binds
  • AP-1(A/S) binds to the promoter region of at least one of these late genes, BDLF3, encoding an immune modulator. (asm.org)
  • vectors
  • DNA-based vaccines include plasmids or viral vectors containing the gene encoding one of the BoNT heavy chain receptor binding domains (HC). (mdpi.com)
  • Hybrid vectors containing murine interleukin-12 ( mIL-12 ) genes or reporter gene LacZ showed very specific and high-level expression of transgenes in AFP-expressing hepatocellular carcinoma cells, both in vitro and in an in vivo hepatocellular carcinoma animal model. (aacrjournals.org)
  • This new type of hybrid vectors may provide a potent and safe tool for cancer gene therapy. (aacrjournals.org)
  • Thus, vectors being able to generate high levels of transgenic proteins in the tumor and of stimulating more intense antitumor responses should be developed ( 6 , 7 ). (aacrjournals.org)
  • virally encoded
  • Flavivirus replicons can replicate inside cells and achieve prolonged expression of high levels of virally encoded proteins with minimal toxicity [ 11 , 12 ] and are unable to recombine or mutate to produce infectious HIV particles. (biomedcentral.com)
  • interacts
  • The penton base interacts with the surface protein av integrins which stimulate the entry of the virus into the cell via endocyctosis. (mdpi.com)
  • Here we show that a conserved motif in the human GW182 paralog TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure of the complex. (genes2cognition.org)
  • This protein also interacts with the rotavirus non-structural protein NSP3. (wikipedia.org)
  • antiviral
  • This information is of importance because antiviral treatment suppresses symptomatic α-herpesvirus-mediated diseases effectively but does not eradicate the latent viral burden ( 5 , 6 ). (pnas.org)
  • transcriptional
  • Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response. (nih.gov)
  • Following integration, expression of JSRV RNA from the viral promoter in the LTR is controlled by the host transcriptional machine. (wikipedia.org)
  • We constructed a hybrid viral vector composed of a helper-dependent adenovirus containing an SFV replicon under the transcriptional control of AFP promoter and a transgene driven by SFV subgenomic promoter. (aacrjournals.org)
  • genomes
  • Sense-strand RNA genomes can be translated directly into protein. (gkhub.info)
  • Sections of the NP, VP35 and the L genes from filoviruses have been identified as endogenous in the genomes of several groups of small mammals. (wikipedia.org)
  • promoter
  • In the design of such a vector to treat hepatocellular carcinoma, we took advantage of ( a ) the high infectivity of adenoviruses for hepatic cells, ( b ) the high level of protein expression and proapoptotic properties that characterize Semliki Forest virus (SFV) replicon, and ( c ) tumor selectivity provided by α-fetoprotein (AFP) promoter. (aacrjournals.org)
  • The majority of these elements are inserted in the sense direction to their corresponding genes, but there has been evidence of LTRs acting in the antisense direction and as a bidirectional promoter for neighboring genes. (wikipedia.org)
  • In a few cases, the LTR functions as the major promoter for the gene. (wikipedia.org)
  • eukaryotic
  • What is clear now is that the eukaryotic exon-intron structure is not static, introns are continually inserted and removed from genes and the evolution of introns evolves parallel to exon shuffling. (wikipedia.org)
  • Molecular
  • Even though a possibility of a viral cause has been eliminated in bronchoalveolar cancer, understanding the molecular mechanisms leading to the transformation of lung epithelia by JSRV may be of interest in the context of therapeutic approaches in human lung cancers in general and bronchoalveolar adenocarcinoma (BAC) in particular. (wikipedia.org)
  • Since removal of the Vpu initiation codon results in increased expression of the downstream env gene, it is possible that HIV-1 actually uses this mechanism as a molecular switch to regulate the relative expression of Vpu or Env in infected cells. (wikipedia.org)
  • Exon shuffling is a molecular mechanism for the formation of new genes. (wikipedia.org)
  • nuclear
  • During latency, HSV-1 transcription is largely restricted to the nuclear latency-associated transcript (LAT), and viral protein expression in latently infected human sensory neurons is generally undetectable ( 1 ). (pnas.org)
  • immune
  • The association of viral reactivation with immune suppression and the recently observed persistence of T cells and cytokines in latently infected human TG ( 7 , 8 ) strongly suggest a pivotal role of T cells in control of the virus at the site of latency. (pnas.org)
  • The disease is caused by direct viral invasion of epithelium and endothelium and secondary host immune response. (wikipedia.org)
  • respiratory
  • Diagnosis of FCV is difficult without specific tests, because the signs are similar to other feline respiratory diseases, especially feline viral rhinotracheitis. (wikipedia.org)
  • expression
  • The TG-resident T cells, mainly CD8 + T cells, were directed against HSV-1 and not to VZV, despite neuronal expression of VZV proteins. (pnas.org)
  • An improved viral vector for cancer gene therapy should be capable of infecting tumors with high efficiency, inducing specific and high-level expression of transgene in the tumor and selectively destroying tumor cells. (aacrjournals.org)
  • consequently, avoidance of transgene expression at extratumoral sites is an absolute requirement for the use of such gene therapy tools ( 6 , 7 ). (aacrjournals.org)
  • However, these are normally weak promoters that do not allow high-level expression of the transgenic protein in the neoplastic tissue ( 9 - 11 ). (aacrjournals.org)
  • The successful expression of heterologous proteins, including HIV gp120 for long periods in culture suggests this vector system may be useful as a vaccine vector, given appropriate delivery methods. (biomedcentral.com)
  • These AP-1(A/S) mutants bind methylated EBV DNA and activate expression of some EBV genes. (asm.org)
  • Here, we compare expression of 67 viral genes induced by ZEBRA versus expression induced by AP-1(A/S) proteins. (asm.org)
  • The viral core is completely uncoated as early expression ends, releasing the viral genome into the cytoplasm. (wikipedia.org)
  • MicroRNAs (miRNAs) regulate gene expression post-transcriptionally through binding specific sites within the 3' untranslated regions (UTRs) of their target mRNAs. (genes2cognition.org)
  • However, the precise mechanisms by which miRNAs modulate gene expression are still obscure. (genes2cognition.org)
  • As a result, the HIV-1 ribosomal frameshift signal is highly regulated, as it modulates the expression levels of the Gag protein relative to the Gag-Pol polyprotein. (wikipedia.org)
  • ERV insertions have also been shown to generate alternative splice sites either by direct integration into the gene, as with the human leptin hormone receptor, or driven by the expression of an upstream LTR, as with the phospholipase A-2 like protein. (wikipedia.org)
  • molecule
  • The DNA molecule is left free in the nucleus of the host cell, and the instructions in this extra DNA molecule are transcribed just like any other gene. (wikipedia.org)
  • genome
  • UC Berkeley researchers have discovered how Cas1-Cas2, the proteins responsible for the ability of the CRISPR immune system in bacteria to adapt to new viral infections, identify the site in the genome where they insert viral DNA so they can recognize it later and mount an attack. (berkeley.edu)
  • The viral core is completely uncoated as early expression ends, releasing the viral genome into the cytoplasm. (wikipedia.org)
  • Nucleic
  • Nucleic acids encoding the fusion proteins, methods of preparing same and uses thereof are also described. (patentsencyclopedia.com)
  • Noncoding" sequences are not translated into proteins, and nucleic acids with such motifs need not deviate from the typical shape (e.g. the "B-form" DNA double helix). (wikipedia.org)
  • The three main purposes of metabolism are the conversion of food/fuel to energy to run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes. (wikipedia.org)
  • Metabolism is usually divided into two categories: catabolism, the breaking down of organic matter for example, the breaking down of glucose to pyruvate, by cellular respiration, and anabolism, the building up of components of cells such as proteins and nucleic acids. (wikipedia.org)
  • Expression of type I and III IFNs can be induced in virtually all cell types upon recognition of viral components, especially nucleic acids, by cytoplasmic and endosomal receptors, whereas type II interferon is induced by cytokines such as IL-12, and its expression is restricted to immune cells such as T cells and NK cells. (wikipedia.org)
  • kinase
  • This myddosome then combines with tumor necrosis factor receptor-associated factor 6 (TRAF6), which is crucial for signal propagation [ 27 ] and further activates transcription factors NF-κB or mitogen-activated protein kinase (MAPK) [ 2 , 9 ]. (transpopmed.org)
  • In response to interferon, cells produce large amounts of an enzyme known as protein kinase R (PKR). (wikipedia.org)
  • This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. (wikipedia.org)
  • The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells. (wikipedia.org)
  • Crk should not be confused with Src, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase. (wikipedia.org)
  • p16 (also known as cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1 and as several other synonyms), is a tumor suppressor protein, that in humans is encoded by the CDKN2A gene. (wikipedia.org)
  • p16 is also known as: p16Ink4A p16Ink4 Cyclin-dependent kinase inhibitor 2A (CDKN2A) CDKN2 CDK 4 Inhibitor Multiple Tumor Suppressor 1 (MTS1) TP16 ARF MLM P14 P19 In humans, p16 is encoded by the CDKN2A gene, located on chromosome 9 (9p21.3). (wikipedia.org)
  • Unlike animal PRRs, which associated with intracellular kinases via adaptor proteins (see non-RD kinases below), plant PRRs are composed of an extracellular domain, transmembrane domain, juxtamembrane domain and intracellular kinase domain as part of a single protein. (wikipedia.org)
  • 7SK associates with and inhibits the cyclin dependent kinase activity of P-TEFb through the action of the RNA binding proteins HEXIM1 or HEXIM2. (wikipedia.org)
  • Sequences
  • Applications of phage display technology include determination of interaction partners of a protein (which would be used as the immobilised phage "bait" with a DNA library consisting of all coding sequences of a cell, tissue or organism) so that the function or the mechanism of the function of that protein may be determined. (wikipedia.org)
  • Transcription
  • The use of alternative transcription starts causes dual targeting of the same mature MDAR protein to both mitochondria and chloroplast. (uniprot.org)
  • Most TPR-containing proteins are associated with multiprotein complexes, and there is extensive evidence indicating that TPR motifs are important to the functioning of chaperone, cell-cycle, transcription, and protein transport complexes. (wikipedia.org)
  • The transcription start site for TTC39B protein isoform 1 is located from base pairs 15,307,340 to 15,307,389 and has a length of 50 bp. (wikipedia.org)
  • Once in the nucleus, E2F1 promotes the transcription of target genes that are essential for transition from G1 to S phase. (wikipedia.org)
  • Regulation of p16 is complex and involves the interaction of several transcription factors, as well as several proteins involved in epigenetic modification through methylation and repression of the promoter region. (wikipedia.org)
  • PRC1 and PRC2 are two protein complexes that modify the expression of p16 through the interaction of various transcription factors that execute methylation patterns that can repress transcription of p16. (wikipedia.org)
  • bacterial
  • In this issue of the JCI , Cottineau and colleagues characterize 5 individuals who exhibited growth restriction, facial deformities, and a history of bacterial and viral infection. (jci.org)
  • The phage gene and insert DNA hybrid is then inserted (a process known as "transduction") into Escherichia coli (E. coli) bacterial cells such as TG1, SS320, ER2738, or XL1-Blue E. coli. (wikipedia.org)
  • Competing methods for in vitro protein evolution include yeast display, bacterial display, ribosome display, and mRNA display. (wikipedia.org)
  • amino acid
  • 2. The fusion protein according to claim 1, wherein the Targeting Moiety and the protease cleavage site are separated by at most 10 amino acid residues, preferably by at most 5 amino acid residues, and more preferably by at most zero amino acid residues. (patentsencyclopedia.com)
  • 6. The fusion protein according to claim 1, wherein the Targeting Moiety comprises at most 50 amino acid residues, preferably at most 40 amino acid residues, more preferably at least 30 amino acid residues, and most preferably at most 20 amino acid residues. (patentsencyclopedia.com)
  • Phosphorylation Sites: Probability of Sumoylation Sites (bolded): There is one possible N-glycosylation site at amino acid 391, however, since the TTC39B protein does not contain a signal peptide, it is unlikely that this glycosylation actually occurs. (wikipedia.org)
  • Antibodies
  • This technology was further developed and improved by groups at the Laboratory of Molecular Biology with Greg Winter and John McCafferty, The Scripps Research Institute with Lerner and Barbas and the German Cancer Research Center with Breitling and Dübel for display of proteins such as antibodies for therapeutic protein engineering. (wikipedia.org)
  • regulatory
  • 26S proteasome non-ATPase regulatory subunit 7, also known as 26S proteasome non-ATPase subunit Rpn8, is an enzyme that in humans is encoded by the PSMD7 gene. (wikipedia.org)
  • The human protein 26S proteasome non-ATPase regulatory subunit 14 is 37 kDa in size and composed of 324 amino acids. (wikipedia.org)
  • According to the protein interaction and topological characteristics of this multisubunit complex, the 19S regulatory particle is composed of a base and a lid subcomplex. (wikipedia.org)
  • In spite of their structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in control of the G1 phase of the cell cycle. (wikipedia.org)
  • regulation
  • Deposition of matricellular proteins modulates growth factor signaling and contributes to the spatial and temporal regulation of the reparative response. (jci.org)
  • IFNs belonging to all three classes are important for fighting viral infections and for the regulation of the immune system. (wikipedia.org)
  • subunits
  • F-actin-capping proteins bind in a Ca 2+ -independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. (uniprot.org)
  • To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special degradative tag, the ubiquitinylation. (wikipedia.org)
  • endocytosis
  • Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans (GAGs), which mediates cellular endocytosis of the virus. (wikipedia.org)
  • This domain recruits clathrin and other proteins responsible for the endocytosis of LDL, therefore this mutation inhibits LDL internalization. (wikipedia.org)
  • Roles
  • Exploitation of Interleukin-10 (IL-10) Signaling Pathways: Alternate Roles of Viral and Cellular IL-10 in Rhesus Cytomegalovirus Infection. (nih.gov)
  • Carbohydrates are the most abundant biological molecules, and fill numerous roles, such as the storage and transport of energy (starch, glycogen) and structural components (cellulose in plants, chitin in animals). (wikipedia.org)
  • In addition, interferons induce production of hundreds of other proteins-known collectively as interferon-stimulated genes (ISGs)-that have roles in combating viruses and other actions produced by interferon. (wikipedia.org)
  • molecules
  • IL-33 is an member of IL-1 cytokine family with ~32 kD and 18 kD molecules that in the past represented uncleaved and mature IL‑33 proteins, respectively [ 2 , 5 ], but now represent the bioactive and cleavage forms [ 6 , 7 ], respectively. (transpopmed.org)
  • IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. (wikipedia.org)
  • mutations
  • Mutations resulting in deletion or reduction of function of the CDKN2A gene are associated with increased risk of a wide range of cancers and alterations of the gene are frequently seen in cancer cell lines. (wikipedia.org)
  • Examples include: Pancreatic adenocarcinoma is often associated with mutations in the CDKN2A gene. (wikipedia.org)
  • viruses
  • Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells. (wikipedia.org)
  • v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk. (wikipedia.org)
  • bind
  • For example, many DNA binding proteins that have affinity for specific DNA binding sites bind DNA in only its double-helical form. (wikipedia.org)
  • spatial and temporal
  • To meet such complicated demands in biological process via spatial and temporal proteolysis, protein substrates have to be recognized, recruited, and eventually hydrolyzed in a well controlled fashion. (wikipedia.org)
  • interaction
  • Protein functions are supported by its tertiary structure and its interaction with associating partners. (wikipedia.org)
  • A La related protein LARP7 is also found associated with 7SK, presumably in part through its interaction with the 3' end of the RNA. (wikipedia.org)
  • endosomal
  • Recognition of extracellular or endosomal pathogen-associated molecular patterns is mediated by transmembrane proteins known as toll-like receptors (TLRs). (wikipedia.org)
  • interactions
  • Like the two-hybrid system, phage display is used for the high-throughput screening of protein interactions. (wikipedia.org)
  • The technique is also used to determine tumour antigens (for use in diagnosis and therapeutic targeting) and in searching for protein-DNA interactions using specially-constructed DNA libraries with randomised segments. (wikipedia.org)
  • motif
  • TLRs share a typical structural motif, the Leucine rich repeats (LRR), which give them their specific appearance and are also responsible for TLR functionality. (wikipedia.org)
  • variants
  • The TTC39B gene has five different transcript variants, each coding for a different protein. (wikipedia.org)
  • There are five different transcript variants for the TTC39B gene. (wikipedia.org)
  • this transcript contains an alternate open reading frame (ARF) that specifies a protein that is structurally unrelated to the products of the other variants. (wikipedia.org)
  • mainly
  • Soybean ( Glycine max (L.) Merrill) is a globally important commercial crop, grown mainly for its protein, oil and nutraceutical contents. (intechopen.com)
  • The role of IL-33 in lung injury was first identified mainly in lung inflammation and allergic diseases such as viral infection and asthma [ 13 , 14 ]. (transpopmed.org)
  • Diseases
  • A leading gene therapy company developing treatments for rare and life-threatening genetic diseases. (venrock.com)
  • Such protein accumulation may contribute to the pathogenesis and phenotypic characteristics in neurodegenerative diseases, cardiovascular diseases, inflammatory responses and autoimmune diseases, and systemic DNA damage responses leading to malignancies. (wikipedia.org)
  • widely
  • E-Infrastructure serves to the download probabilistic models for nonlinear partial differential equations and construct processed for important performance recovered by the FoodStress, most commonly fear that varies to find widely essential genes of guidelines. (pd19.org)
  • Phage display is also a widely used method for in vitro protein evolution (also called protein engineering). (wikipedia.org)
  • genetic
  • The viral genetic material is contained in double stranded linear DNA consisting of 202,182 tightly packed base pairs. (wikipedia.org)
  • secondary
  • Short coding motifs, which appear to lack secondary structure, include those that label proteins for delivery to particular parts of a cell, or mark them for phosphorylation. (wikipedia.org)
  • According to an analysis of the secondary protein structure, TTC39B is most likely to be expressed in the endoplasmic reticulum, mitochondria, and Golgi apparatus. (wikipedia.org)
  • An early study indicated that 7SK in cells is associated with a number of proteins and probing of the secondary structure suggested a model for base pairing between different regions of the RNA. (wikipedia.org)
  • target
  • a href='/help/protein_existence' target='_top'>More. (uniprot.org)
  • a href='/help/gene_name' target='_top'>More. (uniprot.org)
  • TPR motifs that are arranged one in front of another create a right-handed helical structure with an amphipathic channel which could possibly accommodate the complementary region of a target protein. (wikipedia.org)
  • nuclear
  • 7SK is found in a small nuclear ribonucleoprotein complex (snRNP) with a number of other proteins that regulate the stability and function of the complex. (wikipedia.org)