• protein kinase
  • Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. (nih.gov)
  • Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. (wikipedia.org)
  • integrin-mediated
  • Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. (nih.gov)
  • homolog
  • ATF1 NM_005171 ATF2 NM_001880 ATF4 Activating transcription factor 4 NM_001675 ATF6 NM_007348 ATF7 NM_001206682 ATF7IP NM_018179 BTF3 NM_001207 Homo sapiens basic transcription factor 3 E2F4 Homo sapiens E2F transcription factor 4, p107/p130-binding (E2F4), mRNA ERH (gene) Enhancer of rudimentary homolog of drosophila (which in turn is the first enzymatic step in pyrimidine synthesis. (wikipedia.org)
  • Activated by cAMP guanine nucleotide exchange factor Rap guanine nucleotide exchange factor (GEF) 2 ( PDZ-GEF1 ) stimulates PI3K cat class IA activation via v-Ha-ras Harvey rat sarcoma viral oncogene homolog ( H-Ras ). (bio-rad.com)
  • Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene. (wikipedia.org)
  • superfamily
  • The exact size of the GPCR superfamily is unknown, but nearly 800 different human genes (or ~ 4% of the entire protein-coding genome) have been predicted to code for them from genome sequence analysis. (wikipedia.org)
  • cellular
  • In molecular biology, housekeeping genes are typically constitutive genes that are required for the maintenance of basic cellular function, and are expressed in all cells of an organism under normal and patho-physiological conditions. (wikipedia.org)
  • The present invention relates to cellular senescence, markers of cellular senescence, and methods and reagents for identifying senescent cells and agents that alter senescent gene expression expression of cells, as well as for detecting, diagnosing, preventing, and treating senescence-related diseases and conditions in humans and other mammals. (google.es)
  • receptor
  • Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway. (nih.gov)
  • Insulin-like growth factor 1 ( IGF-1 ) signaling promotes activation of Insulin-like growth factor 1 receptor ( IGF-1 receptor ) that forms a complex with Rho guanine nucleotide exchange factor (GEF) 12 ( LARG ) [ 4 ]. (bio-rad.com)
  • activity
  • The 3′-end of the human β-actin gene enhances activity of the β-actin expression vector system: construction of improved vectors," Journal of Biochemical and Biophysical Methods, 1997, vol. 36, No. 1, pp. 63-72. (freepatentsonline.com)
  • Methods of inhibition of Rho kinase activity in a human or animal subject are also provided for the treatment of diseases such as ophthalmologic diseases. (patentsencyclopedia.com)
  • factors
  • The 70-kb pYV is critical to Yersinia's pathogenicity, since it contains many genes known to encode virulence factors and its loss gives avirulence of all Yersinia species. (wikipedia.org)
  • sequences
  • The Gβ genes have very similar sequences, while significantly greater variation is seen in the Gγ genes, indicating that the functional specificity of the Gβγ dimer may be dependent on the type of Gγ subunit involved. (wikipedia.org)
  • 1998). "Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
  • encodes
  • Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. (wikipedia.org)
  • polymerization
  • Moreover, by applying actin polymerization inhibitor cytochalasin D to sciatic nerve crushed rats, we studied the in vivo effect of cytochalasin D and demonstrated that inhibiting actin polymerization would delay the migration of Schwann cells and hinder the repair and regeneration of injured peripheral nerves. (frontiersin.org)
  • human
  • Human gene GC6 is expressed more abundantly in senescent cells than young cells. (google.es)
  • While this constitutes only 0.000165% of the human genome's approximately 6 billion bases (3 billion base pairs), unrepaired lesions in critical genes (such as tumor suppressor genes) can impede a cell's ability to carry out its function and appreciably increase the likelihood of tumor formation and contribute to tumour heterogeneity. (wikipedia.org)
  • control
  • The key criterion for the use of a housekeeping gene in this manner is that the chosen housekeeping gene is uniformly expressed with low variance under both control and experimental conditions. (wikipedia.org)
  • compound
  • 2. A method of treatment of a Rho kinase-mediated disease comprising the administration of a therapeutically effective amount of a compound selected from the group consisting of examples 1 to 15 to a patient in need thereof. (patentsencyclopedia.com)
  • 8. A compound selected from the group consisting of Examples 1 through 15 for use in the manufacture of a medicament for the prevention or treatment of a disease or condition ameliorated by the inhibition Rho kinase. (patentsencyclopedia.com)
  • regulate
  • A 26-kb "core region" in the pYV contains the ysc genes, which regulate the expression and secretion of Yops. (wikipedia.org)
  • The core region also includes yopN, yopB, yopD, tyeA, lcrG, and lcrV, which also regulate Yops gene expression and help to translocate secretory Yops to the target cell. (wikipedia.org)
  • transcription
  • DAXX Death Associated Protein 6 ARAF MAZ (gene) MYC also considered a transcription factor MCM3AP possibly a primase XRCC5 NM_021141 Ku80 XRCC6 NM_001469 Homo sapiens thyroid autoantigen: Single-stranded DNA-dependent ATP-dependent helicase. (wikipedia.org)
  • experimental
  • Although some housekeeping genes are expressed at relatively constant rates in most non-pathological situations, the expression of other housekeeping genes may vary depending on experimental conditions. (wikipedia.org)
  • For experimental purposes, the expression of one or multiple housekeeping genes is used as a reference point for the analysis of expression levels of other genes. (wikipedia.org)
  • expression
  • Validation of housekeeping genes should be performed before their use in gene expression experiments such as RT-PCR. (wikipedia.org)
  • As cells undergo replicative senescence in vitro and in vivo, cells not only lose the ability to divide in response to growth stimuli, but also exhibit significant deleterious changes in the pattern of gene expression (West, 1994, Arch. (google.es)
  • The altered pattern of gene expression exhibited by senescent cells contributes significantly to age-related pathologies. (google.es)