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  • protein kinase
  • Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. (nih.gov)
  • Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. (wikipedia.org)
  • integrin
  • Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. (nih.gov)
  • inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. (nih.gov)
  • The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. (nih.gov)
  • Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway. (nih.gov)
  • Coexpression of alpha6beta4 integrin and guanine nucleotide exchange factor Net1 identifies node-positive breast cancer patients at high risk for distant metastasis. (springer.com)
  • factor
  • ATF1 NM_005171 ATF2 NM_001880 ATF4 Activating transcription factor 4 NM_001675 ATF6 NM_007348 ATF7 NM_001206682 ATF7IP NM_018179 BTF3 NM_001207 Homo sapiens basic transcription factor 3 E2F4 Homo sapiens E2F transcription factor 4, p107/p130-binding (E2F4), mRNA ERH (gene) Enhancer of rudimentary homolog of drosophila (which in turn is the first enzymatic step in pyrimidine synthesis. (wikipedia.org)
  • DAXX Death Associated Protein 6 ARAF MAZ (gene) MYC also considered a transcription factor MCM3AP possibly a primase XRCC5 NM_021141 Ku80 XRCC6 NM_001469 Homo sapiens thyroid autoantigen: Single-stranded DNA-dependent ATP-dependent helicase. (wikipedia.org)
  • Tatsuka & Mitsui in "Elongation factor-1 alpha gene determines susceptibility to transformation" (Nature, 1992, vol. 359, pp. 333-336). (freepatentsonline.com)
  • Insulin-like growth factor 1 ( IGF-1 ) signaling promotes activation of Insulin-like growth factor 1 receptor ( IGF-1 receptor ) that forms a complex with Rho guanine nucleotide exchange factor (GEF) 12 ( LARG ) [ 4 ]. (bio-rad.com)
  • Activated by cAMP guanine nucleotide exchange factor Rap guanine nucleotide exchange factor (GEF) 2 ( PDZ-GEF1 ) stimulates PI3K cat class IA activation via v-Ha-ras Harvey rat sarcoma viral oncogene homolog ( H-Ras ). (bio-rad.com)
  • When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor (GEF). (wikipedia.org)
  • inhibition
  • 8. A compound selected from the group consisting of Examples 1 through 15 for use in the manufacture of a medicament for the prevention or treatment of a disease or condition ameliorated by the inhibition Rho kinase. (patentsencyclopedia.com)
  • Methods of inhibition of Rho kinase activity in a human or animal subject are also provided for the treatment of diseases such as ophthalmologic diseases. (patentsencyclopedia.com)
  • cellular
  • In molecular biology, housekeeping genes are typically constitutive genes that are required for the maintenance of basic cellular function, and are expressed in all cells of an organism under normal and patho-physiological conditions. (wikipedia.org)
  • membrane
  • Analysis of experimental data for Rac membrane cycling reveals that the lower apparent affinity of GDI for RacGTP compared to RacGDP can be fully explained by the faster dissociation of the latter from the membrane. (pubmedcentralcanada.ca)
  • mRNA
  • XIAP overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin-mediated Rho-GDIβ mRNA stability. (semanticscholar.org)
  • factors
  • The 70-kb pYV is critical to Yersinia's pathogenicity, since it contains many genes known to encode virulence factors and its loss gives avirulence of all Yersinia species. (wikipedia.org)
  • cell
  • The core region also includes yopN, yopB, yopD, tyeA, lcrG, and lcrV, which also regulate Yops gene expression and help to translocate secretory Yops to the target cell. (wikipedia.org)
  • identification
  • Brazier H, Stephens S, Ory S, Fort P, Morrison N, Blangy A. Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts. (springer.com)
  • activity
  • The 3′-end of the human β-actin gene enhances activity of the β-actin expression vector system: construction of improved vectors," Journal of Biochemical and Biophysical Methods, 1997, vol. 36, No. 1, pp. 63-72. (freepatentsonline.com)
  • expression
  • Although some housekeeping genes are expressed at relatively constant rates in most non-pathological situations, the expression of other housekeeping genes may vary depending on experimental conditions. (wikipedia.org)
  • For experimental purposes, the expression of one or multiple housekeeping genes is used as a reference point for the analysis of expression levels of other genes. (wikipedia.org)
  • Validation of housekeeping genes should be performed before their use in gene expression experiments such as RT-PCR. (wikipedia.org)
  • A 26-kb "core region" in the pYV contains the ysc genes, which regulate the expression and secretion of Yops. (wikipedia.org)
  • vivo
  • Moreover, by applying actin polymerization inhibitor cytochalasin D to sciatic nerve crushed rats, we studied the in vivo effect of cytochalasin D and demonstrated that inhibiting actin polymerization would delay the migration of Schwann cells and hinder the repair and regeneration of injured peripheral nerves. (frontiersin.org)
  • encodes
  • Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. (wikipedia.org)
  • control
  • The key criterion for the use of a housekeeping gene in this manner is that the chosen housekeeping gene is uniformly expressed with low variance under both control and experimental conditions. (wikipedia.org)
  • chromosome
  • Washington DC, USA ---------------------------------------------------------------------------- Description: Human chromosome 4: entries, gene names and cross-references to MIM Name: humchr04.txt Release: 2018_11 of 05-Dec-2018 ---------------------------------------------------------------------------- This documents lists all the human protein sequence entries whose genes are known to be encoded on chromosome 4 in this release of UniProtKB/Swiss-Prot. (uniprot.org)
  • Methods and compositions for reducing expression of genes on Chromosome 21 ("Chr 21") by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16. (patentsencyclopedia.com)
  • Washington DC, USA ---------------------------------------------------------------------------- Description: Human chromosome 9: entries, gene names and cross-references to MIM Name: humchr09.txt Release: 2018_01 of 31-Jan-2018 ---------------------------------------------------------------------------- This documents lists all the human protein sequence entries whose genes are known to be encoded on chromosome 9 in this release of UniProtKB/Swiss-Prot. (uniprot.org)
  • specificity
  • The Gβ genes have very similar sequences, while significantly greater variation is seen in the Gγ genes, indicating that the functional specificity of the Gβγ dimer may be dependent on the type of Gγ subunit involved. (wikipedia.org)
  • bound
  • Upon activation, Mst1/2 in association with the adaptor protein Salvador (Sav1) phosphorylates and activates Mob1A/B‐bound Lats1/2 kinases that in turn phosphorylate the related transcriptional regulators, Yes‐associated protein (Yap) and transcriptional co‐activator with PDZ‐binding motif (Taz, gene name Wwtr1 ). (embopress.org)
  • target genes
  • The microarray analysis identified matrix metalloproteinase 1 (MMP-1) and urokinase Plasminogen activator (uPA) as potential STA6 target genes involved in the promotion of GBM cell invasion. (beds.ac.uk)
  • protein kinase
  • At the core of the mammalian Hippo pathway is a kinase cassette comprised of the Drosophila Hippo homologs, mammalian STE20‐like protein kinase 1/2 (Mst1/2, gene name Stk4/3 ) and large tumour suppressors 1 and 2 (Lats1/2). (embopress.org)
  • Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. (wikipedia.org)
  • Molecular
  • In molecular biology, housekeeping genes are typically constitutive genes that are required for the maintenance of basic cellular function, and are expressed in all cells of an organism under normal and patho-physiological conditions. (wikipedia.org)
  • phosphorylation
  • βPix is required downstream of both cell density sensing and actin cytoskeletal rearrangements, and we demonstrate that loss of βPix expression in normal mammary epithelial cells strongly reduces Yap/Taz phosphorylation, promotes nuclear localization and increases target gene expression. (embopress.org)
  • pathway
  • Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. (genecards.org)
  • sequence
  • The sequence of amino acid residues in a protein is defined by the sequence of a gene , which is encoded in the genetic code . (ipfs.io)
  • Daughter cells that inherit these wrong bases carry mutations from which the original DNA sequence is unrecoverable (except in the rare case of a back mutation, for example, through gene conversion). (wikipedia.org)

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  • cytoskeleton
  • In particular, the Rho-related genes are important in nuclear trafficking (i.e.: mitosis) as well as with mobility along the cytoskeleton in general. (wikipedia.org)
  • tumor
  • While this constitutes only 0.000165% of the human genome's approximately 6 billion bases (3 billion base pairs), unrepaired lesions in critical genes (such as tumor suppressor genes) can impede a cell's ability to carry out its function and appreciably increase the likelihood of tumor formation and contribute to tumour heterogeneity. (wikipedia.org)
  • receptor
  • MMP-9-induced cell signaling and migration were blocked by inhibiting MMP-9-binding to LRP-1 with receptor-associated protein (RAP) or by LRP-1 gene silencing. (jneurosci.org)
  • encodes
  • Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. (wikipedia.org)
  • factors
  • The 70-kb pYV is critical to Yersinia's pathogenicity, since it contains many genes known to encode virulence factors and its loss gives avirulence of all Yersinia species. (wikipedia.org)

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  • HUMAN
  • Intratumoral 5-fluorouracil Produced by Cytosine Deaminase/5-fluorocytosine Gene Therapy is Effective for Experimental Human Glioblastomas Cancer Research. (jove.com)
  • (merckmillipore.com)
  • expression
  • Kaplan-Meyer survival curves were generated to show the correlation between STAT6 gene expression and patient survival in 343 glioma patients and in a subset of patients with only GBM. (beds.ac.uk)
  • Lastly, a genome-wide expression microarray analysis was performed to compare gene expression in wild-type GBM cells to expression in stable STAT6 knockdown clones. (beds.ac.uk)
  • Although some housekeeping genes are expressed at relatively constant rates in most non-pathological situations, the expression of other housekeeping genes may vary depending on experimental conditions. (wikipedia.org)
  • For experimental purposes, the expression of one or multiple housekeeping genes is used as a reference point for the analysis of expression levels of other genes. (wikipedia.org)
  • Validation of housekeeping genes should be performed before their use in gene expression experiments such as RT-PCR. (wikipedia.org)