Genes regulates homeostasis. Medical search. Frequent questions

14 ). It is important to identify the transcription factors involved in regulation of these genes to reveal potential avenues for modulating transcriptional programs that could be dysfunctional in PD. (nature.com)
We determined that tRNA abundance changes during stress conditions are mainly regulated by tRNA degradation and we identified RNY1, a stress-related ribonuclease, as a key player in the specific regulation of tRNAs during stress conditions. (europa.eu)
The current focus of Dr. Goldring's laboratory is on the mechanisms of gene regulation by which stress- and inflammation-induced signals induce expression of matrix metalloproteinase 13 (MMP-13), the pivotal collagen-degrading proteinase that marks osteoarthritis progression, as well as other catabolic and anabolic responses in cartilage and other joint tissues. (hss.edu)
Collaborative studies with Dr. HI Roach's group (Southampton, UK) have also identified epigenetic regulation via alterations in the methylation status of specific CpG sites in the promoters of MMP13, IL1B, NOS2, and COL9A1, associated with aberrant gene expression in osteoarthritic cartilage. (hss.edu)
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
While NPP1 is a key factor for cementum formation, NPP2 and NPP3 may be involved in regulation of PDL homeostasis. (umich.edu)
Compared with red meat-diet-fed mice, fiber-diet-fed mice presented a shift in the gut microbiome toward increased production of butanoate, which was accompanied by up-regulation of microbiota- and AMP-activated protein kinase (AMPK)-dependent gene expression and decrease in serum concentrations of trimethylamine N -oxide (TMAO), triglyceride (TG) and glucose (GLU). (rsc.org)
With these results, the researchers confirmed, for the first time, that these three genes are involved in the regulation of sleep and they function specifically in peripheral tissues, with neuronal signaling occurring downstream of these pathways. (the-scientist.com)
The goal of this minireview is to provide an update on the regulation of bile acid (BA) homeostasis by the nuclear receptor Farnesoid X receptor (FXR) and the effects on this regulation by exposure to environmental or therapeutic agents. (aspetjournals.org)

The protein encoded by this gene may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane. (nih.gov)
Upon binding of thyroid hormone, the thyroid receptor releases corepressor proteins and undergoes a conformational change that allows for the interaction of coactivating proteins necessary for gene transcription. (nih.gov)
Translation of mRNA into proteins is a central process in gene expression. (europa.eu)
We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
And the LEF / TCF family transcription factor, along with other proteins, binds to DNA and inhibits gene expression. (researchsquare.com)
Intracellular zinc homeostasis regulated by a complex of EVER proteins and zinc transporter proteins may play a role in inhibiting EV-HPV expression. (medscape.com)
Our results reveal a function of HSF proteins in regulating mtROS homeostasis that is independent of the unfolded protein response. (lu.se)
Sterol regulatory element-binding proteins (SREBPs) compose a family of transcriptional factors that regulate the expression of various genes required for the synthesis of phospholipids, fatty acids, and cholesterol. (novusbio.com)

The key TF were identified by functional enrichment analysis from the list of differentially expressed genes identified in liver samples between 35 pigs fed with 1.5% or 3.0% soybean oil. (nature.com)
Furthermore, based on differentially expressed genes and WGCNA analyses, we found that the hypoxia signaling pathway was enriched under heat shock conditions. (biomedcentral.com)
The project will identify key genes, pathways, and biological processes that are differentially regulated in response to hypoxia. (lu.se)

Of the numerous lipid classes implicated in eliciting lipotoxicity, sphingolipid: ceramides are among the most deleterious as they modulate signaling pathways involved in regulating glucose metabolism, triglyceride synthesis, apoptosis, and fibrosis. (frontiersin.org)
Studies from a number of laboratories in the past decade have revealed that the central pathways deregulated in cancer often serve to coordinately regulate both classic oncogenic signaling pathways controlling cell proliferation and cell survival with pathways controlling cell metabolism. (aacrjournals.org)
3 The findings demonstrate that sleep is all about protein homeostasis: endoplasmic reticulum (ER) stress and downregulation of protein biosynthesis in peripheral tissues trigger pathways that induce sleep. (the-scientist.com)
Both pharmacological and genetic inhibition of these same genes and pathways increased sleep duration in mice. (the-scientist.com)
Maintaining bile acid (BA) homeostasis is important and regulated by BA activated receptors and signaling pathways. (aspetjournals.org)

Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. (wikipedia.org)
The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function. (wikipedia.org)
The different genes within a genome, depending on their sequence, might have varying efficiency in using the cellular resources devoted for protein synthesis. (europa.eu)
Our work aims to investigate whether the processes that regulate the tRNA availability in the cell are specific and how they can affect protein translation and directly impact cell fitness. (europa.eu)
This work aimed to uncover new regulatory mechanisms in the cell that may have broad impact in the understanding of how protein synthesis is regulated. (europa.eu)
The SLC20A2 gene provides instructions for making a protein called sodium-dependent phosphate transporter 2 (PiT-2). (medlineplus.gov)
SLC20A2 gene mutations lead to the production of a PiT-2 protein that cannot effectively transport phosphate into cells. (medlineplus.gov)
The PDGFRB gene provides instructions for making a protein that transmits signals from the cell surface into the cell. (medlineplus.gov)
PDGFRB gene mutations result in a protein with impaired signaling ability. (medlineplus.gov)
This research aimed to map NPP1,2, and 3 expression in the developing periodontium in wild-type (WT) mice, as well as in PP i -deficient progressive ankylosis protein ( Ank ) and Enpp1 KO mice, to explore their roles in periodontal homeostasis. (umich.edu)
Cluster of differentiation 97 is a protein also known as BL-Ac [F2] encoded by the ADGRE5 gene. (abcam.com)
At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)
0.001) compared to patients without NI-LGE, with no significant difference in the burden of rare protein altering variants in DCM-associated genes between groups (9.7% vs 6.7%, odds ratio 1.5, 95% CI 0.5-4.4, p=0.41). (imperial.ac.uk)
Thus, it has evolved a protection mechanism against heat stress by increasing the expression of the gene coding for heat shock protein (HSP) 70 under elevated temperatures. (biomedcentral.com)
Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
The team also identified a third gene that affected worm sleep patterns, methionyl-tRNA synthetase ( mars-1 ), which is critical for the translational initiation and elongation steps of protein biosynthesis. (the-scientist.com)
Here, we show that Cryptococcus neoformans heat shock factor 3 (CnHsf3) exhibits an atypical function in regulating mtROS independent of the unfolded protein response. (lu.se)
The cell surface protein Fas (CD95) and its ligand play a pivotal role in regulating lymphocyte apoptosis, and defective expression of either Fas or Fas ligand results in marked overaccumulation of mature lymphocytes and autoimmune disease in mice. (medscape.com)
A second group of methods, which includes DNA microarrays and proteomics, have advantages that overcome the limitations implicit in signature-tagged mutagenesis and in vivo expression technology, namely, the ability to directly measure expression (gene or protein) levels on a true genome-wide scale, but their application to analysis of bacterial pathogens during real infections is still in its infancy. (cdc.gov)

Despite the known impacts of the gut microbiota on host glucose homeostasis, the underlying mechanisms are unknown. (mcmaster.ca)
The gut microbiome is also a potent mediator of gut-derived serotonin synthesis, and this peripheral source of serotonin is itself a regulator of glucose homeostasis. (mcmaster.ca)
Here, we determined whether the gut microbiome influences glucose homeostasis through effects on gut-derived serotonin. (mcmaster.ca)
Mouse knock-out strains demonstrated that T2D-associated candidates regulate glucose homeostasis and body composition in vivo. (lu.se)
Activation of the peroxisome proliferator-activated receptor alpha (PPAR alpha) modulates lipid and glucose homeostasis, cell proliferation and differentiation, and inflammation. (cdc.gov)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Mutations in this gene cause the autosomal recessive disorder, chorea-acanthocytosis. (nih.gov)
Exome sequencing of choreoacanthocytosis reveals novel mutations in VPS13A and co-mutation in modifier gene(s). (nih.gov)
Primary familial brain calcification is caused by mutations in one of several genes. (medlineplus.gov)
These individuals are thought to have mutations in genes that have not yet been linked to the condition. (medlineplus.gov)
Therefore, mutations have been introduced by homologous recombination (HR) in F9 embryonal carcinoma (EC) cells, a cell-autonomous system that differentiates in the presence of RA, in order to disrupt RAR and RXR genes and establish their cellular and molecular functions in RA-induced differentiation. (degruyter.com)
However, due to (i) the complexity in "hormonal" signaling through transduction by the multiple RARs and RXRs, (ii) the functional redundancies (possibly artefactually generated by the mutations) within receptor isotypes belonging to a given gene family, and (iii) in utero or postnatal lethality of certain germline null mutations, these genetic studies through germline mutagenesis have failed to reveal many of the physiological functions of RARs and RXRs, notably in adults. (degruyter.com)
We conclude that spatio-temporally controlled somatic mutations generated in animal models in given cell-types/tissues and at chosen times during pre- and postnatal life, are required to reveal the physiological and pathophysiological functions of the receptor genes involved in the retinoid signaling pathway throughout the life of the mouse. (degruyter.com)
The pathophysiology of epidermodysplasia verruciformis is linked to defective cell-mediated immunity, with elucidation of mutations in EVER1 ( TMC6 ) and EVER2 ( TMC8 ) genes (band 17q25). (medscape.com)
[ 8 ] It has been reported that mutations of EVER genes impair the ZnT-1/EVER complex, leading to increased zinc levels in the cytoplasm and allowing replication of EV HPV and abnormal sensitivity to infections by EV HPV. (medscape.com)
[ 11 ] Sporadic reports have described patients with the epidermodysplasia verruciformis phenotype who exhibit mutations in other genes. (medscape.com)
Kawano found that mutations in three genes made the worms sleep significantly longer than usual. (the-scientist.com)

Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses. (nih.gov)
Results showed that the dietary interventions altered the microbiota composition of cecal digesta, microbiota-mediated metabolism, and the gene expression profile in intestinal epithelial cells. (rsc.org)
The results suggested a new regulatory mechanism via which butanoate and AMPK activation contributed to intestinal integrity and homeostasis by affecting metabolism, intestinal barrier function and transporter expression. (rsc.org)
In addition, FXR is critical in regulating lipid metabolism and reducing inflammation, processes critical in the development of cholestasis and fatty liver diseases. (aspetjournals.org)

Further evidence suggests that during PD progression, transcriptional programs for the expression of genes involved in mitochondrial structure and function are disrupted 11 . (nature.com)
It represses the expression of genes involved in the tricarboxylic acid cycle while promoting expression of genes involved in electron transfer chain. (lu.se)

The functional enrichment analysis detected TF linked to lipid homeostasis and inflammatory response, such as RXRA , EGFR , and SREBP2 precursor. (nature.com)
Here, we investigated the effect of pretreatment with exogenous melatonin on the net photosynthetic rate, the maximum photochemical efficiency of PSII, chlorophyll content, lipid peroxidation, reactive oxygen species (ROS) accumulation, antioxidant potential, and redox homeostasis in leaves of tea plants following cold stress. (mdpi.com)

It is essential for a variety of cellular processes and can be used to maintain biological homeostasis under stress [ 6 ]. (hindawi.com)

Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
Gene expression must be appropriately maintained to regulate development, differentiation, and proliferation of cells. (intechopen.com)

Programmed cell death (apoptosis) of activated lymphocytes is critical to immune homeostasis. (medscape.com)

I will be presenting our advances on uncovering the full set of genes coordinately maintaining energy homeostasis in a metazoan. (colostate.edu)

Alternative splicing of this gene results in multiple transcript variants. (nih.gov)
Loss of function-variants in cohesin genes including RAD21 were found in individuals with holoprosencephaly of whom some demonstrated CdLS features as well (Kruszka et al. (springer.com)
Multiple SNPs were located in the loci of four previously reported genes (GABRG3, CYP19A1, PAPSS2 and CASR), and two of these (GABRG3 and CASR) had significant variants in both African Americans and European Americans. (medscape.com)
For instance, if we identify a set of genes that predispose a person to low-PA, we should modify the exercise training to pose more challenge to potentially make this person respond even if they have the 'wrong' set of variants. (medscape.com)
For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. (who.int)

These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)

It will extend to the identification and characterization of HIF-2α target genes, with a specific emphasis on their role in modulating the fundamental processes associated with intestinal stemness and tissue renewal. (lu.se)

The objective of this study was to investigate the effects of dietary intervention on intestinal microbiota-mediated change in short chain fatty acid (SCFA) profile and intestinal homeostasis. (rsc.org)
Herb-partitioned moxibustion may inhibit excessively activated autophagy and modulate the expression of immune-related factors by regulating the LKB1-mTOR-PI3KC signal transduction networks, thereby alleviating intestinal inflammation in CD rats. (hindawi.com)
BAs are critical molecules for life, and disruption of BA homeostasis has been closely linked to hepatic, intestinal, and systemic diseases, including cholestasis, fatty liver diseases, and hepatic and colon tumors. (aspetjournals.org)
Using available RNA sequencing data from previously published studies on intestinal organoids, the project will compare the gene expression profiles with newly generated RNA sequencing data from our lab's organoid cultures at hypoxia. (lu.se)
The project aims to elucidate the impact of oxygen levels on the HIF-2α pathway and its target genes in the context of intestinal stemness and tissue renewal. (lu.se)
This approach will provide a comprehensive understanding of the potential implications of HIF-2α in intestinal homeostasis. (lu.se)

The gene for LAG-3 lies adjacent to the gene for CD4 on human chromosome 12 (12p13) and is approximately 20% identical to the CD4 gene. (wikipedia.org)
8] The hGR gene is one locus on the long arm of chromosome 5 (q31.3) and consists of 9 exons. (medscape.com)
TCF7L2 was discovered as a type 2 diabetes susceptibility gene after a strong linkage signal was mapped to chromosome 10q in a Mexican-American population. (medscape.com)

As in mammals, the timing and intensity of these dynamic sleep processes in flies is homeostatically regulated and modulated by behavioral experience. (jneurosci.org)
The thyroid hormone receptor regulates a diverse set of genes that control processes from embryonic development to adult homeostasis. (nih.gov)
Alternatively, changes in PDGFRB signaling could disrupt processes that regulate levels of phosphate and calcium in brain cells, leading to the formation of calcium deposits. (medlineplus.gov)

Adipose tissue is a key nutrient-sensing depot that regulates excess energy storage and consumption. (frontiersin.org)
Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy demands, and secrete factors (lipids, peptides, cytokines, and adipokines) to regulate other metabolic tissues. (frontiersin.org)
In this review, we intend to provide a perspective on ceramides and ceramide metabolites in the maintenance of adipose tissue homeostasis and how adipose tissue ceramides contribute to the development of metabolic diseases. (frontiersin.org)

We demonstrate that deletion of ERRγ from DAergic neurons in adult mice was sufficient to cause a levodopa-responsive PD-like phenotype with reductions in mitochondrial gene expression and number, that partial deficiency of ERRγ hastens synuclein-mediated toxicity, and that ERRγ overexpression reduces inclusion load and delays synuclein-mediated cell loss. (nature.com)
Whole-body knockout of the Mig6 gene in mice has been shown to induce osteoarthritis and joint degeneration. (bepress.com)

Leptin is a hormone that regulates homeostasis energy through the central- peripheral mechanism as well as regulates hunger and satiety. (ajol.info)
Genetic screens have revealed three peripheral tissue genes that regulate sleep. (the-scientist.com)
Researchers from the University of Tokyo and University of Tsukuba reported three key genes that are critical for regulating sleep-not in the brain, but in peripheral tissues. (the-scientist.com)

Objective Mitogen-inducible gene 6 (MIG-6) regulates epidermal growth factor receptor (EGFR) signaling in synovial joint tissues. (bepress.com)
Fourteen NAS genes were also found to be upregulated in root tissues under iron deficiency. (isaaa.org)
Central to this investigation is an understanding of what gene products are required and expressed during a natural infection and how this expression changes over time (from initial colonization to causation of disease and spread of the pathogen to new hosts) and space (in different cells or tissues within the host). (cdc.gov)

Our study is a first step to exploit PA genetics to inform future personalized intervention strategies, although it is important to note that the putative genes identified in the current study require substantial further investigation and validation before firm links can be established," they add. (medscape.com)

Under normal conditions, the dynamic balance of T helper type 1 (Th1) and Th2 activities maintains the immune homeostasis of the body. (hindawi.com)

A study by researchers from the University of Melbourne and the University of Adelaide in Australia describes the identification of 21 NAS genes in the hexaploid bread wheat ( Triticum aestivum L.) genome. (isaaa.org)
Although analyses that give information on the expression of a few genes provide insight and have been responsible for a large proportion of the bacterial pathogenesis literature currently available, our ultimate goal is to understand expression changes across the whole genome. (cdc.gov)
The additional information generated by whole genome studies goes far beyond that derived by characterizing in isolation more genes and gene products, because analysis of the whole genome allows complete regulatory networks to be identified and characterized. (cdc.gov)

1, 2, 3] Approximately 20% of the genes expressed in human leukocytes are regulated positively or negatively by glucocorticoids. (medscape.com)

Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, many of which are targets for the transcription factor estrogen-related receptor gamma ( Esrrg /ERRγ). (nature.com)
in fact, these genes are targets of the transcriptional coactivator and master regulator of transcription of mitochondrial genes peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) 12 . (nature.com)
Direct regulators of nuclear-encoded mitochondrial genes are members of the estrogen-related receptor (ERR) family, encoded by Esrra , Esrrb and Esrrg . (nature.com)
In 2012, two siblings who were homozygous for a mutation that created a stop codon in the Ras homolog gene family member H ( RHOH ) gene exhibited an epidermodysplasia verruciformis phenotype and their T cells exhibited impaired T-cell receptor (TCR) signaling. (medscape.com)
A) Schematic representation of the structure of the human glucocorticoid receptor (hGR) gene. (medscape.com)
Alternative splicing of the hGR gene in exon 9 generates 2 highly homologous receptor isoforms, termed α and β. (medscape.com)
The mutation in leptin receptor (LEPR) gene causes splicing abnormality that resulted in truncated receptor, aberrant signal transduction, leptin resistance, and obesity. (ajol.info)
Farnesoid X receptor (FXR) and its regulated target networks in both the liver and the intestines are critical in suppressing BA synthesis and promoting BA transport and enterohepatic circulation. (aspetjournals.org)

Similar to SREBP-1a and SREBP-1c, SREBP-2 acts by first binding to sterol regulatory DNA sequences, and subsequently up-regulating the synthesis of enzymes involved in sterol biosynthesis. (novusbio.com)

These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)
Overall, the findings "suggest that human LTPA may be regulated by the genetic factors through 1) homeostasis and neural reward system, both of which are under the constant control of the nervous system, (and) 2) the structural and metabolic constraints exerted on the capacity to actually perform LTPA," the researchers conclude. (medscape.com)
When the genetic information containing the "blueprint" for these substances is disrupted, cell homeostasis is disrupted, resulting in a wide-range of immediate and/or delayed toxicological effects. (cdc.gov)

Hence, susceptibility to infection can be characterized by a construct that involves not only gene expression patterns of the host but also that of the microorganism, both of which continue to adapt in response to external stimuli. (hindawi.com)

This study aims to determine the association of LEPR gene polymorphisms, rs1137100 and rs1137101, on phenotype and leptin level between obese and control groups in Yogyakarta population. (ajol.info)
The team next used tissue-specific promoters to rescue expression of these genes in different parts of the body and found that expression in the epidermis of the worms restored a normal sleep phenotype. (the-scientist.com)

Additionally, the identified relationship between expressions of host immune genes and stx2 suggests that the host animal may regulate stx2 expression in colonizing STEC through immune functions. (frontiersin.org)

For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)
FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth. (nih.gov)

In other words, expression of specific genes might have relevance to pathogenesis of diseases. (intechopen.com)
Although the role of EVER1 and EVER2 genes in the pathogenesis of epidermodysplasia verruciformis remains unclear, one hypothesis is that they are involved in the control of HPV infection within keratinocytes, or they play a role in the immune response to the infection itself. (medscape.com)

While ERRγ deletion did not fully recapitulate the transcriptional alterations observed in postmortem tissue, it caused reductions in genes involved in synaptic and mitochondrial function and autophagy. (nature.com)
Laser-captured microdissected (LCM) DAergic neurons from postmortem tissue of patients with Lewy-pathology revealed a deficiency in expression for nuclear-encoded genes involved in mitochondrial respiration and function 12 . (nature.com)
The stx1 gene abundance was only detected in tissue samples collected in year 2 and did not differ among breeds. (frontiersin.org)

However, there is still a huge gap in understanding how these chemicals contribute to the dysregulation of BA homeostasis and how this dysregulation may promote NASH development. (aspetjournals.org)

Nicotianamine synthase ( NAS ) genes , which encode enzymes that synthesize NA, are regulated by iron status in most plant species, and plant genomes have been found to contain anywhere from 1 to 9 NAS genes. (isaaa.org)

However, the effects and the mechanisms by which environmental chemicals interact with FXR to affect BA homeostasis are only emerging. (aspetjournals.org)

Bile acids are important liver products, and their levels are tightly regulated. (nih.gov)

Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)

Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)

Also, Quantitative RT-PCR was used to evaluate the mRNA expression level of genes related to the Wnt signal pathway in treated cancer cells and control groups. (researchsquare.com)

Moreover, utilizing advanced bioinformatics tools, the project will employ Gene Set Enrichment Analysis (GSEA) to discern the enrichment patterns of HIF-2α target upregulated genes within the obtained datasets. (lu.se)

Notably, HSP genes, which function as molecular chaperones, play an important role in heat shock response. (biomedcentral.com)

However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)
The DNA-binding domain (DBD) of the hGRα corresponds to amino acids 420-480 and contains 2 zinc finger motifs through which the hGRα binds to specific DNA sequences, the glucocorticoid-response elements (GREs) in the promoter region(s) of target genes. (medscape.com)

The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)

Erosion of bone at ligament entheses was evident by 12 weeks of age, by both histologic and micro-CT assessment.Conclusion MIG-6 expression in chondrocytes is important for the maintenance of cartilage and joint homeostasis. (bepress.com)

This study assessed the abundance and expression of Stx genes and the expression of host immune genes, aiming to determine factors affecting these measures and potential gene markers to differentiate Stx gene expression in the recto-anal junction of feedlot beef cattle. (frontiersin.org)
Finally, we also identified tRNA shuttling between nucleus and cytoplasm as a new player in regulating tRNA abundance. (europa.eu)

Other genes known to be associated with primary familial brain calcification also have roles in cell signaling and phosphate homeostasis. (medlineplus.gov)

ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma. (lu.se)

In the upregulated genes, we identified one HSP70 potentially regulated by HSF1 in response to heat shock. (biomedcentral.com)
Our results revealed that the expression of HSP70 and HSP20 was initially triggered after 2 h of heat shock, and one of the HSP70 genes was potentially regulated by HSF1 . (biomedcentral.com)
Studies in twins have estimated an influence of heritability on leisure-time physical activity (LTPA) in the range of 35% to 83%, and recent work has identified several potentially relevant genes. (medscape.com)

Anatomy33

Organisms11

Diseases8

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Psychiatry and Psychology1

Phenomena and Processes57

Disciplines and Occupations1

Information Science4

Regulation9

Proteins11

Differentially3

Pathways5

Protein19

Glucose5

Mutations12

Metabolism4

Expression of genes invol2

Lipid2

Cellular1

Proliferation2

Apoptosis1

Coordinately1

Variants5

Phenotypes2

Identification and Characterization1

Intestinal6

Chromosome3

Processes3

Adipose tissue3

Mice2

Peripheral3

Tissues3

Putative1

Immune homeostasis1

Genome3

Negatively1

Receptor8

Synthesis1

Genetic3

Susceptibility1

Phenotype2

Suggests1

Receptors2

Pathogenesis2

Tissue3

Dysregulation1

Enzymes1

Mechanisms1

Liver1

Nuclear1

Analyses1

MRNA1

Datasets1

Notably1

Sequences2

Sequence2

Cartilage1

Abundance2

Roles1

Target1

Potentially3