• Stat1
  • STAT1 has a key role in many gene expressions that cause survival of the cell, viability or pathogen response. (wikipedia.org)
  • There are two possible trancripts (due to alternative splicing) that encode 2 isoforms of STAT1 STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. (wikipedia.org)
  • 2 related patients had a homozygous missense STAT1 mutation which caused impaired splicing, therefore a defect in mature protein. (wikipedia.org)
  • cytokines
  • HCC microenvironment consists of (a) stromal cells, such as carcinoma-associated fibroblasts (CAFs), hepatic stellate cells (HSCs), endothelial cells and immune cells, (b) growth factors and inflammatory cytokines, and (c) extracellular matrix proteins [ 1 ]. (hindawi.com)
  • The IL-6-type family of cytokines, which includes IL-6 as well as a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. (novusbio.com)
  • Inhibition
  • Inhibition of SIRT1 by use of SIRT1 siRNA or SIRT1 inhibitors (amurensin G and EX527) effectively potentiated sensitivity of Hsp90 inhibitors (17-AAG and AUY922) in CD44 high K562 stem-like cells expressing high levels of CSC-related molecules including Oct4, CD34, β-catenin, c-Myc, mutant p53 (mut p53), BCRP and P-glycoprotein (P-gp) as well as CD44. (ijbs.com)
  • However, direct inhibition of Hsp90 leads to disruption of complexes of Hsp90 with heat shock factor 1 (HSF1), thereby causing HSF1-mediated induction of cytoprotective heat shock proteins (Hsps) such as Hsp70 and Hsp27, which contribute to resistance to Hsp90 inhibitors [ 10 ]. (ijbs.com)
  • The cellular response in signal transduction cascades involves alteration of the expression of effector genes or activation/inhibition of targeted proteins. (wikipedia.org)
  • mutations
  • Activating mutations in FLT3 have been identified in approximately 30% of patients with acute myelogenous leukemia, making it one of the most common mutations observed in this disease. (jove.com)
  • Activated inflammatory cells release free radicals, such as reactive oxygen species (ROS) and nitric oxide (NO) reactive species, which in turn can cause DNA damage and lead to gene mutations, thus fostering neoplastic transformation. (hindawi.com)
  • Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. (origene.com)
  • antibody
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • Induction
  • Pretreatment of cells with the p38MAPK-specific inhibitor SB202190 downregulates the induction of SOCS3-mRNA expression by IL-6. (uniprot.org)
  • These data indicate that p38MAPK-activation is crucial for IL-6-induced SOCS3 expression and downregulation of IL-6-mediated gene induction. (uniprot.org)
  • Regulation
  • SIRT1 depletion caused significant down-regulation of heat shock factor 1 (HSF1)/heat shock proteins (Hsps) as well as these CSC-related molecules, which led to the sensitization of CD44 high K562 cells to Hsp90 inhibitor by SIRT1 inhibitor. (ijbs.com)
  • inhibits
  • In vivo , CX-4945 inhibits activation of STAT-3, NF-κB p65, and AKT, and promotes survival of mice with intracranial human glioblastoma xenografts. (aacrjournals.org)
  • dimers
  • STAT molecules form dimers and bind to ISGF3G/IRF-9, which is Interferon stimulated gene factor 3 complex with Interferon regulatory Factor 9. (wikipedia.org)
  • bind
  • Heat shock protein 90 (Hsp90) has emerged as a major pharmaceutical target in cancer therapy, since Hsp90 is known to bind and stabilize a wide range of proteins with activity in the cell cycle, signal transduction and transcription, many of which are widely implicated in cancers [ 3 ]. (ijbs.com)
  • Hydrophobic/membrane-associated - are insoluble in water and membrane-associated, being localized at intermembrane spaces, where they can bind to membrane-associated effector proteins. (wikipedia.org)
  • Drosophila
  • During Drosophila research, it was found that a mutation in the gene MAD in the mother repressed the gene decapentaplegic in the embryo. (wikipedia.org)
  • transcript variants
  • Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. (wikipedia.org)
  • This gene has two different alternatively spliced transcript variants. (wikipedia.org)
  • intracellular
  • Indeed, drugs aimed at inhibiting Hsp90 have been shown to possess multiple intracellular targeting capacities and could potentially be active against many types of cancer through degradation of a large number of client proteins [ 4 ]. (ijbs.com)
  • catalytic
  • JAK3 inhibitors target the catalytic ATP-binding site of JAK3 and have there been various moieties utilised to get a stronger affinity and selectivity to the ATP-binding pockets. (wikipedia.org)
  • Additionally
  • Additionally, TRIM32 is known to ubiquitinate dysbindin, a protein associated with both skeletal muscles and neural tissue. (wikipedia.org)
  • Additionally, an oral AXL inhibitor (TP-0903) is expected to enter Phase 1 clinical trial in November 2016 (in advanced solid tumours: NCT02729298). (wikipedia.org)
  • Hsp90
  • The current investigation was undertaken to examine the effectiveness of the combination treatment of Hsp90 inhibitor and SIRT1 inhibitor in inhibiting the growth of chemo-resistant stem-like cells isolated from human chronic myeloid leukemia K562 cells. (ijbs.com)
  • Moreover, 17-AAG-mediated activation of HSF1/Hsps and P-gp-mediated efflux, major causes of Hsp90 inhibitor resistance, was suppressed by SIRT1 inhibitor in K562-CD44 high cells. (ijbs.com)
  • Our data suggest that combined treatment with Hsp90 inhibitor and SIRT1 inhibitor could be an effective therapeutic approach to target CSCs that are resistant to current therapies. (ijbs.com)