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  • PMID
  • They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [ PMID: 10529348 , PMID: 15963892 , PMID: 15718139 , PMID: 17210253 , PMID: 12665246 ]. (ebi.ac.uk)
  • Miz1 binds to the homeobox protein Msx2, enhancing the specific DNA-binding ability of Msx2 [ PMID: 9256341 ]. (ebi.ac.uk)
  • Stat1
  • STAT1 has a key role in many gene expressions that cause survival of the cell, viability or pathogen response. (wikipedia.org)
  • There are two possible trancripts (due to alternative splicing) that encode 2 isoforms of STAT1 STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. (wikipedia.org)
  • 2 related patients had a homozygous missense STAT1 mutation which caused impaired splicing, therefore a defect in mature protein. (wikipedia.org)
  • regulate
  • The function of TFs is to regulate - turn on and off - genes in order to make sure that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. (wikipedia.org)
  • A defining feature of TFs is that they contain at least one DNA-binding domain (DBD), which attaches to a specific sequence of DNA adjacent to the genes that they regulate. (wikipedia.org)
  • Transcription factors bind to either enhancer or promoter regions of DNA adjacent to the genes that they regulate. (wikipedia.org)
  • Other transcription factors differentially regulate the expression of various genes by binding to enhancer regions of DNA adjacent to regulated genes. (wikipedia.org)
  • selective
  • Utilizing CX-4945, the first selective CK2 inhibitor to advance into human clinical trials, we demonstrate the therapeutic effects of inhibiting CK2 activity in flank and intracranial models of glioblastoma-patient derived cells in vivo . (aacrjournals.org)
  • Initially, Tofacitinib was thought to be a selective JAK3 inhibitor but it later it was shown that it is also a potent inhibitor of JAK1 and JAK2. (wikipedia.org)
  • It has been difficult to develop sufficiently selective JAK3 inhibitors. (wikipedia.org)
  • The most advanced AXL selective inhibitor is bemcentinib (BGB324 or R428), an oral small molecule currently in multiple Phase II clinical trials for NSCLC, TNBC, AML and melanoma. (wikipedia.org)
  • tumor
  • We use targeted conditional and inducible mouse models and other cellular and molecular approaches to uncover gene-expression and genomic and epigenetic alteration that occur during tumor development and progression and to functionally analyze the biological significance of these changes in oncogenic transformation. (stanford.edu)
  • TRIM32 additionally promotes cancer formation by ubiquitinating Abl-interactor 2 (Abi2), which is a tumor suppressor and inhibitor of cell migration. (wikipedia.org)
  • Inhibition
  • The cellular response in signal transduction cascades involves alteration of the expression of effector genes or activation/inhibition of targeted proteins. (wikipedia.org)
  • Drosophila
  • During Drosophila research, it was found that a mutation in the gene MAD in the mother repressed the gene decapentaplegic in the embryo. (wikipedia.org)
  • transcript variants
  • Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. (nih.gov)
  • This gene has two different alternatively spliced transcript variants. (wikipedia.org)
  • Genome
  • Analysis of 537 glioblastomas from The Cancer Genome Atlas Project demonstrates the CSNK2A1 gene, encoding CK2α, has gene dosage gains in glioblastoma (33.7%), and is significantly associated with the classical glioblastoma subtype. (aacrjournals.org)
  • Human NR2F1 genome location and NR2F1 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • The number of transcription factors found within an organism increases with genome size, and larger genomes tend to have more transcription factors per gene. (wikipedia.org)
  • There are approximately 2600 proteins in the human genome that contain DNA-binding domains, and most of these are presumed to function as transcription factors, though other studies indicate it to be a smaller number. (wikipedia.org)
  • Additionally
  • Additionally, TRIM32 is known to ubiquitinate dysbindin, a protein associated with both skeletal muscles and neural tissue. (wikipedia.org)
  • Additionally, an oral AXL inhibitor (TP-0903) is expected to enter Phase 1 clinical trial in November 2016 (in advanced solid tumours: NCT02729298). (wikipedia.org)
  • inhibits
  • In vivo , CX-4945 inhibits activation of STAT-3, NF-κB p65, and AKT, and promotes survival of mice with intracranial human glioblastoma xenografts. (aacrjournals.org)
  • extracellular
  • The AXL receptor transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6 (GAS6). (wikipedia.org)
  • In the signal transduction via transmembrane receptors, first messenger bind to the extracellular domain of transmembrane receptor activating it. (wikipedia.org)
  • SMAD7
  • Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. (wikipedia.org)
  • A mutation located in SMAD7 gene is a cause of susceptibility to colorectal cancer (CRC) type 3. (wikipedia.org)
  • interaction
  • The interaction blocks the formation of the IRAK1-mediated IL-1R/TLR signaling complex therefore abrogates NF-κB activity, which subsequently causes reduced expression of pro-inflammatory genes. (wikipedia.org)
  • For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see NFATC1). (wikipedia.org)
  • human
  • We demonstrate for the first time that CSNK2A1 , the gene encoding CK2α, shows frequent gene dosage gains in human glioblastoma tissues. (aacrjournals.org)
  • While the activity of these proteins is tightly regulated under physiological conditions, they can become constitutively activated in a broad range of human cancers. (harvard.edu)
  • novel
  • Employing these systems, one can screen large chemical libraries to identify compounds that specifically block the function of a given STAT. This approach can lead to the identification of compounds that inhibit STATs by a variety of mechanisms, and can suggest novel targets for therapy. (harvard.edu)
  • Activation
  • Abnormal STAT-3 activity has been implicated in the resistance of glioblastoma to temozolomide, and we show that CK2 expression/activity is critical for STAT-3 activation in glioblastomas, highlighting the potential of CK2 inhibitors being used in combination with standards of care. (aacrjournals.org)
  • This inappropriate STAT activation leads to enhanced transcription of genes that can directly lead to the malignant phenotype. (harvard.edu)
  • NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. (wikipedia.org)
  • 2002
  • 2002) G protein-coupled receptor allosterism and complexing. (personal-forex.com)
  • The various theories surrounding Friedman's omission of Leibel and others as co-authors of this paper have been presented in a number of publications, including Ellen Ruppel Shell's 2002 book The Hungry Gene. (wikipedia.org)
  • Furthermore
  • Furthermore we analyzed the degrees of CYP2C55 proteins in liver organ microsomes and of serum 19-HETE using Traditional western blot evaluation and liquid chromatography/tandem mass spectrometry respectively. (researchreport-digital.com)
  • enzyme
  • Malonyl-CoA decarboxylase is firstly processed as a pro-protein or proenzyme, in which the transit peptide, whose role is to transport the enzyme to a specific organelle (in this case the mitochondria), comprises the first 39 amino acids (beginning with a methionine and ending with an alanine). (wikipedia.org)
  • Similarly, a deacetylation in this specific amino acid by SIRT4 (a mitochondrial protein) represses the enzyme activity. (wikipedia.org)
  • N-alpha-acetyltransferase 10 (NAA10) also known as NatA catalytic subunit Naa10 and arrest-defective protein 1 homolog A (ARD1A) is an enzyme subunit that in humans is encoded NAA10 gene. (wikipedia.org)
  • acetylation
  • The last one, which consists of an acetylation in the amino acid lysine in position 472, activates malonyl-CoA decarboxylase activity. (wikipedia.org)
  • Despite the fact that Nα-terminal acetylation of proteins has been known for many years, the functional consequences of this modification are not well understood. (wikipedia.org)
  • amino
  • In addition to carbohydrate adjustments, lectin connections are well guided by amino acidity residues of their focus on receptor necessary protein. (world-of-links.com)
  • The polypeptide chain in the mature protein is comprised between amino acid 40 and 493. (wikipedia.org)
  • Human leptin is a 16-kDa protein of 167 amino acids. (wikipedia.org)
  • Together with its auxiliary subunit Naa15, Naa10 constitutes the NatA (Nα-acetyltransferase A) complex that specifically catalyzes the transfer of an acetyl group from acetyl-CoA to the N-terminal primary amino group of certain proteins. (wikipedia.org)
  • receptor
  • The HGF effect was also mediated at low glucose concentrations via insulin receptor substrate 4 (IRS-4) whereas other IRS proteins did not show any activation. (bioscientifica.com)
  • Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. (wikipedia.org)
  • humans
  • Plasma resistin levels are correlated with markers of inflammation and are predictive of coronary atherosclerosis in humans, independent of plasma C - reactive protein. (biomedcentral.com)
  • More than twenty distinct IFN genes and proteins have been identified in animals, including humans. (wikipedia.org)
  • Interferon type II (IFN-γ in humans): This is also known as immune interferon and is activated by Interleukin-12. (wikipedia.org)
  • In humans, it is encoded by the MLYCD gene. (wikipedia.org)
  • citation needed] The Ob(Lep) gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans. (wikipedia.org)
  • SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene. (wikipedia.org)
  • promoter
  • The PAI-1 promoter was analyzed using electrophoretic mobility shift assays (EMSAs) and luciferase reporter gene assays. (bioscientifica.com)
  • Demethylation of HES1 target sites in the promoter region of astrocyte-specific genes hastens astrocyte differentiation. (wikipedia.org)
  • 2000
  • 2004 Chen and Goldstein 2009 resulting in altered medication efficacies and leading to drug-drug relationships (Honkakoski and Negishi 2000 Once triggered these receptors bind response components located inside the 5′-flanking parts of focus on genes (Honkakoski et al. (researchreport-digital.com)
  • 1998 Honkakoski and Negishi 2000 Sueyoshi and Negishi 2001 Tompkins and Wallace 2007 Mice are significantly Ponatinib used as pet models for human being disease and so are an excellent program to research drug-induced rules of genes. (researchreport-digital.com)
  • cell
  • Today's study aimed to investigate the correlation between insulin-like growth factor binding protein 3 (IGFBP-3) and metastasis-associated gene 1 (MTA1) protein and the clinicopathological features and prognosis of esophageal squamous cell carcinoma (ESCC). (world-of-links.com)
  • These factors act, at least partly, by changing the genes of a cell. (wikipedia.org)
  • The function of activated AXL in normal tissues includes the efficient clearance of apoptotic material and the dampening of TLR-dependent inflammatory responses and natural killer cell activity. (wikipedia.org)
  • mutation
  • Women who carry certain mutation genes, such as BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer. (blogspot.com)
  • A nonsense mutation in the leptin gene that results in a stop codon and lack of leptin production was first observed in mice in 1950. (wikipedia.org)
  • The most common genetic mutation (found in 80-90% of epithelioid sarcomas) is the inactivation of the SMARCB1 gene, or the loss of INI-1 function, which is thought to be a major contributor to disease progression. (wikipedia.org)
  • subunit
  • Nevertheless, the conformational change produced in a subunit when changing from the B state to the U state (which produces the release of the product) coincides with the formation of a new union site in the active site of the neighbour subunit when changing from the U stat to B state. (wikipedia.org)
  • bind
  • Hydrophobic/membrane-associated - are insoluble in water and membrane-associated, being localized at intermembrane spaces, where they can bind to membrane-associated effector proteins. (wikipedia.org)
  • degradation
  • Here, we present evidence that RAD6 is also required for DNA DSB repair via homologous recombination (HR) by specifically regulating the degradation of heterochromatin protein 1? (jove.com)