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ObeseCause obesityVariantsLeptin receptor geneAdipose tissuePolymorphismResearchersMiceRole in obesityInsulin2023Overweight and ObesityAdipocytesAdultsEpidemicDiabetes and ObesityContribute to obesityDiet-induced obesityDevelopment of ObesityMetabolismPrevalence of obesity amongMeasures of obesityHumansMetabolic syndromeAnti-obesityMass-and obesity-associatedType 2 diabetSevere obesityVariationAffectsChromosomeRiskLociGenotypeMorbid obesityPopulationsInfluence ObesityMutationCounteractGlucosePolygenicVariantChildhoodVariations in the FTO genePeople with obesityProne to obesityCure for obesityGenetics of obesityTreatment for obesityGenetically predisposedAlterationsExtreme obesityMultiple genesTraitsStronglyDiseasesPotential obesityCauses Obesity
Obese17
  • Researchers used a modified CRISPR gene editing technique to target the fat cells of obese, diabetic mice. (medicalnewstoday.com)
  • The current study found that the gene HHEX-IDE does not affect birth weight, but makes it more likely that a child will become obese during childhood. (scienceblog.com)
  • The researchers' work on flies showed that the gene is "dose-sensitive" - that is, the various combinations of the gene's variants lead to a range of body types from slim to medium to obese. (medindia.net)
  • The scientific concept of healthy obesity stems from recent studies that show some overweight or obese people are just as healthy as normal-weight individuals since they have normal blood pressure, they are not diabetic and they good cholesterol levels. (time.com)
  • We found small changes in the inflammatory gene RIPK1 in the obese people, and these variations caused an increased amount of the gene being present in their fat tissue, increasing their risk of being obese," Dr. Karunakaran said. (neurosciencenews.com)
  • By finding an increased amount of inflammation in obese people, we can confidently say that obesity increases inflammation. (neurosciencenews.com)
  • Could a gene help make you obese? (nccor.org)
  • These individuals are 70 percent more likely to become obese than people who carry other versions of FTO gene, according to background information in the study published July 15 in the Journal of Clinical Investigation . (nccor.org)
  • This study aims to determine the association of LEPR gene polymorphisms, rs1137100 and rs1137101, on phenotype and leptin level between obese and control groups in Yogyakarta population. (ajol.info)
  • We examined two polymorphisms of LEPR gene, rs1137100 (K109R) and rs1137101 (Q223R) in 110 subjects consisting of 55 obese and 55 healthy adult subjects as controls from Yogyakarta. (ajol.info)
  • SNPs of LEPR gene for obese and control groups were compared using chi-square analysis. (ajol.info)
  • Other studies have compared obese and non-obese people for variation in genes that could influence behaviors (such as a drive to overeat, or a tendency to be sedentary) or metabolism (such as a diminished capacity to use dietary fats as fuel, or an increased tendency to store body fat). (cdc.gov)
  • Small bits of change in our genes have a lot to do with what happens to us in life, including whether we develop certain diseases, or become overweight or obese. (georgiefear.com)
  • At that time we learned that variations in the FTO gene influence people's risk of becoming obese. (blogs.com)
  • I look at developmental patterns that lead to adult-onset obesity in order to understand better about why we become obese," says Schmitt. (bu.edu)
  • I found that not only is there a genetic component to becoming obese in the first place, but there's also a genetic component to this developmental pattern leading to chronic obesity. (bu.edu)
  • No association was observed between the Pro12Ala polymorphism and obesity in Caucasians, but obese subjects carrying the Ala allele displayed an altered blood lipid profile compared with obese Pro/Pro subjects. (edu.au)
Cause obesity5
Variants12
  • Grant and study co-leader Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at Children's Hospital, investigated 20 gene variants, known as single nucleotide polymorphisms (SNPs), previously reported to be associated with type 2 diabetes. (scienceblog.com)
  • Grant cautioned that HHEX-IDE accounts for only a small proportion of the genetic contribution to the risk of type 2 diabetes, so many other gene variants remain to be discovered. (scienceblog.com)
  • "RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice" by Denuja Karunakaran et al. (neurosciencenews.com)
  • While it is well known that there is a strong genetic basis to both diabetes and obesity, and that they are linked, Australian researchers say that there are many rare genetic variants involved, which will pose a significant challenge in the quest to develop effective therapies. (fit-pro.com)
  • Using a longitudinal clinical database, the new evidence presented today demonstrates how the functional IL-1 gene variants, shown to influence periodontitis (PD) severity, affect the previously demonstrated association between obesity and PD progression," stated Lynn Doucette-Stamm, Ph.D., Vice President Development and Clinical Operations. (baycitycapital.com)
  • IL-1 gene variants have been previously shown to amplify the detrimental effects of smoking and diabetes on periodontitis severity. (baycitycapital.com)
  • This study provides additional evidence to guide clinical use of IL-1 gene variants, together with other risk factors, to assist dentists in identifying high risk patients who could potentially benefit from more frequent dental cleanings and monitoring to better maintain oral health. (baycitycapital.com)
  • These studies have identified variants in several genes that may contribute to obesity by increasing hunger and food intake. (cdc.gov)
  • Despite a relatively high heritability of common, non-syndromic obesity (40-70%), the search for genetic variants contributing to susceptibility has been a challenging task. (bioscientifica.com)
  • To date, more than 40 genetic variants have been associated with obesity and fat distribution. (bioscientifica.com)
  • However, since these variants do not fully explain the heritability of obesity, other forms of variation, such as epigenetics marks, must be considered. (bioscientifica.com)
  • Association of PCSK1 and PPARG1 Allelic Variants with Obesity and Metabolic Syndrome in Mexican Adults. (cdc.gov)
Leptin receptor gene1
  • Scholars@Duke publication: Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. (duke.edu)
Adipose tissue7
Polymorphism8
  • Polymorphism of rs1137100 (K109R) and rs1137101 (Q223R) were associated with obesity and leptin level. (ajol.info)
  • Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might influence susceptibility to obesity in survivors of childhood ALL. (duke.edu)
  • CONCLUSION LEPR polymorphism may influence obesity in female survivors of childhood ALL, particularly those exposed to cranial radiation. (duke.edu)
  • The aim of the first investigation was to test whether a common polymorphism (Pro12Ala) in the gene encoding peroxisome proliferator-activated receptor gamma 2 (PPAR-γ2) was associated with obesity and other cardiovascular risk factors in a large group of Caucasian subjects. (edu.au)
  • As the Pro12Ala polymorphism may exacerbate the risk of cardiovascular disease by modifying blood lipid profile in obesity, this relationship was examined further in a separate population. (edu.au)
  • The aim of the second investigation was to determine whether the Pro12Ala polymorphism was associated with obesity, dyslipidaemia, diabetes and carotid intima-medial wall thickening in a population at high risk of developing cardiovascular disease. (edu.au)
  • Role of rs9939506 polymorphism of FTO gene in resistance to eating in male adolescents. (cdc.gov)
  • T gene polymorphism. (bvsalud.org)
Researchers23
  • The researchers then scanned participants' genomes, looking for genes that were tied to an increased risk of obesity . (livescience.com)
  • The researchers noted that, for the average Joe or Jane, cycling and stretching exercises tend to require less energy expenditure than the six exercises that were tied to a lower obesity risk. (livescience.com)
  • Genome mapping has allowed genetic researchers to discover greater numbers of genes affecting common traits or conditions such as diabetes. (cedars-sinai.edu)
  • Pediatric researchers have found that a gene already implicated in the development of type 2 diabetes in adults also raises the risk of being overweight during childhood. (scienceblog.com)
  • The researchers drew on a cohort of nearly 7,200 Caucasian children, aged 2 to 18 years, in an ongoing genome-wide association study of childhood obesity at Children's Hospital. (scienceblog.com)
  • Researchers continue to unravel the complicated role of different diabetes-related genes in influencing body weight toward both lower and higher ends of the scale. (scienceblog.com)
  • Researchers found that exercise reduced the genetic risk of obesity in those in the high activity group. (regenexx.com)
  • Researchers at UT Southwestern Medical Center have discovered a gene, adipose, that controls a person's tendency to pile fat. (medindia.net)
  • The researchers believe that the discovery might lead to develop new ways to counter obesity and diabetes. (medindia.net)
  • Though the researchers' study is very specified to one molecule, it brings into question once again the larger debate about whether there really is such a thing as healthy obesity. (time.com)
  • In a new study, researchers observed that blocking the expression of the gene TRIP-Br2 in mice protects them against obesity and insulin resistance. (bignewsnetwork.com)
  • According to the researchers, understanding the regulation of the factors that control the storage, mobilisation and use of excess energy in fat cells (the adipocytes) can lead to the development of therapies for obesity and its related illnesses, such as type-2 diabetes. (bignewsnetwork.com)
  • The researchers then looked at the effect of turning the inflammatory gene on and off in mice. (neurosciencenews.com)
  • Researchers conducted laboratory trials on two groups of male mice to see how inherited genes affect an offspring's health. (femalenetwork.com)
  • Researchers have discovered a potential genetic explanation for why some people overeat and run a greater risk for obesity. (nccor.org)
  • The researchers first asked a group of 20 men -10 with the double variant, and 10 with a version of the FTO gene linked to lower obesity risk - to rate their hunger before and after a meal. (nccor.org)
  • Ghrelin levels normally increase before meals and fall afterward, but researchers found the men with the double FTO variant had much higher ghrelin levels after a meal and felt hungrier after eating than men who had the variation that carries lower obesity risk. (nccor.org)
  • Researchers from UT Health San Antonio have tied obesity to with 21 Alzheimer's disease -related genes. (salud-america.org)
  • In analyzing 74 Alzheimer's-related genes from the Framingham Heart Study , researchers found that 21 of them were either under-expressed or over-expressed in obesity. (salud-america.org)
  • Medical researchers, including QIMR scientists, have shown that a gene known to have a strong connection to obesity and other bodyweight related health issues also increases the risk of suffering from melanoma. (edu.au)
  • The researchers believe that this study is important when learning more about different subtypes of hand osteoarthritis and it also emphasizes the importance of learning more about which genes play a role in the development of osteoarthritis. (lu.se)
  • Researchers from Australia have investigated the incidence of obesity in patients with OA undergoing knee replacement. (lu.se)
  • Researchers have identified a gene on the X chromosome, GPR101, which was overexpressed 1000-fold more than normal in a genetic study of 43 patients affected by sporadic or inherited gigantism that manifested during childhood or adolescence. (medscape.com)
Mice12
  • Three genes of unknown function (Fts, Ftm and Fto), along with three members of the Iroquois gene family (Irx3, Irx5, and Irx6 from the IrxB gene cluster), are deleted in Ft mice. (gnxp.com)
  • If the gene expression is blocked, the mice increase their lipolysis and their energy expenditure, thus reducing their obesity. (bignewsnetwork.com)
  • The protection of mice with no expression of the gene TRIP-Br2, and its selective elevation in the visceral fat of humans point the way to a future gene therapy to counteract obesity, insulin resistance and excess lipids in the blood," Cristina Mallol, co-author of the study from the Universitat Autonoma de Barcelona, said. (bignewsnetwork.com)
  • A gene that helps to control inflammation increases the risk of obesity and could be turned off in mice to stop weight gain, a study from The University of Queensland has found. (neurosciencenews.com)
  • Without the gene, the mice remained at a normal weight despite eating a high-fat diet and their risk of diabetes was reduced. (neurosciencenews.com)
  • The mice with a normal level of the inflammatory gene put on weight from eating the same high-fat diet. (neurosciencenews.com)
  • Flies and mice that lack this gene have increased fat storage and appear starvation resistant and less active, whereas overexpression of this gene leads to lean metabolically healthy animals. (drsharma.ca)
  • FTO gene was universally expressed in human and mice tissues, including adipocytes. (diabetesjournals.org)
  • In addition, the expression of FTO gene was reduced in adipocytes from db / db mice. (diabetesjournals.org)
  • This study aimed to elucidate hepatic events related to inflammation and lipid metabolism and their linkage with metabolic alterations during NAFLD in American lifestyle-induced obesity syndrome (ALIOS) diet-fed mice. (utu.fi)
  • Here, we profile the gut microbiome and chromatin characteristics in colon epithelium from mice fed either an obesogenic or control diet, followed by an analysis of the resultant changes in gene expression. (biomedcentral.com)
  • Mice that lack the gene develop extreme obesity. (conscienhealth.org)
Role in obesity2
  • Do Genes Have a Role in Obesity? (cdc.gov)
  • Heredity plays a role in obesity but generally to a much lesser degree than many people might believe. (health.am)
Insulin5
20231
Overweight and Obesity3
Adipocytes3
  • In this paper, he explains that adipocytes are difficult cells to target with such gene editing tools. (medicalnewstoday.com)
  • Understanding the regulation of the pathways that lead to proliferation and differentiation of white and brown pre-adipocytes could be crucial for revealing the underlying mechanisms of obesity. (biomedcentral.com)
  • ASIP is a candidate gene for obesity, as it is expressed at high levels in adipocytes, and may participate in several obesity-related processes. (edu.au)
Adults6
  • The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. (gnxp.com)
  • The gene does not appear to predispose to obesity in adults, although by contributing to childhood obesity, it may set the stage for type 2 diabetes in adulthood. (scienceblog.com)
  • Meta-analysis of short sleep duration and obesity in children and adults. (nature.com)
  • In their genetic analyses of around 2000 adults of two ethnically diverse US populations, two WDTC1 SNPs were strongly associated with obesity with homozygote and heterozygote carriers of the major allele i22835A, representing ~96% of the population, having significantly higher mean BMI (around 31) than noncarriers (around 28.6). (drsharma.ca)
  • 1 ) identified a common variant in fat mass-and obesity-associated ( FTO ) gene (rs9939609) that was related to higher BMI in both children and adults. (diabetesjournals.org)
  • While these syndromes are extremely rare, obesity impacts about 1/3 of adults in the US . (punnettssquare.com)
Epidemic8
  • It could explain why so many people struggle to lose weight and suggests an entirely new direction for developing medical treatments that address the current epidemic of diabetes and obesity. (medindia.net)
  • However, he noted that the FTO gene alone cannot explain the obesity epidemic. (nccor.org)
  • In recent decades, obesity has reached epidemic proportions in populations whose environments promote physical inactivity and increased consumption of high-calorie foods. (cdc.gov)
  • Genetic changes in human populations occur too slowly to be responsible for the obesity epidemic. (cdc.gov)
  • Any explanation of the obesity epidemic has to consider both genetics and the environment. (cdc.gov)
  • Childhood obesity has become a worldwide epidemic that can lead to the development of serious and debilitating conditions in later life, including heart disease and type 2 diabetes. (bioscientifica.com)
  • The current epidemic of obesity poses a substantial threat to public health worldwide. (edu.au)
  • Fuelled by cheap calories and sugar-saturated treats and drinks too tempting to resist, the world is in the grip of an obesity epidemic with over a third of the human race now overweight. (thenakedscientists.com)
Diabetes and Obesity1
  • Mark Goodarzi, MD, PhD , director of the Division of Endocrinology, Diabetes and Metabolism and director of Endocrine Genetics Laboratory, is a member of CHARGE and collaborates with the Diabetes and Obesity Research Institute. (cedars-sinai.edu)
Contribute to obesity2
  • Based on their analyses, the authors suggest that the i22835A allele may represent the ancestral "thrifty genotype" that would have conferred resistance to starvation during times of famine, but today contribute to obesity. (drsharma.ca)
  • It all fits nicely together, and it provides the first insights into how FTO might contribute to obesity," Loos said. (nccor.org)
Diet-induced obesity2
  • Here, we employed a mouse model of diet-induced obesity to characterize molecular features of the interplay between host epigenome, gut microbiota, and diet. (biomedcentral.com)
  • Diet-induced obesity led to altered acetylation of lysine 27 on histone H3 (H3K27ac) and to altered monomethylation of lysine 4 on histone H3 (H3K4me1) at numerous loci, with concomitant changes in the expression of genes that were functionally relevant to intestinal cancers. (biomedcentral.com)
Development of Obesity5
  • Nevertheless, the variation in how people respond to the same environment suggests that genes do play a role in the development of obesity. (cdc.gov)
  • The study reported that genetic modifications known to suppress leptin levels were more common in breastfed babies than formula-fed, and that these differences may play a role in the development of obesity. (bioscientifica.com)
  • Dr Omar states, "As we know that these genetic modifications in formula-fed babies reduce leptin levels, which is associated with obesity, these findings suggest that epigenetic mechanisms may play a role in the development of obesity. (bioscientifica.com)
  • The obesogenic diet shapes the microbiome prior to the development of obesity, leading to altered bacterial metabolite production which predisposes the host to obesity. (biomedcentral.com)
  • The murine gut microbiome and its metabolites were altered by an obesogenic diet in a manner that preceded the development of obesity. (biomedcentral.com)
Metabolism7
  • As a case in point - today a story on how fruit fly research helped identify a key gene for lipid metabolism in humans. (drsharma.ca)
  • published in this month's issue of OBESITY , is actually about a gene called WDTC1 , which happens to be the ortholog of the drosophila adp gene, a key gene in fat metabolism. (drsharma.ca)
  • Thus, while this study certainly strongly suggests that the WDTC1 plays a role in human fat metabolism and obesity, we are still far from developing a genetic test or a new treatment for obesity. (drsharma.ca)
  • ALIOS diet altered expression of genes related to inflammation ( Tnfa and IL-6 ) and lipid metabolism ( Cd36, Fasn, Scd1, Cpt1a , and Ppara ). (utu.fi)
  • In this context, the obesity therapeutic property of GA can be understood from a Sestrin activating process through amino acid metabolism . (bvsalud.org)
  • Liver, muscle, and intestine tissue samples were taken to measure mRNA expression of key genes involved in glucose, lipid, and protein metabolism. (frontiersin.org)
  • In Cell Metabolism, a new commentary by Jeffrey Flier and Eleftheria Maratos-Flier points out that many gaps remain in evidence base about this gene. (conscienhealth.org)
Prevalence of obesity among2
Measures of obesity5
  • Background Genome-wide association studies (GWAS) are useful to reveal an association between single nucleotide polymorphisms and different measures of obesity. (uni-regensburg.de)
  • In fact, studies indicate that as much as 50 - 80% of the variation in measures of obesity can be attributed to the effects of genes. (edu.au)
  • Highly polymorphic genetic markers in this region were tested for linkage and association with several measures of obesity in a Caucasian population. (edu.au)
  • None of the measures of obesity were linked to or associated with markers spanning 20q13, suggesting that this chromosomal region does not contain a major locus for obesity in this Caucasian population. (edu.au)
  • In conclusion, extensive study of two established candidate genetic loci revealed no association with measures of obesity. (edu.au)
Humans4
  • It was discovered that the gene, which is also present in humans, is likely to be a high-level master switch that tells the body whether to accumulate or burn fat. (medindia.net)
  • In view of the similarity between the proband and the fat/fat mouse phenotype, we infer that molecular defects in prohormone conversion may represent a generic mechanism for obesity, common to humans and rodents. (nih.gov)
  • By extension, similar deficiencies in humans are felt to be responsible for their obesity as well. (acsh.org)
  • Further studies are required to clarify these associations, especially in relation to rs9939609 (A/T), because, up to this moment, it seems to be the one variant with greatest impact on obesity in humans. (ufrgs.br)
Metabolic syndrome1
  • Environmental influences can include anything from living in a toxic environment ( one study found living close to highways increased the risk of Alzheimer's dementia for example ) to smoking, which is well known to cause cancer, to consuming junk food (e.g., fast food, processed carbs, sugar-laden snacks, etc.) as part of a regular diet, which we know leads to metabolic syndrome and obesity. (regenexx.com)
Anti-obesity6
  • In a 2016 article in the American Journal of Medicine , a team of doctors from Harvard Medical School in Boston, MA, reviewed the FDA-approved anti-obesity drugs available in the United States. (medicalnewstoday.com)
  • Anti-obesity drugs under development have been directed toward restriction of caloric intake by acting on the gastrointestinal tract or the central nervous system . (medicalnewstoday.com)
  • Kim's latest study focuses on avoiding the side effects associated with anti-obesity drugs and improving weight loss by exploiting how cells use their genetic code. (medicalnewstoday.com)
  • But one tried-and-true exercise stood out as the one with the strongest anti-obesity effect: jogging. (livescience.com)
  • Is an anti-obesity pill on the menu? (thenakedscientists.com)
  • But might it be possible to produce an anti-obesity pill that can control how the intestine absorbs calories? (thenakedscientists.com)
Mass-and obesity-associated4
  • OBJECTIVE- To examine the longitudinal association of fat mass-and obesity-associated ( FTO ) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse. (diabetesjournals.org)
  • Variations in the Fat mass and obesity associated gene (FTO) have been shown to associate strongly with obesity. (ufrgs.br)
  • Dias de Castro ML, Horvath JDC, Kops NL, Friedman R. The role of fat mass and obesity associated gene (fto) in satiety and binge eating disorder. (ufrgs.br)
  • Background: Recent studies reported that Fat Mass and Obesity-associated gene (FTO) single nucleotides polymorphisms (SNPs), especially rs9939609, have association with obesity and type 2 diabetes mellitus. (eurekaselect.com)
Type 2 diabet7
  • The association of variation in GLP-1R with fasting glucose and Type 2 diabetes represents the third instance wherein genetic epidemiology identified a gene that codes for a direct drug target in Type 2 diabetes, the other examples being KCNJ11 (codes for the target of sulfonylureas) and PPARG (codes for the target of thiazolidinediones). (cedars-sinai.edu)
  • Obesity is a well-known risk factor for type 2 diabetes. (scienceblog.com)
  • A previous study earlier this year by the same study team found that another type 2 diabetes gene, CDKAL1, affects fetal growth and increases the likelihood that a baby will be underweight at birth. (scienceblog.com)
  • Precision Medicine in Obesity and Type 2 Diabetes: The Relevance of Early-Life Exposures. (cdc.gov)
  • Obesity-related conditions include heart disease, stroke, type 2 diabetes and certain types of cancer , some of the leading causes of preventable death. (health.am)
  • The aim of this thesis was to investigate the role of three distinct genetic loci in obesity and related cardiovascular factors, including type 2 diabetes and dyslipidaemia. (edu.au)
  • On the other hand, many researches confirmed that leptin, an adipocytokine, is related to the obesity and Body Mass Index (BMI) in patients who suffered from Type 2 Diabetes (T2DM). (eurekaselect.com)
Severe obesity4
Variation5
  • The variation caused an increased amount of the gene in fat tissue. (neurosciencenews.com)
  • Conclusions Our data suggest that smoking- and obesity-associated variation of the BDNF gene affects the risk of death, especially due to cardiovascular causes, in smokers. (bmj.com)
  • Thus further study on another Indonesian ethnic population is required to investigate the variation in LEPR gene. (ajol.info)
  • The study published today in the medical journal Nature Genetics, shows that genetic variation in the FTO gene, which is carried by 29 per cent of the population, increases melanoma risk by 16 per cent. (edu.au)
  • and may also be used to direct further research into genetic variation within this candidate gene. (edu.au)
Affects4
  • Shorter sleep duration predisposes to obesity, but the mechanisms whereby sleep deprivation affects body weight are poorly understood. (nature.com)
  • The study provides "an important contribution to understanding the mechanistic process of how the FTO gene affects hunger and obesity," said Emmanuel Pothos, an associate professor in the department of molecular physiology and pharmacology at Tufts University School of Medicine, in Boston. (nccor.org)
  • Epigenetics is a process that affects how our inherited genes are expressed and is a growing area of medical interest, since it can be shaped by experience and environment throughout life. (bioscientifica.com)
  • The causes of obesity are as varied as the people it affects. (health.am)
Chromosome2
  • FTO is a gene of unknown function in an unknown pathway that was originally cloned as a result of the identification of a fused-toe (Ft) mutant mouse that results from a 1.6-Mb deletion of mouse chromosome 8. (gnxp.com)
  • The aim of the third investigation was to confirm the presence of a quantitative trait locus (QTL) for obesity on chromosome 20q13. (edu.au)
Risk36
  • Being overweight or having obesity increases a person's risk of developing diabetes , heart disease , some types of cancer , and musculoskeletal problems, particularly osteoarthritis. (medicalnewstoday.com)
  • Participants with obesity genes who jogged tended to have a lower BMI, lower body fat percentage and a smaller hip circumference than people with similar genetic risk who did not jog. (livescience.com)
  • But for those who loathe jogging, fear not: Five other types of exercise were also tied to a lower BMI among individuals at risk for obesity. (livescience.com)
  • The benefits of these exercises were biggest among those with the greatest genetic risk of obesity. (livescience.com)
  • Interestingly, several other types of exercise failed to counteract the genetic risk of obesity. (livescience.com)
  • Because few participants in this study reported engaging in weight training, badminton, tennis or basketball, the study could not determine whether these exercises offset the risk of obesity genes. (livescience.com)
  • While knowing a person's genetic risk for diabetes is not significantly more predictive than a lifestyle assessment (family history, age, BMI, etc.) in determining whether a patient will develop diabetes, identifying genes contributing to the inherited risks for diabetes affords a greater understanding of the disease's pathophysiology. (cedars-sinai.edu)
  • Not only do our genes determine all the things we learned about in basic biology, such as eye color, body structure, skin color, and so on, but they also determine our risk for diseases (e.g., arthritis, dementia, certain types of cancer, etc. (regenexx.com)
  • However, while we can't change genetic attributes such as eye color, we can adjust our lifestyle to minimize our risk for diseases or conditions we are genetically prone to, such as obesity. (regenexx.com)
  • The intent was to examine the effect of exercise on those at a genetic risk for obesity, specifically whether or not genetic risk could be modified by exercise. (regenexx.com)
  • This may suggest that the longer you exercise as you age, the more impact exercise has on your genetic risk for obesity. (regenexx.com)
  • This increased risk of obesity. (neurosciencenews.com)
  • What this study shows us is that individuals with two copies of the obesity-risk FTO variant are biologically programmed to eat more. (nccor.org)
  • Other studies have found that people with the high-obesity-risk FTO variant weigh on average only 6.5 extra pounds more than people without the variant. (nccor.org)
  • Previous studies utilizing a prospective design of men within the Department of Veterans Affairs (VA) Dental Longitudinal Study have demonstrated a significant relationship between obesity status and future risk of periodontitis. (baycitycapital.com)
  • Interleukin used obesity-related risk factors and IL-1 genetic variations along with other well established risk factors to analyze for significant associations and interactions relative to periodontitis progression. (baycitycapital.com)
  • June 2013) indicate that individuals with certain risk factors, including IL-1 gene variations, benefit significantly from cleanings twice annually, and patients with multiple risk factors appeared to require more than two cleanings annually to maintain health. (baycitycapital.com)
  • PerioPredict® measures variations in genes for Interleukin-1 (IL-1), a key mediator of inflammation, and identifies individuals who are at increased risk for moderate to severe periodontal disease. (baycitycapital.com)
  • CONCLUSIONS- The association between FTO SNP rs9939609 and obesity risk may decline at older age. (diabetesjournals.org)
  • Those observations are in line with prior epidemiological studies that suggested midlife obesity may be a factor in Alzheimer's disease risk in women," Satizabal said in a press release . (salud-america.org)
  • Health care practitioners routinely collect family health history to help identify people at high risk of obesity-related diseases such as diabetes, cardiovascular diseases, and some forms of cancer. (cdc.gov)
  • On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations. (cdc.gov)
  • Previous research has indicated that breastfed children have a lower risk of obesity but how this may be related to epigenetic regulation of leptin has not been investigated. (bioscientifica.com)
  • Dr Omar comments, "Although preliminary, we have shown a possible link between breastfeeding and reduced risk of obesity, and added to the growing body of evidence that breastfeeding is recommended whenever possible. (bioscientifica.com)
  • Given the important roles of the gut microbiome in regulating host physiology and gene expression, a better understanding of the relationship between the host and the symbiont microbiota should provide new insights into human health and disease risk. (biomedcentral.com)
  • It is likely that variations in many genes, each with a small effect, combine to increase the risk of developing this condition. (medlineplus.gov)
  • Some people are more predisposed to gain more weight than others, and research indicates that gaining weight rapidly as an infant is associated with a higher risk of adult obesity. (webmd.com)
  • Because obesity is associated with increased morbidity and mortality in later life, identification of children at high risk might allow for early targeted interventions. (duke.edu)
  • Professor Mann said the discovery of the link between FTO and melanoma adds to the rapidly growing list of genes associated with increased risk of the cancer. (edu.au)
  • It is clear that there are a lot of genetic variations that increase our risk of getting cancer and in the case of melanoma we have been able to show over the last five years that there are at least 15 genes that contribute to our risk and probably a lot more," said Professor Mann. (edu.au)
  • What are some of the factors that increase the risk of obesity? (health.am)
  • Rather than being obesity's sole cause, genes seem to increase the risk of weight gain and interact with other risk factors in the environment, such as unhealthy diets and inactive lifestyles. (health.am)
  • Excessive weight gain during infancy also raises the risk of adult obesity, while being breastfed may lower the risk. (health.am)
  • Television watching is a strong obesity risk factor, in part because exposure to food and beverage advertising can influence what people eat. (health.am)
  • Lack of sleep - another hallmark of the Western lifestyle - is also emerging as a risk factor for obesity. (health.am)
  • Obesity reduces hippocampal structure and function in older African Americans with the APOE-?4 Alzheimer's disease risk allele. (cdc.gov)
Loci4
  • Numerous obesity loci have been identified using genome-wide association studies. (lu.se)
  • Twelve obesity-susceptibility loci were genotyped or imputed in 111,421 participants. (lu.se)
  • article{8ec093ff-a22c-4f74-83bb-2d1330edc6c6, abstract = {{Numerous obesity loci have been identified using genome-wide association studies. (lu.se)
  • A multitude of new loci has recently been reported, but the exact function of most of the according genes is not known. (uni-regensburg.de)
Genotype3
  • The poster (#1290), titled "IL1 Genotype and Obesity Characteristics Interact to Influence Periodontitis Progression," will be presented by Leon Williams, Ph.D., Senior Director of Translational Sciences, Interleukin Genetics, on Thursday, March 12, from 2:00-3:15 p.m. (baycitycapital.com)
  • Tests for association of genotype with obesity characteristics and progression were performed using regression models with or without adjustments for age, smoking, and glucose tolerance. (baycitycapital.com)
  • In other words, according to the "thrifty genotype" hypothesis, the same genes that helped our ancestors survive occasional famines are now being challenged by environments in which food is plentiful year round. (cdc.gov)
Morbid obesity2
Populations1
  • On a related note, Jenny Tung, who's a researcher at Duke University, recently found that gene expression patterns are very, very different between two populations of baboons, one that forages on human foods and one that doesn't, so I'd like to do some work comparing how expression levels of obesity-related genes differ between the captive and wild vervets as well. (bu.edu)
Influence Obesity1
Mutation4
  • Unlike rare genetic diseases that are caused by a single gene mutation, diabetes has many gene contributors whereby each variant has a small effect. (cedars-sinai.edu)
  • A mutation of carboxypeptidase E (CPE), an enzyme active in the processing and sorting of prohormones, causes obesity in the fat/fat mouse. (nih.gov)
  • The mutation in leptin receptor (LEPR) gene causes splicing abnormality that resulted in truncated receptor, aberrant signal transduction, leptin resistance, and obesity. (ajol.info)
  • In a separate analysis of 248 patients with sporadic acromegaly, a mutation in the GPR101 gene was found in about 4% of cases. (medscape.com)
Counteract2
  • A new study suggests that jogging is one of the best exercises to counteract so-called "obesity genes. (livescience.com)
  • Gene therapy is a molecular method aiming to replace defective or absent genes, or to counteract the ones undergoing overexpression. (wikipedia.org)
Glucose1
  • We previously reported that rats prone to obesity exhibit an exaggerated increase in glucose oxidation and an exaggerated decline in lipid oxidation under a low-fat high-carbohydrate (LF/HC) diet. (frontiersin.org)
Polygenic1
Variant9
  • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. (nature.com)
  • People who carry two copies of a variant form of the "FTO" gene are more likely to feel hungry soon after eating a meal, because they carry higher levels of the hunger-producing hormone ghrelin in their bloodstream, an international team of scientists found. (nccor.org)
  • What's more, brain scans revealed this double FTO gene variant changes the way in which the brain reacts to food and ghrelin. (nccor.org)
  • About one in every six people carries two copies of this FTO gene variant. (nccor.org)
  • Having this genetic variant would have conferred a survival advantage," said Batterham, head of obesity and bariatric services and director of Center for Obesity Research at University College London Hospitals. (nccor.org)
  • Study author Batterham said this in no way should convince people with this genetic variant that they are helpless against obesity. (nccor.org)
  • Rarely, a clear pattern of inherited obesity within a family is caused by a specific variant of a single gene (monogenic obesity). (cdc.gov)
  • This particular gene was of great interest because the genetic variant in FTO that predisposes to obesity is very common in the population. (blogs.com)
  • However, the results from the Aboriginal population confirmed the results of the first study: there was no intrinsic association between the Pro12Ala variant and obesity. (edu.au)
Childhood2
  • It has been a bit of a mystery to scientists how or even if these adult diabetes genes function during childhood," said study leader Struan F.A. Grant, Ph.D., a researcher and associate director of the Center for Applied Genomics of The Children's Hospital of Philadelphia. (scienceblog.com)
  • The team plan to conduct larger, multicentre studies assessing the long-term role of genetic and environmental factors on epigenetic regulation of leptin, to put these data into context and explore possible therapeutic interventions that could be developed to prevent and treat childhood obesity. (bioscientifica.com)
Variations in the FTO gene1
  • We've known for a while that variations in the FTO gene are strongly linked with obesity, but until now we didn't know why," said lead author Dr. Rachel Batterham. (nccor.org)
People with obesity2
  • Mutations of the inflammatory RIPK1 gene have been identified in people with obesity. (neurosciencenews.com)
  • Medications and weight-loss (bariatric) surgery are also important for long-term successful treatment for many people with obesity. (msdmanuals.com)
Prone to obesity2
Cure for obesity1
Genetics of obesity2
  • The possibility exists that other hormonal and neural pathways related to obesity are unlocked through the same mechanism that causes increased ghrelin production, said Ruth Loos, director of the genetics of obesity and related metabolic traits program at the Icahn School of Medicine at Mount Sinai, in New York City. (nccor.org)
  • I am impressed by the progress being made by some of my former colleagues who are busily unraveling the complex genetics of obesity. (blogs.com)
Treatment for obesity1
Genetically predisposed2
  • Case in point: A new study suggests that certain types of exercise may help ward off obesity, even for those who are genetically predisposed to the condition. (livescience.com)
  • Many of us really are genetically predisposed to obesity, meaning we carry "obesity genes" passed down from our parents and their parents and so on. (regenexx.com)
Alterations1
  • The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin features and, ultimately, gene expression. (biomedcentral.com)
Extreme obesity1
  • With the exception of rare genetic conditions associated with extreme obesity, currently, genetic tests are not useful for guiding personal diet or physical activity plans. (cdc.gov)
Multiple genes3
  • The fused-toe mutant is a poor model for studying the role of altered Fto activity , because multiple genes are deleted. (gnxp.com)
  • Most obesity…probably results from complex interactions among multiple genes and environmental factors that remain poorly understood," states the Centers for Disease Control and Prevention's explainer on obesity and genetics. (time.com)
  • Most obesity, however, probably results from complex interactions among multiple genes and environmental factors that remain poorly understood (multifactorial obesity). (cdc.gov)
Traits1
  • Identification of genomic-wide genetic links between cutaneous melanoma and obesity-related physical traits via cFDR. (cdc.gov)
Strongly2
  • Several of the genes were more strongly related to obesity in midlife versus in late life, and also to obesity in women versus men," said Dr. Claudia Satizabal , study lead author and assistant professor of population health sciences at UT Health San Antonio. (salud-america.org)
  • This strongly suggests that FTO might have a role in controlling how and when genes are turned on and off. (blogs.com)
Diseases4
  • These findings demonstrate that RIPK1 is genetically associated with obesity, and reducing RIPK1 expression is a potential therapeutic approach to target obesity and related diseases. (neurosciencenews.com)
  • Obesity is a major health problem and one of the biggest predictors of the development of chronic diseases. (ufrgs.br)
  • Understanding how the host epigenome responds to diet and obesity may provide mechanistic insights into obesity-associated diseases. (biomedcentral.com)
  • I think genetic studies on obesity are helpful for those with diseases, but my be taken a little too far in regard to those that are overweight with no genetic influence. (punnettssquare.com)
Potential obesity1
  • Gallic acid as a Sestrin (SESN2) activator and potential obesity therapeutic agent: A molecular docking study. (bvsalud.org)
Causes Obesity1