Genes dyslipidemias. Medical search. Frequent questions

Background: Dyslipidemia in diabetes is common and characterized by hypertriglyceridemia with decreased levels of high‐density lipoprotein. (alquds.edu)
Analysis of the significance of hypertriglyceridemia should take into account coexisting dyslipidemias. (medscape.com)
One of our recent groundbreaking discoveries was the identification of novel loss of function mutations in a gene encoding the pancreatic exocrine elastase Cela2a in patients with diabetes, CAD and MetS traits, including obesity, hypertension, hypertriglyceridemia, NAFLD (OMIM: AOMS4). (yale.edu)
Given its strong safety record, LA may have potential clinical applications for the treatment or prevention of hypertriglyceridemia and diabetic dyslipidemia. (oregonstate.edu)
Hypertriglyceridemia, transient infantile (sequence analysis of GPD1 gene). (mendelian.co)

The eNOS gene has several single nucleotide polymorphisms reported, one of which is G894T. (scirp.org)
Chromosomal abnormalities, HLA phenotypes, and polymorphisms of various genes have been associated with acne. (springer.com)
Polymorphisms in the genes ASMT, AANAT and MTRN1A, which encode proteins of the melatonin system, modulate susceptibility to microvascular complications in Type 1 Diabetes individuals. (usp.br)
The relationship between VDR gene polymorphisms and onset pattern of diabetes was not significant. (who.int)
Single nucleotide polymorphisms (SNPs) in FTO gene are associated to weight gain, while ABC transporters are related to cholesterol efflux, and SNPs in ABCA1, ABCA7 and ABCG1 genes were analyzed in this work. (ufpr.br)
Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)
Recent candidate gene studies [ 13 - 16 ], as well as genome-wide association studies [ 17 - 25 ], have identified polymorphisms that account for a portion of the variation in blood lipid levels. (cdc.gov)

Stroke patients tended to have more proportions of hypertension, diabetics and genotype L, than those of genotype S. Patients with genotype L of HO-1 gene promoter have higher stroke risk in comparison with genotype S especially in dyslipidemia individuals. (tmu.edu.tw)
INTRODUCTION: It is already well described the critical role of oxidative stress induced by hyperglycemia in the etiopathogenesis of diabetes mellitus (DM) complications, alongside with systemic hypertension, dyslipidemia and genetic susceptibility. (usp.br)
NAFLD is often associated with other diseases such as obesity, type 2 diabetes, high blood pressure (arterial hypertension) and a fat metabolism disorder (dyslipidemia). (medicalxpress.com)

We leverage modern techniques of functional genomics, epigenetics, transcriptomics, proteomics, gene editing and model-driven experimentation to understand the underlying causes of atherosclerosis and metabolic syndrome and discover therapeutic targets. (yale.edu)
One of our groundbreaking discoveries was the identification of founder mutations in the DYRK1B gene, underlying atherosclerosis, metabolic syndrome, and fatty liver disease. (yale.edu)
Dyslipidemias / Early atherosclerosis. (mendelian.co)

Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. (nih.gov)
Interestingly, the WWOX locus was also shown to be a target in familial dyslipidemias and metabolic syndrome related conditions. (mdanderson.org)
Unusually low levels of triglycerides can be present in disease states, producing syndromes of malabsorption in addition to patients who carry genes for familial hypobetalipoproteinemia . (medscape.com)

In recent years, bioinformatics analysis and the microarray technology have been used to identify transcriptomic alterations and differentially expressed genes (DEGs), as well as their physiological functions, in many diseases. (hindawi.com)
We identified several differentially expressed genes between early pregnancy anemia, GDM and controls. (lu.se)
Interestingly, we identified several differentially expressed genes associated with neonatal anthropometry indicating their possible role in fetal programming and risk of T2DM in later life due to maternal exposure to early pregnancy anemia and GDM. (lu.se)

The objective of this study was to assess the prevalence of MTHFR C677T polymorphism in Palestinian T2DM patients and to investigate the association between this polymorphism and lipid profile in diabetic patients with and without dyslipidemia. (alquds.edu)
It is a form of hyperlipidemia (high levels of lipids in the blood), hyperlipoproteinemia (high levels of lipoproteins in the blood), and dyslipidemia (any abnormalities of lipid and lipoprotein levels in the blood). (wikipedia.org)
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (nih.gov)
For each patient and control we measured lipid parameters, CRP-us and sought the G894T polymorphism of eNOS gene by PCR-RFLP. (scirp.org)
Lipoprotein disorders (also referred to as Lipid disorders, or Dyslipidemias, or Dyslipoproteinemias ) were first classified in 1967 into different phenotypes by Fredrickson according to the type of lipoproteins that are affected. (wikidoc.org)
Secondary causes of lipid disorders are more common and thus must be ruled out before exploring the primary causes of dyslipidemia. (wikidoc.org)
A deletion in the gene encoding hormone-sensitive lipase, a key enzyme for lipolysis, was associated with abnormalities in adipocyte function and systemic lipid and glucose homeostasis. (medpagetoday.com)
To better understand its role in metabolism, Damcott and colleagues looked at gene sequences in Old Order Amish participants who had significant lipid abnormalities, and compared those analyses with those from 2,738 additional Amish patients. (medpagetoday.com)
They also found that patients with the homozygous genotype developed diabetes early in adulthood and had downregulation of PPAR-gamma-dependent genes that are responsible for adipogenesis and the maintenance of adipocyte function, which "alter[s] the regulation of pathways influencing adipogenesis, insulin sensitivity, and lipid metabolism," they wrote. (medpagetoday.com)
Many genes involved in metabolic pathways have been found to contribute to lipid level variability [ 14 , 26 , 27 ]. (cdc.gov)

The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. (medlineplus.gov)
Primary dyslipidemias are generally consistent in the way they affect the lipoproteins . (wikidoc.org)
Secondary dyslipidemias, on the other hand, may cause elevations in some lipoproteins and reductions in others. (wikidoc.org)
The increase in levels of lipoproteins that occurs with age can result in dyslipidemia. (msdmanuals.com)
LA offset the rise in blood and liver TG by inhibiting liver lipogenic gene expression (e.g. sn-glycerol-3-phosphate acyltransferase-1 and diacylglycerol O-acyltransferase-2), lowering hepatic TG secretion, and stimulating clearance of TG-rich lipoproteins. (oregonstate.edu)
The term dyslipidaemia identifies an elevated level of lipids (cholesterol, triglycerides or both) carried in the blood by lipoproteins. (purplesuite.app)

In this work we proposed to study the role of genetic polymorphism of the eNOS G894T gene in the development of diabetes on the one hand and of these degenerative complications other. (scirp.org)
In a study of Old Order Amish patients, a mutation in the gene that encodes for hormone-sensitive lipase (HSL) was tied to dyslipidemia, hepatic steatosis, systemic insulin resistance, and diabetes, Coleen Damcott, PhD , of the University of Maryland School of Medicine in Baltimore, and colleagues reported online first in the New England Journal of Medicine . (medpagetoday.com)
They concluded that the findings may have implications for the treatment of metabolic syndrome and type 2 diabetes: "Activation of HSL with consequent generation of endogenous ligands for PPAR-gamma, RXR-alpha, or both, may serve as an alternative means of reversing dyslipidemia and glucose intolerance in the metabolic syndrome and type 2 diabetes. (medpagetoday.com)
We are now fully characterizing this protein and evaluating its utility as a drug target for diabetes, dyslipidemia, and fatty liver disease. (yale.edu)
In papers I and II we examined gene expression alterations and associated epigenetic changes due to early pregnancy anemia and gestational diabetes (GDM). (lu.se)

The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction, and peripheral vascular disease. (tmu.edu.tw)
Our work involves population and family-based genetic studies, high throughput sequencing to identify disease genes, with a focus on coronary artery disease (CAD) and metabolic syndrome (MetS). (yale.edu)

After attributing a regional and/or continental ancestry to each individual using genome-wide polymorphism data, we are able to capture the effect of different environmental exposures on gene expression and health-related traits, while simultaneously controlling for genetic relatedness and migration. (nature.com)
Conclusion: The G894T polymorphism of eNOS gene appears to be a risk factor of T2DM. (scirp.org)
immune destruction of insulin-pro- vestigate the relationship of VDR gene ducing beta cells by T-cell infiltration polymorphism to the risk of type 1 DM DNA isolation and PCR experiments of the pancreatic islets [1]. (who.int)
One European study , for example, reported that the prevalence of metabolic syndrome was higher among survivors of testicular cancer who were homozygous for a single-nucleotide polymorphism (SNP), rs523349 (V89L), in 5-α-reductase gene ( SRD5A2 ). (medscape.com)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Currently the Aldaz laboratory is engaged in comprehensive approaches to characterize the genome, transcriptome and methylome of DCIS lesions with the goal of identifying key driver mutations, epigenetic changes and gene expression alterations that occur at pre-invasive stages of breast cancer progression. (mdanderson.org)
Diagnostic certainty is provided by the sweat test, which shows a high concentration of chlorine and sodium in the sweat itself, and/or by the identification of gene mutations. (purplesuite.app)

Insulin stimulates albumin gene expression and albumin secretion from hepatocyte in both healthy subjects and diabetic patients. (biomedcentral.com)
Large fat cells in the visceral region are linked to dyslipidaemia, whereas large subcutaneous adipocytes are important for glucose and insulin abnormalities. (nih.gov)
In paper V we have examined the expression of imprinted genes to better understand their role in insulin secretion, beta-cell development, and function. (lu.se)
Variants in two genes associated with indices of insulin secretion indicating their possible role in beta-cell development. (lu.se)
Additionally, we identified imprinted genes enriched in both fetal and adult pancreas and associated with glucose and insulin traits in a parent-of-origin manner. (lu.se)

Indeed, we recently demonstrated that WWOX modulates HDL metabolism and lipoprotein gene expression. (mdanderson.org)
We have "clock" genes that influence our metabolism. (drbriffa.com)
Among these already know genetic factors there are genes related to metabolism, such as FTO (Fat Mass and Obesity Associated) and the ABC transporters genes. (ufpr.br)

Second-generation antipsychotics including olanzapine are associated with weight gain, dyslipidemia and other metabolic disorders. (edu.au)

At least two transcript variants encoding different isoforms have been found for this gene. (nih.gov)

Treatment of diet-induced obese mice with a REV-ERB agonist decreased obesity by reducing fat mass and markedly improving dyslipidaemia and hyperglycaemia. (drbriffa.com)
Dentre os fatores genéticos já conhecidos encontram-se genes relacionados ao metabolismo, como o gene FTO (Fat Mass and Obesity Associated) e os genes dos transportadores ABC. (ufpr.br)
Abstract: Obesity and dyslipidemias are usually associated, and in most cases have complex origin, resulting from interaction between environmental and genetic factors. (ufpr.br)
2020. Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia. . (oregonstate.edu)

Dyslipidemia is a high level of cholesterol and/or triglycerides or a low level of high-density lipoprotein (HDL) cholesterol. (msdmanuals.com)

The circadian pattern of expression of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. (drbriffa.com)

increases as the total cholesterol level (which includes LDL cholesterol, HDL cholesterol, and VLDL cholesterol) increases, even if the level is not high enough to be considered dyslipidemia. (msdmanuals.com)

In our study, olanzapine-only treatment significantly increased triglyceride accumulation and non-esterified fatty acids (NEFA), and upregulated mRNA expression of sterol regulatory element binding protein 1 (SREBP-1) and its target genes, while these alterations were ameliorated by O + B co-treatment. (edu.au)
The hepatic expression of peroxisome proliferator activated receptor alpha (PPARalpha) target genes involved in fatty acid beta-oxidation was either unchanged or decreased with LA, indicating a different mode of action than for fibrate drugs. (oregonstate.edu)

PTEN (phosphatase and tensin homolog deleted on chromosome 10) belongs to a cancer suppressor gene (one of the protein phosphatases). (aging-us.com)
Chronic Myeloid Leukemia (CML) is associated with translocation between chromosome 9 & chromosome 22, t(9;22)(q34;q11.2) and with the formation of BCR-ABL fusion gene. (who.int)
With artemisinin, the SNPs occurs at the Kelch 13-propeller gene locus on chromosome 13. (bvsalud.org)

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. (nih.gov)
The condition is caused by a defect in the CFTR gene, which encodes a protein whose function is to transport chlorine through epithelial cells. (purplesuite.app)

GXD's primary emphasis is on endogenous gene expression during development. (jax.org)

The mutated genotypes of GT eNOS gene was significantly more frequent in diabetic patients. (scirp.org)
Nous avons génotypé les deux polymorphismes mononucléotidiques du gène ADIPOQ chez 140 patients atteints de DNID sans lien de parenté et 66 témoins non diabétiques en recourant à l'analyse du polymorphisme de longueur des fragments de restriction par réaction en chaîne de polymérase. (who.int)
Un groupe de 69 patients atteints de diabète de type 1 et 45 témoins en bonne santé sans lien entre eux ont été recrutés pour cette étude. (who.int)

A genotipagem de SNPs nos genes ASMT, AANAT e MTNR1A foi realizada por reação em cadeia da polimerase em tempo real nos 489 indivíduos. (usp.br)
CONCLUSÕES: SNPs em genes que codificam receptores de melatonina e enzimas da síntese hormonal modularam a susceptibilidade a complicações microvasculares na população estudada. (usp.br)
Polimorfismos de nucleotídeo único (SNPs) no gene FTO foram associados com o ganho de peso, enquanto os transportadores ABC estão relacionados com o efluxo de colesterol, e, nesse trabalho, foram analisados SNPs dos genes ABCA1, ABCA7 e ABCG1. (ufpr.br)

Researchers have discovered new genes that are responsible for the production of regulatory proteins of the immune-associated GTPase family in humans and mice, respectively, which counteract the accumulation of fat in the liver and thus contribute to the prevention of fatty liver. (medicalxpress.com)
DZD researchers have now discovered new genes that play a role in the development of fatty liver. (medicalxpress.com)

Most of these genes were accompanied by epigenetic changes that correlated with their expression patterns. (lu.se)

We conducted linear regressions analyses (adjusted for sex, waist circumference, physical activity, hormone use, and season) to assess the relationship between 25-hydroxyvitamin D and biomarkers of dysglycemia, dyslipidemia, and inflammation in the study population. (cdc.gov)

Subsequent molecular and physiological studies in human mutation carriers and animal models have allowed us to unravel novel functions of the identified genes, to delineate their cognate pathways and to discover new targets for pharmaceutical intervention. (yale.edu)

This study provided the first evidence that betahistine could act on hepatic H1 receptors via modulation of AMPKα-SREBP-1 and PPARα-dependent pathways to ameliorate olanzapine-induced dyslipidemia in rats. (edu.au)

It is thought that the apolipoprotein E produced from the e4 allele of the APOE gene may disrupt the transport of a protein called alpha-synuclein into and out of cells. (medlineplus.gov)
Additionally, protein-protein interaction network analysis identified 10 hub genes, six ( FLT1 , FLNB , FSTL3 , INHA , TREM1 , and SLCO4A1 ) of which were used to establish a logistic model for PE. (hindawi.com)
If the genes Ifgga2 and Ifgga4 are expressed, proteins of the family of immunity-related GTPases are formed-in the mouse the proteins IFGGA2 and IFGGA4 and in humans the protein IRGM. (medicalxpress.com)

The parents of a child with cystic fibrosis both have a defective CFTR gene and a functioning CFTR gene. (purplesuite.app)
Children with cystic fibrosis have inherited both defective CFTR genes. (purplesuite.app)
One cannot deny that the development of biotechnologies allows the identification of monogenic diseases, i.e., diseases which are highly probable to be caused by the expression of a single gene (for example, cystic fibrosis and Huntington's disease). (bvsalud.org)

Polimorfismos nos genes ASMT, AANAT e MTNR1A, que codificam proteínas do sistema. (usp.br)

Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancestry. (nature.com)
Next, we analyzed the association of these genes with glycemic traits. (lu.se)

Barrier agains t pathogen s gut bacterial genes in the MetaHIT ation when attempting to extrapolate [10], although Proteobacteria, Ver- catalogue were also well represent- results obtained in mouse models to rucomicrobia, and Fusobacteria are ed in the other metagenomes that the situation in humans. (who.int)
In 2014, the MetaHIT consortium by bacteria of the genera Lacto- alytical method used: 66 from 16S published an integrated catalogue bacillus , Prevotella , and Sneathia , rDNA sequencing [11] or 57 from of 10 million bacterial genes de- whereas for infants delivered by whole-metagenome sequencing [5]. (who.int)

HSL, which is encoded by the LIPE gene, is a key player in lipolysis within adipocytes. (medpagetoday.com)

We downloaded the GSE75010 and GSE10588 datasets from the GEO database and performed weighted gene coexpression network analysis (WGCNA) as well as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. (hindawi.com)

KEGG and GO analyses further indicated the involvement of these genes in bioprocesses, such as gonadotropin secretion, immune cell infiltration, and the SMAD and MAPK pathways. (hindawi.com)

It used to be thought that there was not much we could do about our genes, however, recent discoveries in the field of epigenetics reveal that the influence genes have on our health is more malleable than previously recognised. (drbriffa.com)

Inconsistencies might be caused by differences in study design, study populations (geographic and ethnic background), statistical methods and power, allele frequencies, and gene-environment interactions. (cdc.gov)

In humans and mice, respectively, the genes IRGM, Ifgga2 and Ifgga4 are responsible for the production of regulatory proteins of the family of immunity-related GTPases which counteract fat accumulation in the liver. (medicalxpress.com)
In humans and mice, these genes produce regulatory proteins from the family of immunity-related GTPases that counteract fat accumulation in the liver. (medicalxpress.com)

Using molecular markers and statistical methods-quantitative trait locus (QTL) analysis-genes that cause complex human diseases can be identified in mouse strains. (medicalxpress.com)

RESULTADOS: A presença do alelo A no SNP rs4446909 no gene ASMT, que codifica a enzima acetilserotonina-metiltransferase/hidroxindol-O-metiltransferase e é uma das limitantes na produção de melatonina, associou-se a menor risco de RD. Os haplótipos GGCACCGTT e TGGATCGCC no gene AANAT, que codifica outra enzima limitadora da produção de melatonina, associaram-se, respectivamente, a maior e menor risco de declínio da função renal. (usp.br)
Na avaliação do gene MTNR1A, que codifica o receptor de melatonina MT1, a presença do alelo raro A do rs4862705 associou-se a um maior risco para o declínio da função renal no período de seguimento do estudo. (usp.br)
Com relação ao gene FTO, o alelo A do SNP rs9939609 foi associado a um aumento da insulina e HOMA-IR, e diminuição de QUICKI. (ufpr.br)

We used an integrative approach to comprehensively assess the interactions between 1.6 million data points, encompassing a range of environmental exposures, health, and gene expression levels, coupled with whole-genome genetic variation. (nature.com)
Further, in order to capture gene-by-environment interactions through eQTL analyses, we combine whole-transcriptome RNA-Sequencing profiles with whole-genome genotyping and extensive fine-scale environmental exposure data. (nature.com)
However, for this complex disease not only one gene but rather the interactions of different genes and epigenetic factors are responsible. (medicalxpress.com)

There are at least three slightly different versions (alleles) of the APOE gene. (medlineplus.gov)
The e4 version of the APOE gene increases an individual's risk for developing late-onset Alzheimer's disease. (medlineplus.gov)

A total of 100 and 212 differently expressed genes were identified in the GSE75010 and GSE10588 datasets, respectively, and after overlapping with WGCNA results, 17 genes were identified. (hindawi.com)

Administration of synthetic REV-ERB ligands alters circadian behaviour and the circadian pattern of core clock gene expression in the hypothalami of mice. (drbriffa.com)
Our studies in mice have shown that this upregulation results in mTOR activation, lipogenesis and development of NASH and dyslipidemia. (yale.edu)

Multigenic diseases challenge our understanding of the mechanism behind the genome echoing in our misunderstanding of the concept of gene. (bvsalud.org)

Circulating inflammatory markers were not associated with fat cell size or corresponding gene expression in the fat cell regions examined. (nih.gov)

First, we scrutinized gene expression data from adult pancreas, adult pancreatic islets, fetal pancreas, and single cell expression data. (lu.se)

We identified imprinted genes that were specifically expressed in fetal pancreas both on a tissue and single cell level. (lu.se)

Staphylococcus , Corynebacterium , by dietary habits as well as by the ed, the number of frequent genes and Propionibacterium [8]. (who.int)

The recent success gut microbial genes, obtained after has fantastic potential, it has only of faecal microbiota transplantation, sequencing whole faecal microbiota been about 10 years since the sci- especially in the context of Clostridi- metagenomes from 124 European indi- entific community first realized its im- um difficile infection, argues for such viduals [4]. (who.int)
In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)

This gene spans the second most common chromosomal fragile site, FRA16D and as consequence is frequently affected by genomic abnormalities and chromosomal rearrangements. (mdanderson.org)

Diseases4

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Health Care1

Hypertriglyceridemia5

Polymorphisms7

Hypertension3

Atherosclerosis3

Familial3

Differentially expressed genes3

Lipid10

Lipoproteins6

Diabetes5

Coronary artery2

Polymorphism4

Mutations3

Insulin5

Metabolism3

Metabolic Disorders1

Variants1

Obesity4

Triglycerides1

Adipose tissue1

Cholesterol1

Target genes2

Chromosome3

Encodes2

Primary1

Patients3

SNPs3

Fatty liver2

Epigenetic changes1

Biomarkers1

Mutation1

Rats1

Protein3

Cystic fibrosis3

Polimorfismos1

Traits2

Bacterial2

Adipocytes1

Ontology1

Secretion1

Epigenetics1

Allele1

Liver2

Molecular1

Alelo3

Interactions3

APOE2

Datasets1

Mice2

Genome1

Corresponding gene expression1

Pancreatic1

Pancreas1

Frequent1

Microbiota2

Chromosomal1