• CXCR4
  • 4/5 highly differentially expressed genes (SGK1, APOLD1, CXCR4, CXCL2, and FOS) in diabetic gastroparesis were validated in a separate cohort of patients using RT-PCR. (springer.com)
  • binds
  • During HIV-1 infection, the Gp120 envelope glycoprotein subunit binds to a CD4 glycoprotein and a HIV-1 co-receptor expressed on a target cell- forming a heterotrimeric complex. (wikipedia.org)
  • In general, PVNZ-CBP 112.3 binds to CXC chemokines selectively, while PVNZ-CBP 112.6 has strong binding affinity with CC chemokines. (otago.ac.nz)
  • humans
  • The receptor for CCL18 has been identified in humans only recently, which will help scientists understand the molecule's role in the body. (wikipedia.org)
  • C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. (wikipedia.org)
  • inflammation
  • The important roles chemokines play in inflammation and pain make them an attractive therapeutic target. (frontiersin.org)
  • The spectrum of the inflammatory chemokines targeted by the CBPs of BPSV and PVNZ suggest that like orf virus, these Parapoxviruses target inflammation as a strategy to subvert immune cell activation and recruitment to infected tissue. (otago.ac.nz)
  • characterization
  • Characterization of copy number variants for CCL3L1 gene in rheumatoid arthritis for French trio families and Tunisian cases and controls. (nih.gov)
  • stromal
  • The indispensable roles of mesenchymal/stromal androgen receptor (AR) for the prostate organogenesis have been demonstrated by using tissue recombination from wild-type and testicular feminized mice. (wiley.com)
  • immune
  • These receptors are located on the surface of host immune cells whereby they provide a method of entry for the HIV-1 virus to infect the cell. (wikipedia.org)
  • Absence of chemokine (C-C motif) receptor 5 in these knock-out mice affects immune and a number of other physiological responses. (jax.org)
  • The innate immune system is the first line of defense for protecting the host against invading microbial pathogens and involves a number of host defense systems, including chemokine-directed movement of inflammatory cells and pathogen detection via pattern recognition receptors (PRRs) [ 1 - 3 ]. (pubmedcentralcanada.ca)
  • Additionally, CCR4 appears to be a key receptor in the innate immune response as CCR4 −/− mice are more resistant to LPS-induced sepsis [ 16 , 18 ]. (pubmedcentralcanada.ca)
  • During the course of evolution, these complex viruses have gained an extensive repertoire of immunomodulatory genes to evade host immune responses in order to enhance their own survival. (otago.ac.nz)
  • 5%) were common in both diabetic and idiopathic gastroparesis with genes in the top 5 canonical pathways associated with immune signaling. (springer.com)
  • Chemokines are classed as a special type of cytokine that is involved in immune cell trafficking. (wikipedia.org)
  • It functions as a pattern-recognition receptor for a variety of β-1,3-linked and β-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. (wikipedia.org)
  • The C-type lectin receptors are class of signalling pattern recognition receptors which are involved in antifungal immunity, but also play important roles in immune responses to other pathogens such as bacteria, viruses and nematodes. (wikipedia.org)
  • CCR8
  • To date, are three receptors that have been proposed for CCL18: PITPNM3, GPR30, and CCR8. (wikipedia.org)
  • CCR8 is the most recently discovered receptor for CCL18, and the effects of CCR8-CCL18 interactions appear to be physiological, as CCL18 binding to CCR8 induces chemotaxis of Th2 cells. (wikipedia.org)
  • putative
  • The CBP genes have been identified in Orthopoxviruses and Leporipoxviruses, as well as Parapoxviruses (PPVs) that includes Orf virus (ORFV), and genes encoding putative CBPs have been identified in Pseudocowpox virus (PCPV), Bovine papular stomatitis virus (BPSV) and Parapoxvirus of red deer in New Zealand (PVNZ). (otago.ac.nz)
  • extracellular
  • In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). (abcam.com)
  • The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with a partial immunoreceptor tyrosine-based activation motif. (wikipedia.org)
  • peptide
  • The V1-V2 stem can influence "co-receptor usage through its peptide composition as well as by the degree of N-linked glycosylation. (wikipedia.org)
  • but, unlike other chemokines, CCL18 includes 2 pseudo-exons (exons that do not appear in the final peptide) in the first intron. (wikipedia.org)