Leukocyte antigenCD223CLONEReceptorAntibodyProtein-tyrosiDifferentiationMoleculeMRNAProteinsReceptorsLAG3CellsReported in numeHuman1995TranscriptionRetrievalLocusAllelicPathwaysInhibitorExpressionGeneticsMutations10.1038PhenotypesEnhancesMiceCellNAMESGenomeExonSingle-geneChromosomesImmuneFamilyExpresCancerMolecularCluster
Leukocyte antigen2
- LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. (nih.gov)
- The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21. (ox.ac.uk)
CD2233
- LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biologic effects on T cell function. (wikipedia.org)
- Lymphocyte activation gene 3 (LAG-3/CD223) is a CD4 homolog known to be selectively expressed in activated T and NK cells. (nih.gov)
- LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. (novoprolabs.com)
CLONE2
- The following Cd82 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
- One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence. (genscript.com)
Receptor7
- Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
- The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)
- How GC B cells are able to rapidly and repeatedly transition between mutating their B cell receptor genes and then being selected shortly after is not known. (ox.ac.uk)
- The gene has been cloned independently as ILT6 [ immunoglobulin-like transcript 6 ], LIR4 [ leukocyte immunoglobulin-like receptor 4 ], HM43 . (copewithcytokines.org)
- This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. (arigobio.com)
- HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)
- Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4) gene, complete cds. (lu.se)
Antibody3
- LAG-3 may be a better checkpoint inhibitor target than CTLA-4 or PD-1 since antibodies to these two checkpoints only activate effector T cells, and do not inhibit Treg activity, whereas an antagonist LAG-3 antibody can both activate T effector cells (by downregulating the LAG-3 inhibiting signal into pre-activated LAG-3+ cells) and inhibit induced (i.e. antigen-specific) Treg suppressive activity. (wikipedia.org)
- This product is a recombinant Human antibody that recognizes Cytotoxic T lymphocyte antigen-4. (creativebiolabs.net)
- A broad antibody response was detected that included immunoglobulin G (IgG) and IgA subtypes with demonstrable Fc-mediated effector function targeting multiple viral antigens. (cdc.gov)
Protein-tyrosi1
- The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. (cdantigens.com)
Differentiation2
- Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
- Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
Molecule1
- Background E-cadherin is a calcium-dependent intercellular adhesion molecule encoded by the CDH1 gene and present on epithelial cells. (qedbio.com)
MRNA3
- We suggest, however, that the gene on 6q21 is the active locus since the mRNA of cell lines always represents the allelic variants found on chromosome 6. (ox.ac.uk)
- Mus musculus L antigen family, member 3 (Lage3), mRNA. (genscript.com)
- Homo sapiens putative protein kinase NY-REN-64 antigen mRNA, complete cds. (lu.se)
Proteins5
- Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (nih.gov)
- Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class II (MHCII) proteins. (ox.ac.uk)
- Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
- Mesodermal lineage induction of PLA cells and clones resulted in the expression of multiple lineage-specific genes and proteins. (livingroom.health)
- Each HLA gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign proteins. (medlineplus.gov)
Receptors1
- The two receptors share structural similarity as well as overlapping intracellular signaling events, and are believed to have evolved through gene duplication from a common ancestral gene. (rndsystems.com)
LAG32
- Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. (wikipedia.org)
- The LAG3 gene contains 8 exons. (wikipedia.org)
Cells13
- Hem CD, Ekornhol M, Granum S, Sundvold-Gjerstad V, Spurkland A. CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein. (hcdm.org)
- The CD1 family: serving lipid antigens to T cells since the Mesozoic era. (hcdm.org)
- CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens. (hcdm.org)
- CD1a, as other members of the CD1 family, is involved in the immune response by presenting self and non-self lipid and glycolipid antigens to T cells. (hcdm.org)
- Through ectopic expression of a photoconvertible MHCII-mKikGR chimeric gene, we found that individual GC B cells differed in the rates of MHCII protein turnover. (ox.ac.uk)
- The TotalSeq™-C Human TBNK Cocktail has been designed to react with immune cells as defined and classified by the expression of the surface antigens CD19, CD3, CD16, CD4, CD11c, CD56 (NCAM), CD14, CD8, CD45. (biolegend.com)
- Genetic inactivation of the machinery or re-introduction of ANKRD52 frequent patient mutations dampens the JAK-STAT-interferon-γ signaling and antigen presentation in cancer cells, largely by abolishing miR-155-targeted silencing of suppressor of cytokine signaling 1 (SOCS1). (nature.com)
- Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
- 8. Coccia MA, Brams P. High titer, prostate specific antigen-specific human IgG production by hu-PBL-SCID mice immunized with antigen-mouse IgG2a complex-pulsed autologous dendritic cells. (southernbiotech.com)
- 13. Bian H, Fournier P, Moormann R, Peeters B, Schirrmacher V. Selective gene transfer in vitro to tumor cells via recombinant Newcastle disease virus. (southernbiotech.com)
- PLA cells expressed multiple CD marker antigens similar to those observed on MSCs. (livingroom.health)
- Finally, PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression. (livingroom.health)
- These macrophages, in addition to smooth muscle cells, activate T cells by presenting antigens, including oxidized LDL. (medscape.com)
Reported in nume1
- Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. (arigobio.com)
Human4
- Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. (nih.gov)
- Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (nih.gov)
- The gene for LAG-3 lies adjacent to the gene for CD4 on human chromosome 12 (12p13) and is approximately 20% identical to the CD4 gene. (wikipedia.org)
- Of the 30,000 or so genes that are currently thought to exist in the human genome , there is a small subset that seems to be particularly important in the prevention, development, and progression of cancer. (cancerquest.org)
19951
- An initial characterization of the LAG-3 protein was reported in 1992 showing that it was a ligand for MHC class II antigens while a 1995 paper showed that it bound MHC Class II better than CD4. (wikipedia.org)
Transcription5
- Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional pathways and transcriptional signaling identification. (frontiersin.org)
- Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. (arigobio.com)
- These events are dependent on the proper levels of transcription and translation of certain genes. (cancerquest.org)
- These information indicate that AR ERK signal ing regulates the transcription of selective molecular apocrine genes. (cdantigens.com)
- The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
Retrieval1
- Antigen retrieval: Boil tissue section in EDTA buffer, pH 8.0 for 10 minutes followed by cooling at room temperature for 20 minutes. (abcam.com)
Locus2
- This locus represents a member of the cancer/testis gene family 47. (nih.gov)
- Murine MC are divided into three subsets based on surface expression of lymphocyte antigen 6 complex, locus C (Ly6C) ( 3 , 4 ). (frontiersin.org)
Allelic2
- These results imply that germline allelic variation in genes involved in immune homeostasis--and, by extension, derangement of immune homeostasis--influence the risk of MS. (nih.gov)
- Here we demonstrate that the nucleotide substitution which distinguishes the cluster-4 and CD24 antigen genes is due to an allelic polymorphism on chromosome band 6q21. (ox.ac.uk)
Pathways2
- A total of 7,928 SDE genes and 46 canonical pathways derived from it were identified. (frontiersin.org)
- Twenty-four potential transcriptional regulatory pathways were identified based on SDE TFs matched with their corresponding SDE immunological genes. (frontiersin.org)
Inhibitor1
- A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. (nih.gov)
Expression6
- MicroRNAs (miRNAs) are small non-coding RNAs that bind complementary messenger RNAs (mRNAs) to repress gene expression and regulate essentially all cellular processes 19 . (nature.com)
- The fold modifications for gene expression following treat ments were calculated relative to that of your manage group in both cell lines. (cdantigens.com)
- The other molecular apocrine genes both didn't possess a constant reduction or showed a slight boost in gene expression following the inhibition of AR and ERK. (cdantigens.com)
- Impor tantly, PIP and DUSP6 had one of the most prominent reduc tion in gene expression following the inhibition of AR ERK having a fold alter ranging from 0. (cdantigens.com)
- In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)
- We aimed to determine the significance of detecting expression of some antigens that might be pivotal to the process, namely CD44 and CD117, in patients with active pemphigus vulgaris. (who.int)
Genetics1
- Inherited risk for stroke is likely multigenic, although specific single-gene disorders with stroke as a component of the phenotype demonstrate the potency of genetics in determining stroke risk. (medscape.com)
Mutations4
- Mutations in the INS R gene have been linked to insulin-resistant diabetes mellitus, noninsulin-dependent diabetes mellitus and leprechaunism, an extremely rare disorder characterized by abnormal resistance to insulin that results in a variety of distinguishing characteristics, including growth delays and abnormalities affecting the endocrine system. (rndsystems.com)
- Of the 16 genes sequenced, 2 had a crossover between PRB1 and PRB2 and 4 had stop mutations. (umich.edu)
- ALL cancers have lots of additional changes, the so-called 'passenger' mutations, that may contribute to the cancer, but are not the main genes. (cancerquest.org)
- Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. (genscript.com)
10.10381
- doi: 10.1038/sj.gene.6364171. (nih.gov)
Phenotypes1
- There are now 320 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. (springer.com)
Enhances1
- The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation. (exbio.cz)
Mice2
- RNA-seq was performed in blood Ly6C high and Ly6C low MC sorted by flow cytometry from control and HHcy cystathionine β-synthase gene-deficient ( Cbs -/- ) mice. (frontiersin.org)
- Pituitary tumorigenesis in prolactin gene-disrupted mice. (genscript.com)
Cell12
- 1] Ansari, H. R., Raghava, G. P., Identification of conformational B-cell Epitopes in an antigen from its primary sequence. (degruyter.com)
- T cell activation by lipopeptide antigens. (hcdm.org)
- The other approach is to screen CRISPR-Cas9-based guide RNA (gRNA) libraries that target either the whole genome using cancer cell and immune cell co-culture systems 9 , 10 , or focused gene sets using immunocompetent murine tumors 11 , 12 . (nature.com)
- The genes that have been identified to date have been categorized into two broad categories, depending on their normal functions in the cell. (cancerquest.org)
- This first category also includes genes that contribute to tumor growth by inhibiting cell death. (cancerquest.org)
- Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
- We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)
- Many of these genes are responsible for providing the positive signals that lead to cell division. (cancerquest.org)
- As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
- This is in contrast with tumor suppressor genes which must BOTH be defective to lead to abnormal cell division. (cancerquest.org)
- Despite the differences in their normal roles, these genes all contribute to unregulated cell division if they are present in a mutant (oncogenic) form. (cancerquest.org)
- Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. (cusabio.cn)
NAMES1
- Disease names are presented in red and genes in bold and italics. (springer.com)
Genome1
- Whole-genome linkage screens in MS have both confirmed the importance of the HLA region and uncovered non-HLA loci that may harbor susceptibility genes. (nih.gov)
Exon1
- Because longer genes encode longer BPRPs, we investigated the possibility of exon sequencing BPRP alleles encoded by PRB1 and PRB2. (umich.edu)
Single-gene1
- We selected 17 patients clinically and his- is encoded by a single gene located on the tologically proven to be suffering from PV short arm of chromosome 11 [ 6 ]. (who.int)
Chromosomes1
- Genes Chromosomes Cancer, 2006 Apr. (nih.gov)
Immune1
- Because the HLA-DPB1 gene is involved in the immune system, changes in it might be related to the autoimmune response and inflammation in the respiratory tract and kidneys characteristic of GPA. (medlineplus.gov)
Family1
- A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved. (genscript.com)
Expres1
- Up coming, we ranked molecular apocrine genes primarily based on their fold modify in expres sion following the modulation of AR ERK signaling. (cdantigens.com)
Cancer2
- A diagram showing the major cancer genes for some cancers. (cancerquest.org)
- These genes have been found to be either malfunctioning or non-functioning in many different kinds of cancer. (cancerquest.org)
Molecular2
- As a result, in this study we investigated the remaining ten genes which might be extremely ranked within the molecular apocrine signature. (cdantigens.com)
- Further molecular analyses of the isolates using M. haemolytica species-specific and M.haemolytica serotype-1 antigen specific PCR assays revealed, 26 of the isolates were identified as M. haemolytica of which 21 of them were M. haemolytica serotype-1. (biomedcentral.com)