• polymorphisms
  • The genotypes of three single-nucleotide polymorphisms (SNPs) (rs10758669, rs7857730, rs10119004) in the JAK2 and four SNPs (rs6503695, rs744166, rs2293152, and rs12948909) in the STAT3 gene were analyzed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). (arvojournals.org)
  • 5 - 8 Previous studies from our group have shown that polymorphisms for genes encoding small ubiquitin-like modifier 4 (SUMO4), STAT4 , and interleukin (IL)-23R are associated with the susceptibility for BD. (arvojournals.org)
  • 0103
  • 2006, Homozygous Status for HLA-E*0103 Confers Protection from Acute Graft-Versus-Host Disease and Transplant-Related Mortality in HLA-Matched Sibling Hematopoietic Stem Cell Transplantation, Transplantation 2006 82(11) 1436-1440. (usc.edu)
  • These data suggest that the homozygous state for HLA-E*0103 allele behaves as a protective genetic factor against aGVHD and TRM and likely contributes to improved survival in HLA-genoidentical bone marrow transplantation. (usc.edu)
  • The other alleles, A*0102 and A*0103, may confer specific risks. (wikipedia.org)
  • histocompatibility
  • Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
  • AK098434 - Homo sapiens cDNA FLJ25568 fis, clone JTH03907, highly similar to HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN E E*0101/E*0102 PRECURSOR. (usc.edu)
  • AK316327 - Homo sapiens cDNA, FLJ79226 complete cds, highly similar to HLA class I histocompatibility antigen, alphachain E precursor. (usc.edu)
  • An association between class I and II alleles of the major histocompatibility complex and idiopathic chronic urticaria has previously been observed in different populations, but there are still no studies on Brazilian populations in this regard. (scielo.br)
  • DNA was extracted from the blood of 42 patients with idiopathic chronic urticaria and major histocompatibility complex classes I and II alleles were determined using the polymerase chain reaction and a laboratory test for oligonucleotide hybridization using a single-filament probe. (scielo.br)
  • Genome-wide association studies have underscored the genetic association of the major histocompatibility complex (MHC) region with autoimmune diseases, in which case various predisposing alleles have been found ( 2 , 3 ). (frontiersin.org)
  • genetic
  • The association between geographic tongue and psoriasis has been demonstrated in various studies, based on observation of its fundamental lesions, microscopic similarity between the two conditions and the presence of a common genetic marker, human leukocyte antigen (HLA) HLA-C*06. (scielo.br)
  • Genes can further be separated by genetic sequencing and analysis. (wikipedia.org)
  • In all instances so far, HLA-A1 has been found to be linked to disease by association, but there are few that define HLA-A1 has a predominant genetic risk relative to other gene-alleles in the vicinity of the A1 gene on the larger haplotype. (wikipedia.org)
  • uveitis
  • However, anterior uveitis is often one of the syndromes associated with HLA-B27. (wikipedia.org)
  • Behçet disease Crohn's disease Fuchs heterochromic iridocyclitis Granulomatosis with polyangiitis HLA-B27 related uveitis Juvenile idiopathic arthritis Sarcoidosis Spondyloarthritis Sympathetic ophthalmia Tubulointerstitial nephritis and uveitis syndrome Uveitis may be an immune response to fight an infection inside the eye. (wikipedia.org)
  • responses
  • NY-ESO-1 is one of the most immunogenic cancer antigens known to date, inducing humoral and cellular immune responses in a high proportion of patients with advanced NY-ESO-1-expressing cancers. (aacrjournals.org)
  • These findings show that immune pressure on HIV is stronger in subjects with the protective genotype and highlight the potential role of HLA-C-restricted responses in HIV control. (jimmunol.org)
  • This is, to our knowledge, the first in vivo evidence supporting the protective role of HLA-C-restricted responses in nonwhites during HIV infection. (jimmunol.org)
  • However, there is an increasing understanding that pro-inflammatory responses directed to self-antigens become chronic in autoimmune diseases because regulatory mechanisms fail to control them. (frontiersin.org)
  • Haplotype
  • Because of its linkage within the AH8.1 haplotype many studies showed association with A1 or A1,B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. (wikipedia.org)
  • A1-B58 haplotype (A1-B17 where B58 is dominant) may remain associated with anti-neutrophil cytoplasmic antibody (ANCA) With the exception of type 1 diabetes, most of the evidence for direct association of A1 with autoimmune diseases evaporated as DR3 and DQ2 genes were characterized. (wikipedia.org)
  • class
  • Transfection of target cells with NY-ESO-1 combined with different HLA class I alleles confirmed that the NY-ESO-1 peptide was naturally processed and recognized by HLA-B51-restricted CD8+ T cell lines and clones. (aacrjournals.org)
  • HLA-E belongs to the HLA class I heavy chain paralogues. (usc.edu)
  • Rheumatology international 2009 29(11):1293-9, HLA-Cw*06 class I region rather than MICA is associated with psoriatic arthritis in Czech population. (usc.edu)
  • diseases
  • B51 is associated with several diseases, including Behçet's disease. (wikipedia.org)
  • Failing immunological tolerance for critical self-antigens is the problem underlying most chronic inflammatory diseases of humans. (frontiersin.org)
  • In many cases, chronic inflammatory diseases are autoimmune diseases that are caused by a loss of tolerance to self-antigens due to inappropriate activation of the immune system. (frontiersin.org)
  • CD4 + CD25 high FoxP3 + Tregs can prevent autoimmune diseases by maintaining the tolerance to self-antigens. (frontiersin.org)
  • clinical
  • One is in strong linkage disequilibrium (LD) with HLA-B*5701, an allele strongly associated with good clinical outcome of HIV infection. (jimmunol.org)
  • HLA-B27 AAU has characteristic clinical features including male preponderance, unilateral alternating acute onset, a non-granulomatous appearance, and frequent recurrences, whereas HLA-B27 negative AAU has an equivalent male to female onset, bilateral chronic course, and more frequent granulomatous appearance. (wikipedia.org)
  • MICA
  • The MICA*009 allele has been found to also associated with ABD when B51 is also present, IL-8 and other cytokines may also be involved. (wikipedia.org)
  • group
  • There are a large number of alleles within the B*51 allele group. (wikipedia.org)
  • There are a number of alleles within the B*52 allele group. (wikipedia.org)
  • Among patients with EBV+ HL, only 35.5% of people expressed HLA-A*02 compared to 50.9% in the EBV-HL group and 53% in the control group. (wikipedia.org)
  • HLA research didn't heat up until the 1980s when a group of researchers finally elucidated the shape of the HLA-A*02 protein (just one of many specific HLA proteins). (wikipedia.org)
  • We found that in this population group, there was no specific association between the HLA alleles studied and chronic urticaria. (scielo.br)
  • induces
  • Genetically predisposed individuals could be influenced by an environmental trigger (i.e., dietary iodine, infection, pregnancy, cytokine therapy) that induces an autoimmune response against thyroid-specific antigens by infiltrating immune cells. (springer.com)
  • frequency
  • We found an increased frequency of mutations in individuals with highly expressed HLA-C alleles, which also correlated with IFN-γ production by HLA-C-restricted CD8 + T cells. (jimmunol.org)
  • association
  • 2005, Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation. (usc.edu)
  • Early in the study of HLA an association was found between HL A1,B8 in allergic disease, these are found to link to extended HLA A1-B8 region. (wikipedia.org)
  • 2009, Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02). (usc.edu)
  • It is most commonly associated with HLA-B27, which has important features: HLA-B27 AAU can be associated with ocular inflammation alone or in association with systemic disease. (wikipedia.org)
  • proteins
  • as of December 2013 there are 456 different HLA-A*02 proteins. (wikipedia.org)
  • In essence, every individual's immune system is tuned to the specific set of HLA and self proteins produced by that individual. (wikipedia.org)
  • Even more recently, in 2010, the WHO committee responsible for naming all HLA proteins revised their standards for naming to introduce more clarity and specificity in the naming system. (wikipedia.org)
  • protein
  • HIV produces a protein called Nef that binds to the cytoplasmic tail of HLA-A and B and diverts it to the lysosomes for destruction. (wikipedia.org)
  • transplantation
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
  • Such antigens may represent therapeutic targets for posttransplant vaccination or adoptive T-cell therapy to augment the antitumor effects of allogeneic hematopoietic cell transplantation. (aacrjournals.org)
  • subset
  • Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. (usc.edu)
  • protective
  • This polymorphism was recently shown to be a marker for a protective variant in the 3′UTR of HLA-C that disrupts a microRNA binding site, resulting in enhanced HLA-C expression at the cell surface. (jimmunol.org)
  • SUMO4
  • However, B51 tends not to be found in ABD when a certain SUMO4 gene variant is involved, and symptoms appear to be milder when HLA-B27 is present. (wikipedia.org)
  • variant
  • The − 35 SNP is also in strong LD with a variant found in the 3′UTR of the HLA-C gene, which was recently shown to regulate binding of the microRNA miR-148a to its target site, thereby altering HLA-C expression ( 6 ). (jimmunol.org)
  • progression
  • Delayed HIV-1 disease progression is associated with a single nucleotide polymorphism upstream of the HLA-C gene that correlates with differential expression of the HLA-C Ag. (jimmunol.org)
  • immune response
  • In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)
  • Whether individuals with "high" HLA-C expression show a stronger HLA-C-restricted immune response exerting better viral control than that of their counterparts has not been established. (jimmunol.org)
  • disease
  • Homozygotes of B51 showed considerably high risk for disease indicating a possible gene-dose effect. (wikipedia.org)
  • B51 is capable of distinguishing several varieties of disease. (wikipedia.org)
  • HLA-B51 is found more frequently in disease that has an eye involvement. (wikipedia.org)
  • To date, significant progress has been made in identifying and characterizing those genes involved in the disease. (springer.com)
  • contributes
  • Sez12 gene contributes to the chondrocytes differentiation by modulating TGF-ß signaling during postnatal maxillofacial development. (nii.ac.jp)
  • found
  • HLA are not typical antigens, like those found on surface of infectious agents. (wikipedia.org)
  • The associations rapidly expanded to include 'HL-A8' HLA-B8, as the HLA A1 and B8 were found to be commonly linked. (wikipedia.org)
  • A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
  • In Hodgkin's lymphoma HLA-A1, but DR3 was not found higher. (wikipedia.org)
  • viral
  • HLA-A*02-C*16 and HLA-A*02-B*45 have been shown to contribute to significantly increased viral loads (greater than 100,000 copies per milliliter). (wikipedia.org)
  • peripheral
  • HLA-A*02 appears to stimulate peripheral blood mononuclear cells in a manner that inhibits HIV replication. (wikipedia.org)
  • cells
  • Antigen-presenting cells transduced with recombinant adenoviral vectors encoding NY-ESO-1 were used to stimulate CD8+ selected NY-ESO-1-specific T cells. (aacrjournals.org)
  • Using a modified approach we identified the NY-ESO-1 p94-102 peptide as being recognized by CD8+ T cells in the context of HLA- B51. (aacrjournals.org)
  • Mechanisms include the following: regulatory T cells (Tregs), direct inactivation of effector T (Teff) cells by induction of anergy or apoptosis and activities mediated by tolerogenic antigen-presenting cells (APCs). (frontiersin.org)
  • products
  • In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket. (wikipedia.org)
  • expression
  • Vogel R, Al-Daccak R, Drews O, Alonzeau J, Mester G, Charron D, Stevanovic S, Mallet J (2013) Mass spectrometry reveals changes in MHC I antigen presentation after lentivector expression of a gene regulation system. (immunology-tuebingen.de)