• 0103
  • 2006, Homozygous Status for HLA-E*0103 Confers Protection from Acute Graft-Versus-Host Disease and Transplant-Related Mortality in HLA-Matched Sibling Hematopoietic Stem Cell Transplantation, Transplantation 2006 82(11) 1436-1440. (usc.edu)
  • The other alleles, A*0102 and A*0103, may confer specific risks. (wikipedia.org)
  • uveitis
  • However, anterior uveitis is often one of the syndromes associated with HLA-B27. (wikipedia.org)
  • Behçet disease Crohn's disease Fuchs heterochromic iridocyclitis Granulomatosis with polyangiitis HLA-B27 related uveitis Juvenile idiopathic arthritis Sarcoidosis Spondyloarthritis Sympathetic ophthalmia Tubulointerstitial nephritis and uveitis syndrome Uveitis may be an immune response to fight an infection inside the eye. (wikipedia.org)
  • responses
  • NY-ESO-1 is one of the most immunogenic cancer antigens known to date, inducing humoral and cellular immune responses in a high proportion of patients with advanced NY-ESO-1-expressing cancers. (aacrjournals.org)
  • The assessment of spontaneous and vaccine-induced CD8+ T cell responses has been limited to a small number of known NY-ESO-1 epitopes presented by MHC class I alleles. (aacrjournals.org)
  • Therefore, NY-ESO-1 p94-102 is a new candidate peptide antigen for cancer immunotherapy and for the monitoring of spontaneous and vaccine-induced NY-ESO-1-specific T cell responses in HLA- B51+ patients with NY-ESO-1 expressing malignancies. (aacrjournals.org)
  • These findings show that immune pressure on HIV is stronger in subjects with the protective genotype and highlight the potential role of HLA-C-restricted responses in HIV control. (jimmunol.org)
  • This is, to our knowledge, the first in vivo evidence supporting the protective role of HLA-C-restricted responses in nonwhites during HIV infection. (jimmunol.org)
  • However, there is an increasing understanding that pro-inflammatory responses directed to self-antigens become chronic in autoimmune diseases because regulatory mechanisms fail to control them. (frontiersin.org)
  • Haplotype
  • Because of its linkage within the AH8.1 haplotype many studies showed association with A1 or A1,B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. (wikipedia.org)
  • A1-B58 haplotype (A1-B17 where B58 is dominant) may remain associated with anti-neutrophil cytoplasmic antibody (ANCA) With the exception of type 1 diabetes, most of the evidence for direct association of A1 with autoimmune diseases evaporated as DR3 and DQ2 genes were characterized. (wikipedia.org)
  • polymorphism
  • 2005, Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation. (usc.edu)
  • Delayed HIV-1 disease progression is associated with a single nucleotide polymorphism upstream of the HLA-C gene that correlates with differential expression of the HLA-C Ag. (jimmunol.org)
  • This polymorphism was recently shown to be a marker for a protective variant in the 3′UTR of HLA-C that disrupts a microRNA binding site, resulting in enhanced HLA-C expression at the cell surface. (jimmunol.org)
  • chronic
  • We found that in this population group, there was no specific association between the HLA alleles studied and chronic urticaria. (scielo.br)
  • HLA-B27 AAU has characteristic clinical features including male preponderance, unilateral alternating acute onset, a non-granulomatous appearance, and frequent recurrences, whereas HLA-B27 negative AAU has an equivalent male to female onset, bilateral chronic course, and more frequent granulomatous appearance. (wikipedia.org)
  • class
  • Transfection of target cells with NY-ESO-1 combined with different HLA class I alleles confirmed that the NY-ESO-1 peptide was naturally processed and recognized by HLA-B51-restricted CD8+ T cell lines and clones. (aacrjournals.org)
  • HLA-E belongs to the HLA class I heavy chain paralogues. (usc.edu)
  • Rheumatology international 2009 29(11):1293-9, HLA-Cw*06 class I region rather than MICA is associated with psoriatic arthritis in Czech population. (usc.edu)
  • serologic
  • In order to standardize the HLA designation of prior low-resolution typings with the more advanced DNA based typings, all HLA-A, −B and -DR were analyzed using a low resolution serologic equivalent. (biomedcentral.com)
  • clinical
  • One is in strong linkage disequilibrium (LD) with HLA-B*5701, an allele strongly associated with good clinical outcome of HIV infection. (jimmunol.org)
  • HLA typing might be a useful clinical method for screening patients with high risk of progression to ESRD. (biomedcentral.com)
  • association
  • Early in the study of HLA an association was found between HL A1,B8 in allergic disease, these are found to link to extended HLA A1-B8 region. (wikipedia.org)
  • 1 The HLA-B51 gene shows the strongest association with this disease in a variety of ethnic groups, including Iranians, Koreans, Arabs, and Greeks. (arvojournals.org)
  • 2009, Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02). (usc.edu)
  • It is most commonly associated with HLA-B27, which has important features: HLA-B27 AAU can be associated with ocular inflammation alone or in association with systemic disease. (wikipedia.org)
  • haplotypes
  • In addition, there are several HLA-A*02 haplotypes that appear to contribute heavily to higher or lower viral loads in HIV patients. (wikipedia.org)
  • frequency
  • We found an increased frequency of mutations in individuals with highly expressed HLA-C alleles, which also correlated with IFN-γ production by HLA-C-restricted CD8 + T cells. (jimmunol.org)
  • suggests
  • The current work suggests that HLA-DR3 (odds ratio = 1.91, 95 % CI = 1.098-3.324, P = 0.024, Pc = 0.312) and HLA-DR11 (odds ratio = 2.06, 95 % CI = 1.133-3.761, P = 0.021, P c = 0.273) may represent susceptibility risk factors for the development of ESRD in Taiwanese individuals. (biomedcentral.com)
  • MICA
  • The MICA*009 allele has been found to also associated with ABD when B51 is also present, IL-8 and other cytokines may also be involved. (wikipedia.org)
  • group
  • There are a large number of alleles within the B*51 allele group. (wikipedia.org)
  • There are a number of alleles within the B*52 allele group. (wikipedia.org)
  • Among patients with EBV+ HL, only 35.5% of people expressed HLA-A*02 compared to 50.9% in the EBV-HL group and 53% in the control group. (wikipedia.org)
  • HLA research didn't heat up until the 1980s when a group of researchers finally elucidated the shape of the HLA-A*02 protein (just one of many specific HLA proteins). (wikipedia.org)
  • The information of 141 ESRD patients was obtained from the medical record of the Keelung branch of Chang Gung Memorial Hospital and was compared to the HLA type of a control group comprized of 190 healthy unrelated Taiwanese from one of our previous studies. (biomedcentral.com)
  • induces
  • Thus any alteration to the HLA that induces decreased binding to a certain peptide or increased binding to a certain peptide, is expressed as, respectively, increased susceptibility to disease or decreased susceptibility to disease. (wikipedia.org)
  • Genetically predisposed individuals could be influenced by an environmental trigger (i.e., dietary iodine, infection, pregnancy, cytokine therapy) that induces an autoimmune response against thyroid-specific antigens by infiltrating immune cells. (springer.com)
  • proteins
  • as of December 2013 there are 456 different HLA-A*02 proteins. (wikipedia.org)
  • In essence, every individual's immune system is tuned to the specific set of HLA and self proteins produced by that individual. (wikipedia.org)
  • Even more recently, in 2010, the WHO committee responsible for naming all HLA proteins revised their standards for naming to introduce more clarity and specificity in the naming system. (wikipedia.org)
  • protein
  • HIV produces a protein called Nef that binds to the cytoplasmic tail of HLA-A and B and diverts it to the lysosomes for destruction. (wikipedia.org)
  • disease
  • Homozygotes of B51 showed considerably high risk for disease indicating a possible gene-dose effect. (wikipedia.org)
  • B51 is capable of distinguishing several varieties of disease. (wikipedia.org)
  • HLA-B51 is found more frequently in disease that has an eye involvement. (wikipedia.org)
  • To date, significant progress has been made in identifying and characterizing those genes involved in the disease. (springer.com)
  • transplantation
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
  • Such antigens may represent therapeutic targets for posttransplant vaccination or adoptive T-cell therapy to augment the antitumor effects of allogeneic hematopoietic cell transplantation. (aacrjournals.org)
  • subset
  • Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. (usc.edu)
  • found
  • However, B51 tends not to be found in ABD when a certain SUMO4 gene variant is involved, and symptoms appear to be milder when HLA-B27 is present. (wikipedia.org)
  • HLA are not typical antigens, like those found on surface of infectious agents. (wikipedia.org)
  • The associations rapidly expanded to include 'HL-A8' HLA-B8, as the HLA A1 and B8 were found to be commonly linked. (wikipedia.org)
  • A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
  • In Hodgkin's lymphoma HLA-A1, but DR3 was not found higher. (wikipedia.org)
  • The − 35 SNP is also in strong LD with a variant found in the 3′UTR of the HLA-C gene, which was recently shown to regulate binding of the microRNA miR-148a to its target site, thereby altering HLA-C expression ( 6 ). (jimmunol.org)
  • immune response
  • In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)
  • Whether individuals with "high" HLA-C expression show a stronger HLA-C-restricted immune response exerting better viral control than that of their counterparts has not been established. (jimmunol.org)
  • specific
  • Antigen-presenting cells transduced with recombinant adenoviral vectors encoding NY-ESO-1 were used to stimulate CD8+ selected NY-ESO-1-specific T cells. (aacrjournals.org)
  • However, specific HLA types associated with ESRD have not been well documented. (biomedcentral.com)