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  • frequency
  • The Yucpa have an HLA-DQ8 frequency of ~80%, the highest DQ allele frequency in the world, this tribe shows little evidence of European genetic introgression, in addition the closest DQ8 frequency in terms of Africa are the isolated !Kung of Namibia. (wikidoc.org)
  • In order to identify HLA-B alleles associated with autism in Thai population, we compared the frequency of HLA-B allele in 364 autistic subjects with 952 normal subjects by using a two-stage sequence-specific oligonucleotide probe system (PCR-SSOP) method based on flow-cytometry technology. (hindawi.com)
  • We found an increased frequency of mutations in individuals with highly expressed HLA-C alleles, which also correlated with IFN-γ production by HLA-C-restricted CD8 + T cells. (jimmunol.org)
  • 0103
  • 2006, Homozygous Status for HLA-E*0103 Confers Protection from Acute Graft-Versus-Host Disease and Transplant-Related Mortality in HLA-Matched Sibling Hematopoietic Stem Cell Transplantation, Transplantation 2006 82(11) 1436-1440. (usc.edu)
  • These data suggest that the homozygous state for HLA-E*0103 allele behaves as a protective genetic factor against aGVHD and TRM and likely contributes to improved survival in HLA-genoidentical bone marrow transplantation. (usc.edu)
  • The other alleles, A*0102 and A*0103, may confer specific risks. (wikipedia.org)
  • serotypes
  • As of December 2013, there are 456 alleles identified (mostly by sequence homology) as being A2, of those 27 are nulls, and a large majority have unknown serotypes, although it is highly probable that they will all return A2 serotypes. (wikipedia.org)
  • viral
  • HLA-A*02-C*16 and HLA-A*02-B*45 have been shown to contribute to significantly increased viral loads (greater than 100,000 copies per milliliter). (wikipedia.org)
  • Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. (springer.com)
  • Whether individuals with "high" HLA-C expression show a stronger HLA-C-restricted immune response exerting better viral control than that of their counterparts has not been established. (jimmunol.org)
  • polymorphism
  • 2005, Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation. (usc.edu)
  • Delayed HIV-1 disease progression is associated with a single nucleotide polymorphism upstream of the HLA-C gene that correlates with differential expression of the HLA-C Ag. (jimmunol.org)
  • This polymorphism was recently shown to be a marker for a protective variant in the 3′UTR of HLA-C that disrupts a microRNA binding site, resulting in enhanced HLA-C expression at the cell surface. (jimmunol.org)
  • infection
  • Among people with human immunodeficiency virus (HIV) infection, a version of HLA-B designated HLA-B*5701 is associated with an extreme sensitivity to abacavir . (wikipedia.org)
  • Genetically predisposed individuals could be influenced by an environmental trigger (i.e., dietary iodine, infection, pregnancy, cytokine therapy) that induces an autoimmune response against thyroid-specific antigens by infiltrating immune cells. (springer.com)
  • This is, to our knowledge, the first in vivo evidence supporting the protective role of HLA-C-restricted responses in nonwhites during HIV infection. (jimmunol.org)
  • One is in strong linkage disequilibrium (LD) with HLA-B*5701, an allele strongly associated with good clinical outcome of HIV infection. (jimmunol.org)
  • Behçet disease Crohn's disease Fuchs heterochromic iridocyclitis Granulomatosis with polyangiitis HLA-B27 related uveitis Juvenile idiopathic arthritis Sarcoidosis Spondyloarthritis Sympathetic ophthalmia Tubulointerstitial nephritis and uveitis syndrome Uveitis may be an immune response to fight an infection inside the eye. (wikipedia.org)
  • histocompatibility
  • This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
  • Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
  • diseases
  • B51 is associated with several diseases, including Behçet's disease. (wikipedia.org)
  • HLA-B27 is associated with the spondyloarthropathies , a group of disorders that includes ankylosing spondylitis and other inflammatory joint diseases. (wikipedia.org)
  • A1 serotype was associated with a number of diseases as "HL-A"' antigens were first being described. (wikipedia.org)
  • A1-B58 haplotype (A1-B17 where B58 is dominant) may remain associated with anti-neutrophil cytoplasmic antibody (ANCA) With the exception of type 1 diabetes, most of the evidence for direct association of A1 with autoimmune diseases evaporated as DR3 and DQ2 genes were characterized. (wikipedia.org)
  • Yet most HLA-associated diseases (which include infectious diseases and some forms of cancer) do not reveal a simple Mendelian mode of inheritance, either recessive or dominant, are only partially penetrant, and may involve a number of different HLA alleles in addition to non-HLA loci (3). (springer.com)
  • protective
  • Both alleles might have a protective role in disease development. (hindawi.com)
  • These findings show that immune pressure on HIV is stronger in subjects with the protective genotype and highlight the potential role of HLA-C-restricted responses in HIV control. (jimmunol.org)
  • peptides
  • This is a significant decrease and is almost certainly a result of the abnormally efficient binding of HLA-A*02 to peptides originating from EBV. (wikipedia.org)
  • This high affinity increases the probability of CD8+ t-cell recognition of EBV peptides held by HLA-A*02 complexes. (wikipedia.org)
  • Researchers speculate that HLA-B27 may abnormally display to the immune system peptides that trigger arthritis. (wikipedia.org)
  • spontaneous
  • Therefore, NY-ESO-1 p94-102 is a new candidate peptide antigen for cancer immunotherapy and for the monitoring of spontaneous and vaccine-induced NY-ESO-1-specific T cell responses in HLA- B51+ patients with NY-ESO-1 expressing malignancies. (aacrjournals.org)
  • The HLA-A*02 antigen has been associated with spontaneous abortion in infertile couples. (wikipedia.org)
  • association
  • We found that in this population group, there was no specific association between the HLA alleles studied and chronic urticaria. (scielo.br)
  • In all instances so far, HLA-A1 has been found to be linked to disease by association, but there are few that define HLA-A1 has a predominant genetic risk relative to other gene-alleles in the vicinity of the A1 gene on the larger haplotype. (wikipedia.org)
  • Early in the study of HLA an association was found between HL A1,B8 in allergic disease, these are found to link to extended HLA A1-B8 region. (wikipedia.org)
  • 1 The HLA-B51 gene shows the strongest association with this disease in a variety of ethnic groups, including Iranians, Koreans, Arabs, and Greeks. (arvojournals.org)
  • It is most commonly associated with HLA-B27, which has important features: HLA-B27 AAU can be associated with ocular inflammation alone or in association with systemic disease. (wikipedia.org)
  • peptide
  • In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket. (wikipedia.org)
  • Using a modified approach we identified the NY-ESO-1 p94-102 peptide as being recognized by CD8+ T cells in the context of HLA- B51. (aacrjournals.org)
  • The latter are detected by complementary methods, such as HLA-A2/peptide tetramers, ELISPOT and cytotoxicity assays ( 11 , 12 ). (aacrjournals.org)
  • Thus any alteration to the HLA that induces decreased binding to a certain peptide or increased binding to a certain peptide, is expressed as, respectively, increased susceptibility to disease or decreased susceptibility to disease. (wikipedia.org)
  • responses
  • NY-ESO-1 is one of the most immunogenic cancer antigens known to date, inducing humoral and cellular immune responses in a high proportion of patients with advanced NY-ESO-1-expressing cancers. (aacrjournals.org)
  • group
  • There are a large number of alleles within the B*51 allele group. (wikipedia.org)
  • There are a number of alleles within the B*52 allele group. (wikipedia.org)
  • Among patients with EBV+ HL, only 35.5% of people expressed HLA-A*02 compared to 50.9% in the EBV-HL group and 53% in the control group. (wikipedia.org)
  • B*4801 is part of a group of alleles including B*4201 that share Intron 1 sequence with B*0702, which is common over Western and Central Asia, and has a distribution indicating an early and long presence in Eurasian humans. (wikidoc.org)
  • 5801
  • Another version, HLA-B*5801, is associated with an increased risk of severe skin reactions in people treated with allopurinol (a drug used to treat gout , which is a form of arthritis caused by uric acid in the joints). (wikipedia.org)
  • 5701
  • Although previous studies have reported that − 35 SNP is in LD with HLA-B*5701, several groups have shown that − 35 SNP independently associates with HIV control ( 1 , 4 , 5 ). (jimmunol.org)
  • clinical
  • HLA-B27 AAU has characteristic clinical features including male preponderance, unilateral alternating acute onset, a non-granulomatous appearance, and frequent recurrences, whereas HLA-B27 negative AAU has an equivalent male to female onset, bilateral chronic course, and more frequent granulomatous appearance. (wikipedia.org)
  • protein
  • HIV produces a protein called Nef that binds to the cytoplasmic tail of HLA-A and B and diverts it to the lysosomes for destruction. (wikipedia.org)
  • Other research suggests that joint inflammation characteristic of this disorder may result from improper folding of the HLA-B27 protein or the presence of abnormal forms of the protein on the cell surface. (wikipedia.org)
  • transplantation
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
  • Such antigens may represent therapeutic targets for posttransplant vaccination or adoptive T-cell therapy to augment the antitumor effects of allogeneic hematopoietic cell transplantation. (aacrjournals.org)
  • subset
  • Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. (usc.edu)
  • SUMO4
  • However, B51 tends not to be found in ABD when a certain SUMO4 gene variant is involved, and symptoms appear to be milder when HLA-B27 is present. (wikipedia.org)
  • immune response
  • In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)
  • patients
  • Although most patients with ankylosing spondylitis have the HLA-B27 variation, many people with this particular variation never develop the disorder. (wikipedia.org)
  • Serotypes
  • As of December 2013, there are 456 alleles identified (mostly by sequence homology) as being A2, of those 27 are nulls, and a large majority have unknown serotypes, although it is highly probable that they will all return A2 serotypes. (wikipedia.org)
  • Haplotype
  • Because of its linkage within the AH8.1 haplotype many studies showed association with A1 or A1,B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. (wikipedia.org)
  • In all instances so far, HLA-A1 has been found to be linked to disease by association, but there are few that define HLA-A1 has a predominant genetic risk relative to other gene-alleles in the vicinity of the A1 gene on the larger haplotype. (wikipedia.org)
  • A1-B58 haplotype (A1-B17 where B58 is dominant) may remain associated with anti-neutrophil cytoplasmic antibody (ANCA) With the exception of type 1 diabetes, most of the evidence for direct association of A1 with autoimmune diseases evaporated as DR3 and DQ2 genes were characterized. (wikipedia.org)
  • genetic
  • The association between geographic tongue and psoriasis has been demonstrated in various studies, based on observation of its fundamental lesions, microscopic similarity between the two conditions and the presence of a common genetic marker, human leukocyte antigen (HLA) HLA-C*06. (scielo.br)
  • HLA disease associations-Models for the study of complex human genetic disorders. (springer.com)
  • Genes can further be separated by genetic sequencing and analysis. (wikipedia.org)
  • human
  • Previous studies indicate that alterations in Human Leukocyte Antigen (HLA) class I expression are frequent in colorectal tumors. (beds.ac.uk)
  • HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. (wikipedia.org)
  • Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer، Mokhtar Zarea , Shayan Mostafaeib , Ali Ahmadic , Sadegh Azimzadeh Jamalkandid , Atefeh Abedinie , Zahra Esfahani-Monfarede , Ruhollah Dorostkarf , ∗ , Mojtaba Saadatia , ∗∗ ، در Microbial Pathogenesis، سال چاپ 2018. (ac.ir)
  • Most of the previous reports showed the relationship between the Human Leukocyte Antigen (HLA) gene and etiology of autism. (hindawi.com)
  • We found that short tandem repeat (STR) analysis, human leukocyte antigen (HLA) typing, single nucleotide polymorphism (SNP) genomic analysis, mitochondrial DNA sequencing, and gene expression analysis by microarray can be used to fully describe any hESC culture in terms of its identity, stability, and undifferentiated state. (biomedcentral.com)
  • phenotype
  • Alterations in HLA class I phenotype were observed in 8 (38%) of the 21 tumors and comprised loss of a single A or B alleles in 4 cases, and loss of all four A and B alleles in the other 4 cases. (beds.ac.uk)
  • Seven of these 8 tumors were located on the right side of the colon, and those showing loss of both HLA-A and -B membranous expression were all of the MSI-H phenotype. (beds.ac.uk)
  • Hence, an effective tumor immune escape mechanism could occur through a subtle alteration of the tumor cell HLA phenotype, circumventing both CTL and NK cell attack. (beds.ac.uk)
  • A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
  • cytoplasmic
  • HLA staining by IHC is often strongly cytoplasmic, which could potentially obscure functionally relevant membranous co-expression and result in a false negative interpretation. (beds.ac.uk)
  • HIV produces a protein called Nef that binds to the cytoplasmic tail of HLA-A and B and diverts it to the lysosomes for destruction. (wikipedia.org)
  • ocular
  • It is most commonly associated with HLA-B27, which has important features: HLA-B27 AAU can be associated with ocular inflammation alone or in association with systemic disease. (wikipedia.org)
  • Thus
  • Thus, even the loss of a single allele could potentially allow the escape from an antigen-specific anti-tumor response. (beds.ac.uk)
  • found
  • HLA-B51 is found more frequently in disease that has an eye involvement. (wikipedia.org)
  • The MICA*009 allele has been found to also associated with ABD when B51 is also present, IL-8 and other cytokines may also be involved. (wikipedia.org)
  • The associations rapidly expanded to include 'HL-A8' HLA-B8, as the HLA A1 and B8 were found to be commonly linked. (wikipedia.org)
  • In Hodgkin's lymphoma HLA-A1, but DR3 was not found higher. (wikipedia.org)
  • HLA are not typical antigens, like those found on surface of infectious agents. (wikipedia.org)
  • expression
  • Distinct patterns of HLA surface expression might conceal different immune escape mechanisms employed by the tumors and are worth further study. (beds.ac.uk)
  • Vogel R, Al-Daccak R, Drews O, Alonzeau J, Mester G, Charron D, Stevanovic S, Mallet J (2013) Mass spectrometry reveals changes in MHC I antigen presentation after lentivector expression of a gene regulation system. (immunology-tuebingen.de)
  • 19. Farhadi N , Doosti A, Mohammadi J, Mohammadi R. Effects of orally-administered melatonin and long-term exposure to light and dark on serum indices and gene expression of insulin and glucagon in male Wistar rats. (ac.ir)
  • In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)
  • presence
  • Other research suggests that joint inflammation characteristic of this disorder may result from improper folding of the HLA-B27 protein or the presence of abnormal forms of the protein on the cell surface. (wikipedia.org)
  • different
  • The HLA-B gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign invaders. (wikipedia.org)
  • individuals
  • Individuals who have HLA-B*1502 are more likely to experience a severe skin disorder called Stevens-Johnson syndrome in response to carbamazepine (a drug used to treat seizures). (wikipedia.org)
  • peripheral
  • HLA-A*02 appears to stimulate peripheral blood mononuclear cells in a manner that inhibits HIV replication. (wikipedia.org)