• Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. (biomedcentral.com)
  • Thus, as an alternative, we produced EXIQON microarray of brown and white primary murine adipocytes (prior to and following differentiation) to yield global profiles of miRNAs. (biomedcentral.com)
  • Understanding the regulation of the pathways that lead to proliferation and differentiation of white and brown pre-adipocytes could be crucial for revealing the underlying mechanisms of obesity. (biomedcentral.com)
  • It has been suggested that adipogenesis is regulated by PPARβ/δ followed by PPARγ and C/EBPα promoting differentiation into mature adipocytes [ 12 ]. (biomedcentral.com)
  • To understand the development of adiposity, it is crucial to identify the genes which expression is associated with adipogenic differentiation. (biomedcentral.com)
  • Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
  • On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)
  • Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
  • Therefore, growth of adipose tissue includes the hypertrophy of already existing adipocytes and the proliferation and differentiation of new ones from MSCs. (biomedcentral.com)
  • Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. (nih.gov)
  • Constitutive GATA-2 and GATA-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. (nih.gov)
  • Thus, GATA-2 and GATA-3 regulate adipocyte differentiation through molecular control of the preadipocyte-adipocyte transition. (nih.gov)
  • ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al. (nih.gov)
  • Using adenoviral overexpression of a dominant-negative form of adipocyte determination and differentiation factor 1 (ADD1), a transcription factor that binds to the insulin-responsive E box, we demonstrated that ADD1 was required for Ang II regulation of the FAS gene in 3T3-L1 adipocytes. (ttu.edu)
  • PPARα regulates fatty acid oxidation primarily in liver and to a lesser extent in adipose tissue, whereas PPARγ serves as a key regulator of adipocyte differentiation and lipid storage. (northwestern.edu)
  • In addition, various adipokines secreted by adipocytes regulate the proliferation and differentiation of T cells. (frontiersin.org)
  • Simultaneously, adipocytes secrete various cytokines including leptin, resistin, TNF-α and IL-6 to regulate the differentiation and function of T and B lymphocytes. (frontiersin.org)
  • Next, we summarize various cytokines produced by adipocytes that regulate the survival, activation and differentiation of B cells. (frontiersin.org)
  • Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • The origins and basis for these fat deposits are largely unknown, but there is a possibility that the altered mechanical and biological environments lead to dysregulation of MSC/MPC and progression to preferential differentiation towards the adipocyte lineage. (scirp.org)
  • Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • Microarray analysis of MSC during osteogenic differentiation identified three candidate genes for further examination and functional analysis: ID4, CRYAB, and SORT1. (biomedcentral.com)
  • Finally we analyzed the gene expression profiles of MSC during osteogenic differentiation. (biomedcentral.com)
  • It is reasonable to assume that this translocation corresponds to the consistent rearrangement of one or two genes in 12q13 and/or 16p11, and that the loci thus affected are important in the normal control of fat cell differentiation and proliferation. (lu.se)
  • We have used Southern blot technique to test whether a gene of the CCAAT/enhancer binding protein (C/EBP) family, CHOP, which maps to 12q13 and is assumed to be involved in adipocyte differentiation, could be the 12q gene in question. (lu.se)
  • In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
  • We have previously shown that fish primary preadipocytes differentiate into mature adipocytes in vitro and that these cells represent a very helpful model system to study adipose tissue development in fish [ 5 , 6 ]. (biomedcentral.com)
  • While the physiological role of adipose tissue in cholesterol and oxLDL metabolism remains to be established, the induction of OLR1 is a potential means by which PPARγ ligands regulate lipid metabolism and insulin sensitivity in adipocytes. (jci.org)
  • Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the PNPLA2 gene. (wikipedia.org)
  • The adipocyte size was determined by using collagenase digestion of adipose tissue, separation of adipocytes by centrifugation, methylene blue staining of the nuclei, and measurement of the cell diameter. (univr.it)
  • These results suggest that a high level of PPARγ in mouse liver is sufficient for the induction of adipogenic transformation of hepatocytes with adipose tissue-specific gene expression and lipid accumulation. (northwestern.edu)
  • The emergence in traditional white adipose tissue (WAT) depots of multilocular adipocytes that express uncoupling protein 1 (UCP1) and resemble brown adipocytes, the so called 'brite' adipocytes, could contribute to increased energy expenditure. (edu.sa)
  • Adipocytes are the main constituent cells of adipose tissue. (frontiersin.org)
  • This phenotype is associated with increased subcutaneous adipose tissue mass, adipocyte hypertrophy, and inflammation. (medscape.com)
  • Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS. (unc.edu)
  • Adipocyte Senp2 de﫿ciency resulted in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feed- ing. (deepdyve.com)
  • Although less fat stor- adqcKO pose lipid storage in adipocyte-speci﫿c Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
  • Therefore, adipocyte-speci﫿c remain in adipose tissues. (deepdyve.com)
  • Mature adipocytes are known to play an important role controlling energy balance in mammals by storing fatty acids in the form of triglycerides in periods of excess of energy and by releasing fatty acids when are needed. (biomedcentral.com)
  • Adipogenesis has been described as a two-step developmental process consisting on the commitment of undifferentiated MSCs into preadipocytes and the further development of these cells into fully functional mature adipocytes [ 4 ]. (biomedcentral.com)
  • Inactivation of TCF7L2 protein attained by removing the high-mobility group (HMG)-box DNA binding domain in mature adipocytes in vivo leads to whole-body glucose intolerance and hepatic insulin resistance. (medscape.com)
  • Fatty tissues in our bodies contain these immature preadipocytes and the mature adipocytes they become, both of which play key roles in the development of metabolic syndrome accompanied by obesity. (u-tokyo.ac.jp)
  • When one overeats, excess energy is stored as lipids as adipocytes are enlarged and preadipocytes are differentiated into mature adipocytes. (u-tokyo.ac.jp)
  • We found 65 miRNAs regulated during in vitro adipogenesis in primary adipocytes. (biomedcentral.com)
  • When comparing primary adipocyte profiles, with those of cell lines reported in the literature, we found a high degree of difference in 'adipogenesis' regulated miRNAs suggesting that the model systems may not be accurately representing adipogenesis. (biomedcentral.com)
  • Furthermore, the information generated will allow future investigations of specific genes involved in particular stages of fish adipogenesis. (biomedcentral.com)
  • Genes that control the early stages of adipogenesis remain largely unknown. (nih.gov)
  • Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis. (nih.gov)
  • Of interest is that hepatic steatosis per se, induced either by feeding a diet deficient in choline or developing in fasted PPARα -/- mice, failed to induce the expression of these PPARγ-regulated adipogenesis-related genes in steatotic liver. (northwestern.edu)
  • [ 17 , 18 ] TCF7L2 protein is increased during adipogenesis in 3T3-L1 cells and in primary adipocyte stem cells. (medscape.com)
  • They also found that patients with the homozygous genotype developed diabetes early in adulthood and had downregulation of PPAR-gamma-dependent genes that are responsible for adipogenesis and the maintenance of adipocyte function, which "alter[s] the regulation of pathways influencing adipogenesis, insulin sensitivity, and lipid metabolism," they wrote. (medpagetoday.com)
  • Damcott and colleagues noted that the findings were somewhat unusual because a defect in an enzyme critical for lipolysis would be expected to result in excess lipid storage, but the researchers observed the opposite, "providing evidence that HSL plays a key role in maintaining adipogenesis and adipocyte function. (medpagetoday.com)
  • Obesity can be viewed as a state of long-term lipid disequilibrium that is marked by massive adipocyte hypertrophy and is a major risk factor for developing insulin resistance and type 2 diabetes. (jci.org)
  • A wide number of adipocyte genes are regulated by exogenous polyunsaturated fatty acids (PUFA) through the actions of the peroxisome proliferator activated receptor. (umn.edu)
  • A deletion in the gene encoding hormone-sensitive lipase, a key enzyme for lipolysis, was associated with abnormalities in adipocyte function and systemic lipid and glucose homeostasis. (medpagetoday.com)
  • The findings "indicate the physiological significance of HSL in adipocyte function and the regulation of systemic lipid and glucose homeostasis, and underscore the severe metabolic consequences of impaired lipolysis," they wrote. (medpagetoday.com)
  • HSL, which is encoded by the LIPE gene, is a key player in lipolysis within adipocytes. (medpagetoday.com)
  • Egan, J. J., Greenberg, A. S., Chang, M. K. & Londos, C. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. (nature.com)
  • Northern blotting and gene expression profiling results showed that adipocyte-specific genes and lipogenesis-related genes are highly induced in PPARα -/- livers with PPARγ1 over-expression. (northwestern.edu)
  • by regulating lipogenesis-related genes (Ahmadian et al. (deepdyve.com)
  • Moreover, the elevated LEP expression observed in obesity correlated well with increased FOSL2 levels in mice and humans, and adipocyte-specific genetic deletion of Fosl2 in mice reduced Lep expression. (evanrosenlab.com)
  • GATA-3-deficient embryonic stem cells exhibit an enhanced capacity to differentiate into adipocytes, and defective GATA-2 and GATA-3 expression is associated with obesity. (nih.gov)
  • Diabetes, obesity: Is gene editing the answer? (medicalnewstoday.com)
  • 3-Adrenergic receptor ( 3-AR) and uncoupling protein 1 (UCP1) are involved in energy expenditure of the adipocytes, and the polymorphism of these genes has been reported to be associated with the prevalence of obesity and type 2 diabetes. (hindawi.com)
  • In 362 overweight people, they observed gene-dosage effects that link SORLA expression to obesity and glucose tolerance. (medscape.com)
  • Sorl1 gene knockout in mice accelerated the breakdown of triacylglycerides in adipocytes and protected the animals from diet-induced obesity. (medscape.com)
  • For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. (who.int)
  • Knockdown of FOSL2 in human adipocytes decreased LEP expression, and overexpression of Fosl2 increased Lep expression in mouse adipocytes. (evanrosenlab.com)
  • Here we report that antidiabetic thiazolidinediones (TZDs) and other ligands for the nuclear receptor PPARγ dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilitating the exchange of coactivators for corepressors on the OLR1 gene in cultured mouse adipocytes. (jci.org)
  • In conclusion, this is the first report that Ang II regulates adipocyte FAS gene transcription via insulin response sequences in a glucose-dependent manner and that this regulation is mediated at least in part via the ADD1 transcription factor. (ttu.edu)
  • Surprisingly, very little is known about the transcriptional pathways that regulate adipocyte-specific expression of leptin. (evanrosenlab.com)
  • If the capacity of the adipocyte to store lipids is exceeded, it can no longer regulate the release of FFAs into the circulation, which ultimately leads to the abnormal accumulation of lipid in nonadipose depots. (jci.org)
  • Adipocytes can regulate adaptive immunity, which is involved with various metabolic diseases. (frontiersin.org)
  • Since there have been many reports on the regulation of metabolic diseases through adaptive immunity ( 9 - 11 ), we focus on how adipocytes regulate adaptive immunity in this review. (frontiersin.org)
  • In addition to the classic brown adipocytes, a different type of brown fat cells seems to exist in tissues where WAT predominates. (biomedcentral.com)
  • Making use of a short peptide that specifically docks with white adipocytes, the team was able to deliver the CRISPRi components to 99% of cells in a cell culture model. (medicalnewstoday.com)
  • Studies have shown that a key transcription factor, PR domain containing 16 (PRDM16), and fibroblast growth factor 21 (FGF21) are involved in conversion of precursor cells into mitochondria (mt)-enriched beige adipocytes (BA). (nih.gov)
  • Uncoupling protein 1 (UCP1) is responsible for non-shivering thermogenesis in brown/beige adipocytes in humans and rodents. (bvsalud.org)
  • Previous studies using murine brown/beige adipocytes revealed that Ucp1 expression levels are directly increased by forskolin and all-trans retinoic acid (RA). (bvsalud.org)
  • Such genes include the adipocyte lipid-binding protein (ALBP or aP2) which plays a central role in facilitating the trafficking of fatty acids within adipocytes. (umn.edu)
  • In addition to the aP2 gene being a target of activation by fatty acids, at the protein level ALBP/aP2 plays a role in trafficking of fatty acids and/or their metabolises. (umn.edu)
  • Hertzel, AV & Bernlohr, DA 1998, ' Regulation of adipocyte gene expression by polyunsaturated fatty acids ', Molecular and cellular biochemistry , vol. 188, no. 1-2, pp. 33-39. (umn.edu)
  • Increased OLR1 expression, resulting either from TZD treatment or adenoviral gene delivery, significantly augments adipocyte cholesterol content and enhances fatty acid uptake. (jci.org)
  • The adipocyte is the major site of fatty acid storage in the body and plays a critical role in maintaining normal glucose and lipid homeostasis. (jci.org)
  • We have previously shown that angiotensin II (Ang II) increases the expression of the gene encoding adipocyte fatty acid synthase (FAS). (ttu.edu)
  • The aim of this experiment was to evaluate the effects of increasing dietary omega-3 (n-3) polyunsaturated fatty acid (PUFA) supplementation on plasma and follicular fluid resolvin D1 (RvD1) concentration, and the mRNA expression of genes related to RvD1 synthesis, inflammatory response, oxidative stress, reproductive hormone receptors and production, and free fatty acid receptors in ewes. (asas.org)
  • 2003). Selective Cellular uptake of fatty acids and following storage in the form of disruption of Pparγ2 or adipocyte-speci﫿c Pparγ knockout leads TGs in adipocytes are key steps in lipid storage. (deepdyve.com)
  • Moreover, during this phase an enrichment in genes involved in the formation of the lipid droplets was evidenced as well as the activation of the thyroid-receptor/retinoic X receptor (TR/RXR) and the peroxisome proliferator activated receptors (PPARs) signalling pathways. (biomedcentral.com)
  • Therefore, it is important to describe their mechanisms of actions, expression patterns and possible target genes and cellular pathways with which they interact. (mdpi.com)
  • [ 11 ] PIs have also been shown to activate endoplasmic reticulum stress pathways by depleting the calcium in adipocytes. (medscape.com)
  • We report here that in a heterologous system using CV-1 cells transiently transfected with PPARγ2, co-expression of ALBP/aP2 enhances the PPAR-dependent activation of gene transcription. (umn.edu)
  • These data identify OLR1 as a novel PPARγ target gene in adipocytes. (jci.org)
  • This increased browning capacity was translated into the appearance of UCP1- and CIDE-A (cell death-inducing DFFA-like effector A)-positive brite adipocytes in retroperitoneal WAT. (edu.sa)
  • The purpose of our study was to investigate whether the Trp64Arg polymorphism in 3-AR gene and the −3826A/G polymorphism in the UCP1 gene were associated with the reduction in energy expenditure and fat oxidation both in resting and aerobic exercise in Japanese. (hindawi.com)
  • This study evaluated factors affecting Ucp1 gene expression in cultured bovine myogenic cells. (bvsalud.org)
  • A-83-01 significantly increased the expression of some brown fat signature genes such as Pgc-1α, Cox7a1, and Dio2, with a quantitative but not significant increase in the expression of Ucp1. (bvsalud.org)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • The ERAP1 gene provides instructions for making a protein called endoplasmic reticulum aminopeptidase 1. (medlineplus.gov)
  • Each of the ERAP1 gene variants changes a single protein building block (amino acid) in endoplasmic reticulum aminopeptidase 1. (medlineplus.gov)
  • Studies in mouse indicate the 80 aa SMAF1 protein is involved in adipocyte tissue function or regulation. (nih.gov)
  • We further found that SET domain bifurcated 1 (Setdb1) was a SUMOylated protein and that SUMOylation promoted Setdb1 occupancy on the promoter locus of Pparg and Cebpa genes to suppress their expressions by H3K9me3. (deepdyve.com)
  • Concentrations of cholesterol and triglycerides are strongly correlated in the adipocyte, but little is known about mechanisms regulating cholesterol metabolism in fat cells. (jci.org)
  • Mesenchymal stem cells gene signature in high-risk myeloma bone marrow linked to suppression of distinct IGFBP2-expressing small adipocytes. (uams.edu)
  • CRISPR/Cas9-mediated Knockout of the Neuropsychiatric Risk Gene KCTD13 Causes Developmental Deficits in Human Cortical Neurons Derived from Induced Pluripotent Stem Cells. (nih.gov)
  • Obese adipocytes overexpress MHC class II molecules and costimulators to act as antigen-presenting cells (APCs) and promote the activation of CD4 + T cells. (frontiersin.org)
  • This review describes how adipocytes participate in adaptive immunity from the perspective of T cells and B cells, and discusses their role in the pathogenesis of various diseases. (frontiersin.org)
  • Recently, an increasing number of studies have shown that adipocytes have immunological functions capable of recruiting and activating immune cells. (frontiersin.org)
  • Several studies have shown that adipocytes highly express CD1d, which presents lipid antigens to invariant natural killer T (iNKT) cells and stimulates the activation of iNKT cells ( 5 - 7 ). (frontiersin.org)
  • Moreover, like other nucleated cells, adipocytes express MHC class I molecules. (frontiersin.org)
  • However, there is no clear evidence that adipocytes interact directly with CD8 + T cells through antigen:MHCI complex. (frontiersin.org)
  • Adipocytes can directly activate CD4 + T cells through antigen:MHCII complex in a contact-dependent manner. (frontiersin.org)
  • Researchers used a modified CRISPR gene editing technique to target the fat cells of obese, diabetic mice. (medicalnewstoday.com)
  • In a previous study , Kim developed a method to deliver genetically modifying agents to white fat cells, or adipocytes. (medicalnewstoday.com)
  • In this paper, he explains that adipocytes are difficult cells to target with such gene editing tools. (medicalnewstoday.com)
  • They demonstrated that OPN3 is also present in both human and mouse fat cells, or adipocytes. (medicalnewstoday.com)
  • Ampicillin and puromycin antibiotic resistance genes provide selection in bacterial or mammalian cells respectively. (sigmaaldrich.com)
  • A University of Tokyo research group has revealed that novel chromatin domains repress the action of genes involved in fat storage by analyzing the epigenome, the information contained in chemical changes to the genome, in a type of immature cell (preadipocytes) that will later differentiate into mature fat cells (adipocytes). (u-tokyo.ac.jp)
  • Genes function differently in these cells because they have distinct epigenomes, the acquired and re-writable information contained in chemical changes to the genome. (u-tokyo.ac.jp)
  • While the epigenetic mechanism that represses genes in embryonic stem cells has been well studied, the epigenetic mechanism in preadipocytes has not been elucidated. (u-tokyo.ac.jp)
  • Induction of TGF-ß-responsive genes was also lower after treatment with TGF-ß1 in bovine hepatocytes than in human hepatoma cells. (bvsalud.org)
  • This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)
  • Here, we explored the mechanistic role of RIP140 in breast cancer and its involvement in estrogen receptor α (ERα) transcriptional regulation of gene expression. (aacrjournals.org)
  • Over consumption of foods rich in lipids and carbohydrates unchains these events, due to the high amount of lipid accumulation in adipocytes. (scirp.org)
  • Inhibition of CRABP-1 impairs the production of retinoic acid, leading to decreased fat storage and adipocyte apoptosis, with the subsequent release of lipids into the circulation. (medscape.com)
  • In adipocyte Senp2-de﫿ciency mice, accumulation of the SUMOylated Setdb1 suppressed the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes, which would decrease the ability of lipid storage in adipocytes. (deepdyve.com)
  • adqcKO Mechanistically, adipocyte Senp2 de﫿ciency caused the downregula- Senp2 mice exhibit an ectopic lipid accumulation and tion of Pparg and Cebpa as well as their downstream target genes insulin resistance related to lipid storage. (deepdyve.com)
  • The generation of new models will be based on candidate genes identified in WP1 and/or WP2The consortium also aims to use knowledge from genetic and biomarker discovery programmes (in particular, novel pathway information) to support development of novel animal models, and includes European players with a strong track record in this area. (lu.se)
  • In their experiments, the scientists used genetically engineered mice that lack the gene coding for OPN3, called Opn3 , in their adipocytes. (medicalnewstoday.com)
  • When the researchers exposed mice lacking Opn3 in their adipocytes to cold temperatures of 39.2ºF (4ºC), their response to the cold was impaired. (medicalnewstoday.com)
  • Their core body temperatures were lower than those of control mice with intact Opn3 genes. (medicalnewstoday.com)
  • In another set of experiments, the researchers raised mice with intact Opn3 genes under lights that lacked the specific blue light wavelengths that normally stimulate OPN3. (medicalnewstoday.com)
  • SUMMIT will also generate animals in which alteration of gene function can be induced in later life: this will involve both conventional methods (using tetracycline and tamoxifen) as well as a novel lentiviral transgenesis technology which allows in vivo siRNA-knockdown of genes that would be embryonic lethal using conventional technologies. (lu.se)
  • In addition, they also interfere with the expression of regulator genes, CHOP , ATF4 , and XBP , which further alters lipid metabolism and autophagy. (medscape.com)
  • Maturation of BAT and WAT follow a similar adipogenic transcriptional program, albeit several genes show cell type-dependent expression. (biomedcentral.com)
  • Once these factors are down-regulated, there is an interruption with lipogenesis and adipocyte maturation. (medscape.com)
  • Gene expression-phenotype associations in adults with eosinophilic esophagitis. (unc.edu)
  • This allows one to examine the effect of transduction of a short-hairpin on gene expression and interpret the knockdown effect seen with shRNA clones. (sigmaaldrich.com)
  • I ly region 4 gene was transferred to a retrovirus and inserted nfection with human adenovirus 36 (Adv 36) has been into preadipocytes in vitro, the gene was capable of induc- reported to cause a large accumulation of fat in 4 animals ing the enzymes and enhancing fat accumulation ( 13 ). (cdc.gov)
  • With the use of transfections as well as glucose transport assays, we further demonstrated that Ang II stimulation of the FAS gene was dependent on glucose. (ttu.edu)
  • DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
  • 3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
  • Lipolytic breakdown performed by ATGL would impact regulatory functions including but not limited to cell death, growth, signaling, metabolism, and gene expression. (wikipedia.org)
  • To better understand its role in metabolism, Damcott and colleagues looked at gene sequences in Old Order Amish participants who had significant lipid abnormalities, and compared those analyses with those from 2,738 additional Amish patients. (medpagetoday.com)
  • Genotypes of the genes involved in energy expenditure also affect efficiency of the aerobic exercise, but it remains unclear whether the strength and the length of the aerobic exercise should be modified by the genotypes of each patient with diabetes. (hindawi.com)
  • The purpose of our study was to investigate whether the energy expenditure and the fat oxidation during aerobic exercise were affected by the presence of mutant alleles in these genes. (hindawi.com)
  • Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (nih.gov)
  • Apart from rodents, the consortium will have access to expertise (Tryggvason) in the use of zebra fish for rapid initial functional screening of genes with unknown functions. (lu.se)
  • In 2009, Yehuda and Bierer posited that epigenetic modifications, such as DNA methylation, may occur in response to environmental influences such as trauma exposure, thus altering the functional expression of genes. (cdc.gov)
  • It was known that the epigenome structure H3K27me3 is involved in the repression of genes in the embryonic stem cell," says Professor Sakai. (u-tokyo.ac.jp)
  • From recent studies in humans, it is thought that the 3826A/G polymorphism in the UCP-1 gene is associated with vulnerability to weight gain and higher BMI [ 9 ]. (hindawi.com)
  • In preadipocytes the researchers identified novel chromatin domains containing H3K4me3, which activates genes, and H3K9me3, which represses them, in tandem on approximately 200 genes. (u-tokyo.ac.jp)
  • Finally, they revealed that the novel chromatin domains repress genes involved in lipid accumulation in preadipocytes. (u-tokyo.ac.jp)
  • Preadipocytes and adipocytes have the same nucleotide sequence in their genomes. (u-tokyo.ac.jp)
  • In preadipocytes, however, genes involved in lipid storage are repressed, while in adipocytes, the same genes are activated. (u-tokyo.ac.jp)
  • The research group of Professor Juro Sakai, Assistant Professor Yoshihiro Matsumura and their colleagues at the Research Center for Advanced Science and Technology focused on the epigenome structure H3K9me3 as potentially involved in gene suppression in preadipocytes. (u-tokyo.ac.jp)
  • The Symposium Proceedings addresses 21st Century Genetics: Genes at Work, and provides a current synthesis of genetic mechanisms and genome/chromosome biology. (cshlpress.com)
  • Since the first microRNA was identified in 1993 by Victor Ambros and colleagues (the lin-4 heterochronic gene in C. Elegans ), more than 24,000 microRNAs have now been identified. (mdpi.com)
  • The techniques will include generation of models featuring tissue-specific disruption of selected genes using Cre-loxP systems (in adipocytes, muscle, endothelium, pericytes and myocardium as required). (lu.se)
  • Administration of the CAF diet, associated with higher adiposity, produced the strongest impact on the parameters studied while its withdrawal restored basal conditions.Conclusions:Acquisition of brown adipocyte features in WAT could evidence an adaptation to try to counteract increased adiposity due to the intake of HF diets. (edu.sa)
  • Adipocyte size in epicardial fat was significantly smaller in valve-replacement patients than in coronary artery bypass graft patients. (univr.it)
  • Adiponectin gene expression was lower in the latter than in the former, although not significantly. (univr.it)
  • In our recent research, we observed that adipocytes express MHC class II molecules and co-stimulatory molecules CD80/CD86, and that their expression significantly increases in response to high fat diet (HFD) challenges ( 8 ). (frontiersin.org)
  • The level of fat oxidation at rest and aerobic exercise of the male subjects with Trp/Arg of the 3-AR gene was significantly lower than that of the Trp/Trp genotype. (hindawi.com)
  • Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. (nature.com)
  • Not only do Adipocytes have energy storage and endocrine functions, but they also play an immunological role. (frontiersin.org)
  • Thus, we discuss the role of adipocytes in adaptive immunity in the context of inflammatory and autoimmune diseases. (frontiersin.org)
  • There are indications that this gene may play a role in cancer as well as in diabetes. (medscape.com)