• receptors
  • The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor is one among the five classes of prostanoid receptors and was the first eicosanoid receptor cloned. (wikipedia.org)
  • The receptor binding affinity Dissociation constant Kd (i.e. ligand concentration needed to bind with 50% of available EP1 receptors) is ~20 nM and that of PGE1 ~40 for the mouse receptor and ~25 nM for PGE2 with the human receptor. (wikipedia.org)
  • Prostaglandin E2 receptor 2 (53kDa), also known as EP2, is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER2: it is one of four identified EP receptors, the others being EP1, EP3, and EP4, which bind with and mediate cellular responses to PGE2 and also, but with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). (wikipedia.org)
  • Shortly thereafter, a second report found this same gene, indicated that it coded for a G protein receptor with its amino acid sequence similarities closest to purinergic receptors GPR91 and P2Y1, and named the gene and its protein GPR99 and GPR99, respectively. (wikipedia.org)
  • Receptor
  • Low M.J., Grandy D.K., Rubinstein M. (2002) Analysis of Dopamine D4 Receptor Function in Gene Knockout Mice: A Role in Cortical Excitability. (springer.com)
  • The gene responsible for directing the synthesis of the thromboxane receptor, TBXA2R, is located on chromosome 19 at position p13.3, spans 15 kilobases, and contains 5 exons. (wikipedia.org)
  • Since these rodents are used as animal models to define the functions of genes and their products, their failure to have two TP isoforms has limited understanding of the individual and different functions of each TP receptor isoform. (wikipedia.org)
  • In addition, JDP2 has been shown to directly associate with the progesterone receptor (PR) and functionally acts as a coactivator of progesterone-dependent PR-mediated gene transcription. (wikipedia.org)
  • Prostaglandin E2 receptor 1 (EP1) is a 42kDa prostaglandin receptor encoded by the PTGER1 gene. (wikipedia.org)
  • 4) It suppresses stress-induced impulsive behavior and social dysfunction in mice by suppressing the activation of Dopamine receptor D1 and Dopamine receptor D2 signaling. (wikipedia.org)
  • 2-Oxoglutarate receptor 1 (OXGR1), also known as cysteinyl leukotriene receptor E (CysLTE) and GPR99, is a protein that in humans is encoded by the OXGR1 (also termed GPR99) gene. (wikipedia.org)
  • The Gene has recently been nominated as a receptor not only for 2-oxogluterate (see alpha-Ketoglutaric acid) but also for the three cysteinyl leukotrienes (CysLTs), particularly leukotriene E4 (LTE4) and to far lesser extents LTC4 and LTE4. (wikipedia.org)
  • alleles
  • 1993). At the molecular-genetic level some alleles of the highly polymorphic human D4R gene (DRD4) have been associated with human diseases, personality traits including attention deficit hyperactivity disorder, opiate and alcohol use, and novelty-seeking behavior. (springer.com)
  • novel
  • Here, we characterize HCC developed in Lkb1 (+/−) mice and demonstrate Lkb1 LOH in all of the HCC tissues examined, suggesting a novel molecular mechanism for HCC development. (aacrjournals.org)
  • 2012). Hence, novel UCP3 gene variants which associated to childhood obesity and even the effect of fatty acid oxidation prevention in triglyceride storage(C V Musa et al. (wikipedia.org)
  • He showed that 'smart' mice suffered more pain, GluN2B and AC1 are novel therapeutic targets for treating chronic pain In 2003, he moved to the University of Toronto, and identified NB001 as a selective inhibitor for AC1. (wikipedia.org)
  • transcription
  • This gene has tissue-specific transcription initiation with other transcription initiation sites upstream of SM-1 (major skeletal muscle site). (wikipedia.org)
  • EP2 also activates the a) GSK-3 pathway which regulates cell migratory responses and innate immune responses including pro-inflammatory cytokine and interleukin production and b) Beta-catenin pathway which regulates not only cell-cell adhesion but also activates the Wnt signaling pathway which, in turn, stimulates the transcription of genes responsible for regulating cell migration and proliferation. (wikipedia.org)
  • Deletion
  • Mice homozygous for this deletion also had increased duodenal iron absorption, elevated plasma iron and transferrin saturation levels, and iron overload, mainly in hepatocytes. (wikipedia.org)
  • chronic
  • In this thesis interactions between dynorphin and the dopaminergic system in cocaine addiction have been addressed using preprodynorphin gene knockout mice treated with a chronic "binge" cocaine protocol. (bl.uk)
  • Discovered the gene CPA1, which causes chronic pancreatitis, in collaboration with Asian Institute of Gastroenterology. (wikipedia.org)
  • genome
  • The CNN2 gene is located at 19p13.3 in the human chromosomal genome, encoding the protein calponin 2. (wikipedia.org)
  • hepatic
  • Iron-related traits of Hfe−/− mice, including increased iron absorption and hepatic iron loading, are inherited in an autosomal recessive pattern. (wikipedia.org)
  • rats
  • Mice and rats express only the TPα isoform. (wikipedia.org)
  • Studies in mice, rats, and guinea pigs have found EP1 Messenger RNA and protein to be expressed in the papillary collecting ducts of the kidney, in the kidney, lung, stomach, thalamus, and in the dorsal root ganglia neurons as well as several central nervous system sites. (wikipedia.org)
  • Function
  • It is possible to delete part or all of a gene of interest in mice (or other experimental animals) as a means of studying function of the gene and its protein. (wikipedia.org)
  • cell
  • Mice lacking MAPK3 have reduced T cell development past the CD4+CD8+ stage. (wikipedia.org)
  • Independently, Joe Z. Tsien has pioneered the use of Cre-loxP system for cell type- and region-specific gene manipulation in the adult brain where hundreds of distinct neuron types may exist and nearly all neurons in the adult brain are known to be post-mitotic. (wikipedia.org)
  • Neuroscience Research
  • NIH Blueprint for Neuroscience Research has created several hundreds of Cre driver mouse lines which are currently used by the worldwide neuroscience community. (wikipedia.org)
  • In particular, the clear demonstration of its usefulness in precisely defining the complex relationship between specific cells/circuits and behaviors for brain research, has promoted the NIH to initiate the NIH Blueprint for Neuroscience Research Cre-driver mouse projects in early 2000. (wikipedia.org)
  • To date, NIH Blueprint for Neuroscience Research Cre projects have created several hundreds of Cre driver mouse lines which are currently used by the worldwide neuroscience community. (wikipedia.org)
  • This transformative technique has led to NIH Blueprint for Neuroscience Research in launching several Cre-driver Mouse Resource projects. (wikipedia.org)
  • adult
  • Tsien is also the first to show that defective Alzheimer's genes (e.g. presenilin-1) impaired adult neurogenesis in the dentate gyrus of the hippocampus, revealing the role of adult neurogenesis in memory clearance. (wikipedia.org)
  • study
  • Joe Z. Tsien is a neuroscientist who pioneered Cre/lox-neurogenetics in the mid-1990s, a versatile toolbox for neuroscientists to study the complex relationships between genes, neural circuits, and behaviors. (wikipedia.org)
  • Role
  • To investigate the role of LKB1 in vivo , we have recently constructed Lkb1 gene knockout mice. (aacrjournals.org)
  • Western blotting and PCR analyses showed loss of Lkb1 heterozygosity in all of the HCC tissues examined, indicating a tumor suppressor role of LKB1 in the mouse liver. (aacrjournals.org)
  • mechanism
  • To determine whether the HFE gene of black rhinoceroses has undergone mutation as an adaptive mechanism to improve iron absorption from iron-poor diets, Beutler et al. (wikipedia.org)
  • found
  • Two splice variants have been found for this gene. (wikipedia.org)
  • A significant level of calponin 2 is found in human and mouse platelets. (wikipedia.org)
  • Although HFE was well conserved across the species, numerous nucleotide differences were found between rhinoceros and human or mouse, some of which changed deduced amino acids. (wikipedia.org)
  • addition
  • In addition, Tsien has developed a method capable of selectively erasing a memory of choice, such as a particular fear memory, in the mouse brain. (wikipedia.org)
  • active
  • only a relatively few of the active CYP genes code for EET-forming epoxygenases, i.e. protein enzymes with the capacity to attach atomic oxygen (see Allotropes of oxygen#Atomic oxygen) to the carbon-carbon double bonds of unsaturated long chain fatty acids such as arachidonic acid. (wikipedia.org)
  • More active polymorphisms of the MAOB gene have been linked to negative emotionality, and suspected as an underlying factor in depression. (wikipedia.org)