• Introduction The advantage of transplantation of bone tissue marrow-derived mesenchymal stem cells (MSCs) after cardiac infarction continues to be evaluated in lots of preclinical and scientific research [1,2]. (mycareerpeer.com)
  • Potential systems of MSC-mediated safety from ischemic damage will be the differentiation of MSCs into cardiomyocytes, the excitement of cardiac stem cell proliferation, and/or cells that enhance vascularization [3]. (mycareerpeer.com)
  • Nevertheless, the reduced retention price of MSCs after transplantation and their low propensity to differentiate right into a cardiac phenotype [4] make it improbable that cell alternative is the major mechanism of great benefit. (mycareerpeer.com)
  • However, a postconditioning benefit of MSCs was also demonstrated when cells were injected 2?h after ischemic injury [21]. (mycareerpeer.com)
  • Methods AF-MSCs, hepatic progenitor-like (HPL) cells and hepatocyte-like (HL) cells derived from AF-MSCs were transplanted into CCl 4 -injured NOD/SCID mice with the AHF phenotype in order to evaluate their therapeutic potential. (bmj.com)
  • Conditioned medium (CM) derived from AF-MSCs or HPL cells was then delivered intrahepatically in order to determine whether the engraftment of the cells or their secreted molecules are the most important agents for liver repair. (bmj.com)
  • Conclusions Human spindle-shaped AF-MSCs or HPL cells might be valuable tools to induce liver repair and support liver function by cell transplantation. (bmj.com)
  • The recent emergence of cell-based therapies such as autologous bone marrow-derived mesenchymal stem cells (ABM-MSCs) and mononuclear cells (ABM-MNCs) seems to offer a pragmatic approach to augment β-cell function/mass. (drcalapai.com)
  • Improvement in insulin sensitivity with MSCs and increase in C-peptide response with MNCs provide newer insights in cell-based therapies. (drcalapai.com)
  • Due to their immunomodulatory properties, mesenchymal stem cells (MSCs) have come into focus as a potential therapeutic concept. (biomedcentral.com)
  • The aim of this study was to investigate the influence of MSCs on the phenotype, cytokine profile, and functionality of naive and non-naive CD4 + T-cells from healthy donors (HD) and patients with autoimmune arthritis under Th17-cytokine polarizing conditions in an explorative way using a transwell system prohibiting any cell-cell-contact. (biomedcentral.com)
  • Magnetically isolated naive and non-naive CD4 + T-cells were stimulated under Th17-polarizing proinflammatory cytokine conditions in presence and absence of bone marrow derived mesenchymal stromal cells (MSCs). (biomedcentral.com)
  • In isolated naive CD4 + T-cells from HD and patients, MSCs suppressed the differentiation of naive towards an effector phenotype while memory and naive cells showed higher percentages in culture with MSCs. (biomedcentral.com)
  • In patients, MSCs significantly decreased the proportion of IL-9 and IL-17 producing effector T-cells. (biomedcentral.com)
  • The results of the study indicate significant immunomodulatory properties of MSCs, as under Th17-polarizing conditions MSCs are still able to control T-cell differentiation and proinflammatory cytokine production in both HD and patients with autoimmune arthritis. (biomedcentral.com)
  • Mesenchymal stem cells (MSCs) are multipotent adult stem (or stromal) cells with the capacity of self-renewal and differentiation potential towards several mesodermal linages such as osteogenic, chondrogenic and adipogenic differentiation (more citations) [ 1 ]. (biomedcentral.com)
  • A shift from Th1 to Th2 cells demonstrated by an increase in the levels of IL-4 has been observed upon treatment with MSCs [ 8 ]. (biomedcentral.com)
  • Mesenchymal stem cells (MSCs) are known to have a potential for articular cartilage regeneration. (stemcellbio.com)
  • Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
  • Mechanical stimulation led to a significant increase in chondrogenic gene expression, while histological analysis detected sulphated glycosaminoglycans and collagen II only in loaded specimens, confirming MC hydrogel suitability to support load induced MSCs chondrogenesis. (nature.com)
  • Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) have been shown to prevent brain damage and improve neurocognition following intraventricular hemorrhage (IVH). (biomedcentral.com)
  • Mesenchymal stem cells (MSCs) transplantation has been used for therapeutic applications in various diseases. (oncotarget.com)
  • The novel neoplasm was found on the tail of female rat after injection with male rat bone marrow-derived MSCs (rBM-MSCs) and the new tumor cell line, K3, was isolated from the neoplasm. (oncotarget.com)
  • The K3 cells expressed surface antigens and pluripotent genes similar to those of rBM-MSCs and presented tumor cell features. (oncotarget.com)
  • Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
  • However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
  • hiPSC-MSC-derived chondrocytes showed significantly increased Col2A1, GAG, and SOX9 gene expression compared to hiPSC-MSCs. (mdc-berlin.de)
  • The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)
  • Mesenchymal stem cells (MSCs) have been widely tested for treating a variety of refectory medical indications such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease due to their multiple differentiation potentials and immunomodulation capability [1-5]. (researchsquare.com)
  • In spite of tissue origin, many other elements such as culture method and further modulations also influence the heterogeneity of MSCs, leading to differential gene expression profiles, growth phenotype, and differentiation potentials [15-17]. (researchsquare.com)
  • Over the past few years, MSCs researches have achieved some inspiring results and some of which moved up to clinic period from preclinical phases, resulting in the marketing approval of a few cell-based therapy products (CTPs) by different national regulatory authorities [18]. (researchsquare.com)
  • We established a Good Manufacturing Practice (GMP) grade cell facility to produce clinic-grade human umbilical cord derived MSCs (HUCMSCs) for treating premature ovarian failure (POF) and recurrent uterine adhesion [18, 20]. (researchsquare.com)
  • MesenCult™ Adipogenic Differentiation Medium (Human) is specifically formulated for the in vitro differentiation of primary human mesenchymal stromal cells, and hPSC-derived mesenchymal progenitor cells (also known as mesenchymal stem cells or MSCs) into adipogenic lineage cells. (stemcell.com)
  • This kit is suitable for the differentiation of MSCs derived from human bone marrow (BM), adipose tissue, umbilical cord, or pluripotent stem cells (PSCs) that have been previously culture-expanded in serum- and animal component-free medium (e.g. (stemcell.com)
  • Researchers are investigating the utilization of mesenchymal stem cells (MSCs) and adipose-derived stem cells (ADSCs) to stimulate hair follicle regeneration. (issca.us)
  • In recent years, one of the main research strategies used to induce angiogenesis in vivo has been via stem cell therapy, especially therapy using mesenchymal stem cells (MSCs). (minervamedica.it)
  • METHODS: Both AT-MSCs and UC-MSCs were obtained from an established cell bank and expanded in vitro . (minervamedica.it)
  • The concentrations of growth factors (such as HGF, bFGF, and VEGF) in the cell culture supernatants collected from culture media of the hypoxia-preconditioned AT-MSCs and UC-MSCs (as well as those from AT-MSCs and UC-MSCs cultured in normoxia) were measured by ELISA. (minervamedica.it)
  • The angiogenic potency was evaluated based on the area and length of blood vessels formed in the quail embryos on days 1, 3, 5, and 7 after transplantation with hypoxic AT-MSCs, normoxic AT-MSCs, hypoxic UC-MSCs, or normoxic UC-MSCs, and compared to placebo control (PBS injection). (minervamedica.it)
  • Adhesion of MSCs to DLT molded in silicone and particularly in collagen initiates polygonal morphology and monolayer formation and enhances not only transcription of CEC typical genes such as ZO-1, Na/K-ATPase, PITX2, and COL-8 but also expression of the corresponding proteins. (lww.com)
  • We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
  • Expression of pluripotency genes and triploblastic differentiation are self-renewable over generations. (wikipedia.org)
  • Replenish new functional cells through spontaneous differentiation into tissue-compatible cells after homing to damaged tissue. (wikipedia.org)
  • The stromal cell system has been proposed to consist of marrow mesenchymal stem cells that are capable of self-renewal and differentiation into various connective tissue lineages. (nih.gov)
  • Recent data from in vitro models demonstrating the essential role of stromal support in hematopoiesis shaped the view that cell-cell interactions in the marrow microenvironment are critical for normal hematopoietic function and differentiation. (nih.gov)
  • Microarray analysis of MSC during osteogenic differentiation identified three candidate genes for further examination and functional analysis: ID4, CRYAB, and SORT1. (biomedcentral.com)
  • Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)
  • We monitored these cells during their expansion ex vivo with respect to proliferation kinetics, surface marker profile and differentiation potential. (biomedcentral.com)
  • Finally we analyzed the gene expression profiles of MSC during osteogenic differentiation. (biomedcentral.com)
  • These stem cells play an important role in several applications including cell differentiation, gene regulation, gene therapy and transplantation. (iomcworld.org)
  • In the presence of TGF-β, IL-9 may induce differentiation of naive CD4 + T-cells towards Th17 cells, while IL-9 also affects thymus-derived natural Tregs (nTregs) and enhances their suppressive function in vitro [ 26 ]. (biomedcentral.com)
  • However, current approaches for chondrogenic differentiation of hiPSCs are complicated and inefficient primarily due to intermediate embryoid body formation, which is required to generate endodermal, ectodermal, and mesodermal cell lineages. (mdc-berlin.de)
  • There has been an increasing interest in recent years in the stromal cell system functioning in the support of hematopoiesis. (nih.gov)
  • Data from preclinical transplantation studies suggested that stromal cell infusions not only prevent the occurrence of graft failure, but they have an immunomodulatory effect. (nih.gov)
  • Ramos CA, Asgari Z, Liu E, Yvon E, Heslop HE, Rooney CM, Brenner MK, Dotti G " An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies. . (bcm.edu)
  • Our results provide an initial step to determine the mechanisms of action and to optimize cell therapy for SCI. (uab.cat)
  • During the past decade, different strategies to initiate pacemaker function by gene therapy were developed. (nih.gov)
  • iPSCs are powerful tools applicable in biomedicine, cell therapy, pharmacology and toxicology. (ipsc21.com)
  • Therefore, the use of iPSCs in stem cell therapy has immense prospects and offer remarkable applications in regenerative medicine. (ipsc21.com)
  • A poor prognosis for patients, the likelihood of developing pulmonary fibrosis after infection, according to several researchers, can be corrected by cell therapy. (genescells.ru)
  • The combined efforts of many research groups can lead to reliable information on the cell therapy benefit and the need to include it in the standards of treatment of patients with this extremely severe pathology. (genescells.ru)
  • My laboratory group has received funding from SFI to study the immunologic basis of acute and chronic kidney disease and how this might be altered by stem cell-based therapy. (universityofgalway.ie)
  • Depending on the patient's medical condition, a refractory disease patient also requires an on-time selective option, such as less invasive cellular therapy options or curative organ transplantation that can function immediately after transplantation. (frontiersin.org)
  • Dr. Gerson has distinguished himself in a number of realms, including his research in DNA repair and stem cell therapy, which has resulted in numerous publications and patents. (case.edu)
  • He is also the co-editor of the internationally recognized textbook, "Gene Therapy of Cancer Translational Approaches from Preclinical Studies to Clinical Implementation 3" (Elsevier Limited, Oxford, United Kingdom) and the textbook "Clinical Hematology. (case.edu)
  • He identified a gene therapy strategy method that creates drug-resistant stem cells capable of selectively repopulating the recipient without the need for high dose toxic therapy. (case.edu)
  • His research has generated 12 patents in the area of gene therapy and cancer drug development that have been licensed to three companies. (case.edu)
  • Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
  • The use of olfactory progenitors as a cell-based therapy for Parkinson's disease (PD) would allow harvest without invasive surgery, provide an autologous cell population, eliminate need for immunosuppression and avoid the ethical concerns associated with embryonic tissues. (scirp.org)
  • Callaway, E. (2011) Gene therapy offers hope for Parkinson's disease. (scirp.org)
  • However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
  • The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
  • The recent decade has seen encouraging outcomes of mesenchymal stem cell therapy that holds promise to alleviate the burden of neurological disorders Moreover, initial study data of preclinical trials have also indicated the effectiveness, tolerance, and safety of MSC-based therapy [ 10 ]. (hindawi.com)
  • Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
  • We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
  • As a post-doctoral fellow of the University of Michigan Medical Center, she worked on developing immunological strategies for prolonging whole organ transplantation tolerance through the use of viral gene therapy and adult mesenchymal stem cells. (ma.edu)
  • Stem cell therapy has emerged as a promising strategy within the realm of hair transplantation. (issca.us)
  • Gene therapy is gaining traction as a cutting-edge approach to addressing hair loss at its core. (issca.us)
  • Tissue engineering, stem cell-based approaches, gene therapy, nanotechnology, and the integration of AI and machine learning are reshaping the landscape of hair restoration. (issca.us)
  • Corneal transplantation is currently the only therapy for severe corneal disorders. (lww.com)
  • Join our webinar, "CAR-T: Historical Perspectives, Manufacturing, and Clinical Applications," to uncover the revolutionary world of CAR-T cell therapy. (isctglobal.org)
  • This webinar will delve into the revolutionary field of CAR-T cell therapy, exploring its impact in crucial areas such as history and principles, manufacturing processes, and its diverse range of clinical applications. (isctglobal.org)
  • CAR-T cell therapy has emerged as a groundbreaking immunotherapy, holding immense promise in the treatment of various diseases, particularly hematologic malignancies. (isctglobal.org)
  • By delving into the historical perspectives of CAR-T cell therapy, we aim to provide participants with a comprehensive understanding of its development and evolution. (isctglobal.org)
  • The importance of this webinar lies in the transformative potential of CAR-T cell therapy and its ability to bring about positive changes in patients' lives. (isctglobal.org)
  • Dr. Stroncek's research is focused on developing new cell therapies, improving the manufacturing of cell therapies, investigating the mechanism of action of cellular therapies and identifying cell therapy potency markers. (isctglobal.org)
  • The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
  • They are collectable from commercially obtainable mesenchymal cells such as human fibroblasts, bone marrow-mesenchymal stem cells and adipose-derived stem cells. (wikipedia.org)
  • To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)
  • Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)
  • However, for cell therapies MSC have to be expanded and/or manipulated to obtain a sufficient amount of cells that can be subsequently used for treatment. (biomedcentral.com)
  • Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
  • Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. (hindawi.com)
  • Innovative therapies, such as progenitor and mesenchymal stem cell transplantation, targeting the specific altered pathway rather than the symptoms, are in the process of development. (smw.ch)
  • Ongoing research in stem cell-based therapies continues to unveil their potential to revolutionize hair restoration techniques. (issca.us)
  • Techniques such as CRISPR-Cas9 gene editing hold immense potential for altering gene expression associated with hair follicle development, offering personalized regenerative therapies. (issca.us)
  • However, the worldwide shortages of corneal donor material generate a strong demand for personalized stem cell-based alternative therapies. (lww.com)
  • The CCE is a comprehensive facility that develops and manufactures a wide range of cell and gene therapies for early phase clinical trials. (isctglobal.org)
  • We found that both MSC and OEC transplanted acutely after injury induce an early up-regulation of genes related to tissue protection and regeneration. (uab.cat)
  • In contrast, cells transplanted at 7 days after injury down-regulate genes related to tissue regeneration. (uab.cat)
  • Muse cells are shown to home into the damage site by S1P-S1P recptor 2 axis and spontaneously differentiate into tissue-compatible cells according to the microenvironment to contribute to tissue regeneration when infused into the blood stream. (wikipedia.org)
  • however, their role in β-cell regeneration remains elusive. (drcalapai.com)
  • These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
  • Human induced pluripotent stem cells (hiPSCs) have demonstrated great potential for hyaline cartilage regeneration. (mdc-berlin.de)
  • In this research, we examined the effectiveness of human umbilical cord blood mononuclear cells (hUCB-MCs), genetically modified using the VEGF and GDNF genes using adenoviral vectors, on posttraumatic regeneration after transplantation in to the site of spinal-cord injury (SCI) in rats. (mdm2-inhibitors.com)
  • offering enhanced manifestation of 79307-93-0 neuroprotective genes and excitement of regeneration at the website of damage. (mdm2-inhibitors.com)
  • By nurturing follicular cells, tissue engineering techniques hold immense potential in enhancing transplantation outcomes and promoting tissue regeneration. (issca.us)
  • We study genes, proteins and signaling pathways that might be essential for RGC and optic nerve development, function, survival, and regeneration. (nih.gov)
  • This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
  • Specifically, 9 patients received systemic infusion of mesenchymal stem cells derived from adipose tissue and followed up for a 12-month follow-up period. (sscb-stembiotech.com)
  • abstract = "Transplantation of bone marrow derived mesenchymal stromal cells (MSC) or olfactory ensheathing cells (OEC) have demonstrated beneficial effects after spinal cord injury (SCI), providing tissue protection and improving the functional recovery. (uab.cat)
  • Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
  • As iPSCs can differentiate to different cell types, we can generate the required cells for the study or treatment of numerous diseases and determination of drug toxicity. (ipsc21.com)
  • Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells. (lww.com)
  • A Muse cell (Multi-lineage differentiating stress enduring cell) is an endogenous non-cancerous pluripotent stem cell. (wikipedia.org)
  • Therapeutic Candidate or Device The therapeutic candidate is a patient specific (autologous) induced pluripotent stem cell derived retinal pigment epithelium (AiPSC-RPE) product. (ca.gov)
  • 1. Basic immunology with an emphasis on dendritic cell, monocyte and T cell biology. (universityofgalway.ie)
  • To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
  • An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)
  • In february 2023, however, Mitsubishi Chemical Group decided to discontinue the development of a regenerative medicine product (CL2020) using Muse Cells. (wikipedia.org)
  • Pluripotent stem cells of keen interest in the field of regenerative medicine as they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease. (ipsc21.com)
  • 4. Stem cell and regenerative medicine related immunology. (universityofgalway.ie)
  • Individual umbilical cable bloodstream mononuclear cells (hUCB-MCs), a well-known way to obtain stem and progenitor cells [6], are appealing both as regenerative cells so that as a healing gene carrier for the treating distressing SCI. (mdm2-inhibitors.com)
  • Evaluation of the data suggested which the gene-cell hUCB-MC build with a combined mix of thevegfandgdnfgenes acquired the best potential to improve posttraumatic recovery and enhance the regenerative influence from the carrier cells. (mdm2-inhibitors.com)
  • In the realm of regenerative medicine, hair transplantation has experienced remarkable progress in recent years. (issca.us)
  • The integration of tissue engineering principles into hair transplantation has opened new avenues for regenerative medicine. (issca.us)
  • These unique regenerative cells promote hair growth and significantly enhance the success rate of transplantation procedures. (issca.us)
  • As active contributors to the advancement of regenerative medicine, staying informed about the latest developments in hair transplantation is crucial. (issca.us)
  • Miami, Florida - Global Stem Cells Group, a leading organization in the field of regenerative medicine, is pleased to announce the appointment of Dr. Salih Yildirim as the new President of the International Society for Stem Cell Application (ISSCA), a division of Global Stem Cells Group. (issca.us)
  • Anderson, L. and Caldwell, M.A. (2007) Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease. (scirp.org)
  • We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)
  • This can be explained in part by their intrinsically low telomerase activity, eradicating the risk of tumorigenesis through unbridled cell proliferation. (wikipedia.org)
  • IL-2 promotes further T cell proliferation to augment the immunogenic response to injury. (medscape.com)
  • IL-1 stimulates the proliferation of inflammatory cells and promotes angiogenesis through endothelial cell replication. (medscape.com)
  • HP75 cells treated with overexpressed miR-543 exhibited increased cell proliferation, migration and invasion, while decreased cell apoptosis as well as expression of Cleaved caspase-3 and Cleaved caspase-8 were observed. (cancerindex.org)
  • and (3) 79307-93-0 improvement of neovascularization and proliferation of neural stem cells and Schwann cells [19C22]. (mdm2-inhibitors.com)
  • We discovered that myocilin increased cell proliferation and survival. (nih.gov)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
  • Transplantation in to the SCI of genetically improved by NT-3 gene individual mesenchymal stem cells produced from umbilical cable blood continues to be demonstrated to decrease pathological cavitation, confer security to myelinated fibres, and promote useful recovery [7]. (mdm2-inhibitors.com)
  • The importance of proinflammatory T-cells and their cytokine production in patients with autoimmune arthritis has been widely described. (biomedcentral.com)
  • The most important change after MSC or OEC transplant was a marked increase in expression of genes associated with foreign body response and adaptive immune response. (uab.cat)
  • Torres-Espín, A , Hernández, J & Navarro, X 2013, ' Gene Expression Changes in the Injured Spinal Cord Following Transplantation of Mesenchymal Stem Cells or Olfactory Ensheathing Cells ', PLoS ONE , vol. 8, e76141. (uab.cat)
  • BMMSCs also significantly improved the expression level of microtubule-associated protein 1 light chain 3 (LC3)-II in both DCD donor livers and ROS-induced injured IAR-20 cells, including upregulating the expression of ferritin. (medscimonit.com)
  • 0.05) accompanied with an increase in insulin receptor substrate-1 gene expression was observed in the ABM-MSC group. (drcalapai.com)
  • The expression of the immediate-early gene c-fos was used as a marker of neuronal activity to investigate the cervical spinal interneuron populations involved in the corticomotoneuronal pathway. (shengsci.com)
  • Expression of this gene is induced by TGFBR1. (cancerindex.org)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Knocking down PARVB expression in vitrocaused apparent decreases in cell migration and wound healing, implying that PARVB has a crucial role in cellular motility. (refine.bio)
  • Therapeutic Candidate or Device Autologous blood stem cells edited to restore iduronidase expression Indication Severe Mucopolysaccharidosis Type 1 (MPS1/ Hurler's syndrome) Therapeutic Mechanism Autologous blood stem cells undergo genome editing to restore the production of the missing enzyme. (ca.gov)
  • Therapeutic Candidate or Device Hematopoietic stem and progenitor cells collected from X-CGD patients modified with a highly regulated lentiviral vector Indication X-linked Chronic Granulomatous Disease Therapeutic Mechanism Lentiviral vector (LV) modification of autologous hematopoietic stem and progenitor cells (HSPCs) to restore physiologic gp91phox expression. (ca.gov)
  • Transcription factor expression and the rate-limiting enzyme in dopamine synthesis tyrosine hydroxylase (TH) were detected in the transfected cells after 4 month-selection with G418, indicating transfected hONPs were stably restricted towards a dopaminergic lineage. (scirp.org)
  • Changes in morphology were imaged, and changes in gene expression of CEC typical genes such as zonula occludens (ZO-1), sodium/potassium (Na/K)-ATPase, paired-like homeodomain 2 (PITX2), and collagen 8 (COL-8) were measured with real-time polymerase chain reaction. (lww.com)
  • Oppositely, expression of mutated myocilin sensitizes cells to apoptosis induced by oxidative stress. (nih.gov)
  • Olfactomedin 1 (Olfm1) and the closely related genes Olfactomedin 2 (Olfm2) and Olfactomedin 3 (Olfm3) show overlapping expression patterns demonstrating preferential expression in the developing and adult neuronal tissues. (nih.gov)
  • It has become clear, however, that the susceptibility of cells to infection with TSE agents cannot be reliably predicted either from their tissue of origin or level of expression of PrP C ( 11 , 12 ). (cdc.gov)
  • We tested various specimens (blood, cerebrospinal fluid, intraocular fluid, serum, and tissues) from the organ donor and recipients by serology, RT-PCR, immunohistochemistry, metagenomic next-generation sequencing, and host gene expression, and conducted a traceback of blood transfusions received by the organ donor. (cdc.gov)
  • Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)
  • Recent efforts demonstrated that the multiple mesenchymal lineages can be clonally derived from a single mesenchymal stem cell, supporting the proposed paradigm. (nih.gov)
  • Many investigators once believed that TSE agents infected mainly, if not exclusively, cells of neuronal and lymphoid lineages. (cdc.gov)
  • The most recent advances include overexpression of bioengineered ion channels and genetically modified stem cells. (nih.gov)
  • The CCE is currently manufacturing chimeric antigen receptor (CAR) T-cells, T-cell receptor (TCR)-engineered T-cells, cancer vaccines, induced pluripotent stem cells (iPSC), retinal pigmented epithelial cells derived from autologous iPSC and genetically modified hematopoietic stems cells. (isctglobal.org)
  • More importantly, the factors they release may also play an important role in cell treatment in diseases of the liver. (bmj.com)
  • To investigate the metastatic potential of K3 cells, we established the nude mouse models of liver and lung metastases and isolated the corresponding metastatic cell lines K3-F4 and K3-B6. (oncotarget.com)
  • MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. (cancerindex.org)
  • Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). (cancerindex.org)
  • Clinical assessment and identification of immuno-oncology markers concerning the 19-gene based risk classifier in stage IV colorectal cancer. (cdc.gov)
  • Preclinical and early clinical safety studies are paving the way for further applications of mesenchymal stem cells in the field of transplantation with respect to hematopoietic support, immunoregulation, and graft facilitation. (nih.gov)
  • The accumulated experience of preclinical experiments made it possible to urgently proceed to conduct clinical trials of the safety of their use in patients with ARDS and to search for optimal indications to obtain maximum benefits for patients after transplantation. (genescells.ru)
  • Patient-derived autologous stem cells present a safe option for this treatment since these will not induce immune rejection and thus multiple treatments are possible without any risk for allogenic sensitization, which may arise from allogenic stem cell transplantations. (stemcellbio.com)
  • Artificial reproduction of Descemet membrane with respect to topography and similar stiffness offers a potential innovative way to bioengineer a functional CEC monolayer from autologous stem cells. (lww.com)
  • A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. (nih.gov)
  • We examined the neuroregenerative capability conferred by hUCB-MCs in harmed rat spinal-cord, aswell as their impact on phenotype of engrafted cells when genetically improved using the recombinant adenoviruses encoding VEGF and GDNF. (mdm2-inhibitors.com)
  • Opportunistic testing of BRCA1, BRCA2 and mismatch repair genes improves the yield of phenotype driven hereditary cancer gene panels. (cdc.gov)
  • Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
  • 하지만, 이러한 줄기세포를 이용한 골결손의 치료에 있어 지금까지 대부분 실험실적 조건에서 미분화된 줄기세포 (undifferentiated stem cell)를 여러 첨가 물질 및 인공 조작을 통해 특정 세포로 분화시킨 후 적용한 경우가 대부분이어서, 이러한 실험실적 조작(in vitro manipulation)에 의한 예측 불가능한 다양한 부작용이 실제 임상적용을 어렵게 하는 난제가 있다. (stemcellbio.com)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
  • Can be isolated as cells positive for SSEA-3, a well known human embryonic stem cell marker. (wikipedia.org)
  • Pluripotent stem cells can be directly obtained from normal human tissues without using artificial manipulations such as gene introduction. (wikipedia.org)
  • Muse cells are identified as cells positive for SSEA-3+, a well-known marker for undifferentiated human ES cells. (wikipedia.org)
  • This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle degeneration, epidermolysis bullosa, skin injury, stroke and spinal cord injury. (wikipedia.org)
  • Hela cells and human fibroblast-derived iPS cells showed high telomerase activity while Muse was at nearly the same level as that in somatic cells such as fibroblasts (these data are shown without running control for the telomerase activity, the comparison is not scientific thought). (wikipedia.org)
  • Background There is increasing interest in the therapeutic potential of human mesenchymal stem cells (hMSCs), especially in diseases such as acute hepatic failure (AHF) that are predominantly caused by a variety of drugs and viruses. (bmj.com)
  • In this study we asked if human MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if cultivation conditions exert any influence on their stem cell maintenance. (biomedcentral.com)
  • Induced Pluripotent Stem Cells (iPS) iPSCs are derived from skin or blood cells that have been reprogrammed back into an embryonic-like pluripotent state that enables the development of an unlimited source of any type of human cell needed for therapeutic purposes. (ipsc21.com)
  • We evaluated the therapeutic effects of human adipose tissue-derived stem cells (ASCs) in an animal model of ALS. (stemcellbio.com)
  • Animals were divided into three groups: (i) a half million of human ATMSC, (ii) a half million of murine CLTA4Ig gene-transduced human ATMSC (CTLA4Ig-MSC), or (iii) normal saline (as control), which were administered intravenously four times within a 3-week period. (stemcellbio.com)
  • 2 Despite having high metabolic activity, human CECs (hCECs) do not proliferate in vivo because these cells arrest in the G1 phase of the cell cycle. (lww.com)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • In this investigation we sought to answer the question concerning the presence of mast cells in human and rat dental pulp tissues, under normal and inflammatory conditions. (bvsalud.org)
  • Studies using human samples have shown that such cells are present in dental pulps 1,2 whilst others have demonstrated the absence of those cells 3,4,5 . (bvsalud.org)
  • Besides the cell source choice, also mechanical stimuli are crucial in the development and maintenance of articular cartilage. (nature.com)
  • Cucchiarini, M., Madry, H. Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair. (uniklinikum-saarland.de)
  • Adipose tissue-derived mesenchymal stem cells have recently demonstrated the possibility of treating neurological disorders. (stemcellbio.com)
  • With a variety of assays we could show that MSC represent a cell population which can be expanded for therapeutic applications. (biomedcentral.com)
  • An important factor in interstitial aggression is the appearance of autoreactive clones of plasma cells, dissemination of virusinfected leucocytes throughout the body with the involvement of various organs and systems, which exacerbates multiple organ failure. (genescells.ru)
  • I developed specific interest in the immune-modulating properties of Vitamin D, the molecular basis for chronic kidney transplant rejection, complications of organ transplantation and the involvement of cells from the immune system in kidney disease. (universityofgalway.ie)
  • The ideal treatment option for terminally ill patients is organ transplantation. (frontiersin.org)
  • Organ transplantation is the ultimate treatment option for patients suffering from refractory diseases. (frontiersin.org)
  • However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
  • Her deep interest in how immunological cells mediate whole organ transplantation tolerance led her to Dartmouth's Geisel School of Medicine where she obtained her Ph.D. in Molecular and Cellular Immunology. (ma.edu)
  • BACKGROUND: In 2021, four patients who had received solid organ transplants in the USA developed encephalitis beginning 2-6 weeks after transplantation from a common organ donor. (cdc.gov)
  • Recent infection with yellow fever virus was confirmed in all four organ recipients by identification of yellow fever virus RNA consistent with the 17D vaccine strain in brain tissue from one recipient and seroconversion after transplantation in three recipients. (cdc.gov)
  • Following transplantation of hiPSC-MSC and hiPSC-MSC-derived chondrocytes into osteochondral defects of arthritic joints of athymic rats, magnetic resonance imaging studies showed gradual engraftment, and histological correlations demonstrated hyaline cartilage matrix production. (mdc-berlin.de)
  • The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
  • However, the changes induced by these cells after their transplantation into the injured spinal cord remain largely unknown. (uab.cat)
  • We analyzed the changes in the spinal cord transcriptome after a contusion injury and MSC or OEC transplantation. (uab.cat)
  • The mRNA of the spinal cord injured segment was extracted and analyzed by microarray at 2 and 7 days after cell grafting. (uab.cat)
  • Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that selectively affects motor neurons in the cortex, brain stem, and spinal cord. (stemcellbio.com)
  • With other REMEDI researchers we are specifically studying the immune therapeutic properties of mesenchymal stem cells (MSC). (universityofgalway.ie)
  • Researchers are exploring the application of nanomaterials and nanoparticles to enhance the targeted delivery of growth factors, drugs, and stem cells directly to the hair follicles. (issca.us)
  • PARVB overexpression increases migration capability and defines high risks for endophytic growth and metastasis in tongue squamous cell carcinoma. (refine.bio)
  • Tongue squamous cell carcinoma (TSCC) varies in characteristics even in early stages and is mainly classified into three subtypes, which are superficial, exophytic and endophytic types, based on a macroscopic appearance of tumor growth.Of these subtypes, endophytic tumor has a poorer prognosis because of its invasive feature and higher frequency to have metastasis. (refine.bio)
  • This is a tool to help students find the right project for their Bachelor's and Master's thesis at Lund Stem Cell Center. (lu.se)
  • One great advantage of MSC is that these cells may be directly obtained from individual patients, thereby eliminating the complications associated with immune rejection of allogenic tissue and infectious diseases. (biomedcentral.com)
  • Functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis resulted in the differentially expressed proteins in the FM and OA groups are mostly involved in the coagulation and complement system-related pathways, serotonin pathways, dopamine pathways, glutamate pathways and acute phase reactions. (ncl.edu.tw)
  • BACKGROUND/AIMS: Early initiation of enteral nutrition (EN) is recommended for acute stroke patients, but it is time-consuming. (bvsalud.org)
  • METHODS: Consecutive acute stroke patients with severe dysphagia within 72 h of hospital admission who received EN were retrospectively enrolled. (bvsalud.org)
  • Kamble RT, Guo S, Ramos CA, Carrum G " Acute gout at engraftment following hematopoietic transplantation. . (bcm.edu)
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
  • Thus, crosstalk between periosteal and growth plate stem cells is essential for post-developmental skeletal growth. (nature.com)
  • In this phase one clinical trial, the efficacy of these cells for the treatment of refractory lupus nephritis (LN) was verified. (sscb-stembiotech.com)