• NEW YORK (GenomeWeb News) - A team led by researchers at Columbia University Medical Center uncovered a new gene linked with pulmonary arterial hypertension, and as the group reported in The New England Journal of Medicine this week, the effects of some mutations in this gene may be mitigated by drug treatment. (genomeweb.com)
  • Pulmonary arterial hypertension is a rare, progressive, and fatal disorder marked by increased pulmonary artery pressure, which leads to decreased blood flow from the heart to the lungs. (genomeweb.com)
  • The most exciting thing about our study is not that we've identified a new gene involved in pulmonary hypertension, but that we've found a drug that can 'rescue' some mutations," said Wendy Chung, an associate professor of pediatrics and medicine at Columbia and a co-senior author of the paper, in a statement. (genomeweb.com)
  • A new UCLA study has identified a gene on the Y chromosome that protects against pulmonary hypertension - a rare but fatal disease that occurs four times more often in women than men. (uclahealth.org)
  • Pulmonary hypertension, a chronic disease characterized by high blood pressure affecting the lung arteries and heart, appears most often in young women. (uclahealth.org)
  • Being male is the single biggest factor in avoiding the development of pulmonary hypertension. (uclahealth.org)
  • Previous research from the group doing the current study found that women have higher rates of pulmonary hypertension because they lack the Y chromosome's protective features, but which gene created that protection was not known. (uclahealth.org)
  • To conduct the experiment, which was done in mice, researchers silenced each gene, one by one, in the Y chromosome to tease out which gene is linked to the development of pulmonary hypertension. (uclahealth.org)
  • The researchers also induced pulmonary hypertension in female rats and then treated them with AMG-487, a drug that blocks inflammation and was developed as a treatment for psoriasis. (uclahealth.org)
  • After dosing the rats twice a day for two weeks, the researchers found that AMG-487 was effective in treating the pulmonary hypertension by blocking the inflammation that leads to pulmonary hypertension. (uclahealth.org)
  • Article: Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines. (uclahealth.org)
  • Pulmonary arterial hypertension (PAH) is a rare complication of primary Sjögren's syndrome (pSS). (biomedcentral.com)
  • Pulmonary hypertension, or high blood pressure in the arteries of the lungs and heart, affects more than 10 million Americans and millions more worldwide. (upmc.com)
  • While there are some medications for specific types of pulmonary hypertension, there is no treatment that prevents or reverses the disease. (upmc.com)
  • Pulmonary hypertension, which makes it difficult for your heart to pump blood due to narrowed and hardened arteries, results in shortness of breath and exercise intolerance, but over time, it can progress to heart failure and death. (upmc.com)
  • New UPMC research from the laboratory of Dr. Stephen Chan, published today in the journal Circulation , demonstrates that mutations in a gene called BOLA3 can lead to a syndrome that results in pulmonary hypertension in affected individuals. (upmc.com)
  • BOLA3 has been linked to the metabolism of the amino acid glycine, which is known to be elevated in patients with pulmonary hypertension, but with unclear significance to the disease. (upmc.com)
  • Over the course of three years, using a combination of state-of-the-art experimental strategies including the study of rare cells from patients with the BOLA3 mutation and special human and animal disease models of pulmonary hypertension, the Chan lab defined BOLA3 as a crucial regulator of glycine production from blood vessels in the lung, with a direct impact on PH development. (upmc.com)
  • These results provide a molecular explanation for the puzzling clinical and genetic associations linking pulmonary hypertension with high glycine," said Chan, director of the Center for Pulmonary Vascular Biology and Medicine at the University of Pittsburgh and UPMC. (upmc.com)
  • Based on these results, future work can utilize glycine as a testable marker to diagnose pulmonary hypertension, potentially early on in the disease process. (upmc.com)
  • Furthermore, altering glycine metabolism or decreasing glycine levels could be explored as a therapeutic option for pulmonary hypertension. (upmc.com)
  • This work supports the growing likelihood that genetic testing of mutations that predispose to pulmonary hypertension could be instrumental in identifying a currently undefined population of individuals at-risk for developing this devastating condition," said Chan. (upmc.com)
  • Visit the UPMC website for additional information on pulmonary hypertension. (upmc.com)
  • A Combined Targeted and Whole Exome Sequencing Approach Identified Novel Candidate Genes Involved in Heritable Pulmonary Arterial Hypertension. (nih.gov)
  • Combination Therapy in Pulmonary Arterial Hypertension: Is This the New Standard of Care? (ajmc.com)
  • Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease characterized by elevated pulmonary artery pressure with no apparent cause. (medscape.com)
  • IPAH is also termed WHO Group I pulmonary hypertension (PH), precapillary pulmonary hypertension, and, previously, primary pulmonary hypertension. (medscape.com)
  • In approximately a third of patients with pulmonary arterial hypertension (PAH), Doppler echocardiography demonstrates right-to-left shunting across a patent foramen ovale. (medscape.com)
  • Chest radiography: A chest radiograph may help identify secondary causes of, or contributors to, pulmonary hypertension. (medscape.com)
  • Equally important, the echocardiogram helps to exclude secondary causes of, or contributors to, pulmonary hypertension, such as left-sided heart disease (eg, left ventricular dysfunction, valvular heart disease). (medscape.com)
  • Nuclear lung ventilation/perfusion scanning: This is performed to exclude chronic thromboembolic pulmonary hypertension (Group IV PH). (medscape.com)
  • The authors report the first description of a case of primary pulmonary hypertension (PPH) in patient with APECED, caused by R257X mutation in AIRE. (ersjournals.com)
  • The findings from this study, provided that other similar cases are reported, suggest that immune deregulation plays a role in the pathogenesis of primary pulmonary hypertension. (ersjournals.com)
  • Primary pulmonary hypertension (PPH) is a disorder characterised by lesions of pulmonary arterioles, which increase vascular resistance and lead to elevated pulmonary arterial pressure. (ersjournals.com)
  • Pulmonary hypertension is increased pressure in the pulmonary circulation. (msdmanuals.com)
  • Severe pulmonary hypertension leads to right ventricular overload and failure. (msdmanuals.com)
  • Many conditions and drugs cause pulmonary hypertension. (msdmanuals.com)
  • In the first group (pulmonary arterial hypertension [PAH]), the primary disorder affects the small pulmonary arterioles. (msdmanuals.com)
  • At least four mutations in the AGTR1 gene have been found to cause a severe kidney disorder called renal tubular dysgenesis. (medlineplus.gov)
  • Renal tubular dysgenesis can be caused by mutations in both copies of any of the genes involved in the renin-angiotensin system. (medlineplus.gov)
  • The AGTR1 gene mutations that cause this disorder likely change or block the AT1 receptor's ability to stimulate signaling, which results in a nonfunctional renin-angiotensin system. (medlineplus.gov)
  • Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. (medlineplus.gov)
  • Mutations in the gene bone morphogenic protein receptor type 2 ( BMPR2 ) were reported as the most common genetic cause of PAH and have proven to be associated with long-term outcomes in IPAH, HPAH, and anorexigen-associated PAH [ 5 ]. (biomedcentral.com)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • They found that mutations in this molecule impair cell-to-cell communication, which causes oversecretion of the hormone aldosterone, which in turn leads to hypertension. (go.jp)
  • Although several gene mutations have been identified as causative genes for hypersecretion of aldosterone, other unknown causes still exist. (go.jp)
  • The research group discovered that mutations in the CADM1 gene were present in aldosterone-producing adenomas. (go.jp)
  • Mutations in the same gene were found in six other cases during an international joint research project of Dr. Brown with collaborators in Europe, the United States, and Japan. (go.jp)
  • Determination of a known mutation can be accomplished by checking several key online resources that list gene mutations and the diseases or disorders they are known to cause or be in association with it. (mlo-online.com)
  • 11,12 Autosomal recessive or X-linked recessive mutations in known genes could also be identified. (mlo-online.com)
  • Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by mutations in the autoimmune regulator (AIRE) gene, which has a central function in maintaining immunological tolerance. (ersjournals.com)
  • The worldwide frequency of MYO15A gene mutations in patients with non-syndromic hearing loss: A meta-analysis. (cdc.gov)
  • and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein. (bvsalud.org)
  • And while a number of genes have been linked to familial and idiopathic PAH, the genetic cause of about a quarter of familial cases of the disease is unknown. (genomeweb.com)
  • The candidate pathogenic genes may be the potential genetic markers for early warning of this disease. (biomedcentral.com)
  • Hypertension may be primary, which may develop as a result of environmental or genetic causes, or secondary, which has multiple etiologies, including renal, vascular, and endocrine causes. (medscape.com)
  • Moreover, in the subgroups older than 57 years old, dominant genetic model demonstrated a negative association with CAD combined with hypertension (OR = 0.31 [95% CI 0.10-0.95] P = 0.04). (bvsalud.org)
  • This article is a review of exciting, recently generated genetic, biochemical and clinical data from studies that have examined the importance of the tissue kallikrein-kinin system in protection from hypertension, vascular remodeling and renal fibrosis. (nature.com)
  • The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
  • In Japan, a total of 19 426 individuals underwent testing for genetic associations with systolic BP (SBP)/diastolic BP (DBP) and 9271 individuals (3460 cases and 5811 controls) underwent testing for genetic associations with dichotomous hypertension. (elsevierpure.com)
  • These results highlight the necessity of a thorough analysis of all reported variants of a candidate gene in the elucidation of genetic susceptibility to a complex disease like hypertension, even when the variants are in the same haplotype block. (tmu.edu.tw)
  • As one can imagine, identification of a given patient's genetic variations via gene sequencing is merely the tip of the proverbial iceberg. (mlo-online.com)
  • Researchers at Queen Mary University of London, UK, have traced hypertension to its genetic sources. (medicalxpress.com)
  • In this work we proposed to study the role of genetic polymorphism of the eNOS G894T gene in the development of diabetes on the one hand and of these degenerative complications other. (scirp.org)
  • To explore a mechanistic link between SH2B3 and hypertension, we targeted the SH2B3 gene for mutation on the Dahl salt-sensitive (SS) rat genetic background with zinc-finger nucleases. (mcw.edu)
  • The aetiology of hypertension involves the complex interplay of environmental and pathophysiological factors that affect multiple systems, as well as genetic predisposition. (nature.com)
  • They also found genetic links to coronary artery disease and hypertension, rheumatoid arthritis, bipolar disorder and type 2 diabetes. (newscientist.com)
  • We conducted the study to determine if this genetic risk score can identify people with Type 2 diabetes who have a higher risk for cardiovascular events and if tight control of blood sugar impacts the link between genetic hypertension risk and cardiovascular outcomes. (heart.org)
  • Post-mortem genetic investigation of cardiac disease-associated genes in sudden infant death syndrome (SIDS) cases. (cdc.gov)
  • DALLAS, April 4, 2022 - A risk score based on a gene map predicted the likelihood of high blood pressure leading to heart problems or stroke in people with Type 2 diabetes , according to a study published today in the American Heart Association's peer-reviewed journal Hypertension . (heart.org)
  • Association of Klotho gene polymorphism with hypertension and coronary artery disease in an Iranian population. (bvsalud.org)
  • The present study was carried out aiming to investigate the association of Klotho-rs564481 (C1818T) gene polymorphism with hypertension and CAD. (bvsalud.org)
  • Moreover, aging enhanced positive effects of the Klotho polymorphism on CAD combined with hypertension , indicating the possibility that the KLOTHO gene might play a part in the age-related occurrence of CAD combined with hypertension . (bvsalud.org)
  • To study the relationship between the ACE insertion/deletion (I/D) polymorphism, blood pressure and risk of hypertension in current, former and non-smokers in a population-based cohort. (nih.gov)
  • In each group, we assessed the relationship between the ACE I/D polymorphism, systolic (SBP) and diastolic (DBP) blood pressures and risk of hypertension. (nih.gov)
  • The D allele of the ACE polymorphism is associated with a significantly increased SBP and risk of hypertension in smokers. (nih.gov)
  • A suggestive association with SBP (P=0.042), DBP (P=0.01) and hypertension (P=1.4 × 10 -5 ) was also detected for ACE rs4340 (a proxy for ACE D/I polymorphism) in the joint meta-Analysis. (elsevierpure.com)
  • Several of these genes were further investigated for association with hypertension in multiple validation cohorts using qRT-PCR, regression analysis, phenome-wide association study and case-control analysis of a missense polymorphism. (nih.gov)
  • Furthermore, homozygosity for a missense single nucleotide polymorphism in LTF that decreases antimicrobial function and increases protein levels (rs1126478) was over-represented in patients with hypertension relative to controls (odds ratio 1.16). (nih.gov)
  • Although previous reports have revealed a significant interaction between the END1 Lys198Asn (G/T) polymorphism and body mass index in association with hypertension, no such relationship was observed in the present study. (geneticsmr.com)
  • Polymorphism in the third intron of the interferonγ gene is associated with susceptibility to multiple sclerosis. (geneticsmr.com)
  • Polymorphism E23K (rs5219) in the KCNJ11 gene in Euro-Brazilian subjects with type 1 and 2 diabetes. (geneticsmr.com)
  • Although some single polymorphism analyses of the angiotensinogen (AGT) gene have been found to be associated with hypertension, the results are still inconsistent. (tmu.edu.tw)
  • For each patient and control we measured lipid parameters, CRP-us and sought the G894T polymorphism of eNOS gene by PCR-RFLP. (scirp.org)
  • Conclusion: The G894T polymorphism of eNOS gene appears to be a risk factor of T2DM. (scirp.org)
  • The rs2234762 polymorphism, sited in the NTS gene promoter, was statistically more frequent in the lowest pro-NTS level group. (lu.se)
  • The aim of this study was to find out the association between angiotensinogen Nf235T gene polymorphism and the risk of developing hypertenMon. (bvsalud.org)
  • These data demonstrate that monocytes exhibit enhanced pro-inflammatory gene expression in hypertensive individuals and identify IL18RAP and LTF as potential novel mediators of human hypertension. (nih.gov)
  • These data further support a role for the immune system as a modulator of disease severity in the pathogenesis of hypertension and provide insight into inflammatory mechanisms at play in human hypertension and renal disease. (mcw.edu)
  • Journal of Human Hypertension , 37(8), pp. 619-625. (gla.ac.uk)
  • Klotho, possibly an age-regulating protein , is considered an important factor contributing to the lifespan and pathophysiology of hypertension and coronary artery disease (CAD). (bvsalud.org)
  • Recent studies suggested that this gene might have smoking-dependent effects on the development of cardiovascular disease. (nih.gov)
  • The intact KCNJ11-encoded (K ATP ) channel is thus a required safety element preventing hypertension-induced heart failure, with channel dysfunction a molecular substrate for stress-associated channelopathy in cardiovascular disease. (elsevierpure.com)
  • Many of the methylated genes were found in earlier studies to be involved in cardiovascular functioning. (nih.gov)
  • Systemic arterial hypertension is the most important modifiable risk factor for all-cause morbidity and mortality worldwide and is associated with an increased risk of cardiovascular disease (CVD). (nature.com)
  • Studies have shown that the longevity-associated variant (LAV) of the BPIFB4 gene is associated with a longer lifespan in humans and has protective effects in rodent models of cardiovascular disease. (medicalnewstoday.com)
  • A recent study published in Cardiovascular Research suggests that LAV-BPIFB4 , a gene variant that previous research ha shown to be highly expressed by individuals with an exceptionally long lifespan, could also protect cardiac and vascular function in old age. (medicalnewstoday.com)
  • Our study underlines the importance of gene-environment interactions in the study of candidate genes for hypertension. (nih.gov)
  • Association with seven notable candidate genes was tested, namely, ACE, ADD1, ADRB2, AGT, CYP11B2, GNB3 and NOS3, followed by a joint meta-Analysis involving previously reported multi-study populations, including 20 000 individuals (for SBP/DBP) and 17 000 individuals (for hypertension). (elsevierpure.com)
  • All 11 selected SNPs within candidate genes were verified by polymerase chain reaction (PCR) sequencing. (bmj.com)
  • Differential expression of six of seven candidate genes were confirmed. (bmj.com)
  • Recently, two single nucleotide polymorphisms in EDN1 have been reported to be associated with hypertension: Lys198Asn and 3A/4A (-134delA) located in the 5'-untranslated region. (geneticsmr.com)
  • The objectives of this study are to evaluate the association of the genotype and haplotype distributions of three single-nucleotide polymorphisms (SNPs) (G-217A, A-6G, and M235T) in the AGT gene with hypertension. (tmu.edu.tw)
  • The eNOS gene has several single nucleotide polymorphisms reported, one of which is G894T. (scirp.org)
  • To obtain evidence for blood pressure (BP) trait association, we conducted an association study of selected candidate gene variants. (elsevierpure.com)
  • Hypertension association reached genome-wide significance for the two variants, specifically, P=7.3 × 10 -10 for AGT rs699 and P=3.9 × 10 -8 for CYP11B2 rs1799998. (elsevierpure.com)
  • Our data provide evidence for true BP trait associations with two candidate gene variants. (elsevierpure.com)
  • Thus, certain variants in genes with clinical and physiological relevance are likely to account for a portion of BP variance in the general population and are worth following up via a target gene approach. (elsevierpure.com)
  • Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. (nature.com)
  • The NT gene (NTS) was sequenced for potential functional variants, evaluating its entire genomic and. (lu.se)
  • The NT gene (NTS) was sequenced for potential functional variants, evaluating its entire genomic and potentially regulatory regions, in DNA from 28 individuals, stratified by low and high pro-NT levels. (lu.se)
  • April 9, 2010 - The US Food and Drug Administration (FDA) has approved the first generic formulations of losartan potassium tablets, alone and in combination with hydrochlorothiazide ( Cozaar and Hyzaar , Merck & Company, Inc), for the treatment of hypertension. (medscape.com)
  • Development of novel therapeutic approaches to bolster kinin activity in the vascular wall and in specific compartments in the kidney might be a highly effective strategy for the treatment of hypertension and its complications, including cardiac hypertrophy and renal failure. (nature.com)
  • Fewer than half of those with hypertension are aware of their condition, and many others are aware but not treated or inadequately treated, although successful treatment of hypertension reduces the global burden of disease and mortality. (nature.com)
  • The AGTR1 gene provides instructions for making a protein called the angiotensin II receptor type 1 (AT1 receptor). (medlineplus.gov)
  • The gene is responsible for production of a protein that forms part of the membrane of cells. (go.jp)
  • Human genome-wide association studies have linked SH2B adaptor protein 3 (SH2B3, LNK) to hypertension and renal disease, although little experimental investigation has been performed to verify a role for SH2B3 in these pathologies. (mcw.edu)
  • In patients with severe hypertension and in age and sex matched controls the circulating levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-LI were measured. (lu.se)
  • 1) elevated BP, with a systolic pressure (SBP) between 120 and 129 mm Hg and diastolic pressure (DBP) less than 80 mm Hg, and (2) stage 1 hypertension, with an SBP of 130 to 139 mm Hg or a DBP of 80 to 89 mm Hg. (medscape.com)
  • Hypertension is defined as a systolic blood pressure (SBP) of 140 mm Hg or more, or a diastolic blood pressure (DBP) of 90 mm Hg or more, or taking antihypertensive medication. (medscape.com)
  • In individuals with hypertension, arterial pressure (recorded as two numbers: systolic and diastolic pressure) is the most important measurement to obtain. (encyclopedia.com)
  • Hypertension is defined as a systolic blood pressure equal to or above 140 mmHg and/or diastolic blood pressure equal to or above 90 mmHg. (who.int)
  • PCBs that exceeded 3.5 for both systolic and diastolic hypertension. (cdc.gov)
  • In genetics, it's common to identify a gene that is the source of a disease. (genomeweb.com)
  • We have also attempted to verify a series of differentially expressed candidate susceptibility genes to lung tumours in our previous microarray analysis with semiquantitative reverse transcriptase PCR (RT-PCR). (bmj.com)
  • This gene is named after the character Tin Woodman who lacks a heart, as flies with nonfunctional tinman genes have cardiac deformities. (wikipedia.org)
  • Defective decoding of hypertension-induced metabolic distress signals in the (K ATP ) channel knockout set in motion pathological calcium overload and aggravated cardiac remodeling through a calcium/calcineurin-dependent cyclosporine-sensitive pathway. (elsevierpure.com)
  • This study demonstrates that it is also possible to make human cardiac cells younger and older mice hearts by transferring a gene expressed by centenarians. (medicalnewstoday.com)
  • We also demonstrate that the benefit is related to the ability of the gene to reprogram cardiac cells to become more resistant to stress and build up the machinery ( ribosomes ) that make proteins. (medicalnewstoday.com)
  • Next generation RNA sequencing identified differentially expressed genes in a small discovery cohort of normotensive and hypertensive individuals. (nih.gov)
  • To determine the association of these two polymorphisms with hypertension, we genotyped patients and controls (N = 537) and compared the allele and genotype frequencies between groups. (geneticsmr.com)
  • There was no significant difference in the genotype frequencies of these two polymorphisms between healthy controls and hypertension patients. (geneticsmr.com)
  • Conclusion: The A GT M235T genes of the TT genotype and the T allele are associated with an increased risk of hypertension among the Ethiopian patients. (bvsalud.org)
  • The number of people suffering with hypertension has doubled from 650 million in 1990 to a staggering 1.3 billion in 2019. (medicaldaily.com)
  • Anteroposterior x-ray from a 28-year old woman who presented with congestive heart failure secondary to her chronic hypertension, or high blood pressure. (medscape.com)
  • Other studies may be obtained on the basis of clinical findings or in individuals with suspected secondary hypertension and/or evidence of target-organ disease, such as CBC, chest radiograph, uric acid, and urine microalbumin. (medscape.com)
  • When a disease, other physical problems, medications, or even temporary physical exertion or stress cause high blood pressure, the condition is called secondary hypertension. (encyclopedia.com)
  • The evaluation of patients with hypertension includes accurate standardized blood pressure (BP) measurement, assessment of the patients' predicted risk of atherosclerotic CVD and evidence of target-organ damage, and detection of secondary causes of hypertension and presence of comorbidities (such as CVD and kidney disease). (nature.com)
  • Emergency department visits for hypertension with complications and secondary hypertension also rose, from 71.2 per 100,000 population in 2006 to 84.7 per 100,000 population in 2011, while again, admission rates fell, dropping from 77.79% in 2006 to 68.75% in 2011. (medscape.com)
  • Angiotensin II type 1 receptor gene polymorphisms in humans: physiology and pathophysiology of the genotypes. (medlineplus.gov)
  • Inflammation and oxidative stress play a key role in the pathophysiology of advanced chronic liver disease (ACLD) and portal hypertension (PH). (mdpi.com)
  • To investigate the gene frequency of the T235 allele and its relationship with hypertension in two Japanese populations. (lww.com)
  • Hypertension, in particular that associated with a positive family history of hypertension, was more common in individuals homozygous for the T235 allele. (lww.com)
  • The T235 angiotensinogen allele was more common in Japanese than in Caucasians, and was a predisposing factor for hypertension. (lww.com)
  • The purpose of our study was to use an unbiased approach to determine whether hypertensive individuals on conventional therapy exhibit an altered monocyte gene expression profile and to perform validation studies of selected genes to identify novel therapeutic targets for hypertension. (nih.gov)
  • We identified 60 genes that were significantly differentially expressed in hypertensive monocytes, many of which are related to IL-1β. (nih.gov)
  • Uni- and multivariate regression analyses of the expression of these genes with mean arterial pressure (MAP) revealed four genes that significantly correlated with MAP in normotensive and/or hypertensive individuals. (nih.gov)
  • In a sample of 461 hypertensive and 327 normotensive patients in Taiwan, we found that -217AA and -6GG homozygotes conferred independently an increased risk to hypertension (P = 0.008 and P = 0.037, respectively), as illustrated by their significant associations with hypertension in both single SNP and pair-wise SNPs analyses. (tmu.edu.tw)
  • In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. (genomeweb.com)
  • Higher maternal blood pressure in pregnancy is associated with chemical modifications to placental genes, according to a study by researchers from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health (NIH). (nih.gov)
  • In our study panels, the most significant association was found for CYP11B2 rs1799998 with all three BP traits: P=1.5 × 10 -5 for SBP, P=1.8 × 10 -5 for DBP and P=2.3 × 10 -5 for hypertension. (elsevierpure.com)
  • Genes under intense study are those that regulate a group of hormones known as the angiotensin-reninaldosterone system. (encyclopedia.com)
  • A mother's "TLC" not only can help soothe pain in infants, but it may also impact early brain development by altering gene activity in a part of the brain involved in emotions, according to new study from NYU Langone Medical Center. (neurosciencenews.com)
  • The main objective of the study was to determine the G894T SNP in the eNOS gene such as risk factor for T2DM in Tunisian population. (scirp.org)
  • Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. (mcw.edu)
  • The study -- the first to separate and compare adaptations that occurred before and after the Neolithic Revolution -- reveals that these dietary practices are reflected in the genes of Europeans. (sciencedaily.com)
  • To our knowledge, this study is the first to document changes in gene expression occurring even after a bacterial infection has been treated with appropriate antibiotics," said John Aucott, MD, assistant professor of medicine at the Johns Hopkins University School of Medicine and a senior investigator on the study. (universityofcalifornia.edu)
  • The largest ever study of genes and disease has found 10 new genes linked to seven of the most common conditions. (newscientist.com)
  • This study in Baghdad, Iraq investigated the possible association of diabetes mellitus, hypercholesterolaemia and hypertension with ABO type. (who.int)
  • Our study also identified the clinical risk factors for hypertension, such as, total cholesterol, triglycerol, low density lipoprotein-cholesterol, and high density lipoprotein-cholesterol Inels, which were significantly higher in patients compared to controls (P (bvsalud.org)
  • Unlike just about any other study on sodium excretion, the Flemish Study on Genes, Environment, and Health Outcomes (1985-2004) and the European Project on Genes in Hypertension used honest-to-goodness 24-hour urine collections for all 3,681 participants. (medscape.com)
  • Of those, the G203D missense variant in KCNK3 stood out to the researchers as a strong disease-causing variant as the gene encodes a potassium channel. (genomeweb.com)
  • After observing each gene's function, the researchers found that the gene, Uty, stops an inflammatory pathway in the lungs in male mice and thereby halts the development of the disease. (uclahealth.org)
  • Click on a disease name to see all genes associated with that disease. (jax.org)
  • Knowledge of a carrier status for a recessive disease gene can trigger additional testing in relatives as it may significantly impact the patient's children, future pregnancies, or other family members. (mlo-online.com)
  • The 21-hydroxylase (21OH) gene, CYP21A2, encodes the 21OH steroidogenic enzyme which is the primary autoantigen in autoimmune Addison s disease (AAD). (endocrine-abstracts.org)
  • This mutation significantly attenuated Dahl SS hypertension and renal disease. (mcw.edu)
  • Researchers at UC San Francisco and Johns Hopkins may have found a new way to diagnose Lyme disease, based on a distinctive gene "signature" they discovered in white blood cells of patients infected with the tick-borne bacteria. (universityofcalifornia.edu)
  • In an effort to find better ways of diagnosing the disease, and discovering molecular pathways that might explain how Lyme disease could cause long-term symptoms, researchers used a next-generation sequencing technique, called RNA-seq, to investigate the transcriptome - the genes that are being turned on - in peripheral blood mononuclear cells. (universityofcalifornia.edu)
  • Compared to patients with other active bacterial or viral infections, the Lyme disease patients had distinctive gene signatures that persisted for at least three weeks, even after they had taken the antibiotics. (universityofcalifornia.edu)
  • At six months, the gene signatures of Lyme disease patients showed some similarities to those from patients with immune diseases like systematic lupus erythematosus, rheumatoid arthritis and chronic fatigue syndrome. (universityofcalifornia.edu)
  • It represents the biggest single haul of disease-associated genes so far, and may lead better understanding of the diseases and new treatments. (newscientist.com)
  • Their findings include the discovery of four new chromosome regions containing genes that can predispose people to type 1 diabetes, and three new genes for Crohn's disease, the most common form of inflammatory bowel disease. (newscientist.com)
  • Hypertension affects approximately 75 million adults in the United States and is a major risk factor for stroke, myocardial infarction, vascular disease, and chronic kidney disease. (medscape.com)
  • We totally identified 141 pathogenic variant loci of 129 genes in these 34 pSS-PAH patients, using WES analysis. (biomedcentral.com)
  • Together with references 3 and 4, these large-scale studies analysed the genomes of ∼ 1 million individuals, identifying new BP-associated loci, doubling the number of reported BP-associated genes and helping to identify potential new targets for BP treatment. (nature.com)
  • Studies on the role of the angiotensin-converting enzyme (ACE) gene in the development of hypertension have yielded conflicting results. (nih.gov)
  • In summary, these two END1 polymorphisms do not appear to affect the development of hypertension in the Chinese population. (geneticsmr.com)
  • On the basis of likelihood ratio test, only the set of haplotypes that constituted the A-6G and the M235T polymorphisms was associated with hypertension (χ 2 = 20.91, P = 0.0008), which was mainly due to the increased frequency of the recombinant haplotypes (-6A ≡ 235M and -6G ≡ 235T), and a pathophysiological role in the predisposition to hypertension was hence indicated. (tmu.edu.tw)
  • Most groups, including the JNC, the American Diabetes Associate (ADA), and the American Heart Association/American Stroke Association (AHA/ASA) recommend lifestyle modification as the first step in managing hypertension. (medscape.com)
  • Excitingly, the team found a single gene that was associated with both Crohn's diseases and type 1 diabetes, suggesting the two auto-immune disorders are linked and share a biological pathway. (newscientist.com)
  • The data were derived from 920 patients with diabetes mellitus, hypertension and hypercholesterolaemia attending hospitals, clinics and laboratories in Baghdad, and 200 healthy control individuals. (who.int)
  • Métodos: ensayo clínico aleatorizado, doble ciego, https://orcid.org/0000-0003-4003-1365 realizado con personas con diabetes tipo 2, en unidades de atención primaria de salud. (bvsalud.org)
  • Endereço: Avenida Nossa Senhora de de presión arterial en personas con diabetes. (bvsalud.org)
  • In humans, the wide variety of carcinogens and varying degrees of exposure make identifying the predisposing genes difficult, but in a mouse model, such confounding variables can be controlled. (bmj.com)
  • Identification of the genes predisposing to mouse lung cancer could have considerable implications for diagnosis, treatment, or chemoprevention of lung cancer in humans. (bmj.com)
  • Analysis of ancient DNA revealed that prior to humans' farming, the animal-based diets of European hunter-gatherers predominantly favored the opposite version of the same gene, which limits the activity of FADS1 enzymes and is better suited for people with meat and seafood-based diets. (sciencedaily.com)
  • The results are expected to lead to new diagnoses of hypertension and the development of therapeutic agents. (go.jp)
  • Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as hypertension. (geneticsmr.com)
  • In non-smokers and former smokers, blood pressure and the risk of hypertension did not differ significantly between genotypes. (nih.gov)
  • The mutated genotypes of GT eNOS gene was significantly more frequent in diabetic patients. (scirp.org)
  • Significantly, many of the genes found were in areas of the genome not previously thought to have been related to the conditions, opening up completely new options for treatment. (newscientist.com)
  • Researchers have identified the chromosomes (11 and 18) that house the genes responsible for blood pressure regulation, although narrowing down the range of specific genes involved in hypertension is more difficult. (encyclopedia.com)
  • By carefully analyzing what genes were active in infant rat brains when the mother was present or not present, the NYU researchers found that several hundred genes were more, or less, active in rat infants experiencing pain than in those that were not. (neurosciencenews.com)
  • An optimal prognostic model based on gene expression for clear cell renal cell carcinoma. (cdc.gov)
  • Experimental and clinical evidence implicate an imbalance between endogenous vasoconstrictor and vasodilator systems in the development and maintenance of hypertension. (nature.com)
  • The ability to sequence genes in a cost-effective and efficient manner has provided the opportunity to offer whole exome and whole genome sequencing in the clinical laboratory setting. (mlo-online.com)
  • But if an individual presents with a clinical phenotype that can have heterogeneous origins so that a number of genes may potentially contribute to the phenotype, then WES or WGS may be warranted. (mlo-online.com)
  • Once the variations are identified one must determine for each variation if it has been reported previously and has a known consequence, if it has not been reported previously but would be likely to contribute to a clinical phenotype based on the type of mutation and the gene in which it resides, or if the significance of the mutation is completely unknown. (mlo-online.com)
  • Les données ont été recueillies à partir des dossiers de 920 patients atteints de diabète, d'hypertension et d'hypercholestérolémie en consultation dans des hôpitaux, des cliniques et des laboratoires d'analyses de Bagdad, et de 200 témoins en bonne santé. (who.int)
  • A 10-gene signature as a predictor of biochemical recurrence after radical prostatectomy in patients with prostate cancer and a Gleason score ≥7. (cdc.gov)
  • Development and validation of a metabolic gene signature for predicting overall survival in patients with colon cancer. (cdc.gov)
  • It is unclear how this AGTR1 gene variation contributes to the risk of these conditions. (medlineplus.gov)
  • In conclusion, Klotho C1818T variant may be associated with a decreased risk of hypertension . (bvsalud.org)
  • Its strong interaction with other vasoactive hormone systems suggests that the ET-1 gene (EDN1) is a potential candidate molecule that influences the risk of developing hypertension. (geneticsmr.com)
  • Added weight puts you at risk of heart attack , cancer , hypertension, and sleep apnea . (webmd.com)
  • Hypertension is the most important, tion has been paid to environmental exposures as risk easily recognized risk factor for stroke, myocardial infarc- factors for hypertension. (cdc.gov)
  • Logistic regression with a 95% confidence interval (CI) was employed to assess the risk correlations ofAGT gene M235Tpolymorphisms with hypertension. (bvsalud.org)
  • High blood pressure, or hypertension, is a condition in which the blood vessels have persistently raised pressure, increasing the pumping function of the heart and leading to hardening of the vessels. (who.int)
  • Compared with regular hypertension, this condition is often accompanied by complications of the heart and blood vessels and requires medical attention. (go.jp)
  • Background: Hypertension is a major public health problem in both developing and developed nations because it is highly prevalent and is associated with complications. (bvsalud.org)