Genes hla c antigens. Medical search. Frequent questions

for example the MHC Class II antibody based on clone IVA12 recognizes the shared epitopes of human leucocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. (antibodies-online.com)
Variants of this protein can lead to more or less efficient processing of microbial proteins before they are loaded onto HLA molecules for presentation to the immune system. (nih.gov)
The evolution pathways that led to the hyper-mutation clusters in single human leukocyte antigen (HLA) molecules were identified. (elifesciences.org)
Among them the differential expression of HLA-DRB molecules in different types of antigen-presenting cells, which was investigated here in detail. (hu-berlin.de)
When HLA molecules bind to antigens that are not recognized, immune responses are triggered. (medicalxpress.com)
Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)
Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)

Association of various HLA haplotypes with SARS-CoV-2 infection and the course of COVID-19 could improve assessment of viral severity in the population. (antibodies-online.com)
IgA-deficient individuals have been reported to have one of a few specific HLA haplotypes. (nih.gov)
HLA haplotypes identified among the control group, Ebola survivors, and persons who died of Ebola virus disease in Guinea, 2015-2017. (cdc.gov)
In a previous study, several HLA-B and HLA-C alleles and haplotypes were positively or negatively associated with the occurrence and prognosis of glioblastoma multiforme (GBM). (cdc.gov)
Several mechanisms have been described how these HLA haplotypes impact on the disease. (hu-berlin.de)
The promoters of the disease associated HLA-DR4 to the neutral DR7 and DR9 haplotypes were analyzed for sequence polymorphisms resulting in functional differences. (hu-berlin.de)
All three haplotypes carry as a second functional DRB gene the DRB4 gene, which is regulated by the DRB4A or -B promoter. (hu-berlin.de)

Human leukocyte antigen: the major histocompatibility complex of humans. (medlineplus.gov)
In humans, MHC proteins are encoded by the Human Leukocyte Antigen (HLA), a group of more than 200 genes located closely together on the short arm of chromosome 6. (antibodies-online.com)
If humans and Neanderthals (and Denisovans) paired up, researchers should detect Neanderthal genes within the human genome. (reasons.org)
Disease associated human leukocyte antigen (HLA) genes have been identified in humans where they are assumed to promote the susceptibility and/or progression of rheumatoid arthritis. (hu-berlin.de)
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)

He has published over 600 papers on gene therapy, cell cycle, genetics of cancer, and epidemiology. (newswise.com)
Research suggests that people with certain genetics, namely the human leukocyte antigen (HLA) genes, have a significantly increased risk of developing RA. (everydayhealth.com)
A person can be of African or European ancestry in terms of immune function genes, but the identifiers 'black," 'brown' and 'white' don't really line up with those categories," said Diogo Meyer, a professor at USP who specializes in population genetics and was the principal investigator for the study. (medicalxpress.com)

The protein is called human leukocyte antigen B27 (HLA-B27). (medlineplus.gov)
Human leukocyte antigen B27 ( HLA-B27 ) is the major genetic susceptibility marker in AS. (molvis.org)
Human leukocyte antigen B27 (HLAB 27) positive patients in particular -mostly those in the subgroup with ankylosing spondylitis- are affected. (molvis.org)

HLA-B27 is a blood test to look for a protein that is found on the surface of white blood cells. (medlineplus.gov)
The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. (nih.gov)
HLA produces a protein which holds any foreign material (such as small foreign particles, viruses or bacteria) on the surface of the cell. (easydna.co.uk)
Ingesting even small amounts of gluten causes a select group of genes, the HLA class II antigens, to exhibit an immune response to the protein factions found in gluten-rich foods. (bellaonline.com)
The secret lies with the human leukocyte antigen (HLA), or protein markers that signal the immune system. (technologynetworks.com)
The protein diversity of mammalian cells is determined by arrays of isoforms from genes. (elifesciences.org)
While protein expression is dictated by the level of gene expression, the structure and function of the protein is largely determined by the isoforms of the mRNA of a given gene and are impacted by mutations or other structural alterations to the amino acids ( Faustino and Cooper, 2003 ). (elifesciences.org)
It has been hypothesised that low molecular weight chemicals could act as haptens and combine with a body protein to form a complete antigen. (bmj.com)
[ 10 ] The protein products of the HLA genes are critical components of cell-to-cell communication in the immune system. (medscape.com)

Population frequency of HLA types (or supertypes) and their capacity to elicit cytotoxic T lymphocyte responses are also negatively correlated. (unige.ch)
Background: Human leukocyte antigen (HLA) class I genes mediate cytotoxic T-lymphocyte responses and natural killer cell function. (cdc.gov)

Human leukocyte antigens (HLAs) are proteins that help the body's immune system tell the difference between its own cells and foreign, harmful substances. (medlineplus.gov)
Class I HLAs present peptides from inside the cell whereas class II HLAs present antigens from outside of the cell to T-lymphocytes. (antibodies-online.com)
HLAs are genes that play a significant role in disease and immune defence. (health-e.org.za)

A recent study shows that individuals with the allele HLA-B*46:01 have the fewest predicted binding peptides for SARS-CoV-2, suggesting they may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS. (antibodies-online.com)
A different allele, HLA-B*15:03, showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting it could enable cross-protective T-cell based immunity. (antibodies-online.com)
Sequencingbased HLA-A genotyping established that A*3201 was the single A*32 allele underlying the observed association. (cdc.gov)
In conclusion, this study indicates that the +14 bp HLA-G allele defines a nearly unique exon 8 haplotype, and fetuses homozygous for this haplotype [SNP 2995(C)/SNP 3127(G)/SNP 3172(A)/SNP 3181(G)/+14 bp] are associated with severe pre-eclampsia in primiparas. (ruc.dk)
Alleles defined by DNA sequencing are named to identify the gene, followed by an asterisk, numbers representing the allele group (often corresponding to the serologic antigen encoded by that allele), a colon, and numbers representing the specific allele (eg, A*02:01, DRB1*01:03, DQA1*01:02). (msdmanuals.com)

2 These observations point towards a potential influence of different HLA composition - the haplotype - in the present SARS-CoV-2 pandemic. (antibodies-online.com)
Percentage of each haplotype was calculated and defined as the number of persons with the HLA haplotype (n) divided by the number of individuals (N) in the studied group. (cdc.gov)
Conditional logistic regression models did not reproduce the association of HLA-B*07 or the B*07-Cw*07 haplotype with GBM. (cdc.gov)

MHC stands for major histocompatibility complex, a group of genes that help the immune system recognize foreign substances. (medicalxpress.com)

However, HLA-B27 is found in some normal people and does not always mean you have a disease. (medlineplus.gov)
Classical class I and class II Human Leukocyte Antigen (HLA) are leading candidates for infectious disease susceptibility. (antibodies-online.com)
Class I and II human leukocyte antigens were determined by a standard microlymphocytotoxity test in a group of 45 pediatric patients with selective immunoglobulin A deficiency (IgA-D), 33 of them with frequent respiratory tract infections, allergic diseases, or gastrointestinal disorders (RTIAG), and 12 with celiac disease (CD). (nih.gov)
Patients with HLA types associated with rapid disease progression recognize a significantly smaller fraction of their known repertoire of viral epitopes than do patients with HLA types associated with slow progression. (unige.ch)
Our Celiac disease genetic test will confirm whether you carry the genes involved in celiac disease and will effectively rule out the disease with an accuracy of 99% . (easydna.co.uk)
You have a 5-10% chance of inheriting the gene if you have a family member who has celiac disease. (easydna.co.uk)
Only a genetic test such as ours can confirm whether you have the genes implicated in celiac disease. (easydna.co.uk)
Even if results of a genetic test confirm you carry the genes which cause celiac disease, it does not mean you suffer from the illness or that you will ever develop it. (easydna.co.uk)
However, if you do not carry the genes, you can have your mind at rest that you will not develop celiac disease. (easydna.co.uk)
The HLA DQ2 and DQ8 are the 2 genes which we most often observe in people with celiac disease. (easydna.co.uk)
These 2 genes are the most common although not the only potential gene involved in celiac disease. (easydna.co.uk)
However, the National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) notes that celiac disease can only occur in people whose DNA harbor specific genes. (medicalnewstoday.com)
There is an increased risk of celiac disease if someone has certain forms of the human leukocyte antigen (HLA)-DQA1 and HLA-DQB1 genes. (medicalnewstoday.com)
The NIDDK advises that celiac disease may occur in some people with one of two gene variants: DQ2 and DQ8. (medicalnewstoday.com)
People who do not have these gene variants are very unlikely to develop celiac disease. (medicalnewstoday.com)
While genes are the main cause of someone developing celiac disease, the NIDDK notes that scientists are studying other factors which may raise a person's chance of developing the disease. (medicalnewstoday.com)
However, this gene is neither necessary nor sufficient to cause the disease. (deepdyve.com)
Identification of disease associations with antigens/antibodies that have positive predictive (diagnostic) value. (nih.gov)
For nearly 2,000 years, traders used this 4,000-mile network linking the Far East with Europe to exchange goods, culture and, in the case of the Silk Road disease, genes. (nih.gov)
Genetic factors are thought to play a role in susceptibility to Behcet's disease, with the human leukocyte antigen (HLA) B-51 gene region of the genome, accounting for about 20 percent of genetic risk for the disease. (nih.gov)
An important association between Behcet's disease and a gene called ERAP1. (nih.gov)
The variants of ERAP1 identified in this study increase the risk of Behcet's disease, but only in those individuals with one specific HLA type, HLA-B51, which has previously been associated with Behcet's disease. (nih.gov)
This data is thus indicative of an impact of elevated HLA-DR expression on the progression of the disease. (hu-berlin.de)
Indeed, in some cases, HLA genes are more highly related to lupus-associated autoantibodies than to the disease itself. (medscape.com)
While certain genetic variants of the human leucocyte antigen (HLA) genes influence susceptibility to SO, 4 5 single nucleotide polymorphisms (SNPs) in cytokine genes influence severity of disease. (bmj.com)
In light of this, a multiplicative gene-gene interaction model was developed to allow for estimating the combinatorial contribution of multiple genetic variants to disease risk. (cdc.gov)

While a rare individual can be IgA1 deficient on the basis of heavy-chain deletions of alpha 1 genes in concert with other heavy-chain genes on chromosome 14, such individuals are quite rare, and from a clinical point of view, those reported have usually been healthy. (nih.gov)
Two years ago, the research team identified gene associations at two other specific chromosome locations, or loci. (nih.gov)
The major histocompatibility complex (MHC) on chromosome 6, which contains the human lymphocyte antigens (HLA), was the first described genetic link to SLE. (medscape.com)
Both polypeptide chains are encoded by genes in the HLA-DP, -DQ, or -DR region of chromosome 6. (msdmanuals.com)

A genome-wide study in a northern European population replicated the association of SLE with susceptibility genes related to B-cell receptor pathway signaling, as well as confirmed the association of SLE with genes at the interferon regulatory factor 5 (IRF5)-TNPO3 locus. (medscape.com)
This model was developed using data collected from molecular epidemiology studies of allergic asthma that examined variants in 16 susceptibility genes. (cdc.gov)

In the Atalante-1 trial, participants had locally advanced (unresectable and not eligible for radiotherapy) or metastatic (without alteration of the EGFR and ALK genes) non-small cell lung cancer that was resistant to previous immunotherapy. (medscape.com)

These genes are called HLA (human leukocyte antigen) class II genotypes. (cdc.gov)
To our knowledge, angiotensin converting enzyme ( ACE ) gene I/D polymorphisms have not yet been investigated in AS patients in Turkish population.This study was conducted in Turkish patients with AS to determine the frequency of I/D polymorphism genotypes of angiotensin converting enzyme gene. (molvis.org)

NIH researchers identify new gene variants associated with risk for complex inflammatory syndrome. (nih.gov)
She noted that not all of the 800,000 gene variants analyzed were directly genotyped. (nih.gov)
The most studied variants are linked to the HFE gene. (scielo.br)

Many observations point to a major role for classical HLA loci in determining susceptibility to viral infections 1 . (antibodies-online.com)
The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)
Individual serologically defined antigens encoded by the class I and II gene loci in the HLA system are given standard designations (eg, HLA-A1, -B5, -C1, -DR1). (msdmanuals.com)
The DNA methylation content of 33 CpG loci was linked with the presence of MIS-C. Of these sites, 18 (54.5%) were located in described genes. (cdc.gov)

People born with specific genes are more likely to develop certain types of arthritis, such as rheumatoid arthritis (RA) , systemic lupus erythematosus (SLE) , and ankylosing spondylitis. (cdc.gov)
As a result of our study, angiotensin converting enzyme gene I/D polymorphism DD genotype could be a genetic marker in ankylosing spondylitis in a Turkish study population. (molvis.org)

The HLA gene complex controls immune responses by producing proteins that help the immune system recognize proteins from foreign invaders. (everydayhealth.com)

The Major Histocompatibility Complex (MHC) comprises a number of genes that occur in many species. (antibodies-online.com)
While many individuals with these supratypes are not IgA deficient, these findings encourage the notion that the secretion of IgA could be at least partly controlled by genes residing in the major histocompatibility locus. (nih.gov)

Additional evaluation of HLA-A promoter and exon 1 sequences did not detect any unexpected single nucleotide polymorphisms that could suggest differential allelic expression. (cdc.gov)
Other polymorphisms, besides the 14 bp polymorphism (rs66554220), in the 3′-untranslated region (3′-UTR) (exon 8) of the HLA-G gene might be associated with severe pre-eclampsia, especially in primiparas. (ruc.dk)

Browse our portfolio of HLA antibodies down below! (antibodies-online.com)

The combination of gene expressions, fusion gene transcripts, and mutation gene expressions significantly improved the classification of liver cancer cells versus benign hepatocytes. (elifesciences.org)

Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)

The increased intestinal permeability was accompanied by augmented expression of genes marking immune cell infiltration and encoding key proteins for immune cell adhesion, antigen presentation, and cytokine signaling in the orbital tissue. (frontiersin.org)

There are significant associations between possession of certain HLA class I alleles and rate of progression to AIDS. (unige.ch)
With few exceptions, mothers of subjects with persistent maternal microchimerism were HLA incompatible with subjects for class I and class II alleles. (jci.org)

This is because human leukocyte antigen (HLA) markers used in matching donors are inherited. (health-e.org.za)
The National Marrow Donor Program/Be The Match, the largest registry of HLA-typed volunteer donors in the U.S., matches donors with people who need bone marrow transplants. (technologynetworks.com)
One thing we haven't addressed so far is whether what makes it hard for Brazilians with African ancestry to find donors is having African chromosomes or having an admixture of African and European genes," he said. (medicalxpress.com)

Tedopi is composed of synthetic tumoral neo-epitopes (peptide fragments) that target five tumoral antigens, permitting the activation of tumor-specific T-lymphocytes for patients who are HLA-A2 positive. (medscape.com)

To understand the role of each cell in an organism, broad spectrum mRNA isoform and mutational gene expression analyses at the single-cell level is necessary. (elifesciences.org)
T-cells, an important part of the immune system, can distinguish between antigens produced by the organism and invaders. (medicalxpress.com)

Here we report, using the pathogenic model of antiretroviral therapy-treated, SIV-infected rhesus macaques that sequential interleukin-21 and interferon alpha therapy generate terminally differentiated blood natural killer cells (NKG2a/c low CD16 + ) with potent human leukocyte antigen-E-restricted activity in response to SIV envelope peptides. (nature.com)

It also helped to open a very exciting avenue of research involving investigators with expertise in different aspects of growth control and cancer.Giordano's lab also discovered the tumor suppressor gene RB2/p130 and the cell cycle kinases CDK9 and CDK10, two other key players in cell cycle regulation and cell differentiation. (newswise.com)

R software was used in this study to identify DEGs in HT and PTC using data in Gene Expression Omnibus (GEO). (medsci.org)
Abnormal human leukocyte antigen G (HLA-G) expression may be involved in pre-eclampsia. (ruc.dk)
Multiparameter flow cytometric analysis of HLA-DR expression on Human peripheral blood leucocyte populations. (bdbiosciences.com)
The bivariate pseudocolor density plot showing the correlated expression of HLA-DR (or Ig Isotype control staining) versus side-light scatter (SSC-A) signals was derived from gated events with the side and forward light-scatter characteristics of intact leucocyte populations. (bdbiosciences.com)
The results showed evolutionary patterns of single molecule mutational gene expression from benign hepatocytes to liver cancer cells. (elifesciences.org)
Im Rahmen dieser Arbeit wurde die differentielle Expression von HLA-DRB-Genen in unterschiedlichen Antigen-präsentierenden Zellen als möglicher Mechanismus untersucht. (hu-berlin.de)
Dagegen wurde die INF-gamma-Stimulation der HLA-DR-Expression von THP-1- aber auch von BJAB-Zellen durch die für die HLA-DR-Promotoren spezifische X-Box vermittelt. (hu-berlin.de)
Bei der Analyse von DR4-, DR7- und DR9-positiven Patienten einer bereits gut charakterisierten RA-Kohorte stellte sich heraus, daß der DRB4B-Promotor, welcher im Vergleich zu DRB4A eine höhere transkriptionelle Aktivität besitzt, mit einem schweren Krankheitsverlauf assoziiert ist, so daß eine erhöhte HLA-DR-Expression den Krankheitsverlauf negativ zu beeinflussen scheint. (hu-berlin.de)
By contrast, the INF-gamma stimulation of HLA expression in THP-1 and BJAB was mediated via the unique X box. (hu-berlin.de)
These products have several anti-inflammatory properties of any/multiple islet autoantibodies (242 and 151 events, respec- such as regulation of immune-related gene expression and cy- tively) and T1D (71 events) by soluble fiber intake were calculated tokine release (8). (lu.se)

In 95% of cases, tumors express at least one of these five antigens. (medscape.com)

B cells, another group of immune cells that were initially seen as idle bystanders, are now thought to raise the alarm by presenting antigens to T cells, urging them to take action. (nih.gov)
A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. (portlandpress.com)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
The process called parthenogenesis uses unfertilized human eggs and results in the cells inheriting a duplicate set of human leukocyte antigen (HLA) genes. (blogspot.com)
Unlike induced pluripotent stem cells (iPS), hpSC do not require the transfection of genes into somatic cells with the associated possibility of introducing unwanted additional genes. (blogspot.com)
A mutation in one of the genes coding for HLA appears to help virus-killing T cells identify SARS-CoV-2 and launch a lighting attack. (technologynetworks.com)
These results clearly indicate that HLA-disparate maternal cells can persist in immunocompetent offspring well into adult life. (jci.org)
The department focuses on research that aims to develop gene therapy for hematopoietic cells using viral vectors. (lu.se)

In the Brazilian cases, the patients' families do not exhibit a high incidence of cancer, and a single, unique mutation at codon 337 in exon 10 of the TP53 gene is consistently observed. (oncolink.org)
A 14 bp insertion/deletion polymorphism exists in exon 8 of the HLA-G gene. (ruc.dk)

This particular test establishes whether you carry a certain gene mutation which makes you unable to produce the enzyme required to digest lactose. (easydna.co.uk)
The mutation - HLA-B*15:01 - is quite common, carried by about 10% of the study's population. (technologynetworks.com)

In the case of individuals carrying defective HLA genes, the body is unable to correctly distinguish gluten from HLA which results in an auto-immune reaction. (easydna.co.uk)

Liu C, Pan Y, Li Q, Zhang Y. Bioinformatics analysis identified shared differentially expressed genes as potential biomarkers for Hashimoto's thyroiditis-related papillary thyroid cancer. (medsci.org)

Now the largest-ever genetic analysis of people being treated with checkpoint inhibitors has found that certain genes people are born with (called germline genes) may play a critical role. (mskcc.org)

Fetal +14/+14 bp HLA-G genotype may predispose to pre-eclampsia in the mother. (ruc.dk)
In an actual transplant case, HLA typing has to be done to a high degree of precision, and the donor must be in good health and have a carefully analyzed genotype to make sure they're genuinely compatible. (medicalxpress.com)
Based on the product of single gene variant odds ratios, the risk of developing asthma was assigned to genotype profiles, and the frequency of each profile was estimated for the general population. (cdc.gov)

Although some single genes have been implicated to play a causative role in SLE, current knowledge points toward a large number of genes being involved in a multifactorial-type inheritance pattern in most patients. (medscape.com)

HLA ( human leukocyte antigen ) immune function genes bind to antigens, including potentially toxic residues of cellular metabolism or fragments of an invading pathogen. (medicalxpress.com)

It is characterized by loss of tolerance to self-antigens, formation of immune complexes, and an activated type I interferon system. (medscape.com)

Nonetheless, HLA-A*32, which has previously been shown to predispose GBM patients to a favorable prognosis, was negatively associated with occurrence of GBM (odds ratio = 0.41, p = 0.04 by univariate analysis). (cdc.gov)

Each of the four newly identified gene regions is already known to play a role in immune regulation. (nih.gov)

Researchers from the NIDDK are studying which other genes may trigger the condition in people with DQ2 or DQ8. (medicalnewstoday.com)
Researchers don't know exactly what causes the immune system to invade the synovium, but it's believed that genes and environmental factors play a role in the development of RA. (everydayhealth.com)
Researchers have been aware of the HLA B-51 association for about 40 years. (nih.gov)
They're more than twice as likely as those who become symptomatic to carry a specific gene variation that helps them obliterate the virus, according to a new study led by UC San Francisco researchers. (technologynetworks.com)
UCSF researchers found that 20% of people in the study who remained asymptomatic after infection carried at least one copy of the HLA-B*15:01 variant, compared to 9% of those who reported symptoms. (technologynetworks.com)
Researchers suspected early on that HLA was involved, and fortunately a national registry existed that contained the data they were looking for. (technologynetworks.com)

We developed sensitive human leukocyte antigen-specific (HLA-specific) PCR assays and targeted nonshared maternal HLA genes to test for persistent maternal microchimerism in subjects with scleroderma and in healthy normal subjects. (jci.org)
HLA-specific PCR also frequently revealed persistent maternal microchimerism in healthy control subjects. (jci.org)

Nonetheless, carriage of specific alleles of HLA imparts about a 2-fold risk of SLE above that of the general population. (medscape.com)

The vaccine is effective for patients who express the HLA-A2 gene, which is present in around half of the population. (medscape.com)
Methodology/Principal Findings: As an extension of the Upper Midwest Health Study, we have performed HLA genotyping for 149 GBM patients and 149 healthy control subjects from a non-metropolitan population consisting almost exclusively of European Americans. (cdc.gov)
This is a rule of thumb, however, and there are exceptions, especially in a highly admixed population like Brazil's, where it's not unusual for a person who self-identifies as 'preto' to have European HLA genes. (medicalxpress.com)

HLA testing is also used to match donated tissue with a person's tissue who is getting an organ transplant. (medlineplus.gov)
That includes immune function genes, which are the ones that matter in the case of a transplant," Meyer said. (medicalxpress.com)

HLA and infectious diseases. (antibodies-online.com)
Bioinformatics approaches can identify differentially expressed genes (DEGs) and analyze DEG functions in diseases. (medsci.org)

Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs. (cdc.gov)
Further analyses restricted to female GBM cases and controls revealed a second association with a specific HLA-B sequence motif corresponding to Bw4-80Ile (odds ratio = 2.71, p = 0.02). (cdc.gov)

KIR3DL2 has shown peptide-specific binding to some HLA-A antigens, including A3 and A11 (4, 7, 8). (rndsystems.com)

These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV. (unige.ch)

Experts do not know why people with these genes are at higher risk for developing arthritis or why it can make their arthritis worse. (cdc.gov)
Human leukocyte antigen (HLA) B27 is a strong genetic risk factor for AS. (deepdyve.com)
[ 16 ] More commonly, a low gene copy number of C4 is seen as a risk factor for SLE, whereas a high copy number of C4 is protective against SLE. (medscape.com)

The HLA-A2 biomarker, detected via a blood test, can identify appropriate patients. (medscape.com)

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