Genes databases genetic. Medical search. Frequent questions

We show that although point mutations and structural variants that drive cancer are less frequent in non-coding genes and regulatory sequences than in protein-coding genes, additional examples of these drivers will be found as more cancer genomes become available. (lu.se)
Mapping of the oil palm tree genome has revealed a single gene responsible regulating its yield, offering the possibility to breed new variants for increased production, say scientists behind the project. (foodnavigator.com)
TRPV1 is the target of several novel analgesics drugs under development and therefore, TRPV1 genetic variants might represent promising candidates for pharmacogenetic modulators of drug effects. (researchgate.net)
Here, we investigated the hypothesis that the common substrate serves as an intermediate phenotype to detect genetic risk variants relevant for psychiatric disease. (nature.com)
In conclusion, our study identified that common genetic variation indeed influences the common substrate, but that these variants do not directly translate to increased disease risk. (nature.com)
For a specific condition to be included in MedlinePlus Genetics, it must have a known or suspected genetic component, meaning that gene variants cause the condition or increase the risk of development of the condition. (medlineplus.gov)
Now that it seems clear that common genetic variants have only small effects on disease risk, the field has shifted toward studies of rare variants with large effects. (cdc.gov)
Database of human genetic variants associated with longevity. (senescence.info)
while some genes were already potentially associated with sudden death in children, several variants in genes previously not associated with SUDP were identified. (cureepilepsy.org)
Earlier work from these researchers had highlighted a link between SIDS and variants in a gene called SCN1A , which is associated with epilepsy and SUDEP. (cureepilepsy.org)
The team performed a genetic technique called exome sequencing , where the parts of genes that eventually become functional proteins were analyzed for variants that may have caused or contributed to sudden death. (cureepilepsy.org)
Working with only with DNA sequences they had uploaded and using GEDMatch's 'research mode' so as not to interact with other users' data, they showed that IBS baiting could be used to identify specific genetic variants (single nucleotide polymorphisms, or SNPs) in the database. (eurekalert.org)
Many inherited disorders and phenotypes are genetically heterogeneous - that is, pathogenic variants in more than one gene can cause one phenotype (e.g., dilated cardiomyopathy, ataxia, hereditary hearing loss and deafness) or one genetic disorder (e.g. (nih.gov)

Our analyses confirm previously reported drivers6,7, raise doubts about others and identify novel candidates, including point mutations in the 5' region of TP53, in the 3' untranslated regions of NFKBIZ and TOB1, focal deletions in BRD4 and rearrangements in the loci of AKR1C genes. (lu.se)
People with homozygous mutations of the PRDM12 gene experience congenital insensitivity to pain (CIP). (wikipedia.org)
In humans, mutations in the PRDM12 gene can cause loss of pain perception brought on by defects in the development of sensory neurons. (wikipedia.org)
There are a number of diseases and conditions that can result from mutations in the PRDM12 gene. (wikipedia.org)
Chromatin play a huge role in neuron development, so researcher hypothesized that mutations in the PRDM12 gene prevent nociceptors and nerve fibers from developing normally. (wikipedia.org)
Another condition caused by mutations in the PRDM12 gene is hereditary sensory and autonomic neuropathy type VIII. (wikipedia.org)
Scouring genetic databases for people with the same mutations revealed how unusual the case is. (newscientist.com)
Only eight in 10,000 people in the databases had one of the parents' mutations, and no one had the other. (newscientist.com)
The finding has, however, prompted the team to look for other mutations in interferon-related genes, in children who have had severe flu. (newscientist.com)
data are preliminary and based on broth microdilution susceptibility testing and/or presence of resistance genes and mutations found in whole genome sequences of bacterial DNA. (cdc.gov)
The aim of this study is to investigate both novel and proven mutations of 11 MODY genes in Turkish children by using targeted next generation sequencing. (degruyter.com)
Eighteen patients have GCK mutations, four have HNF1A , one has HNF4A , one has HNF1B , two have NEUROD1 , one has PDX1 gene variations and one patient has both HNF1A and HNF4A heterozygote mutations. (degruyter.com)
Very high frequency of novel mutations (42%) in our study population, supports that in heterogenous disorders like MODY sequence analysis provides rapid, cost effective and accurate genetic diagnosis. (degruyter.com)
Drug resistance largely results from changes (mutations) in the genetic material that code for these enzymes, rendering ART less effective. (canada.ca)
The HIV virus is constantly changing, and mutations in the virus's genetic material occur on a daily basis. (canada.ca)
Genotypic tests identify mutations in the viral genetic material through sequencing the viral genes of interest. (canada.ca)
By comparing the generated sequences with databases containing resistance-conferring mutations, the presence or absence of drug resistance can be determined. (canada.ca)
Reporting in American Journal of Human Genetics today (August 11), the researchers independently pinpointed the cause of the kids' deaths to inherited mutations in a single gene, PPA2, which codes for a mitochondrial enzyme. (the-scientist.com)
The two families who had approached Amiel and another family who had lost a baby at four months of age each had different mutations present in the gene, her team found. (the-scientist.com)
For example, gene mutations giving resistance to quinolones have arisen and spread at least 94 times since 1990, with nearly all of these (97%) originating in South Asia. (medicalxpress.com)
[ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)

GEO provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-throughput gene expression and genomic hybridization experiments. (nih.gov)
The three central data entities of GEO are platforms, samples and series, and were designed with gene expression and genomic hybridization experiments in mind. (nih.gov)
Cost-effectiveness of MODY genetic testing: translating genomic advances into practical health applications. (degruyter.com)
Coop and Edge calculate that with as few as 100 uploaded DNA sequences, an attacker could use this method to obtain most of the genomic information in a database. (eurekalert.org)
The database represents a unique international resource that enables clinicians to quickly find relevant information on cytogenetic aberrations and gene fusions in cancer and relate the findings to clinical data, in particular the diagnostic and prognostic significance of specific cytogenetic/genomic changes. (lu.se)
The continuously updated material also makes it possible to address scientific questions related to the mechanisms through which chromosomal/genomic changes participate in the carcinogenic process by elucidating why, how and when chromosome abnormalities are formed, the chromosomal anatomy of cytogenetic changes and genes involved in fusions, the role chromosome aberrations play in the formation of fusion genes, and the mechanisms by which gene fusions exert their effects. (lu.se)
Mitelman F, Johansson B, Mertens F, Schyman T, Mandahl N. Cancer chromosome breakpoints cluster in gene-rich genomic regions. (lu.se)

Predictions achieve correlations of 0.68 with true values, and maintain accurate differentially expressed genes (AUC 0.81). (nih.gov)
The differentially expressed genes (DEGs) in AD were screened in GSE48350 dataset. (nature.com)

Their approach included using stem-cell-generated human neurons and identifying chemical changes that occur in the cell when individual genes are turned on and off. (sciencedaily.com)
To survey individual genes and learn more about their functions, Kampmann employed a technique called CRISPR activation/interference, or CRISPR a/i, which he co-developed as a UCSF post-doctoral scholar working on cancer cells with Jonathan Weissman, PhD, a former UCSF faculty member and current Whitehead Institute member and investigator with the Howard Hughes Medical Institute. (sciencedaily.com)
Genetic alterations of EPHA/EFNA in breast cancer varied from 1.1% to 10% for individual genes, as determined by the cBioPortal database. (hindawi.com)

There are three different genes that can be mutated to cause CIP. (wikipedia.org)
Sheep have more than 20,000 different genes but not all of these are expressed in each tissue type in the body. (ed.ac.uk)
Researchers reported prevalence odds ratios (PORs) for 943 comparisons in 82 different genes/serotypes. (cdc.gov)

Quinoa has the potential to provide a highly nutritious food source to the world's growing population and a new genetic map can help researchers to breed in useful traits. (foodnavigator.com)
Transcription Factors, Gene Regulatory Networks, and Agronomic Traits. (routledge.com)
Their results represent a major step towards understanding how the sheep's genetic information influences its physical traits. (ed.ac.uk)
The new resource represents a major step towards understanding how the sheep's genetic information influences its physical traits, and provides a foundation to use this information to generate sustainable improvements in the productivity of livestock animals. (ed.ac.uk)
Furthermore, accessing detailed, breed-specific information on genetic traits, including original research and mutation information, is time-consuming and difficult. (avma.org)
What's more, environment has as big an impact on most traits as genes do. (stanford.edu)
The database summarizes heritable traits and provides information on both the trait and experimentally determined genetic causes. (go.jp)
It may be possible for an attacker to pull out the genetic information of most people in a database or to identify people with specific genetic traits such as Alzheimer's Disease. (eurekalert.org)

MedlinePlus Genetics uses standardized gene terminology from the National Center for Biotechnology Information (NCBI) Gene database. (medlineplus.gov)

A cohort of 80 healthy subjects of Western European descent was screened to evaluate and validate the detection of exomic sequences of the coding genes with 25 base pair exon padding. (researchgate.net)
But according to Professor Graham Coop and postdoctoral researcher Michael 'Doc' Edge at the UC Davis Department of Evolution and Ecology, someone with a bit of expertise in genetics and computing could design and upload DNA sequences that extract far more from these databases than some lost cousins. (eurekalert.org)
The public databases, however, allow anyone to upload DNA sequences and search for other users with matching sequences. (eurekalert.org)
These sites work by using software to compare DNA sequences uploaded by users with sequences already in their database. (eurekalert.org)
Additionally, large data gaps were identified in the Middle East region, as indicated by the lack of current influenza sequences in the database from many countries in the region. (who.int)

A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. (nih.gov)
The mutation of this gene results in a non-functioning protein, which in-turn causes a failure to develop the pain-sensing nerve endings and an organism without sensitivity to pain. (wikipedia.org)
First, a mutation in the SCN9A makes it impossible for nociceptors to respond to harmful stimuli because it causes the gene to lose its function. (wikipedia.org)
Second, a mutation in the NTRK1 causes a loss of function for the gene and leads to a failure in nociceptor development. (wikipedia.org)
Each of her parents had a different mutation in one of their copies of the gene that codes for a protein called IRF7. (newscientist.com)
Those hardest hit by the 2009 "swine flu" pandemic were 20 times more likely to have a mutation disabling a gene called IFITM3 than those who got less sick. (newscientist.com)
Programs like DeepVariant could use their complex data analysis abilities to predict the effects of a mutation, predicting which genes might activate. (stanford.edu)

It is hoped that further study may reveal target genes of PRDM proteins so a greater understanding of the functions of the PRDM family can be achieved. (wikipedia.org)
The team focused on genetic material called RNA, which is produced as an intermediate step when DNA code is translated into the proteins and molecules that make up cells and tissues. (ed.ac.uk)
The "unknome" database ranks human proteins by how little we know about them. (sciencenews.org)
Many proteins, and the genes that make them, aren't well understood, and there's still much to learn from the human genetic instruction book. (sciencenews.org)
These genes code for proteins that are involved in cell-cell adhesions (CTNNA3), glutathione conjugation for xenobiotic metabolism (GST gene family), and immune system response (HLA gene family). (cdc.gov)

The samples were genotyped for 7 SNPs from genes thought to be involved in chronic obstructive pulmonary disease (COPD) or asthma, based on prior studies. (cdc.gov)

Enrichment analysis was performed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. (nature.com)
A putative function has been assigned, using the gene ontology approach, to the set of genes harboring at least one SSR. (researchgate.net)

The diagnostic utility of exome sequencing has consistently been 20%-30% (i.e., a diagnosis is identified in 20%-30% of individuals who were previously undiagnosed but had features suggestive of a genetic condition) [ Gahl et al 2012 , Lazaridis et al 2016 ]. (nih.gov)
Genes Chromosomes Cancer 55:291-310, 2016. (lu.se)

12, 13] Systemic conditions and associated genes affect the entire body, and syndromic conditions include genes for metabolism and those responsible for the functioning of multiple body systems. (cureepilepsy.org)
These are designed by a laboratory to include genes commonly associated with a broad phenotype (e.g., cardiomyopathy, ataxia, intellectual disability) or a recognizable syndrome with genetic heterogeneity (e.g. (nih.gov)
These include genes selected by a clinician for analysis by clinical sequencing. (nih.gov)

PRDM12 therefore represents an attractive candidate tumour suppressor gene within the der(9) [derivative chromosome 9] CDR [commonly deleted region]. (wikipedia.org)
This identified approximately 140 chromosome loci where nucleotides deviated from the reference sequence GRCh37 hg19 comprising the three genes TRPV1, LTB4R and LTB4R2. (researchgate.net)
This SNP mapped to a locus on chromosome 5q35.2 harboring genes involved in neuronal development and regeneration. (nature.com)
The Database of Chromosome Aberrations and Gene Fusions in Cancer, established in 1980, is an attempt to register systematically all published cytogenetic aberrations reported in cancer, including patient and tumor characteristics, gene fusions identified by cytogenetics or massively parallel sequencing, and studies pertaining to the clinical relevance of cytogenetic aberrations and/or gene rearrangements. (lu.se)

The differentially expressed oxidative stress genes (DEOSGs) were analyzed by intersection of DEGs and oxidative stress-related genes. (nature.com)
Our study identified 9 key genes associated with oxidative stress and immune reaction in AD pathogenesis. (nature.com)
Oxidative stress is involved in the modulation of gene expression patterns and metabolic activities, characterized by the disruption of redox homeostasis 7 . (nature.com)
They were looking specifically for downstream changes in gene expression that would produce oxidative stress in the cell, a circumstance in which highly reactive forms of oxygen can create a toxic environment. (sciencedaily.com)
Among the most interesting of his findings was that switching off the gene for a protein called prosaposin, which normally assists with the cell's recycling of waste products, greatly increased the levels of oxidative stress. (sciencedaily.com)
Protein network functions for the DA-associated genes from this review include: antigen processing, lymphocyte activation, cytokine production regulation, and response to oxidative stress. (cdc.gov)

Researchers have now successfully catalogued this effect in the human neuron by separately toggling each of the 20,000 genes in the human genome. (sciencedaily.com)
In a new study appearing May 24 in Nature Neuroscience , UCSF researchers have successfully catalogued this effect in the human neuron by separately toggling each of the 20,000 genes in the human genome. (sciencedaily.com)

Brother and sister with mesomelic dysplasia (homozygous dyschondrosteosis gene) and a woman with Leri-Weill syndrome. (medscape.com)
It is caused by homozygous inheritance of genes for hemoglobin. (msdmanuals.com)

Instead, MedlinePlus Genetics offers links to other trusted resources for genetic testing options and clinical trials. (medlineplus.gov)
Describes clinical and genetic information on individual genetic tests and their use. (avma.org)
A panel of 11 MODY genes were screened in 43 children with MODY diagnosed by clinical criterias. (degruyter.com)
Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. (degruyter.com)
Phenotypic heterogeneity in monogenic diabetes: The clinical and diagnostic utility of a gene panel-based next-generation sequencing approach. (degruyter.com)
In the past ten years, improvements in massively parallel sequencing techniques have led to the development and widespread clinical use of multigene panels, which allow simultaneous testing of two to more than 150 genes. (nih.gov)
For example, classification of many spinocerebellar ataxias Hereditary ataxias has been changed from one based on clinical criteria to one based on genetic criteria. (msdmanuals.com)

OMIM is a database of human disease and genetic information and the online representation of Mendelian Inheritance in Man, a project initiated in the 1960s. (go.jp)
The database is manually curated by experts and can be searched by OMIM ID, gene, disease, or phenotype. (go.jp)
The Online Mendelian Inheritance in Man ( OMIM ) database is a searchable catalog of human genes and genetic disorders. (msdmanuals.com)

Epidemiological studies show that only a subset of workers exposed to diisocyanate s develop diisocyanate -induced occupational asthma ( diisocyanate asthma, DA), indicating that genetic susceptibility may play a role. (cdc.gov)
The purpose of this systematic literature review was to compile and meta-analyze the reported data on genetic susceptibility markers for DA. (cdc.gov)
Downregulation of the Ppo5 gene results in reduced susceptibility to black spot bruise development. (cbd.int)

Gene expression profiling of in vitro drug perturbations is useful for many biomedical discovery applications including drug repurposing and elucidation of drug mechanisms. (nih.gov)
A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
Projects focused on gene expression profiling of ageing and of dietary manipulations of ageing, such as caloric restriction. (senescence.info)

How does MedlinePlus Genetics cover diagnosis and management of genetic conditions? (medlineplus.gov)
Diagnosis of a genetic disorder often indicates that relatives of the affected person should be screened for the genetic defect or for carrier status. (msdmanuals.com)

9, 10] Additionally, since the mechanisms underlying SUDP are complex and not yet fully known, the team took a "multidisciplinary undiagnosed diseases approach" [ 11] that combined genetic analysis, autopsy data, and in-depth study of the child's phenotype (or observable characteristics). (cureepilepsy.org)
Prior to the development of massively parallel sequencing (also known as next-generation sequencing ), the only cost-effective way to test more than one gene was serial single-gene testing (i.e., complete testing of one gene that might account for the phenotype before proceeding to testing of the next gene) ‒ an expensive and time-consuming approach with a potentially low yield. (nih.gov)

Researchers hope to learn more from this type of genetic research to help people with aversions to certain foods eat more vegetables in the future. (foodnavigator.com)
In doing so, they've created a technique that can be employed for many different cell types, as well as a database where other researchers using the new technique can contribute similar knowledge, creating a picture of gene function in disease across the entire spectrum of human cells. (sciencedaily.com)
The researchers found that suppression of the gene led to buildup of a substance called age pigment, which has been seen in aging cells whose lysosomes no longer degrade material as efficiently. (sciencedaily.com)
Researchers have identified two genes that may contribute to Raynaud phenomenon, a condition where blood vessels in the extremities constrict and limit blood flow. (medscape.com)
Researchers looked through electronic medical records from the UK Biobank, a large-scale database that contains genetic and health information on half a million participants. (medscape.com)
The researchers identified two genes that are likely involved with Raynaud. (medscape.com)
The researchers hope this resource will help to further understanding of the sheep's genetic make-up. (ed.ac.uk)
In a genetic map as complex as complex as the DNA configuration shown here, a patented sequence has the potential to block progress for researchers with limited funding. (howstuffworks.com)

Wing colours The same gene that turned peppered moths black to camouflage them in industrial pollution is also behind colour variation in bright tropical butterflies, research shows. (abc.net.au)
Human genome epidemiology has grown, too, but studies of genetic variation and disease in populations-i.e., groups of people not defined by family relationships-still accounts for only a small fraction of the total (Figure 1). (cdc.gov)
The HuGE Navigator will remain online as a freely accessible resource for all who are interested in human genetic variation and population health. (cdc.gov)
Human Variome Project quality assessment criteria for variation databases. (lu.se)
Guidelines for reporting and using prediction tools for genetic variation analysis. (lu.se)

Resistance-conferring genes in the 7,658 sequenced genomes were identified using genetic databases. (medicalxpress.com)
In IBS tiling, an attacker uploads several genomes found in public research databases and keeps track of which ones match with other genomes in the database, and where. (eurekalert.org)

When a single gene in a cell is turned on or off, its resulting presence or absence can affect the function and survival of the cell. (sciencedaily.com)
CRISPR a/i allows a researcher to temporarily turn a single gene off or on and see how that change affects the expression of other genes. (sciencedaily.com)
By simply inactivating a single gene," Kampmann said, "in only days we could generate a hallmark of aging that would normally take decades to develop in the human body. (sciencedaily.com)

An extensive analysis of the hereditary hemochromatosis gene HFE and neighboring histone genes. (tripod.com)

Chromatin can turn genes off and on by attaching itself to chromosomes and acting as an epigenetic switch. (wikipedia.org)
MedlinePlus Genetics provides information for the general public about the main features and inheritance of genetic conditions as well as the normal function of related genes and chromosomes and how genetic variations contribute to conditions. (medlineplus.gov)
Genes Chromosomes Cancer 58:149-154, 2019. (lu.se)

His team was interested in pinpointing genes that might be involved in neurodegenerative diseases such as Alzheimer's and related forms of dementia. (sciencedaily.com)
IBS probing can be used to hunt for people who carry a specific genetic variant - for example, a gene tied to Alzheimer's disease. (eurekalert.org)

In this case, 294 genes plausibly related to SUDP, called SUDP genes were studied, many of which were associated with neurologic disorders, cardiac disorders, or systemic/syndromic conditions. (cureepilepsy.org)
Investigation of (Epi)genetic causes in syndromic short children born small for gestational age. (cdc.gov)

The method adds a large amount of genetic information as a basis for complete analysis of TRPV1 ion channel genetics and its functional consequences. (researchgate.net)
There are lots of human genetics studies linking specific genes to specific diseases," Kampmann said. (sciencedaily.com)
To find out why she was hit so badly, Jean-Laurent Casanova and his team at the Imagine Institute of Genetic Diseases in Paris, turned to genetics. (newscientist.com)
For a particular gene to be associated with a condition in MedlinePlus Genetics, genetic variations must have been identified in two or more affected, unrelated individuals or families or have a significant influence on the risk of the development of the condition. (medlineplus.gov)
How are genetic conditions named in MedlinePlus Genetics? (medlineplus.gov)
Many genetic conditions on MedlinePlus Genetics are known by more than one name, such as different scientific, informal, and historical names. (medlineplus.gov)
How are gene names and symbols chosen in MedlinePlus Genetics? (medlineplus.gov)
MedlinePlus Genetics italicizes symbols for human genes in accordance with the HGNC Guidelines for Gene Nomenclature. (medlineplus.gov)
MedlinePlus Genetics lists many genes under more than one name or symbol, especially when the same gene is known by different scientific, informal, and historical names. (medlineplus.gov)
Aunque las variantes proteicas truncadas pueden estar asociadas a una enfermedad, no siempre ocurre y, de hecho, en ocasiones ejercen un efecto protector , como él mismo descubrió en un artículo publicado en Nature Genetics en 2011, que demostraba cómo una variante que afecta a un sitio de corte y empalma (splicing) en el gen CARD9 proporciona una fuerte protección contra la enfermedad de Crohn y la colitis ulcerosa. (stanford.edu)
Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)

Whole-exome sequencing and high through put genotyping identified KCNJ11 as the thirteenth MODY gene. (degruyter.com)
Exome sequencing is a laboratory test designed to identify and analyze the sequence of all protein-coding nuclear genes in the genome. (nih.gov)

The mRNA expression of diagnostic genes was determined by qRT-PCR analysis. (nature.com)

Development of an Open Database of Genes Included in Hereditary Cancer Genetic Testing Panels Available From Major Sources in the US. (bvsalud.org)

A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)

This is the key next step in uncovering the mechanisms behind disease genes," said Martin Kampmann, PhD, associate professor, Institute for Neurodegenerative Diseases and the UCSF Weill Institute for Neurosciences, noting that the work leverages recent advances in gene sequencing, stem cell technology, and CRISPR. (sciencedaily.com)
This and other studies have suggested that SUDP is an overarching disorder consisting of rare and yet-undiagnosed diseases with potentially overlapping genetic mechanisms. (cureepilepsy.org)
A catalog of genetic tests and reviews of many genetic diseases with diagnostic strategies and recommendations for risk counseling are available from the Genetic Testing Registry . (msdmanuals.com)

Coop and Edge notified the database companies of the problem in July, 2019 to allow them time to put countermeasures in place before publishing a preprint in October. (eurekalert.org)
Coop and Edge carried out a proof-of-concept test with the GEDMatch database in December 2019. (eurekalert.org)

Rivas made the Global Biobank Engine , which is essentially a search engine for genes potentially associated with any disease. (stanford.edu)

The diagnostic value of hub genes was assessed by receiver operating characteristic analysis and validated in GSE1297. (nature.com)
Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)
The database features an initial group of 18 providers of genetic tests and more than 300 genetic tests, from parentage and panel tests to disease and diagnostic tests, cataloged by breed and type. (avma.org)

This terminology typically includes the official gene name and gene symbol as designated by the HUGO Gene Nomenclature Committee ( HGNC ). (medlineplus.gov)

the hypothesis for this work is that there are common, underlying, genetic mechanisms behind the three entities of sudden childhood death, epilepsy and sudden unexpected death in epilepsy (SUDEP). (cureepilepsy.org)

Guidelines for establishing locus specific databases. (lu.se)
Recommendations for locus-specific databases and their curation. (lu.se)

Future studies should investigate gene-by-environment interactions and employ functional imaging to understand how salience network structure translates to psychiatric disorder risk. (nature.com)
RNA serves as a functional read-out of exactly which genes are expressed in which tissues at any one time. (ed.ac.uk)

The GM Approval Database, or GMAD, is one of ISAAA's unique features that compiles all the available information about biotech/GM crops that have been approved for planting and importation for food and feed, and commercialization. (isaaa.org)

A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. (nih.gov)
Matches from the database are likely to be people with this genetic variant. (eurekalert.org)
Curating gene variant databases (LSDBs): toward a universal standard. (lu.se)

PR domain zinc finger protein 12 is a protein that in humans is encoded by the PRDM12 gene. (wikipedia.org)
Ongoing comparative analysis will provide insights to help us understand gene function across all large animal species, including humans. (ed.ac.uk)
Sanmenxia Clade 2.3.2.1c-like H5N1 viruses possess the closest genetic identity to A/Alberta/01/2014 (H5N1), which recently caused a fatal respiratory infection in Canada with signs of meningoencephalitis, a highly unusual symptom with influenza infections in humans. (nature.com)

In follow-up analyses, rs17076061 was not robustly associated with psychiatric disease, and no overlap was found between the broader genetic architecture of the common substrate and genetic risk for major depressive disorder, bipolar disorder, or schizophrenia. (nature.com)
Analyses using the AnAge database to study the evolution of longevity and ageing in vertebrate lineages. (senescence.info)
Genetic and phylogenetic analyses revealed that this Sanmenxia H5N1 virus was a novel reassortant, possessing a Clade 2.3.2.1c HA gene and a H9N2-derived PB2 gene. (nature.com)

The Office of Public Health Genomics has compiled this database since 2001 via weekly systematic sweeps of PubMed performed by a single curator. (cdc.gov)

XDR Shigella strains can spread antimicrobial resistance genes to other enteric bacteria. (cdc.gov)
Phenotypic tests assess growth of a virus containing the genes of interest in the presence of drugs against which resistance is being determined. (canada.ca)
Strains were classified as multidrug-resistant (MDR) if they contained genes giving resistance to classical front-line antibiotics ampicillin, chloramphenicol, and trimethoprim/sulfamethoxazole. (medicalxpress.com)
The authors also traced the presence of genes conferring resistance to macrolides and quinolones, which are among the most critically important antibiotics for human health. (medicalxpress.com)

It could be down to a gene that controls cells' ability to process caffeine, scientists have found. (foodnavigator.com)
Scientists have mapped which genes are turned on and off in the different tissues and organs in a sheep's body. (ed.ac.uk)
An online database has been created from the results, which is freely accessible to scientists working anywhere in the world. (ed.ac.uk)
Huge genetic databases are changing how scientists study disease. (stanford.edu)
As machine learning unlocks predictions from DNA databases, scientists say parents could have choices never before possible. (stanford.edu)
The genetic analysis included a candidate-gene approach where scientists have some information to suggest that a certain gene may be associated with a certain disease. (cureepilepsy.org)

Genetic inheritance patterns are known. (msdmanuals.com)

Beyond GWAS—Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19? (mdpi.com)
The HuGE published literature database will continue to be updated weekly with automatic indexing of gene symbols, study type (meta-analysis, GWAS), and category (pharmacogenomics, genetic testing). (cdc.gov)

Reconstructing dinosaurs from ancient DNA has been dealt a blow with a new study finding genetic material can only last one million years. (abc.net.au)

Methods A next-generation sequencing (NGS) panel was created for the human TRPV1 gene and in addition, for the leukotriene receptors BLT1 and BLT2 recently described to modulate TRPV1 mediated sensitisation processes rendering the coding genes LTB4R and LTB4R2 important co-players in pharmacogenetic approaches involving TRPV1. (researchgate.net)
High-Throughput Approaches for Characterization and Efficient Use of Plant Genetic Resources. (routledge.com)
Coop and Edge found three approaches to attacking these databases. (eurekalert.org)

The immune-related DEOSGs and hub genes were identified by weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) analysis, respectively. (nature.com)
We obtained 66 immune-related DEOSGs by intersecting turquoise module with the DEOSGs and identified 15 hub genes through PPI analysis. (nature.com)
Gene-Expression Analysis of Cell-Cycle Regulation Genes in Virus-Infected Rice Leaves. (routledge.com)
Although rigorous meta-analysis can be useful for assessing and refining gene discoveries, it does not suggest next steps. (cdc.gov)
In a secondary analysis, the team also used health records from the Queen Mary University of London Genes & Health Study, which contains health information on individuals of South Asian ancestry. (medscape.com)
A new study * , which was an outgrowth of the earlier CURE Epilepsy funded research, included 352 SUDP cases and employed state-of-the-art genetic techniques, in-depth analysis of family history and circumstances of death, and analysis of parental genetic information as well. (cureepilepsy.org)
EXTREME SURVIVALIST Genetic analysis of tardigrades like this Ramazzottius varieornatus shown in a scanning electron micrograph are revealing what makes the tough little creatures tick. (sciencenews.org)
Genetic analysis of the haemagglutinin gene revealed multiple introductions of influenza viruses into Lebanon from different geographic sources during each season. (who.int)

For the first five years, a complex PubMed query was used to identify studies of genotype prevalence, gene-disease association, gene-environment interaction, and the performance characteristics of genetic tests. (cdc.gov)

Fresh insights into the genetic code of sheep could aid breeding programmes to improve their health and productivity. (ed.ac.uk)

Other methods are needed to integrate genetic data into ways of thinking that can help us understand, prevent and treat disease. (cdc.gov)

The team's work , published in Nature Communications , focused in on a particular type of genetic oddity that halts proper protein formation before it's complete. (stanford.edu)

The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data. (nih.gov)
GEO is not intended to replace in house gene expression databases that benefit from coherent data sets, and which are constructed to facilitate a particular analytic method, but rather complement these by acting as a tertiary, central data distribution hub. (nih.gov)
These newly identified genes will hopefully lead to new therapeutic options, said Maik Pietzner, PhD , chair in health data modeling at Queen Mary University of London's Precision Healthcare University Research Institute (PHURI) and group leader in the Computational Medicine Group at the Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Germany. (medscape.com)
Less is known about this gene, but the data we do have suggest that it is involved with regulating the dilation of blood vessels, Pietzner noted. (medscape.com)
A database, called "Cynara cardunculus MicroSatellite DataBase" (CyMSatDB) was developed to provide a searchable interface to the SSR data. (researchgate.net)
You have to submit your DNA as a saliva sample to get access to their genetic data. (eurekalert.org)
They also carried out a proof of concept test in the GEDMatch database but without interacting with other users' DNA data. (eurekalert.org)
Pulmonary function data from 1988 to 2003 were retrieved from the Phoenix Fire Department's medical monitoring database. (cdc.gov)

This is the first study including molecular studies of 11 MODY genes in Turkish children. (degruyter.com)

The work we're doing can provide insight into how changes in these genes lead to disease and allow us to target them with treatments. (sciencedaily.com)
It caught our attention because this gene had recently been linked to Parkinson's disease," Kampmann said. (sciencedaily.com)
following up on these discoveries to unravel genetic contributions to disease, however, remains extremely challenging. (cdc.gov)
This is a stronger approach to studying genetic contributions to a disease process, especially for SUDP, where a genetic link is suspected. (cureepilepsy.org)
It's the first time this gene has been implicated in disease. (the-scientist.com)
Screening may be appropriate for people with a family history of a dominantly inherited disorder that manifests later in life, such as Huntington disease or cancers associated with abnormalities of the BRCA1 and BRCA2 genes. (msdmanuals.com)

Chemicals and Drugs1

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Phenomena and Processes2

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Variants13

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20162

Include genes3

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20,0002

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Variation5

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20192

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