Genes 1992 acidic fibroblast growth factor 9. Medical search. Frequent questions

Gene sequencing revealed that this group was in fact the same FGF2 protein and that it was a member of a family of FGF proteins. (wikidoc.org)
[3] [5] FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules. (wikidoc.org)
In this protocol you will learn about factors both inside your body and from the external environment that can damage skin, hair and nail proteins. (lifeextension.com)
The problem is intrinsic factors, such as the biological aging process, as well as extrinsic factors, such as ultraviolet radiation from sun exposure, compromise the structure and function of these proteins. (lifeextension.com)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
Unlike yeast, most mammalian ribosomal proteins are thought to be encoded by a single gene copy, raising the possibility that heterogenous populations of ribosomes are unique to yeast. (prolekarniky.cz)

Integrin engagement by ECM can modulate growth factor signaling pathways, increasing the activity of growth factor RTKs (7, 8) and their downstream intracellular mediators (9, 10). (123dok.org)
Consistently, expression of genes enriched in neural development pathways is significantly disturbed. (biomedcentral.com)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
The most responsible genes and pathways involved in the pathology of this disorder have not been fully understood. (genominfo.org)
We aimed to identify differentially expressed genes (DEGs), the most critical hub genes, transcription factors, signaling pathways, and biological processes (BPs) associated with the pathogenesis of primary SGC. (genominfo.org)
The most significant pathways and BPs that were deregulated in the primary disease condition were associated with the cell cycle and fibroblast proliferation procedures. (genominfo.org)
Despite many types of investigation that have been performed, the most critical genes and signaling pathways taking part in the etiology of the disease have not been fully demonstrated [ 5 ]. (genominfo.org)

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. (wikipedia.org)
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. (wikipedia.org)
Fibroblast growth factor receptor 4 has been shown to interact with FGF1. (wikipedia.org)
1994). "Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). (wikipedia.org)
It was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase . (wikidoc.org)
Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src. (123dok.org)
Integrin-in-duced epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) RTK phosphorylation depends on the kinase activity of the receptor (7, 13). (123dok.org)
Despite the cited progress in this area of research, the molecular mechanisms underlying growth factor receptor activation by integrins remain to be defined. (123dok.org)
The dsRNA acts like a trigger for the production of interferon (via Toll Like Receptor 3 ( TLR 3 ) a pattern recognition receptor of the innate immune system which leads to activation of the transcription factor IRF3 and late phase NF kappa Beta). (wikidoc.org)
A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
Kim and Morshead, 2003), and the fibroblast that SSEA4 associated with CD133 can be used for growth factor (FGF) receptor 4 (Cai et al. (lu.se)

The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. (wikipedia.org)
growth, differentiation, and survival. (123dok.org)
Microarray analysis of MSC during osteogenic differentiation identified three candidate genes for further examination and functional analysis: ID4, CRYAB, and SORT1. (biomedcentral.com)
Finally we analyzed the gene expression profiles of MSC during osteogenic differentiation. (biomedcentral.com)
In addition to an essential role in regulating cell growth and differentiation, Ras signaling has more recently been linked to a wide range of neuronal functions including synaptic and behavioral plasticity (for review see Thomas and Huganir, 2004 ). (rupress.org)
The winged-helix transcription factor Foxd3 suppresses intemeuron differentiation and promotes neural crest cell fate. (forexsignalx.com)

Output from the circadian clock is transduced through regulating transcription of downstream genes directly by the oscillator components. (go.jp)

FGF2 , also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene . (wikidoc.org)
Basic fibroblast growth factor (Fgf2) is required for the generation of founder cells within the dorsal pseudostratified ventricular epithelium, which will generate the cerebral cortex, but the ganglionic eminences are not affected. (jneurosci.org)

Our interest in mechanisms of neural injury and repair prompted us to investigate the role of trophic factor interactions in a well characterized model of collateral sprouting in the adult rat hippocampus. (jneurosci.org)
Here we review the most recent advancements on C. concisus and other human hosted Campylobacter species including their clinical relevance, transmission, virulence factors, disease associated genes, interactions with the human immune system and pathogenic mechanisms. (frontiersin.org)
Plant growth is controlled by the clock through interactions with light and phytohormone signaling. (go.jp)

Integrin-based effects on growth factor re-ceptors include enhancement of cell migration (11, 12), survival (13), and proliferation (14 -17). (123dok.org)

Molecular characterization of these benign yet rapidly proliferating tumors has been limited to evaluating a few mutations in few genes. (frontiersin.org)
Mutation analysis indicated the presence of germline mutations in three genes and somatic mutations in two other genes. (frontiersin.org)
In cases where multiple other mutations, in genes such as TP53, ATRX, and others, recurrence of the tumor is a possibility. (frontiersin.org)
These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
Cancer is a complex genetic disease caused by abnormal alteration (mutations) in DNA sequences that leads to dyregulation of normal cellular processes thereby driving tumor growth. (intechopen.com)
Multiple endocrine neoplasia syndrome type 1 (MEN-1), loss-of-function germline mutations in the tumor suppressor gene MEN1 increase the risk of developing pituitary, parathyroid and pancreatic islet tumors, and less commonly thymic carcinoids, lipomas and benign adrenocortical tumors. (intechopen.com)
A growing number of human diseases have been linked to mutations in genes encoding factors involved in ribosome biogenesis and protein synthesis [5] , [6] . (prolekarniky.cz)

This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. (wikipedia.org)

Development (1994) 120 (9): 2555-2566. (biologists.com)

Reports from several laboratories suggest that a phenomenon termed epithelial-mesenchymal transformation, in which epithelial cells transform into fibroblasts capable of producing connective tissue matrix, is an important feature of tissue remodelling 10 , 11 . (ersjournals.com)
The tumor is heterogeneous with meningeal tumor cells, mainly a mixture of fibroblast like cells, and neuroepithelial cells in a background of connective tissue. (frontiersin.org)

MSP was discov-ered as a serum factor that regulates the motility of macro-phages (22). (123dok.org)
The gene is located on chromosome 12q23 [ 26 ] and regulates transforming growth factor (TGF)-beta 1 activity as well as the cell cycle [ 27 ] . (encyclopedia.pub)
M1 is a structural matrix protein that stabilizes viral particles, whereas the ion channel protein M2 is embedded in the viral envelope and regulates the uncoating of vRNP [ 9 ]. (biomedcentral.com)

The apelin gene located at chromosome Xq25-26.1, encodes a 77 amino acid preproprotein [ 1 ] [ 2 ] . (encyclopedia.pub)

Like other FGF family members, basic fibroblast growth factor possess broad mitogenic and cell survival activities, and is involved in a variety of biological processes, including embryonic development , cell growth , morphogenesis , tissue repair , tumor growth and invasion. (wikidoc.org)
We show that, during embryonic devel-opment, the extramacrochaetae gene is expressed in complex patterns that comprise derivatives of the three embryonic layers. (biologists.com)

Genes Chromosomes Cancer. (wikipedia.org)
In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
HMGB1 is also related to the hallmarks of cancer as described by Hanahan and Weinberg [ 9 ]. (hindawi.com)
Although hundreds of genes are known to be mutated in cancers our understanding of mutational events in cancer cells remains incomplete ( Futreal PA et al, 2004 ). (intechopen.com)
As we are in the era of evidence-based molecular diagnosis, predictive testing, genetic counseling, gene-informed cancer risk assessment, and preventative and personalized medicine, therefore, studying the Mendelian genetics of the familial forms of cancer is one approach that can set up the basis for gene-informed risk assessment and management for the patient and family. (intechopen.com)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)

E1A transfection results in the transformation of peripheral lung epithelial cells and normal lung fibroblasts to a phenotype intermediate between that of the two primary cells. (ersjournals.com)
The changes that occur during adenoviral E1A transformation of primary guinea pig PLECs were also compared with those occurring during the transformation of the fibroblasts that frequently contaminate primary epithelial cultures, and evidence is presented that both cell types are transformed to an intermediate phenotype. (ersjournals.com)

Detailed analysis of the m 6 A-methylomes of Ythdf2 −/− NSPCs identifies that the JAK-STAT cascade inhibitory genes contribute to neuroprotection and neurite outgrowths show increased expression and m 6 A enrichment. (biomedcentral.com)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)

As to the basis for their collaboration, integrins and growth factor receptors may form macromolecular complexes on the cell membrane (7, 8, 13, 16 -18). (123dok.org)
Recent data suggest that integrin association with RTKs might also protect the latter against the activity of phosphatases (17, 19) and/or ensure the correct subcellular juxtaposition of cytoplasmic tails of dimer-ized growth factor receptors (17). (123dok.org)

Although much evidence supports the role of endogenous NGF in promoting neuronal survival in vivo ( Barde, 1989 ), less is known about its ability to influence axonal growth. (jneurosci.org)

the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. (wikidoc.org)
It is involved in various metabolic processes, such as acting on white adipose tissue to upregulate brown adipose tissue-specific genes, enhancing PGC-1α expression to increase lipid oxidation, suppressing inflammation in skeletal muscles, inhibiting cardiometabolic risk factors, and suppressing endoplasmic reticulum stress in hepatoblastoma cells. (encyclopedia.pub)
to find regulatory genes of the achaete-scute complex (AS-C). The AS-C comprises four proneural genes that confer to cells the ability to become neuroblasts or sensory organ mother cells ( Campuzano and Modolell, 1992 , review). (biologists.com)
Guinea pig primary peripheral lung epithelial cells (PLECs) transfected with adenovirus E1A (E1A-PLECs) were compared to guinea pig normal lung fibroblasts (NLFs) transfected with E1A (E1A-NLFs). (ersjournals.com)
Adenoviral DNA is retained by peripheral epithelial cells of the lung (PLECs) in humans in whom the viral E1A gene is expressed 4 without replication of a complete virus 5 . (ersjournals.com)
Furthermore, E1A DNA and protein persisted in epithelial cells in the lungs of these animals 9 . (ersjournals.com)
Inflammation leads to excessive uptake of calcium by cells, and is a factor in obesity, depression, and the degenerative diseases. (raypeat.com)
In normal cells, the fate of pyruvate depends on many factors, one of which is oxygen availability. (hindawi.com)
The gene that codes for this cytokine is switched on in an infected cell, and the interferon synthesized and secreted to surrounding cells. (wikidoc.org)
Resident cells within the lung such as fibroblasts and alveolar type II cells may be induced by cigarette smoke to synthesize chemokines attracting and potentially activating inflammatory cells. (atsjournals.org)
Consistent with the hypothesis that either ribosomal protein can support translation, knockdown of Rpl22l1 impairs growth of cells lacking Rpl22 . (prolekarniky.cz)
These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)
To confirm the importance of M2 splicing in the replication of H1N1 and H3N2, we treated infected cells with splicing inhibitor herboxidiene and analyzed the viral growth using plaque assay. (biomedcentral.com)

Numerous research efforts have sought to elucidate the function of trophic factors in neural development, maintenance of connections in the mature brain, and reparative processes after injury. (jneurosci.org)

To investigate the molecular mechanisms of cholinergic sprouting in the hippocampus after removal of entorhinal cortical inputs, we evaluated trophic factor gene expression in the denervated hippocampus. (jneurosci.org)
In the present study, the hypothesis that adenoviral infection followed by persistent expression of its E1A gene is capable of producing epithelial-mesenchymal transformation was examined by investigating guinea pig PLECs that express adenoviral E1A. (ersjournals.com)
The effect of CTGF silencing on the TGF-β2-modulated expression of these genes was investigated by transfection of CTGF small interfering (si)RNA before TGF-β2 treatment. (arvojournals.org)
2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)

HemoHIM itself did not inhibit melanoma cell growth in vitro , and did not disturb the effects of cisplatin in vitro . (biomedcentral.com)
Complementary and alternative medicine does not inhibit tumor growth. (biomedcentral.com)
Splicing of PB2 generates PB2-S1, which was only identified in pre-2009 human H1N1, and may inhibit the retinoic acid-inducible gene I signaling pathway [ 4 ]. (biomedcentral.com)

Most yeast ribosomal protein genes are duplicated and their characterization has led to hypotheses regarding the existence of specialized ribosomes with different subunit composition or specifically-tailored functions. (prolekarniky.cz)

Previous studies have reported that chemotherapy and radiation therapy are low effective and have several side effects such as hyposalivation, neutropenia, swallowing disorder, and several neurological difficulties [ 8 , 9 ]. (genominfo.org)

BAIBA (C 4 H 9 NO 2 ) is a small, non-protein myokine with a molecular weight of 103.6 Da that was first discovered in human urine in 1951 [ 11 ] . (encyclopedia.pub)

Endogenous circadian rhythms regulate many aspects of an organism's physiological and morphological growth and development. (go.jp)
SPIB , FOXM1 , and POLR2A significantly regulate all the hub genes. (genominfo.org)

These findings highlight the need for continued surveillance for diabetes among youths to monitor overall and group-specific trends, identify factors driving these trends, and inform health care planning. (cdc.gov)

The hub genes of PIM were discovered, and their associated gene regulatory network was built to determine the master regulators involved in the pathogenesis of primary SGC. (genominfo.org)

Our aim was to establish a live cell culture to enable the understanding of the cellular processes driving the non-malignant growth of these tumors. (frontiersin.org)
Protein synthesis is a major energy consuming process involving intricate coordination of translation machinery in response to nutrient availability and stress sensing signals, as well as hormonal and growth factor cues in multi-cellular organisms. (prolekarniky.cz)

The underlying molecular mechanisms and the responsible pathogenic factors leading to these changes in outflow resistance remain unknown. (arvojournals.org)

Murre and Baltimore, 1992 , reviews) characteristic of a large family of transcriptional reg-ulators that function as homo-or hetero-dimers. (biologists.com)

Similar to other tumors, the risk factors for the development of meningiomas can be divided into those with clearly defined genetic etiology and those that are attributed to environmental and other nongenetic factors. (medscape.com)

Recently, significant progress was made in defining the mechanisms by which plant growth on a day-to-day basis is activated at specific times of the day in a manner dependent on photoperiod and temperature conditions. (go.jp)

Different cell types generate different classes of proteinases with differing modes of gene regulation. (atsjournals.org)

Statistical data have shown that the amount of this factor is significantly increased in the AH of approximately 50% of patients with POAG. (arvojournals.org)

Although inhalation of toxic gases and particles is the major risk factor for COPD 3 , viral infections, particularly childhood infection, add to the risk of developing this condition 1 . (ersjournals.com)
Each segment is wrapped by a nucleoprotein (NP) into a viral ribonucleoprotein (RNP) complex along with a viral RNA polymerase complex comprising polymerase basic 1 (PB1) polymerase, cap‐binding PB2 subunit, and polymerase acidic (PA) endonuclease. (biomedcentral.com)

The majority of studies has investigated the function of nerve growth factor (NGF), the best-characterized member of the neurotrophin family of trophic molecules ( Korsching, 1993 ). (jneurosci.org)
We reported a dichorionic diamniotic placental twin (DD twin) with a family history of a congenital nephrotic syndrome of the Finnish type (CNF), of which the parent had heterozygous for the NPHS1 gene mutation. (bvsalud.org)
In 51 patients, 26 aberrant genes were identified, of which, 20 (76.9%) caused disease in 1 family each. (bvsalud.org)

This study illustrated several hub genes and their master regulators that might be appropriate targets for the therapeutic aims of primary SGC. (genominfo.org)

There are explicit indications, however, that transforming growth factor (TGF)-β2 may be involved in the pathogenesis of POAG. (arvojournals.org)

Despite the proposed role for nerve growth factor (NGF) in this sprouting, we observed no change in NGF mRNA or protein at several postlesion time points. (jneurosci.org)

In 1965, Urist recognized BMP as an important factor in osteogenesis and bone formation [ 17 ] . (encyclopedia.pub)

It is, therefore, likely that multiple growth factors act coordinately to elicit the structural and functional changes that take place during dynamic growth processes. (jneurosci.org)

Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1 , [13] RPL6 [14] and ribosomal protein S19 . (wikidoc.org)

The PKR is indirectly activated by the dsRNA (actually by 2'-5' oligoadenylate produced by the 2'-5' oligoadenylate-synthetase which is produced due to TLR3 activation), and begins transferring phosphate groups ( phosphorylating ) to a protein known as eIF-2 , a eukaryotic translation initiation factor. (wikidoc.org)
Therefore, TGF-β2 could be a factor in the initiation of the modification of ECM in the glaucomatous ONH. (arvojournals.org)

The function of the Drosophila extramacrochaetae ( emc ) gene has been characterized almost exclusively in relation to the pat-terning of the fly's sensory organs (chaetae and other types of sensilla). (biologists.com)

Anatomy4

Organisms2

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes11

Information Science3

Proteins7

Pathways7

Receptor11

Differentiation6

Downstream1

FGF22

Interactions3

Proliferation1

Mutations7

Binds1

19941

Connective2

Regulates3

Chromosome1

Embryonic2

Cancer6

Phenotype2

Inhibitory2

Receptors2

Survival1

Cells13

Neural1

Expression4

Inhibit3

Characterization1

Radiation1

Human1

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Diabetes1

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Cellular2

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Transcriptional1

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Mechanisms1

Regulation1

Significantly1

Viral2

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