Genes 15 chromosomes human pair 15. Medical search. Frequent questions

The latest company targeted by Myriad Genetics for offering a genetic diagnostic test encompassing the human BRCA 1 and BRCA 2 genes is Invitae Corp. located in San Francisco. (patentdocs.org)
Ch 12 Human Genetics - Ch 12 Human Genetics By Miss Dreher 12.1 The nucleus contains an information rich genome Genome: an organism s complete set of DNA. (powershow.com)
The genetics of chromosome pairing and meiotic recombination is complicated by the allopolyploid nature of many crops, a widespread feature in the plant kingdom 3 . (nature.com)
American journal of human genetics. (wustl.edu)
Annals of Human Genetics , 49 (4), 267-274. (elsevierpure.com)

In shi(mld), the MBP gene is duplicated and its reduced expression is mainly determined by the level of mRNA. (elsevierpure.com)
A recombinational event including the inversion seemed to have occurred within gene 1 and its possible relationship to the reduced expression of MBP is discussed. (elsevierpure.com)
Expression of the gene in transgenic mice results in late prenatal lethality, suggesting that the dosage of its gene product is strictly controlled 4 . (princeton.edu)
This assay will be of general use in assaying allele-specific gene expression. (princeton.edu)
Expression of the gene in transgenic mice results in late prenatal lethality, suggesting that the dosage of its gene product is strictly controlled4. (princeton.edu)
The UBE3A gene demonstrates maternal-specific expression in neurons and loss of maternal UBE3A causes Angelman syndrome, a neurodevelopmental disorder with some overlapping neurological features to Dup15q. (ox.ac.uk)
At this time, there is a paucity of information as to the expression of the Gimap genes in specific cell types. (hindawi.com)
The genetic structure includes 4 zinc-finger regions, which suggest that WT1 may be important in controlling the expression of other genes. (medscape.com)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
The widely used CRISPR-Cas9 gene-editing technology has enabled researchers to alter genome sequence or gene expression with great precision, says JAX Assistant Professor Albert Cheng, Ph.D., first and co-corresponding author of a paper published in Cell Research . (jax.org)
That means one-step modeling of complex gene expression profiles. (jax.org)
dCas9 can be fused to protein tags or the effector domains of transcription factors (proteins that bind DNA in promoter regions and simultaneously bind other regulatory proteins via effector domains, which can activate or repress transcription and thereby affect gene expression) to develop customized DNA binding proteins. (jax.org)
For example, it can be fused to domains that activate or repress gene expression, allowing researchers to increase or decrease gene expression at will without changing the actual sequence. (jax.org)
Many diseases involve variations in gene expression rather than genetic sequence. (jax.org)
MicroRNA (miRNA) molecules, a series of single-stranded non-coding RNA chains measuring 20-25 nucleotides in length, regulate gene expression at the transcriptional level by complementary pairing with target gene mRNA ( 5 ). (spandidos-publications.com)
The expression of genes through miRNA is regulated by endogenous regulatory pathways, resulting in high stability and biocompatibility ( 5 ). (spandidos-publications.com)
The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. (ox.ac.uk)
Here we show that in the presence of the risk haplotype, the expression of the KIAA0319 gene is reduced but the expression of the other two genes remains unaffected. (ox.ac.uk)
Using in situ hybridization, we detect a very distinct expression pattern of the KIAA0319 gene in the developing cerebral neocortex of mouse and human fetuses. (ox.ac.uk)
Expression of this gene is induced by TGFBR1. (cancerindex.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
The major positive erythroid-specific regulatory element controlling alpha-globin gene expression lies equidistant between the promoters of the alpha-globin genes and the 3-methyladenine DNA glycosylase gene. (ox.ac.uk)
Interestingly, in contrast to the alpha-globin genes, expression of the 3-methyladenine DNA glycosylase gene is not influenced by the regulatory element in the human erythroleukemia cell line K562. (ox.ac.uk)
Four SNPs exhibited allele-dependent increases in gene expression (rs2287231, rs2513789, rs11571537 and rs2446824). (cdc.gov)
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
Relapsing fever Borrelia undergo Vmp gene conversion at a single expression locus to generate new serotypes by antigenic switching which is the basis for immune evasion that causes relapsing fever in patients. (cdc.gov)
PCR analysis of the gene expression locus in the reisolates showed vsp1 was replaced by Vlp-encoded genes. (cdc.gov)

Two patients had large direct duplications of 15q11q13 [dir dup(15)(q11q13)] that extended through the entire Angelman syndrome/Prader-Willi syndrome (AS/PWS) chromosomal region. (nih.gov)
The following chromosomal conditions are associated with changes in the structure or number of copies of chromosome 15. (medlineplus.gov)
15q13.3 microdeletion is a chromosomal change in which a small piece of chromosome 15 is deleted in each cell. (medlineplus.gov)
Chromosomal mapping by in situ hybridization suggested that the duplicated MBP genes were located closely to each other at the distal part of chromosome 18. (elsevierpure.com)
These syndromes result from the loss of chromosomal material from the short arm of chromosome 11. (medscape.com)
The pathogenic germline deletion of varying lengths of chromosomal material along the short arm of chromosome 11, including WT1 and PAX6 , is the underlying defect. (medscape.com)
The brain-derived neurotrophic factor ( BDNF ) gene is also located in the region of chromosomal loss associated with WAGR syndrome. (medscape.com)
WAGR syndrome is caused by the contiguous loss of chromosomal material from the short arm of chromosome 11. (medscape.com)
Telomeres are protective DNA structures that are located at the end of chromosomes, and proper telomere maintenance is indispensable for chromosomal integrity and overall genomic stability. (oncotarget.com)
This advantage enables more efficient gene modulation and labeling of chromosomal loci in live cells. (jax.org)

The murine immunoglobulin kappa (κ) light-chain multigene family includes the constant region (Cκ), joining-region genes, and approximately 30 kappa-variable (Vκ) region families. (elsevierpure.com)
This human cytochrome P‐450 is encoded by a member of a multigene family. (elsevierpure.com)

This parent-specific gene activation results from a phenomenon called genomic imprinting. (medlineplus.gov)
PWS occurs due to abnormalities affecting certain genes in the proximal long arm of chromosome 15 when deleted from the father's chromosome 15 and hence referred to as a genomic imprinting disorder which depends on the sex of the parent donating the chromosome leading to the chromosome defect in the child. (rarediseases.org)
We have isolated cDNA and genomic clones coding for the human α 7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by α-bungarotoxin. (johnshopkins.edu)
With this feature, Casilio can now conduct different functions at different genomic sites--e.g., upregulating one set of genes while repressing another set. (jax.org)
Our analysis revealed lineage-specific (LS) genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome. (nature.com)

The dominant gene determines the actual color of the person's eyes. (windows2universe.org)
Dominant means that only one of the chromosomes in the #22 pair needs to be affected in order to have the disorder. (vcfsef.org)
Others can arise from the presence of an abnormal gene in any autosome: if the gene is dominant, it results always in what is called a dominant condition, whereas if it is recessive many of these diseases appear only when the gene is inherited from both parents (and are thus called recessive conditions). (who.int)

Analysis of human metaphase chromosomes by in situ hybridization localizes this cytochrome P‐450 gene family further to the long arm of chromosome 19 in the region q13.1→qter. (elsevierpure.com)

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)

This is the latest reviewed version , checked on 15 August 2022 . (wikibooks.org)

An isodicentric chromosome contains mirror-image segments of genetic material and has two constriction points (centromeres), rather than one centromere as in normal chromosomes. (medlineplus.gov)
If the parent is mosaic, the risk is similar, although these people may also have offspring with normal chromosomes. (msdmanuals.com)

In one patient, the duplication originated from two different maternal chromosomes, while in the other patient it arose from the same maternal chromosome. (nih.gov)
Dup15q syndrome arises only if the chromosome abnormality occurs on the copy of the chromosome inherited from the mother (the maternal copy). (medlineplus.gov)
However, some genes on this chromosome, including some of those in the 15q11.2-q13.1 region, are turned on (active) only on the maternal copy. (medlineplus.gov)
The H19 gene maps to the distal segment of mouse chromosome 7, in a region that is parentally imprinted 5 , a process by which genes are differentially expressed on the maternal and paternal chromosomes. (princeton.edu)
Hamer and his colleagues conducted extensive interviews with 76 pairs of gay brothers and their family members and found that homosexuality seemed to be inherited through the maternal line. (geeayewhy.com)

VCFS is a genetic disorder associated with a deletion of chromosome #22q11. (vcfsef.org)

DNA extracted from a panel of 12 independent human‐rodent somatic cell hybrids was analysed by Southern blot hybridization with the cloned cDNA. (elsevierpure.com)

We recently reported the presence of four genes lying between the human alpha-globin gene cluster and the telomere of the short arm of chromosome 16 (16p). (ox.ac.uk)

In wheat, a complex allohexaploid that has a diploid-like behaviour, meiotic recombination between homoeologous or alien chromosomes is suppressed through the action of several loci. (nature.com)
Here, we report positional cloning of Pairing homoeologous 2 (Ph2) and functional validation of the wheat DNA mismatch repair protein MSH7-3D as a key inhibitor of homoeologous recombination, thus solving a half-century-old question. (nature.com)
ZIP4 is a ZMM protein involved in homologous recombination and may act as a hub through physical interactions with components of the chromosome axis and other ZMMs 19 . (nature.com)
The positional cloning and subsequent identification of the Gimap5 gene on RNO4 were in part established through generation of the DR. lyp congenic rat line along with recombination events following our method of marker assisted breeding of DP with F344 rats [ 2 , 4 , 5 ]. (hindawi.com)
Then the researchers used a technology called SCRaMbLE (Synthetic Chromosome Recombination and Modification by LoxP-mediated Evolution) to shuffle the genes in the synthetic chromosome. (nbcnews.com)
Thanks to the randomness of chromosome segregation and a process called recombination, siblings' genomes are not always 50 percent the same. (eogn.com)

in 2016, a tenth type was defined based on mutations in the AP3D1 gene. (medscape.com)

The mouse Pitx2 gene encodes three distinct protein isoforms (Pitx2a, b, c), and Pitx2c plays a determinant role in left-right atrium signaling from early somitogenesis onward 5 . (nature.com)
THE mouse H19 gene encodes one of the most abundant RNAs in the developing mouse embryo 1 . (princeton.edu)
We now report that one of these genes encodes 3-methyladenine DNA glycosylase, an enzyme important in the repair of DNA after damage by alkylating agents. (ox.ac.uk)
5] Syrzycka et al[6] demonstrated that the pink gene encodes the Drosophila ortholog of the human HPS5 gene. (medscape.com)

However, in contrast to the non-lymphoid cell lines, the replication of this locus occurred predominantly during the first half of S. The κ locus contains both early- and late-replicating genes, and early replication is usually associated with transcriptional activity. (elsevierpure.com)
[1] [2] These chromosomes display a complex three-dimensional structure, which plays a significant role in transcriptional regulation . (wikipedia.org)

Family with sequence similarity 49, member A, also known as FAM49A, is a protein which in humans is encoded by the FAM49A gene. (wikipedia.org)
It has 1512 base pairs in the reference sequence mRNA transcript. (wikipedia.org)
Most people with a 15q13.3 microdeletion are missing a sequence of about 2 million DNA base pairs, also written as 2 megabases (Mb). (medlineplus.gov)
Claim 16: A pair of single-stranded DNA primers for determination of a nucleotide sequence of a BRCA1 gene by a polymerase chin reaction, the sequence of said primers being derived from human chromosome 17q, wherein the use of said primers in a polymerase chain reaction results in the synthesis of DNA having all or part of the sequence of the BRCA1 gene. (patentdocs.org)
Claim 17: The pair of primers of claim 16 wherein said BRCA1 gene has the nucleotide sequence set forth in SEQ ID NO:1. (patentdocs.org)
A pair of single-stranded DNA primers of at least 15 nucleotides in length for determination of the nucleotide sequence of a BRCA2 gene by a polymerase chain reaction, the sequence of said primers being isolated from human chromosome 13, wherein the use of said primers in a polymerase chain reaction results in the synthesis of DNA comprising all or at least 15 contiguous nucleotides of the BRCA2 gene. (patentdocs.org)
A 712-bp nucleotide sequence upstream of the first exons of both of the duplicated MBP genes of shi(mld) was completely consistent with that of the control. (elsevierpure.com)
It lacks a common open reading frame in the 2.5-kilobase RNA, but has considerable nucleotide sequence similarity between the genes of rodents and humans 2,3 . (princeton.edu)
It lacks a common open reading frame in the 2.5-kilobase RNA, but has considerable nucleotide sequence similarity between the genes of rodents and humans2,3. (princeton.edu)
Isolation of a DNA sequence (lambda EMBL3.123, D4S64) from chromosome 4 showing a BglII polymorphism. (ox.ac.uk)
In comparison to Ph1 , the causative gene sequence for Ph2 is yet to be determined. (nature.com)
Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
The fact that the Gimap genes are located together in a tight cluster on RNO4 (and in conserved synteny with many other species), combined with their sequence similarities, suggests the possibility that the proteins carry out similar function. (hindawi.com)
The pins and white diamonds on this illustration show where changes were made in the native sequence of yeast chromosome III to produce a custom-designed synthetic chromosome. (nbcnews.com)

Genetic and cytogenetic studies have revealed the presence of several pairing homoeologous ( Ph ) loci that ensure wheat behaves as a diploid during meiosis, with only homologous chromosomes of the same sub-genome (AA, BB or DD) pairing and recombining. (nature.com)
4. During meiosis, chromosomes pair up during the division. (yale.edu)
During meiosis, the number of chromosomes in the parent cell is reduced by half: a cell with 46 chromosomes produces four gametes, each containing just 23 chromosomes, one from each pair. (eogn.com)

Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. (jax.org)

These are designed to come from pathways found from genes in a QTL (Quantitative Trait Loci) region, and from pathways found from genes differentially expressed in a microarray study. (myexperiment.org)

Chromosome 15 likely contains 600 to 700 genes that provide instructions for making proteins. (medlineplus.gov)
Genes are discrete stretches of nucleotides that carry the information the cell uses to make proteins. (markedbyteachers.com)
The impaired function of specific organelles indicates that the causative genes encode proteins operative in the formation of lysosomes and vesicles. (medscape.com)

Practice thousands of multiple choice questions created by CBSE Class X Science experts & teachers, You can get instant results and also download certificate for passing CBSE Class 10 Science Heredity And Evolution Online Test Set A. a.Vegetative propagation b.Contraception c.Different combination of genetic material, gene mutation d.Fertility 3. (mercinewyork.com)
Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
Our data substantiates the Gimap5 frameshift mutation as the primary defect with only limited contributions to lymphopenia from the remaining Gimap genes. (hindawi.com)
Positional cloning of the lyp gene revealed a frame shift mutation in Gimap5 (previously known as Ian5 or Ian4L1 ). (hindawi.com)
Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)
HPS-2 is caused by a mutation in the gene encoding the beta-3A subunit of the heterotetrameric AP3 complex (ADTB3A), which resides on chromosome 5. (medscape.com)
Mutation of the BTK gene and clinical feature of X-linked agammaglobulinemia in mainland China. (lu.se)
De novo mutation in the BTK gene of atypical X-linked agammaglobulinemia in a patient with recurrent pyoderma. (lu.se)

Although the gene is widely expressed, the abundance of its mRNA is considerably higher in a colon adenocarcinoma cell line (HT29) than in other cell lines that were tested. (ox.ac.uk)

Among the lambda clones containing promoter regions of the duplicated MBP genes in shi(mld), one (gene 1) had the same restriction enzyme pattern as that in control mice, but another (gene 2) had a rearrangement on a distal part of the promoter. (elsevierpure.com)

Chromosome 15 spans more than 102 million DNA building blocks (base pairs) and represents more than 3 percent of the total DNA in cells. (medlineplus.gov)
LINES (long interspersed elements) ~6000 to 7000 base pairs. (powershow.com)
Those words were strung together into paragraphs consisting of 750 to 1,000 base pairs. (nbcnews.com)
The researchers started out with 316,617 base pairs in the natural chromosome, and slimmed the code down to 272,871 base pairs. (nbcnews.com)
Fourteen years later, neither Bocklandt nor any other researcher has pinpointed the precise base pairs that might turn a man gay. (geeayewhy.com)
Based on a previous GWAS study, 14 DA associated loci and flanking regions were selected for NGS (6,996,180 base pairs). (cdc.gov)

were able to cluster all genes into 15,389 groups called "gene families. (blogspot.com)

Amira Nicola January, 2001 The Human Genome Project The Human Genome project is a scientific research effort to analyse the DNA of human beings and that of several other types of organism. (markedbyteachers.com)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

Chromosomes are normally visible under a light microscope only during the metaphase of cell division (where all chromosomes are aligned in the center of the cell in their condensed form). (wikipedia.org)
During metaphase the X-shaped structure is called a metaphase chromosome, which is highly condensed and thus easiest to distinguish and study. (wikipedia.org)

Furthermore, neuronal-related genes and genetic pathways are starting to emerge from the CNV loci associated with schizophrenia. (nih.gov)
The KEGG gene identifiers are then used to searcg for pathways in the KEGG path. (myexperiment.org)
Each KEGG gene id is then sent to the KEGG pathway database and its relevant pathways returned. (myexperiment.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)

Crop wild relatives provide a valuable source of genes and allelic variants for abiotic stress tolerance, disease resistance and quality traits that are important for breeding, particularly in the context of human population growth and a changing climate. (nature.com)
Several transcript variants encoding different isoforms have been found for this gene. (cancerindex.org)
We have investigated DA associated genotypes, using candidate gene studies, GWAS and Next Generation Sequencing (NGS) to identify gene variants associated with DA. (cdc.gov)

V. faba has a diploid (2n) chromosome number of 12 (six homologous pairs). (wikipedia.org)

In this unit, we will explore what genes are, how heredity works, what evolution is and so much more. (mercinewyork.com)
In his famous textbook The Cell in Development and Heredity , Wilson linked together the independent work of Boveri and Sutton (both around 1902) by naming the chromosome theory of inheritance the Boveri-Sutton chromosome theory (the names are sometimes reversed). (wikipedia.org)

All living things that have eukaryotic cells , such as dogs, butterflies, and fish, have chromosomes in their cells. (windows2universe.org)

An organism has the same genes for its entire life. (windows2universe.org)
A chromosome is a long DNA molecule with part or all of the genetic material of an organism. (wikipedia.org)

The deletion occurs on the q arm of the chromosome at a position designated q13.3. (medlineplus.gov)
But before the chromosome pairs get split apart, a sort of genetic reshuffling occurs. (eogn.com)
A 21q21q translocation chromosome, which occurs when the extra chromosome 21 is attached to another chromosome 21, is much less common. (msdmanuals.com)
In this variant, a 16-base pair frame shift duplication occurs at exon 15 of the HPS1 gene. (medscape.com)
In the Swiss variant, a frame shift occurs at codon 322 of the HPS1 gene. (medscape.com)

In all cases of dup15q syndrome, the duplicated genetic material results in extra copies of certain genes involved in development. (medlineplus.gov)

This is significant as an example of synthetic genomes aimed well beyond making mere copies of chromosomes," Harvard geneticist George Church, who was not involved in the project, told NBC News. (nbcnews.com)
a , Maximum-likelihood tree using concatenated protein sequences of 100 genes randomly selected from 4,694 Fusarium orthologous genes that have clear 1:1:1:1 correlation among the Fusarium genomes and have unique matches in Magnaporthe grisea , Neurospora crassa and Aspergillus nidulans . (nature.com)

In about 95% of cases, there is an extra separate chromosome 21 (trisomy 21), which is typically maternally derived. (msdmanuals.com)

This workflow searches for genes which reside in a QTL (Quantitative Trait Loci) region in the mouse, Mus musculus. (myexperiment.org)

Characterization of novel Bruton's tyrosine kinase gene mutations in Central European patients with agammaglobulinemia. (lu.se)

Duplication of a region of the long (q) arm of chromosome 15 can result in 15q11-q13 duplication syndrome (dup15q syndrome), a condition whose features can include weak muscle tone (hypotonia), intellectual disability, recurrent seizures (epilepsy), and characteristics of autism spectrum disorder affecting communication and social interaction. (medlineplus.gov)
It is unclear how a loss of these genes increases the risk of intellectual disability, seizures, behavioral problems, and psychiatric disorders in some individuals with a 15q13.3 microdeletion. (medlineplus.gov)
Maternally derived copy number gains of human chromosome 15q11.2-q13.3 (Dup15q syndrome or Dup15q) cause intellectual disability, epilepsy, developmental delay, hypotonia, speech impairments, and minor dysmorphic features. (ox.ac.uk)

We have recently identified a risk haplotype associated with dyslexia on chromosome 6p22.2 which spans the TTRAP gene and portions of THEM2 and KIAA0319. (ox.ac.uk)

Some genetic diseases, such as haemophilia, are carried on the X-chromosome (these X-linked disorders occur mainly in men). (who.int)

Twenty-two of these pairs are called autosomes, and the final pair are sex chromosomes (XX or XY). (eogn.com)
Autosomes line up in their pairs and exchange bits of genetic information, resulting in each egg and sperm cell having its own unique combination of genes. (eogn.com)
Anomalies that affect autosomes (the 22 paired chromosomes that are alike in males and females) are more common than those that affect sex chromosomes. (msdmanuals.com)

Four novel and three recurrent mutations of the BTK gene and pathogenic effects of putative splice mutations. (lu.se)

[5] In animal cells, chromosomes reach their highest compaction level in anaphase during chromosome segregation . (wikipedia.org)
Initially, using two fine-mapping strategies in a mouse model (recombinant progeny testing [RPT] and recombinant inbred segregation test [RIST]), we mapped a pain-related quantitative trait locus (QTL) (Pain1) into a 4.2-Mb interval on chromosome 15. (huji.ac.il)

Myriad's complaint is similar to Myriad's complaints against other defendants, and includes infringement allegations relating to its mutY homolog (MUTYH) test for hereditary colon cancer in addition to its BRCA gene patent-based claims. (patentdocs.org)
On information and belief, Defendant offers full gene sequencing and deletion/duplication analyses for the BRCA 1, BRCA 2, and MUTYH genes as part of multiple hereditary cancer panels that test cancer susceptibility using next-generation sequencing technology. (patentdocs.org)

People with dup15q syndrome resulting from an interstitial duplication often have milder signs and symptoms than those in whom the disorder results from an isodicentric chromosome 15. (medlineplus.gov)

We describe the clinical and molecular characteristics of three patients with de novo dup(15). (nih.gov)

The most common chromosome abnormality that leads to 15q11.2-q13.1 duplication, occurring in about 80 percent of people with dup15q syndrome, is called an isodicentric chromosome 15. (medlineplus.gov)

These conditions are described as genetic diseases because a defect in one or more genes or chromosomes leads to a pathological condition. (who.int)

Autosomal refers to the fact that the deletion is not found on the sex chromosomes and both males and females can be affected. (vcfsef.org)

[ 2 ] The product of the WT1 gene has zinc finger arrays that bind to specific DNA sequences, whereas the amino terminus appears to regulate transcription. (medscape.com)
Working with JAX Distinguished Visiting Professor Haoyi Wang, Ph.D., and other colleagues, Cheng was looking for a way to regulate multiple genes in the mouse and other cell and animal models. (jax.org)

The PITX gene encode the paired-like homeodomain transcription factor family. (nature.com)

Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere. (ox.ac.uk)

[4] Before this happens, each chromosome is duplicated ( S phase ), and both copies are joined by a centromere , resulting either in an X-shaped structure (pictured above), if the centromere is located equatorially, or a two-arm structure, if the centromere is located distally. (wikipedia.org)

Smad7 was confirmed as a target gene of miR-543. (cancerindex.org)

Genes are located in the center of each cell in tiny but complex molecules called chromosomes. (windows2universe.org)
The chromosome molecules contain all sorts of information about what makes you special and different from everyone else. (windows2universe.org)

Finally, we showed that human CACNG2 polymorphisms are associated with chronic pain in a cohort of cancer patients who underwent breast surgery. (huji.ac.il)
Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). (cancerindex.org)
1979. Chemicals and industrial processes associated with cancer in humans. (cdc.gov)

Duplications of chromosome region 15q11q13 often occur as a supernumerary chromosome 15. (nih.gov)
The identification of the gene responsible for Wilms tumor did not occur until 1990, when 3 groups independently identified the WT1 gene on band 11p13. (medscape.com)

We have recently isolated a cloned cDNA coding for a cytochrome P‐450 of human liver microsomal membranes, which corresponds to a major phenobarbital‐inducible cytochrome P‐450 of rat liver. (elsevierpure.com)

We have mapped the human α 7 -nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures. (johnshopkins.edu)

2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)

Experimentally, we demonstrate the transfer of two LS chromosomes between strains of F. oxysporum , converting a non-pathogenic strain into a pathogen. (nature.com)
Transfer of LS chromosomes between otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F. oxysporum . (nature.com)

Gene organization and transcription of duplicated MBP genes of myelin deficient (shi(mld)) mutant mouse. (elsevierpure.com)
Dive into the research topics of 'Gene organization and transcription of duplicated MBP genes of myelin deficient (shi(mld)) mutant mouse. (elsevierpure.com)

The project's goal is to identify the location of every human gene and to determine each gene's precise chemical structure in order to understand its function in health and disease. (markedbyteachers.com)
Multiple disease genes cause hypertrophic cardiomyopathy. (ox.ac.uk)
Condyloma acuminata (CA), a common sexually transmitted disease, is caused by human papillomavirus (HPV) ( 1 ). (spandidos-publications.com)
Disease associated SNPs were detected near ODZ3 and CDH17 genes (rs908084, p=8.59x10-9 and rs2514805, p=1.22x10-8, respectively). (cdc.gov)
The interaction of genes with each other and with environmental factors underlies many aspects of human health and disease. (who.int)
for instance, carriers of sickle-cell disease and thalassaemia genes may be protected from contracting malaria. (who.int)
for carriers of a gene and make the gene more common, even though it causes a disease when inherited from both parents. (who.int)
Understanding Genetic and Environmental Causes of Human Disease A recent article in the Archives of General Psychiatry by Hallmayer et al. (cdc.gov)

Otto Bütschli was the first scientist to recognize the structures now known as chromosomes. (wikipedia.org)

Dup15q syndrome is caused by the presence of at least one extra copy of a region of chromosome 15 called 15q11.2-q13.1. (medlineplus.gov)
The exact size of the deleted region varies, but it typically contains at least six genes. (medlineplus.gov)
Subsequent physical mapping localised Ph1 to a 2.5 Mbp region on chromosome 5BL 15 . (nature.com)
Analysis of the irradiation-mutant ph2a in comparison to the syntenic region on rice chromosome 1 estimated the deletion to be at least 80 Mb in size 22 , but more likely to span a 120 to 125 Mb region 23 on the terminal portion of 3DS. (nature.com)
Research aiming to identify Ph2 has resulted in the isolation of a number of candidate meiotic genes from this region on 3DS. (nature.com)
Although ∼40 genes are located in the 15q11.2-q13.3 region, overexpression of the ubiquitin-protein E3A ligase (UBE3A) gene is thought to be the predominant molecular cause of the phenotypes observed in Dup15q syndrome. (ox.ac.uk)
Data is then extracted from BioMart to annotate each of the genes found in this region. (myexperiment.org)
3. Creating awareness among ministries of health in the African Region will provide them with critical and relevant information on the reproductive cloning of human beings and its implications to the health status of the general population. (who.int)

This workflow takes in Entrez gene ids then adds the string "ncbi-geneid:" to the start of each gene id. (myexperiment.org)

Anatomy66

Organisms8

Diseases26

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology1

Phenomena and Processes174

Disciplines and Occupations2

Technology, Industry, Agriculture2

Information Science4

Health Care1

Genetics5

Expression27

Chromosomal10

Multigene Family2

Genomic5

Dominant3

Long arm of chromosome1

Centers for Diseas1

20221

Normal chromosomes2

Maternal5

Deletion of Chromosome1

Hybridization1

Short arm of chromosome1

Recombination6

20161

Encodes4

Transcriptional2

Sequence14

Meiosis3

Mouse chromosome1

Differentially expressed1

Proteins3

Mutation8

MRNA1

Mice1

Base pairs6

Cluster1

20012

Metaphase2

Pathways4

Variants3

Homologous1

Heredity2

Eukaryotic1

Organism2

Occurs5

Certain genes1

Genomes2

Trisomy1

Loci1

Characterization1

Intellectual disability3

Spans1

Disorders1

Autosomes3

Mutations1

Segregation2

Hereditary2

Interstitial1

Novo1

Duplication1

Defect1

Males and females1

Regulate2

Encode1

Telomere1

Centromere1

Target gene1

Molecules2

Cancer3

Occur2

Inducible1

Clinical1

Diploid1

Pathogenic2

Transcription2

Disease8

Structures1

Region8

Entrez Gene1