• renal
  • Despite the potential for renal impairment when used at anesthetic doses, no significant adverse effects have been reported in the literature when it is used at the lower doses (up to 6 milliliters) used for producing analgesia and sedation. (wikipedia.org)
  • doses
  • In general, twice daily dosing may provide a greater effect at the end of the dosing interval for higher doses of 40-80 mg/day. (pdr.net)
  • Amethocaine
  • procaine amethocaine lidocaine (also known as lignocaine) prilocaine bupivacaine levobupivacaine ropivacaine mepivacaine dibucaine cocaine Local anesthetics are agents that prevent transmission of nerve impulses without causing unconsciousness. (wikipedia.org)
  • potency
  • Meyer and Overton had discovered the striking correlation between the physical properties of general anaesthetic molecules and their potency: the greater is the lipid solubility of the compound in olive oil the greater is its anaesthetic potency. (wikipedia.org)
  • From the correlation between lipid solubility and anaesthetic potency, both Meyer and Overton had surmised a unitary mechanism of general anaesthesia. (wikipedia.org)
  • interact
  • In the last 10 years, however, numerous studies have reported that volatile anesthetic agents interact with membrane structures of the myocardium and thereby attenuate cardiac mechanical dysfunction and limit ultrastructural abnormality on reperfusion after prolonged ischemia in the myocyte. (clinicaltrials.gov)
  • Biophysical studies using state-of-the-art NMR spectroscopy has provided molecular details of how inhaled anesthetics interact with three amino acid residues (G29, A30 and I31) of amyloid beta peptide and induce aggregation. (wikipedia.org)
  • anaesthetic
  • An anesthetic (or anaesthetic) is a drug to prevent pain during surgery. (wikipedia.org)
  • The nonspecific mechanism of general anaesthetic action was first proposed by Von Bibra and Harless in 1847. (wikipedia.org)
  • They assumed that solubilization of lipophilic general anaesthetic in lipid bilayer of the neuron causes its malfunction and anaesthetic effect when critical concentration of anaesthetic is reached. (wikipedia.org)
  • skeletal muscle relaxation
  • For inpatients and outpatients as adjunct to general anesthesia, to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation in the intensive care unit (ICU). (drugs.com)
  • Production of skeletal muscle relaxation during surgery after general anesthesia has been induced. (drugs.com)
  • Vecuronium bromide, sold under the brand name Norcuron among others, is a medication used as part of general anesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation. (wikipedia.org)
  • Researchers
  • citation needed] All these common features of general anaesthetics made it hard for early researchers to believe that general anaesthetics act in a specific manner and their action on neuronal membrane was[timeframe? (wikipedia.org)
  • anaesthesia
  • These drugs are generally administered by an anaesthetist/anesthesiologist in order to induce or maintain general anaesthesia to facilitate surgery. (wikipedia.org)
  • They suggested that general anaesthetics may act by dissolving in the fatty fraction of brain cells and removing fatty constituents from them, thus changing activity of brain cells and inducing anaesthesia. (wikipedia.org)
  • dose-dependent
  • In a series of several hundred studies, for example, Consortium members identified dose-dependent effects of every major anesthetic and sedative on thermoregulatory control, and consequent alterations in heat balance. (wikipedia.org)
  • drugs
  • A wide variety of drugs are used in modern anesthetic practice. (wikipedia.org)
  • ATC code N01 Anesthetics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. (wikipedia.org)
  • Other anesthetic drugs are considered safe[by whom? (wikipedia.org)
  • practice
  • Most general practice veterinarians perform routine surgery [neuters (spay and castration), minor mass excisions, etc.], some also perform additional procedures. (wikipedia.org)
  • liver
  • Liver and kidney: The release of fluoride, bromide, and other metabolic products of the halogenated hydrocarbons can affect these organs, especially with repeated anesthetic administration over a short period of time. (slideshare.net)
  • effects
  • Combinations of anesthetics are sometimes used for their synergistic and additive therapeutic effects. (wikipedia.org)
  • Partly because of its side effects, enflurane never gained widespread popularity. (wikipedia.org)
  • Individual general anesthetics vary with respect to their specific physiological and cognitive effects. (wikipedia.org)
  • Below are several key targets of general anesthetics that likely mediate their effects: GABAA receptors are chloride channels that hyperpolarize neurons and function as inhibitory CNS receptors. (wikipedia.org)
  • It has long been believed that general anaesthetics exert their effects (analgesia, amnesia, immobility) by modulating the activity of membrane proteins in the neuronal membrane. (wikipedia.org)
  • patients
  • The study concluded that the OAT Procedure represents an excellent alternative for frozen shoulder patients not wishing to undergo painful prolonged lengthy treatment programs or higher risk procedures such as surgery or manipulation under general anesthesia. (frozenshoulderclinic.com)
  • targets
  • General anaesthetics are a structurally diverse group of compounds whose mechanisms encompasses multiple biological targets involved in the control of neuronal pathways. (wikipedia.org)
  • It looks like inhaled anesthetics act on multiple molecular targets. (wikipedia.org)