AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesNamed GroupsHealth Care
C-Reactive ProteinBlood SedimentationBiological MarkersArthritis, RheumatoidAcute-Phase ReactionSerum Amyloid A ProteinTuberculosis, MiliarySpondylitis, AnkylosingAntirheumatic AgentsNephelometry and TurbidimetryGold Sodium ThiomalatePolyarteritis NodosaLeukocyte CountMendelian Randomization AnalysisBacterial InfectionsRheumatoid FactorOrosomucoidPolymyalgia RheumaticaProspective StudiesArthritis, PsoriaticAcute DiseaseComplement C4Meningitis, ViralStatistics, NonparametricSynovitisCalcitoninSeverity of Illness IndexLatex Fixation TestsFeverCrohn DiseaseInfant, Premature, DiseasesSynovial FluidOsteoarthritisAcute-Phase ProteinsArthritisSepsisInterleukin-6Infant, NewbornPancreatitisCase-Control StudiesEnzyme-Linked Immunosorbent AssayAngina, UnstableRisk FactorsPrednisoloneTreatment OutcomePrognosisCross-Sectional StudiesTime FactorsDouble-Blind MethodInflammationFalse Positive ReactionsFollow-Up StudiesInflammation MediatorsAnti-Inflammatory AgentsCardiovascular DiseasesPredictive Value of TestsImmunoglobulin GTumor Necrosis Factor-alphaChi-Square DistributionAntibodies, MonoclonalCoronary DiseaseGlucocorticoidsAnalysis of VarianceAutoantibodiesROC CurveLipidsBody Mass IndexDrug Therapy, CombinationPilot ProjectsSensitivity and SpecificityCohort StudiesTroponin TDisease ProgressionMolecular WeightRetrospective Studies
High-sensitivity C-reactivBiomarkersFibrinogenInflammationBiomarkerCoagulationSerum albuminLipidsOxygen speciesPentraxin familyLipoproteinAcute-phase pConcentrationsLevelsQuantitativeViralTherapeuticAntibodiesAutoimmuneInterleukinMeasurementsEvaluateSystemicMarkersClinicallyIndicatorPurificationInflammatory diseaseSpikeDiagnosisPredictOutcomesBloodCardiovascular diseasePlasmaLaboratoryAminoSignificantlyPracticePatientsMechanismsStudyChronicPopulationEffectsEnzymesTestFamilyAffectsTestsResponseReference
High-sensitivity C-reactiv3
  • Despite abundant knowledge about the relationship between inflammation and coronary atherosclerosis, it is still unknown whether systemic inflammation measured as high-sensitivity C-reactive protein (hsCRP) is associated with coronary atherosclerosis in a general population. (lu.se)
  • A more sensitive CRP test, called a high-sensitivity C-reactive protein (hs-CRP) assay, is available to determine a person's risk for heart disease. (medlineplus.gov)
  • The fatty acid profile in plasma lipids contributes to the increase of plasma high sensitivity C-reactive protein (hsCRP), a marker of inflammation and predictor of cardiovascular risk. (karger.com)
Biomarkers3
  • We sought to confirm the prognostic importance of simple clinically available biomarkers of C-reactive protein, serum albumin, and ferritin prior to allogeneic hematopoietic cell transplantation. (haematologica.org)
  • It is one of the most common chronic infections and is associated with a moderate systemic inflammatory response, 3 such as raised concentrations of C reactive protein and other inflammatory biomarkers. (bmj.com)
  • 4. Investigate the utility of some biomarkers (e.g. complement reactive proteins, pro- calcitonin) and inflammatory cells in detecting neonatal sepsis. (who.int)
Fibrinogen4
  • Objective To examine if self reported toothbrushing behaviour is associated with cardiovascular disease and markers of inflammation (C reactive protein) and coagulation (fibrinogen). (bmj.com)
  • They also had increased concentrations of both C reactive protein (β 0.04, 0.01 to 0.08) and fibrinogen (0.08, −0.01 to 0.18). (bmj.com)
  • Thus, oral infections might add to the inflammatory burden of the individual and result in increased levels of cardiovascular risk based on serum C reactive protein and fibrinogen concentrations as a consequence of the systemic inflammatory response subsequent to low grade chronic infections. (bmj.com)
  • 8 C reactive protein and fibrinogen are sensitive markers used to evaluate the inflammatory status of an individual, and the results of prospective longitudinal studies indicate that these markers might be useful predictors for future cardiovascular events in various populations. (bmj.com)
Inflammation10
  • Serum or plasma C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are employed in routine clinical practice as laboratory markers of systemic inflammation. (jabfm.org)
  • C-reactive protein is considered one of the best measures of the acute phase response to an infectious disease or other cause of tissue damage and inflammation. (cdc.gov)
  • or have other any general inflammation, acute or chronic. (medscape.com)
  • It is one of a group of proteins, called acute phase reactants that go up in response to inflammation. (medlineplus.gov)
  • These proteins are produced by white blood cells during inflammation. (medlineplus.gov)
  • The CRP test is a general test to check for inflammation in the body. (medlineplus.gov)
  • C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. (wikipedia.org)
  • C-reactive protein, an indicator of acute inflammation, is the subject of considerable controversy as an important biomarker of cardiovascular health. (ift.org)
  • 2 3 Moreover, highly sensitive assays for C reactive protein and serum amyloid A protein are now available that can detect low grade inflammation that would previously have been unnoticed. (bmj.com)
  • Several reports have suggested that plasma C reactive protein and other possible markers of low grade inflammation can predict increased risks of coronary heart disease, but it is not known whether the associations are causal. (bmj.com)
Biomarker2
  • Is C-Reactive Protein a Valid Biomarker? (ift.org)
  • However, we have shown that statin therapy results in a greater clinical benefit when levels of the inflammatory biomarker C-reactive protein (CRP) are elevated and that statins lower CRP levels in a manner largely independent of LDL cholesterol levels. (natap.org)
Coagulation3
  • It is not related to C-peptide (insulin) or protein C (blood coagulation). (wikipedia.org)
  • The association between oral hygiene and inflammatory markers and coagulation was examined in a subsample of participants (n=4830) by using general linear models with adjustments. (bmj.com)
  • Can C-reactive protein predict coagulation in off pump coronary artery bypass grafting? (researchsquare.com)
Serum albumin2
  • Plasma concentrations of C reactive protein, serum amyloid A protein, and serum albumin and leucocyte count. (bmj.com)
  • Circulating concentrations of C reactive protein, serum amyloid A protein, and serum albumin and the leucocyte count can fluctuate widely during acute responses to tissue damage or infection. (bmj.com)
Lipids2
  • This course will cover the structure and function of different biological molecules, including proteins, carbohydrates, lipids and nucleic acids. (uaeu.ac.ae)
  • We applied novel statistical tools for polygenic architectures to investigate if there are common genes for depression, coronary artery disease and cardiovascular risk factors (body mass index, blood pressure, lipids, type 2 diabetes and c-reactive protein). (plos.org)
Oxygen species4
  • Oxygen is required to support life, but its metabolites such as Reactive Oxygen Species (ROS) can modify cell functions, endanger cell survival, or both. (scialert.net)
  • The excessive generation of oxygen free radicals in the form of reactive oxygen species by abnormal spermatozoa and by contaminating leukocytes has been identified as one of the few defined etiologies for male infertility. (scialert.net)
  • Another mechanism of action is related to the benefits of hormesis and the transient spike in reactive oxygen species. (truthseekerforum.com)
  • Characteristic early signaling events include Ca 2+ influx, protein phosphorylation and generation of reactive oxygen species (ROS). (biomedcentral.com)
Pentraxin family2
  • C-reactive protein (CRP) is an acute-phase protein of the pentraxin family produced in the liver in response to inflammatory signals, particularly interleukin-6, which is synergistically enhanced by IL-1β. (nature.com)
  • It is a member of the pentraxin family of proteins. (wikipedia.org)
Lipoprotein2
  • Background: Statins lower the levels of low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP). (natap.org)
  • Loci associated with increased risk for depression were also associated with increased risk of coronary artery disease and higher total cholesterol, low-density lipoprotein and c-reactive protein levels, while there was a mixed pattern of effect direction for the other risk factors. (plos.org)
Acute-phase p1
  • It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. (wikipedia.org)
Concentrations1
  • Conclusions: Up to a concentration of 160 mg/L, the Nycocard test correlated well with the reference test, while the QuikRead test underestimated concentrations above 60 mg/L. The Nycocard test seems a good candidate for CRP point-of-care testing in general practice. (eur.nl)
Levels11
  • The levels of acute phase reactants increase in response to certain inflammatory proteins called cytokines. (medlineplus.gov)
  • Until now, the relationship between C-reactive protein (CRP) levels and amyotrophic lateral sclerosis (ALS) risk has not been fully established. (frontiersin.org)
  • It is necessary to assess whether there is a causal relationship between C-reactive protein levels and ALS risk. (frontiersin.org)
  • Here, we performed a two-sample Mendelian randomization to further understand the causal effects of C-reactive protein levels on the risk of ALS. (frontiersin.org)
  • Explain the four levels of protein structure. (uaeu.ac.ae)
  • A negative correlation between high levels of IL-6-specific c-aAb and plasma levels of C-reactive protein was observed, indicating cytokine-neutralizing levels of c-aAb in healthy blood donors. (ku.dk)
  • These data suggest that autoimmunity against endogenous cytokines is a relatively common phenomenon in healthy individuals, and that predictive factors for high, potentially neutralizing c-aAb levels vary depending on the cytokine in question, and may differ from predictors of general c-aAb presence. (ku.dk)
  • Therefore, this research project tested the hypotheses that 1) compared to the general population, law enforcement officers have higher levels of pro-atherogenic inflammatory mediators and lower levels of anti-atherogenic inflammatory mediators and 2) job -related stress is associated with these differences. (cdc.gov)
  • [ 4 ] Tachycardia and elevated levels of creatine kinase, C-reactive protein, and creatinine may also suggest necrotizing fasciitis. (medscape.com)
  • Outcomes included circulating levels of interleukin 6 and C-reactive protein. (bvsalud.org)
  • Recession hardship predicted higher blood levels of inflammatory proteins associated with long-term health. (bvsalud.org)
Quantitative1
  • C-reactive protein (CRP) estimation for quantitative analysis to assess anti-inflammatory action of nonsteroidal anti-inflammatory drugs (NSAIDs) after surgery in maxillofacial surgery. (ijdr.in)
Viral2
  • Background: Point-of-care testing for C-reactive protein (CRP) may be helpful in differentiating viral from bacterial infection. (eur.nl)
  • We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
Therapeutic1
  • General recommendations and organism-specific therapeutic regimens for necrotizing fasciitis are provided below, including those for Streptococcus pyogenes , methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S aureus (MRSA), and Clostridium species. (medscape.com)
Antibodies3
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
  • In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
Autoimmune1
  • Five serious adverse events were reported, of which two were in the vaccine group (pyrexia and transverse myelitis) and three were in the control group (autoimmune haemolytic anaemia, increased C- reactive protein and myelitis). (who.int)
Interleukin1
  • Macrophages activated at the site of tissue injury produce interleukin (IL), which induces hepatocyte to synthesize acute phase proteins (APPs). (ijdr.in)
Measurements2
  • Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice. (jabfm.org)
  • Compared with men in the bottom third of baseline measurements of C reactive protein, men in the top third had an odds ratio for coronary heart disease of 2.13 (95% confidence interval 1.38 to 3.28) after age, town, smoking, vascular risk factors, and indicators of socioeconomic status were adjusted for. (bmj.com)
Evaluate3
  • The aim was to evaluate two point-of-care CRP tests (Nycocard and QuikRead) in febrile children in general practice, compared to a reference immunoturbidimetric assay. (eur.nl)
  • This study aimed to evaluate the C-reactive protein-to-albumin (CRP/albumin) ratio at diagnosis of pediatric inflammatory bowel disease (IBD). (medscimonit.com)
  • To evaluate whether preoperative C-reactive protein (CRP) can be a novel marker of postoperative bleeding in patients having off-pump coronary artery bypass grafting (CABG). (researchsquare.com)
Systemic1
  • We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)
Markers1
  • Complete blood count with some serological markers such as C-reactive protein (CRP), Amyloid A and pro-calcitonin are being used to support the diagnosis. (who.int)
Clinically1
  • 9. In good general health without clinically significant medical conditions, based on medical history, physical examination, vital signs, and clinical laboratory results as deemed acceptable by the principal investigator. (who.int)
Indicator1
  • Under a latent class model, radiography is a more efficient indicator then C reactive protein (CRP), which is, in turn, more efficient than other clinical signs and symptoms. (nih.gov)
Purification2
  • Standard protein purification and characterization techniques, enzyme activity assays, as well as immunoassays (ELISA) will also be taught. (uaeu.ac.ae)
  • Demonstrate An Understanding Of The Various Protein Purification Techniques. (uaeu.ac.ae)
Inflammatory disease1
  • In this general adult population with no overt inflammatory disease, the discordant pattern of high ESR and normal CRP was associated with greater age, whereas the pattern of high CRP and normal ESR was associated with higher BMI. (jabfm.org)
Spike1
  • We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
Diagnosis1
  • Rapid immunochromatographic test for the qualitative detection of C-reactive protein (CRP) in human whole blood, serum and plasma samples as an aid in diagnosis of acute inflammatory disorders. (tubuva.com)
Predict1
Outcomes2
  • Primary outcomes were change from baseline to end of treatment on the Positive and Negative Syndrome Scale (PANSS total, positive, negative, and general symptoms) between treatment groups. (nih.gov)
  • Secondary outcomes evaluated stress and inflammatory indices using the Perceived Stress Scale (PSS), S100 calcium-binding protein B (S100B), and C-reactive protein (CRP). (nih.gov)
Blood1
  • If this guy wants to lower his blood glucose, he may need to increase his fat intake and decrease his protein. (robbwolf.com)
Cardiovascular disease2
  • Cardiovascular disease (CVD) accounts for a significant portion of this excess illness, with published prevalences as high as 1.7 times that of the general population. (cdc.gov)
  • Patients with rheumatoid arthritis (RA) and other inflammatory joint disorders (IJD) have increased cardiovascular disease (CVD) risk compared with the general population. (bmj.com)
Plasma3
  • C-reactive protein and ferritin were centrally quantified by ELISA from cryopreserved plasma whereas each center provided pre-transplant albumin. (haematologica.org)
  • Previous studies have shown that in the general population, elevated serum or plasma CRP may lead to future vascular events [ 13 - 16 ]. (hindawi.com)
  • However, the direct effects of MCA proteins on osmotic-induced Ca 2+ influx through the plasma membrane and the osmotic signaling pathways are little understood. (biomedcentral.com)
Laboratory2
  • See the general documentation on second day laboratory exams. (cdc.gov)
  • The aim of this course is to introduce basic biochemical laboratory techniques, with emphasis on protein biochemistry. (uaeu.ac.ae)
Amino2
  • Amino acids, peptides, and proteins. (medlineplus.gov)
  • Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)
Significantly2
  • In general, β-lactams are found to be significantly more reactive than our previously studied β-lactones. (rsc.org)
  • Beginning at 4 weeks and continuing to the end of treatment, WSE produced significantly greater reductions in PANSS negative, general, and total symptoms (Cohen d: 0.83, 0.76, 0.83), but not positive symptoms, when compared to placebo. (nih.gov)
Practice1
  • Methods: A cross-sectional study was carried out of febrile children aged 3 months to 6 years presented to a general practice out-of-hours service. (eur.nl)
Patients2
  • C-reactive protein (CRP), an acute-phase reactant, was discovered in the serum of patients with pneumonia by Tillett and Francis in 1930. (ijdr.in)
  • This early study suggests that adjunctive treatment with a standardized extract of Withania somnifera provides significant benefits, with minimal side effects, for negative, general, and total symptoms and stress in patients with recent exacerbation of schizophrenia. (nih.gov)
Mechanisms2
  • 2 6 A variety of mechanisms by which C reactive protein might directly promote vascular disease have been proposed, 7 but none is proved. (bmj.com)
  • Since the prevalence of traditional CVD risk factors among law enforcement officers is similar to the general population, other mechanisms must be involved in this excessive morbidity. (cdc.gov)
Study3
  • This is the first study to explore clinician attitudes towards C reactive protein point-of-care tests (CRP POCT) for acute respiratory infections in adults in US primary care settings. (bmj.com)
  • o General: this study aims to 1. (who.int)
  • 2. Investigate associated acute phase reactive proteins/cells of neonatal sepsis o Specific: this study aims to 1. (who.int)
Chronic1
  • Chronic urticarial rash, mostly due to chronic spontaneous urticaria (CSU), is seen in up to 1 - 4% of the general population. (iasp-pain.org)
Population6
  • Setting Scottish Health Survey, which draws a nationally representative sample of the general population living in households in Scotland. (bmj.com)
  • As stated previously, DRIs are reserved for the general, healthy population. (prohealth.com)
  • Background Many studies show a link between forced expiratory volume in 1 s (FEV 1 ) and survival in the general population and this has been interpreted as a link between airway obstruction and survival. (bmj.com)
  • Over the last 40 years many studies have demonstrated a relation between survival and forced expiratory volume in 1 s (FEV 1 ) in general population samples, 1 2 and have shown that low FEV 1 is associated with high mortality from cardiovascular causes. (bmj.com)
  • Law enforcement officers have higher all-cause morbidity and mortality than the general population. (cdc.gov)
  • 1 In fact, the large number of U.S. entries from Southeast Asia during this period likely contributed to the increases observed in overall rates of stunting among the general U.S. Asian population. (cdc.gov)
Effects1
  • General linear regression models tested main effects interactions between primary predictor variables. (bvsalud.org)
Enzymes1
  • Explain The Various Ways That Enzymes Can Be Regulated, Including Post-Translational Modifications Of Proteins And Their Degradation. (uaeu.ac.ae)
Test1
Family1
  • Objective To explore clinicians views of the barriers and facilitators to use of C-reactive protein (CRP) point-of-care tests (POCT) in US family medicine clinics for the management of acute respiratory tract infections (ARTIs) in adults. (bmj.com)
Affects1
  • In general, nutrition affects cancer development somewhat indirectly. (nature.com)
Tests1
Response1
  • In addition, it wil investigate associated reactive proteins (CRP, Pro-calcitonin) and cel ular response during neonatal sepsis in major NICUs in Sana'a. (who.int)
Reference1