• CREB
  • CREB is a critical signaling node in Lysophosphatidic acid-Lysophosphatidic acid receptor and Galpha12/gep proto-oncogene stimulated oncogenic signaling in ovarian cancer cells. (nih.gov)
  • EP300 is closely related to another gene, CREB binding protein, which is found on human chromosome 16. (wikipedia.org)
  • The p300 interaction with transcription factors is managed by one or more of p300 domains: the nuclear receptor interaction domain (RID), the KIX domain (CREB and MYB interaction domain), the cysteine/histidine regions (TAZ1/CH1 and TAZ2/CH3) and the interferon response binding domain (IBiD). (wikipedia.org)
  • Regulation
  • The role of microRNA genes in carcinogenesis is recently explored and appears to be an early event in the pathogenesis of this as well as other disease processes and occurs via gene regulation by their own products, the microRNAs. (ejomr.org)
  • MicroRNA genes up-regulation can be the result of amplification, deregulation of a transcription factor or demethylation of CpG islands in promoter regions. (ejomr.org)
  • The N-terminus contains two complementary transcriptional activation domains, with a major one at residues 1-42 and a minor one at residues 55-75, specifically involved in the regulation of several pro-apoptotic genes. (wikipedia.org)
  • The proteasomal degradation pathway is essential for many cellular processes, including the cell cycle, the regulation of gene expression, and responses to oxidative stress. (wikipedia.org)
  • Heat shock prote
  • Mouse Anti Human Heat shock protein HSP 90-alpha HSP90 Alpaha antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Mouse Anti Human Heat shock protein HSP 90-alpha HSP90 Alpaha. (antibody-antibodies.com)
  • Mouse Anti Human Heat shock protein HSP 90-alpha HSP90 Alpaha Human samples 80 % of the research is conducted on human samples. (antibody-antibodies.com)
  • GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Mouse Anti Human Heat shock protein HSP 90-alpha HSP90 Alpaha. (antibody-antibodies.com)
  • Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene. (wikipedia.org)
  • subunit
  • A tyrosine residue at the C-terminus of the Galpha subunit plays an important role in controlling activation of G-protein coupled receptors. (nih.gov)
  • The proteasome subcomponents are often referred to by their Svedberg sedimentation coefficient (denoted S). The proteasome most exclusively used in mammals is the cytosolic 26S proteasome, which is about 2000 kilodaltons (kDa) in molecular mass containing one 20S protein subunit and two 19S regulatory cap subunits. (wikipedia.org)
  • 26S proteasome non-ATPase regulatory subunit 10 or gankyrin is an enzyme that in humans is encoded by the PSMD10 gene. (wikipedia.org)
  • genome
  • The identification though of microRNA genes in regions of the genome that are consistently involved in chromosomal rearrangements in cancer cells and do not contain oncogenes or tumour suppressor genes signifies a causative event in carcinogenesis [ 7 - 9 ]. (ejomr.org)
  • Their preclinical proof of principle has been proven in vivo using the antiapoptotic survivin gene PPRHs can be designed for virtually any gene in the genome by searching for polypirimidine stretches in the sequence of the desired gene. (wikipedia.org)
  • This information was gathered from both NCBI Gene and the UCSC Genome Browser. (wikipedia.org)
  • chromosomal
  • Pandolfi's elucidation of fusion oncoproteins and genes involved in the chromosomal translocations of acute promyelocytic leukemia (APL) led to the development of effective therapies. (wikipedia.org)
  • While a medical student, Pandolfi cloned and characterized PML-RARa (retinoic acid receptor alpha), the product of the long-sought after t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL) and its normal counterpart promyelocytic leukemia protein (PML). (wikipedia.org)
  • ubiquitin protea
  • This review describes the role of F-box proteins and the use of the ubiquitin-proteasome system in virus-host interactions. (mdpi.com)
  • Before the discovery of the ubiquitin proteasome system, protein degradation in cells was thought to rely mainly on lysosomes, membrane-bound organelles with acidic and protease-filled interiors that can degrade and then recycle exogenous proteins and aged or damaged organelles. (wikipedia.org)
  • As part of the Ubiquitin-Proteasome System (UPS), the proteasome maintains cardiac protein homeostasis and thus plays a significant role in cardiac Ischemic injury, ventricular hypertrophy and Heart failure. (wikipedia.org)
  • Chromosome
  • The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. (wikipedia.org)
  • These rearrangements, called translocations, disrupt the region of chromosome 22 that contains the EP300 gene. (wikipedia.org)
  • Glutamate-rich protein 3, also known as Uncharacterized Protein C1orf173 or Chromosome 1 Open Reading Frame 173, is a protein encoded by the ERICH3 gene. (wikipedia.org)
  • The ERICH3 gene in humans is 105,628 bases and is encoded on the minus strand at position 31.1 on the short arm of chromosome 1 from base pair 75,033,795 bp to 75,139,422 bp from pter. (wikipedia.org)
  • subunits
  • The outer two rings each contain seven α subunits whose function is to maintain a "gate" through which proteins enter the barrel. (wikipedia.org)
  • These α subunits are controlled by binding to "cap" structures or regulatory particles that recognize polyubiquitin tags attached to protein substrates and initiate the degradation process. (wikipedia.org)
  • Humans
  • There are 68 predicted genes coding FBPs in humans, 11 in yeast, 326 in Caenorhabditis elegans , about 700 in Arabidopsis thaliana and 600 in rice ( Oriza sativa ) [ 2 , 3 , 4 , 5 , 6 ]. (mdpi.com)
  • Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. (wikipedia.org)
  • The C1orf173 protein in humans is 1,530 amino acids in length and contains two domains of unknown function, DUF4590 and DUF4543. (wikipedia.org)
  • There are currently three known isoforms of the C1orf173 protein in humans, Q5RHP9-1 (canonical), Q5RHP9-2 and Q5RHP9-3. (wikipedia.org)
  • In humans this represents a network of roughly 2,000 interacting proteins. (wikipedia.org)
  • bind
  • The last four domains, KIX, TAZ1, TAZ2 and IBiD of p300, each bind tightly to a sequence spanning both transactivation domains 9aaTADs of transcription factor p53. (wikipedia.org)
  • Once expressed Hsp90A dimers operate as molecular chaperones that bind and fold other proteins into their functional 3-dimensional structures. (wikipedia.org)
  • PI3K can also be activated by G protein-coupled receptors (GPCR), via G-protein βγ dimers or Ras which bind PI3K directly. (wikipedia.org)
  • Factor
  • Results show that RMP serves as a potent factor contributing to portal vein tumor thrombus by promoting IL-6 transcription. (nih.gov)
  • This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in the stimulation of hypoxia-induced genes such as VEGF. (wikipedia.org)
  • A tandem of nine-amino-acid transactivation domains (9aaTAD) was identified in the AD1 and AD2 regions of transcription factor p53. (wikipedia.org)
  • It was then discovered that a previously identified protein associated with proteolytic degradation, known as ATP-dependent proteolysis factor 1 (APF-1), was the same protein as ubiquitin. (wikipedia.org)
  • degradation
  • Proteins are tagged for degradation with a small protein called ubiquitin. (wikipedia.org)
  • The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into shorter amino acid sequences and used in synthesizing new proteins. (wikipedia.org)
  • However, work by Alfred Goldberg in 1977 on ATP-dependent protein degradation in reticulocytes, which lack lysosomes, suggested the presence of a second intracellular degradation mechanism. (wikipedia.org)
  • Later, the ATP-dependent proteolytic complex that was responsible for ubiquitin-dependent protein degradation was discovered and was called the 26S proteasome. (wikipedia.org)
  • Receptor
  • Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1) at extracellular loop 2 (ECL2) controls G12/13 versus Gq G-proteins coupling specificity in response to thrombin stimulation. (nih.gov)
  • tumour
  • Common abnormalities seen in tumour cells include translocations involving FKHR and either the PAX3 or PAX7 genes. (cancerindex.org)
  • Cancer is the product of alterations in oncogenes, tumour suppressor genes and most recently microRNA genes not as a single event or single change but rather as a multistep process. (ejomr.org)
  • Pleckstrin
  • citation needed] Akt possesses a protein domain known as a PH domain, or Pleckstrin Homology domain, named after Pleckstrin, the protein in which it was first discovered. (wikipedia.org)
  • peptides
  • KO mutations and position for p53 interaction with TFIID are listed below: The competence of the p53 transactivation domains 9aaTAD to activate transcription as small peptides was reported. (wikipedia.org)
  • regulatory
  • 9aaTADs mediate p53 interaction with general coactivators - TAF9, CBP/p300 (all four domains KIX, TAZ1, TAZ2 and IBiD), GCN5 and PC4, regulatory protein MDM2 and replication protein A (RPA). (wikipedia.org)
  • histone
  • Later work on modification of histones led to the identification of an unexpected covalent modification of the histone protein by a bond between a lysine side chain of the histone and the C-terminal glycine residue of ubiquitin, a protein that had no known function. (wikipedia.org)
  • interactions
  • Besides the F-box domain, other domains and motifs related to protein-protein interactions are usually present in the C -terminal region of FBPs, such as leucine rich repeats (LRR), WD40 repeats (WD), Kelch repeats, proline-rich and others. (mdpi.com)
  • Other animals tend to have a multitude of variant forms of this gene C1orf173 is predicted to be a nuclear protein based on PSORT II analysis and the suggested protein interactions found between c1orf173 and other proteins such as TAF5L. (wikipedia.org)
  • roles
  • Pandolfi showed that both proteins play critical and essential roles in both developmental processes and cancer pathogenesis. (wikipedia.org)
  • proteasome
  • The result is a polyubiquitin chain that is bound by the proteasome, allowing it to degrade the tagged protein. (wikipedia.org)
  • Subsequently, a compromised proteasome complex assembly and function lead to reduced proteolytic activities and the accumulation of damaged or misfolded protein species. (wikipedia.org)
  • binds
  • Alternatively, adaptor molecule Grb2 binds to phospho-YXN motifs of the RTK and recruits p85 via Grb2-associated binding (GAB) scaffold protein. (wikipedia.org)
  • eukaryotes
  • F-box proteins (FBPs) are a large and diverse family of proteins present in all eukaryotes that are characterized by presence of the F-box domain [ 1 ]. (mdpi.com)
  • p300
  • The p300 protein appears to be critical for normal development before and after birth. (wikipedia.org)
  • These mutations result in the loss of one copy of the gene in each cell, which reduces the amount of p300 protein by half. (wikipedia.org)
  • Some mutations lead to the production of a very short, nonfunctional version of the p300 protein, while others prevent one copy of the gene from making any protein at all. (wikipedia.org)
  • Although researchers do not know how a reduction in the amount of p300 protein leads to the specific features of Rubinstein-Taybi syndrome, it is clear that the loss of one copy of the EP300 gene disrupts normal development. (wikipedia.org)
  • amino
  • However, the actual mass of the full-length p53 protein (p53α) based on the sum of masses of the amino acid residues is only 43.7 kDa. (wikipedia.org)