• distantly related species
  • This sequence similarity in the 5' UTR and 3' UTR does not extend past mammalian species, and shows almost no similarity in a Dot Plot of the Human gene with distantly related species, such as Xenopus tropicalis. (wikipedia.org)
  • The NRDE (DUF883) domain, is a domain of unknown function spanning majority of the C22orf25 gene and is found among distantly related species, including viruses. (wikipedia.org)
  • UniGene
  • The human expression profile from NCBI UniGene suggests that this gene has widespread expression in many different tissues in the body. (wikipedia.org)
  • causative
  • From analysis of chromosomal breakpoints, as well as gene sequencing in suggestive cases, Kleefstra and colleagues identified EHMT1 as the causative gene. (wikipedia.org)
  • Most of these studies have served to rule-out genes as causative factors in MRKH, but thus far, only WNT4 has been associated with MRKH with hyperandrogenism. (wikipedia.org)
  • binds
  • Sequence-specific transcription factor that binds gene promoters and activates their transcription. (genecards.org)
  • Expression
  • Real-time PCR primer assay designed for SYBR ® Green gene expression analysis. (bio-rad.com)
  • Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis. (bio-rad.com)
  • This expression profile suggests that this gene is a "housekeeping gene," one that has important effects in all cells, regardless of tissue. (wikipedia.org)
  • This expression data does not seem to give any clues into specific function, except to suggest that the gene is involved in a "housekeeping" function of nearly all cells. (wikipedia.org)
  • The highest levels of expression are located in mammary glands and testis. (wikipedia.org)
  • phenotype
  • The phenotype observed in the two patients was very different, as patient 2, who had the largest deletion, had severe kyphosis not observed in patient 1. (biomedsearch.com)
  • Bmx deletion does not result in any obvious phenotype ( 6 ), suggesting redundancy where other members of this gene family compensate for Bmx functions during development. (aacrjournals.org)
  • homologue
  • In Caenorhabditis elegans, the snt-1 gene (C22orf25 homologue) was expressed in the nerve ring, ventral and dorsal cord processes, sites of neuromuscular junctions, and in neurons. (wikipedia.org)
  • Adult
  • In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. (wikipedia.org)
  • Transcription
  • Near the start of transcription site in the human C16orf13 gene, there is high conservation among the primates in which upstream data was available, specifically the human, orangutan, and rhesus monkey C16orf13 gene orthologs. (wikipedia.org)