Gene is expressed expressed sequence tags. Medical search. Frequent questions

A total of 600,000 sequencing attempts were made, generating a total of 438,321 quality ESTs. (auburn.edu)
In order to select reliable SNPs, contigs containing four or more ESTs should be used and the minor allele sequence should be represented at least twice. (auburn.edu)
Application of such quality assessment measures, along with large resources of ESTs, should provide effective means for SNP identification in species where genome sequence resources are lacking. (auburn.edu)
The parallel analysis of ESTs from the two closely related ictalurid catfishes should also provide powerful means for the evaluation of ancient and recent gene duplications, and for the development of high-density microarrays in catfish. (auburn.edu)
We produced 6578 ESTs, which represented 3628 unique genes (unigenes), from cDNA libraries of cold-, drought-, and salinity-stressed plants from the Yukon ecotype of Thellungiella. (mcmaster.ca)
Some of the ESTs in this collection have low sequence similarity with those in Genbank suggesting that they may encode functions that may contribute to Thellungiella's high degree of stress tolerance when compared with Arabidopsis. (mcmaster.ca)
The chromosome bin map of ESTs is a unique resource for SNP analysis , comparative mapping, structural and functional analysis , and polyploid evolution, as well as providing a framework for constructing a sequence-ready, BAC-contig map of the wheat genome . (bvsalud.org)
We aimed to identify resistance gene analogs (RGAs) from peanut expressed sequence tags (ESTs) and to develop polymorphic markers. (jipb.net)
The protein sequences of 54 known R genes were used to identify homologs from peanut ESTs from public databases. (jipb.net)
A total of 1,053 ESTs corresponding to six different classes of known R genes were recovered, and assembled 156 contigs and 229 singletons as peanut-expressed RGAs. (jipb.net)
Sequencing of 16 M. persicae cDNA libraries generated 26,669 expressed sequence tags (ESTs). (nih.gov)
In most microarray experiments, a significant fraction of the differentially expressed mRNAs identified correspond to expressed sequence tags (ESTs) and are generally discarded from further analyses. (elsevierpure.com)
The GeneExpress® software system Fold Change Analysis Tool was used and 60 ESTs were identified that were expressed at levels at least 3-fold greater in the pancreatic cancers as compared to normal tissues. (elsevierpure.com)
Searches against the human genomic sequence and comparative genomic analysis of human and mouse genomes was carried out using basic local alignment search tools (BLAST), BLASTN, and BLASTX, for identifying protein coding genes corresponding to the ESTs. (elsevierpure.com)
We were able to definitively map 43 of the 60 ESTs to known or novel genes, and 15 of the ESTs could be localized in close proximity to a gene in the human genome although we were unable to establish that the EST was indeed derived from those genes. (elsevierpure.com)
Expressed sequence tags (ESTs) have given researchers a quick if dirty look at the coding potential of the human genome. (the-scientist.com)
Single pass sequencing of such libraries will be used to create a catalogue of Expressed Sequence Tags (ESTs) that will be used to develop single nucleotide polymorphic (SNP) markers. (europa.eu)
The short cDNA sequence Fragments when making this method are called expressed sequence tags , or ESTs. (multi-mania.be)
The NIH Office of Technology Transfer and Venter decided to use synthesis ESTs in an attempt to patent the genes they 'those given based on hun studies or mRNA expression in the human brain. (multi-mania.be)
Analysis of 20,257 high-quality ESTs yielded 6372 unique genes comprised of 3059 tentative consensus (TC) sequences and 3313 singletons (available at http://aksoylab.yale.edu ). (umd.edu)

A chromosome bin map of 16,000 expressed sequence tag loci and distribution of genes among the three genomes of polyploid wheat. (bvsalud.org)
New evidence for genome-wide duplications at the origin of vertebrates using an amphioxus gene set and completed animal genomes. (mpg.de)
Transfers of a single gene, a complete metabolic pathway 10 , whole chromosomes 11 or even cases of the integration of almost complete genomes from bacterial endosymbionts into their eukaryotic hosts 12 have been described. (nature.com)
Here, we identified RON genes from 14 vertebrate genomes and found that RON exists in all types of vertebrates including fish, amphibians, birds and mammals. (spandidos-publications.com)
BioSystems currently contains biological pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) and the EcoCyc ( Escherichia coli K-12 MG1655) subset of the BioCyc databases and is designed to accommodate other data in the future. (nih.gov)
DLGP: A database for lineage-conserved and lineage-specific gene pairs in animal and plant genomes. (openwetware.org)
LCGserver: a webserver for exploring evolutionary trajectory of gene orders in a large number of genomes. (openwetware.org)

One-third of the 471 genes predicted to encode transcription factors are differentially expressed during sexual development of S. commune . (nature.com)
In this study, a suppression subtractive hybridization cDNA library approach was used for the identification of pathogen and plant genes that were differentially expressed during infection of the susceptible cultivar BRS Pérola of Phaseolus vulgaris L. A total of 979 unigenes (430 contigs and 549 singletons) were obtained and classified according to their functional categories. (frontiersin.org)

Subsequently, in order to pick the most relevant candidate genes for a more detailed analysis, we looked for domains/motifs in the open reading frames using SMART and Pfam programs. (elsevierpure.com)
Sequence data of the revised genome annotation including several hundreds of novel transcripts, improved gene models and candidate genes for alternative splicing have been made accessible in a comprehensive database. (biomedcentral.com)
In addition candidate genes for gum production will be isolated and haplotype based association genetic tests will be used to identify and validate the association of candidate genes with gum quality. (europa.eu)

Of these unique sequences, over 35% had significant similarities to known genes by BLASTX searches, which allowed the identification of 14,776 unique genes in the catfish. (auburn.edu)
The Agilent eArray platform was used to design an M. persicae oligonucleotide microarray representing over 10,000 unique genes. (nih.gov)

An examination of the content and distribution of repetitive DNA sequences to identify the location of such sequences within specific chromosomes and their conservation across species of the Pinaceae family. (le.ac.uk)
Fluorescent in situ hybridisation (FISH) on metaphase chromosomes and on extended chromatin will be used to physically locate repetitive as well as single copy DNA sequences on conifer chromosomes and to integrate physical and genetic maps. (le.ac.uk)
This showed chromosomes carry genes and described the chromosome recombination. (timetoast.com)
Barbara McClintock found out that genes can jump around on chromosomes. (timetoast.com)
Array comparative genomic hybridization (aCGH) is a type of microarray now routinely used to identify deleted or duplicated regions of DNA sequence in specific chromosomes on a genome-wide basis. (msdmanuals.com)

Once prohibitively expensive, whole genome sequencing (WGS) was, until recently, only available to the very wealthy and accomplished and/or to researchers with unique access. (cdc.gov)
High-Quality Draft Genome Sequences for Four Drug-Resistant or Outbreak-Associated Shigella sonnei Strains Generated with PacBio Sequencing and Whole-Genome Maps. (cdc.gov)
Revisiting the taxonomy of the genus Elizabethkingia using whole-genome sequencing, optical mapping, and MALDI-TOF, along with proposal of three novel Elizabethkingia species: Elizabethkingia bruuniana sp. (cdc.gov)

This large scale EST sequencing project would allow the identification of majority of catfish transcriptome. (auburn.edu)
These expressed RGAs are the source for RGA-tagged marker development and identification of peanut resistance genes. (jipb.net)
Liu Z, Feng S, Pandey MK, Chen X, Culbreath AK, Varshney RK, Guo B (2013) Identification of expressed resistance gene analogs from peanut ( Arachis hypogaea L.) expressed sequence tags. (jipb.net)
We report here the identification of a gene associated with the hyperparathyroidism-jaw tumor (HPT-JT) syndrome. (nih.gov)
An annotated genomic sequence of the corn anthracnose fungus Colletotrichum graminicola has been published previously, but correct identification of gene models by means of automated gene annotation remains a challenge. (biomedcentral.com)
RNA-Seq offers the potential for substantially improved gene annotations and for the identification of posttranscriptional RNA modifications, such as alternative splicing and RNA editing. (biomedcentral.com)
Large-scale genomics and transcriptomics approaches have been proven to enable the identification of pathogenicity genes in fungi affecting humans or plants [ 8 ], which makes them valuable tools towards a better understanding of fungal infection mechanisms. (biomedcentral.com)
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (nih.gov)
2009. Identification and functional characterisation of effectors in expressed sequence tags from various life cycle stages of the potato cyst nematode Globodera pallida . (hutton.ac.uk)
2009. Identification of putative expansin-like genes from the pine wood nematode, Bursaphelenchus xylophilus, and evolution of the expansin gene family within the Nematoda . (hutton.ac.uk)
Identification of immune-relevant genes by expressed sequence tag analysis of head kidney from grass carp (Ctenopharyngodon idella). (openwetware.org)
Gene expression analyses using NGS platforms were carried out in the vegetative and reproductive tissues such as shoot, root, mature leaf, ﬂower bud, young pod, seed and nodule by various groups which resulted in identification of several tissue-specific transcripts. (intechopen.com)

hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (nih.gov)

These include previously unknown sequence data, a collection of expressed genes, molecular markers, and a DNA microarray that can be used to study aphid gene expression. (nih.gov)
use microarray experiments to conclude that the human genome project will uncover many genes not previously discovered by EST sequencing (Nat Genet 2000, 26:315-318). (the-scientist.com)
Approximately one half of the ORFs are expressed in at least some of the ten tissues and cell types queried by the microarray. (the-scientist.com)
Gene expression patterns in human liver cells exposed to tetrachloroethylene and it's metabolite using microarray analysis. (cdc.gov)
Over the last two decades, several laboratories have used a wide range of techniques encompassing expressed sequence tag (EST) analysis, serial analysis of gene expression (SAGE), microarray and next-generation sequencing (NGS) technologies for analysing the chickpea transcriptomes. (intechopen.com)

Hence, it means that human testis could also play a crucial role in human speciation if these two tissues exhibit similar gene expression patterns. (karger.com)
Determining the large scale anatomy of gene expression patterns of various human tissues could draw a more convincing conclusion, and better our understanding of the correlation/inter-correlation among different tissues. (karger.com)
Among the 17 tissues, the highest similarity in gene expression patterns was between human brain and testis, based on DDD and clustering analysis. (karger.com)
Bortoluzzi S, Alessi FD, Romualdi C, Danieli GA: Differential expression of genes coding for ribosomal proteins in different human tissues. (karger.com)
Sequence based assays will be developed following the creation of cDNA libraries from selected tissues of A. senegal. (europa.eu)

In addition to the information found in the GenBank records, which includes properties such as sequence, position, length and description about introns, exons and protein-coding regions, Xpro provides annotations on the splice sites and intron phases. (edu.au)
Nucleotide sequences located at the ends of EXONS and recognized in pre-messenger RNA by SPLICEOSOMES. (bvsalud.org)

The transporter was identified by probing a mammalian-expressed sequence tag database with 2 fungal mitochondrial ornithine carrier protein sequences. (medscape.com)

Analysis of genetic diversity and population structure of peanut cultivars and breeding lines from China, India and the US using simple sequence repeat markers [J]. J Integr Plant Biol. (jipb.net)
This work refines the genetic and physical location of rpt.r and rpt.k and provides an initial step towards the map-based cloning of these two genes. (usda.gov)
Genetic drift and selective forces have shaped the individual structure of a given receptor gene but also of the species-specific receptor repertoire - a process that is still ongoing. (springer.com)
Entrez is NCBI's primary text search and retrieval system that integrates the PubMed database of biomedical literature with 38 other literature and molecular databases including DNA and protein sequence, structure, gene, genome, genetic variation and gene expression. (nih.gov)
Prospective association analysis based on core drought-regulated genes may simplify the process of identifying favourable alleles, and help to understand the genetic basis of the response to terminal drought. (biomedcentral.com)
We report haplotyping data for 17 starch biosynthesis/degradation genes demonstrating the broad diversity among H. spontaneum accessions and H. vulgare landraces but rather limited genetic variance in the current elite breeding germplasm by fixing certain haplotypes. (biomedcentral.com)
Through a laborious genetic sequencing analysis, Dunn and an international team of scientists have settled the long-standing debate and determined that acoelomorpha belongs as a sister clade to other bilateral animals. (brown.edu)
The team used a genetic sequencing technique called expressed sequence tags to carry out the phylogenetic studies. (brown.edu)
Next-generation sequencing technologies have dramatically changed the approach to genetic diagnosis. (msdmanuals.com)
This revolutionary and rapidly evolving technology has moved a significant portion of the technical aspects of genetic diagnosis to next-generation sequencing and has become the mainstay of genetic diagnosis. (msdmanuals.com)
It has long been predicted that affordable WGS will revolutionize the practice of medicine and for people with rare genetic diseases, sequencing is already a useful diagnostic tool. (cdc.gov)

Analysis of gene ontology using the best matched Arabidopsis locus showed that the Thellungiella unigenes represented all biological processes and all cellular components, with the highest number of sequences attributed to the chloroplast and mitochondria. (mcmaster.ca)
GOblet: annotation of anonymous sequence data with Gene Ontology and pathway terms. (mpg.de)

The transcriptional profile of 11 fungal genes related to pathogenicity and virulence were evaluated by reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR). (frontiersin.org)

Single pass sequencing of cDNA clones provides a rapid route to gene discovery and production of EST's (2). (le.ac.uk)
Systematic sequencing of cDNA clones derived from xylem and leaf tissue will produce a new generation of research tools for conifer biology. (le.ac.uk)

In silico comparison of cDNA libraries identified aphid genes with tissue-specific expression patterns, and gene expression that is induced by feeding on Nicotiana benthamiana. (nih.gov)

The full-length viral genome sequence was characterized coronaviruses (9). (cdc.gov)
Biased phylodynamic inferences from analysing clusters of viral sequences. (cdc.gov)

Several hundred partial genomic DNA sequences as nucleotide-binding-site leucine-rich repeat (NBS-LRR) resistance genes ( R ) have been identified, but a small portion with expressed transcripts has been found. (jipb.net)
In previous work we identified a region near the centromere of barley chromosome 6H that harbored two closely linked net form net blotch resistance genes (rpt.r and rpt.k). (usda.gov)
Ten markers adjacent to the two resistance loci were tested on 20 barley net blotch resistance gene differential lines, and only two and one lines were found to have the same haplotype as Kombar and Rika, respectively, suggesting the other lines may contain different resistance genes. (usda.gov)

The differential expression of a subset of genes was confirmed at the protein level by immunohistochemical labeling of tissue microarrays (inhibin β A [INHBA] and CD29) and/or at the transcript level by RT-PCR (INHBA, AKAP12, ELK3, FOXQ1, EIF5A2, and EFNA5). (elsevierpure.com)
Initial studies with isozymes (1) indicate that pines exhibit conservation of gene order and this hypothesis will be examined further by the use of transcript based linkage maps. (le.ac.uk)

In fact, the very first individual genome sequenced, belonging to acclaimed genomics pioneer Craig Venter, was completed in 2007 at a cost of $2.7 billion . (cdc.gov)

Previous data has reported similarity between human brain and testis gene expression patterns. (karger.com)
Present results provide evidence to support the proposal that human testis and brain share the highest similarity of gene expression patterns. (karger.com)
In our laboratory, studies have been conducted to determine changes in gene expression patterns in cultured human cells exposed to TCE and TCA. (cdc.gov)
Whether difference in the expression patterns of these genes is associated with difference in carcinogenic potential of TCE and/or TCA needs to be elucidated. (cdc.gov)
Phylogenetic analyses revealed several kinds of evolutionary patterns that occurred during GPCR evolution including one-to-one orthologous relationships, species-specific gene expansion, and episodic duplication of the entire GPCR repertoire in certain species lineages. (springer.com)
The expression patterns of drought regulated genes were monitored during plant ontogeny, mapped and the location of these genes was incorporated into a comprehensive barley SNP linkage map. (biomedcentral.com)

Haplotypes within a set of 17 starch biosynthesis/degradation genes were defined, and a particularly high level of haplotype variation was uncovered in the genes encoding sucrose synthase (types I and II) and starch synthase. (biomedcentral.com)
The high level of haplotype variation among starch biosynthesis/degradation genes in the progenitors of cultivated barley shows that domestication and breeding have greatly eroded their allelic diversity in current elite cultivars. (biomedcentral.com)

HRPT2 is a ubiquitously expressed, evolutionarily conserved gene encoding a predicted protein of 531 amino acids, for which we propose the name parafibromin. (nih.gov)
Plastid-LCGbase: a collection of evolutionarily conserved plastid-associated gene pairs. (openwetware.org)

Twenty-eight simple sequence repeats (SSRs) were identified from 25 peanut expressed RGAs. (jipb.net)
Transcriptome analysis has facilitated the development of molecular markers such as simple sequence repeats (SSRs), single-nucleotide polymorphisms (SNPs) and potential intron polymorphisms (PIPs) that are being used to expedite the chickpea breeding programmes. (intechopen.com)

Comparative expressed sequence tag analysis. (mpg.de)
Comparative analysis of RNA-Seq data and the genome sequence did not provide evidence for RNA editing in C. graminicola . (biomedcentral.com)
Comparative analyses of its 38.5-megabase genome, which encodes 13,210 predicted genes, reveal the species's unique wood-degrading machinery. (nature.com)
In this study, we mined expressed sequence tag (EST) databases developed from barley and developed markers for further mapping of this region in a population derived from barley cultivars Rika and Kombar as well as did a comparative analysis of this region to other grass species. (usda.gov)

Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention. (mpg.de)
Determine level of synteny or conservation of gene order between species within the Pinaceae family. (le.ac.uk)

Furthermore, Xpro validates intron positions using alignment information between the record's sequence and EST sequences found in dbEST. (edu.au)

Among the unigenes, 94.1% encoded products that were most similar in amino acid sequence to Arabidopsis and 1.5% had no match with a member of the family Brassicaceae. (mcmaster.ca)
Unigenes from the cold library were more similar to Arabidopsis sequences than either drought- or salinity-induced sequences, indicating that latter responses may be more divergent between Thellungiella and Arabidopsis. (mcmaster.ca)
Here we report mapping of 7104 expressed sequence tag (EST) unigenes by Southern hybridization into a chromosome bin map using a set of wheat aneuploids and deletion stocks. (bvsalud.org)
These Unigenes represent a wide range of genes classified according to their characterization and function. (karger.com)

In the Fp subunit of SQR, and the closely related membrane-associated fumarate reductase of anaerobic organisms, FAD is covalently attached via an 8α-N(3)-histidyl linkage to a histidine (His) in a conserved sequence in the N-terminal part of the polypeptide. (lu.se)

The BioProject database is a searcheable collection of complete and incomplete (in-progress) large-scale molecular projects including genome sequencing and assembly, transcriptome, metagenomic, annotation, expression and mapping projects. (nih.gov)

They scan 350 Mb of finished and draft human sequence using three different gene-finding algorithms. (the-scientist.com)
Single-gene knockout-coupled omics analysis identifies C9orf85 and CXorf38 as two uncharacterized human proteins associated with ZIP8 malfunction. (nih.gov)
DNA sequence and analysis of human chromosome 9. (nih.gov)
Biotin labeled cRNA transcripts were synthesized, fragmented and hybridized to HuGeneFL GeneChip probe arrays representing more than 6800 human genes and expressed sequence tags. (cdc.gov)
The human RON gene was originally cloned from keratinocytes ( 1 ). (spandidos-publications.com)
Conserved transcription factor-binding sites within promoter regions of human RON genes were then searched. (spandidos-publications.com)
Functional networking of human divergently paired genes. (openwetware.org)
and he Began to use it to Identify genes welke are Expressed in the human brain. (multi-mania.be)
Venter believed therein shotgun sequencing was the fastest and must effective way to get useful human genome data. (multi-mania.be)
[26] The goal of the company was to sequence the entire human genome and release it into tje public domain for non-commercial use in much less time and for much less cost dan the public human genome project. (multi-mania.be)
By comparing the sequences of humans and other primates, Stedman's team estimated that MYH16 had lost its function in human ancestors around 2.4 million years ago. (johnhawks.net)
The human coding sequence of MYH16 has a frameshift mutation that prevents translation of the functional product. (johnhawks.net)
The human SLC6A19 gene was cloned independently by 2 groups of researchers in 2004. (medscape.com)
Now within reach, our personal genomic sequence offers an incredible reflection of who we are, and great promise to improve human health, but there are serious concerns about embracing it too quickly. (cdc.gov)
Francis Collins, Director of the National Institutes of Health described the human genome sequence as "… our own instruction book previously only known to God. (cdc.gov)

Among the nTARs, 146 share significant similarity with proteins that have been identified in other species suggesting that they are hitherto unidentified genes in C. graminicola . (biomedcentral.com)
These processes have left footprints in the genomic sequence that can be detected by bioinformatic methods and may help to interpret receptor function in the light of a given species in its environment. (springer.com)

Over 300,000 putative SNPs have been identified, of which over 48,000 are high quality SNPs as defined by contig size of at least four sequences and the minor allele presence of at least twice in the contig. (auburn.edu)
The localization of the HKE2 gene to the class II region, its cytoplasmic expression and putative protein-binding domain suggest that HKE2 may function in adaptive immunity and cancer. (genscript.com)
We analysed the putative fat body transcriptome based on homology to other gene products with known functions available in the public domain. (umd.edu)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

It is the only mushroom-forming fungus for which genes have been inactivated by homologous recombination. (nature.com)
investigated the fungus at the level of gene expression, and performed proteome-level studies ( Yajima and Kav, 2006 ). (frontiersin.org)

Sequencing of the two leading filamentous fungi used in cheese making, P. roqueforti and P. camemberti , and comparison with the penicillin producer P. rubens reveals a 575 kb long genomic island in P. roqueforti -called Wallaby -present as identical fragments at non-homologous loci in P. camemberti and P. rubens . (nature.com)

these effects are thought to involve alterations in gene expression. (jneurosci.org)
These effects are, in part, mediated by sustained alterations in gene expression in selected brain regions. (deepdyve.com)

The valuable source of large-scale genomic information initiated attempts to identify the origin(s) of G protein-coupled receptors (GPCR), count and categorize those genes, and follow their evolutionary history. (springer.com)
Thus the present study was designed to determine gene expression profiles in the hippocampus and cerebellum of 6-month-old APP Sw mice compared with age-matched controls and to identify potential mechanisms responsible for protecting neurons from Aβ toxicity. (jneurosci.org)

Genes contributing to the similarity include ribosomal protein (RP) genes as well as genes involved in transcription, translation and cell division. (karger.com)
Expression analysis of the three yolk proteins indicates that all are detected in females, while only the yolk protein with similarity to lipases, is expressed in males. (umd.edu)

The extracellular sequences of RON contain several domains including an N-terminal semaphorin (sema) domain, followed by the plexin, semaphorin, integrin (PSI) domain, and four immunoglobulin, plexin, transcription factor (IPT) domains. (spandidos-publications.com)

Segregating populations will be characterised with both single locus (microsatellites) and multi-locus (AFLPs) marker systems providing framework maps for the eventual location of cDNAs generated from single pass sequencing. (le.ac.uk)

The following PFDN6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)

Reasonable intraspecies sequence variability in GPCR is either physiologically tolerated or promotes individual phenotypes and adaptation, but also susceptibilities for diseases. (springer.com)

Alice: Endosperm-preferred expression of maize genes as revealed by transcriptome-wide analysis of expressed sequence tags. (embrapa.br)

These rapid adaptations in fungi provide excellent models for studying general processes of eukaryotic genome evolution, including the functional and ecological impact of horizontal gene transfer 1 and changes in metabolism 2 . (nature.com)
The importance of S. commune as a model system is also exemplified by the fact that its recombinant DNA constructs will express in other mushroom-forming fungi 5 . (nature.com)

When Barbara figured out that genes can "jump" she than correlated microscopic arrangments of chromosome placements. (timetoast.com)
S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. (cancerindex.org)

Mutations in the SLC6A19 gene, which encodes the SLC6A19 (B 0 AT1) neutral amino acid transporter, causes a failure of the transport of neutral (ie, monoaminomonocarboxylic) amino acids in the small intestine and the renal tubules. (medscape.com)

Despite these examples, the lack of specific evolutionary trends in reported cases of lateral gene transfer in eukaryotes has led to the view of ancient, sporadic and isolated events with relatively little global impact on eukaryotic kingdoms, rather than a more frequently and widely occurring phenomenon. (nature.com)
The chapter summarizes evolutionary processes working on GPCR genes and sheds light on their consequences at the levels of receptor structure and function. (springer.com)
Sequence comparison does not support an evolutionary link between halobacterial retinal proteins including bacteriorhodopsin and eukaryotic G-protein-coupled receptors. (springer.com)
Our findings on the age of the inactivating mutation in the MYH16 gene raise the intriguing possibility that the decrement in masticatory muscle size removed an evolutionary constraint on encephalization, as suggested by the anatomy of the muscle attachments relative to the sutures. (johnhawks.net)

Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)

This technology involves breaking the entire genome into small segments, sequencing the segments, and then reassembling the sequences using intensive computational techniques to provide the base-by-base sequence of the entire genome or more limited regions, such as the expressed portion of the genome known as the exome. (msdmanuals.com)

The tagged DNA binds to its complementary DNA segment and can be detected by measuring the amount and type of fluorescence. (msdmanuals.com)

Using a positional candidate approach, we identified thirteen different heterozygous, germline, inactivating mutations in a single gene in fourteen families with HPT-JT. (nih.gov)
It was just a study of a single gene, but this work generated an outsized reaction. (johnhawks.net)

Soon after, the genome of James Watson, the co-discoverer of the DNA molecule, was sequenced as well. (cdc.gov)

Xpro is a relational database that contains all the eukaryotic protein-encoding DNA sequences contained in GenBank with associated data required for the analysis of eukaryotic gene architecture. (edu.au)
The intron-containing genes in the Xpro are also classified as experimental or predicted based on the intron position validation and specific keywords in the GenBank records that are present in predicted genes. (edu.au)
In 2004, a causative gene, SLC6A19 (MIM#608893, Genbank accession NM 001003841) , was located on band 5p15.33. (medscape.com)

Anatomy9

Organisms15

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes42

Disciplines and Occupations3

Technology, Industry, Agriculture4

Information Science12

Health Care1

ESTs20

Genomes7

Differentially expressed2

Candidate genes3

Unique genes2

Chromosomes5

Whole genome3

Identification12

Representing over 10,0001

Microarray5

Tissues5

Exons2

Protein sequences1

Genetic11

Ontology2

Fungal1

CDNA clones2

Libraries1

Viral2

Resistance genes3

Transcript2

Genomics1

Patterns6

Biosynthesis2

Evolutionarily conserved2

Simple sequenc2

Comparative4

Synteny2

DbEST1

Unigenes4

Linkage1

Annotation1

Human15

Species2

Putative3

Datasets1

Fungus2

Fragments1

Alterations in gene expression2

Identify2

Similarity2

Transcription1

CDNAs1

RefSeq1

Phenotypes1

Analysis of expressed1

Fungi2

Chromosome2

Encodes1

Evolutionary4

Genetics1

Base Sequence1

Complementary1

Single gene2

Molecule1

Genbank3