• protein-codin
  • A recent study found only one-fifth of transcription across the human genome is associated with protein-coding genes, indicating at least four times more long non-coding than coding RNA sequences. (wikipedia.org)
  • Quantitatively, lncRNAs demonstrate ~10-fold lower abundance than mRNAs in a population of cells, which is explained by higher cell-to-cell variation of expression levels of lncRNA genes in the individual cells, when compared to protein-coding genes. (wikipedia.org)
  • While long ncRNAs are located and transcribed within the intergenic stretches, the majority are transcribed as complex, interlaced networks of overlapping sense and antisense transcripts that often includes protein-coding genes. (wikipedia.org)
  • It is estimated that 1 to 5% of all mammalian genes encode for miRNA, which regulate the expression of approximately 30% of all of the protein-coding genes [ 4 , 5 ], and that each miRNA on average regulates 200 target genes through an interaction between the seed sequence and the complementary target sites [ 6 ]. (ijbs.com)
  • cellular
  • The GENCODE consortium has collated and analysed a comprehensive set of human lncRNA annotations and their genomic organisation, modifications, cellular locations and tissue expression profiles. (wikipedia.org)
  • sequence
  • There have been several attempts to delineate the different categories of selection signatures seen amongst lncRNAs including: lncRNAs with strong sequence conservation across the entire length of the gene, lncRNAs in which only a portion of the transcript (e.g. 5' end, splice sites) is conserved, and lncRNAs that are transcribed from syntenic regions of the genome but have no recognizable sequence similarity. (wikipedia.org)
  • study
  • An extensive study considering 37 higher plant species and six algae came out at the end of 2015 and identified ~200,000 non-coding transcripts using an in-silico approach. (wikipedia.org)
  • With this study it was created the Green Non-Coding Database (GreeNC), which is a repository of plant lncRNAs. (wikipedia.org)