• metabolism
  • This gene encodes an essential enzyme of nucleotide metabolism. (wikipedia.org)
  • Since many chemotherapeutic agents such as 5-fluorouracil treat neoplastic diseases, including head and neck cancer, breast cancer, and gastrointestinal cancer, by targeting TS in thymidylate metabolism, DUT may protect against the cytotoxic side effects by countering dUTP accumulation. (wikipedia.org)
  • Mice
  • SCID mice with tumour xenografts with inducible MT1h expression had lower tumour volumes as well as fewer metastases and deaths than uninduced controls. (biomedsearch.com)
  • A study on mice found that a specific subset of mouse genes (7%) was deregulated in the absence of HDAC1. (wikipedia.org)
  • human chromosome
  • The PTGER4 gene is located on human chromosome 5p13.1 at position p13.1 (i.e. 5p13.1), contains 7 exons, and codes for a G protein coupled receptor (GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see rhodopsin-like receptors#Subfamily A14). (wikipedia.org)
  • encodes
  • In humans, this gene encodes a homotrimeric enzyme with two isoforms characterized by their distinct subcellular localizations: the nuclear isoform (DUT-N) and mitochondrial isoform (DUT-M). Northern blot analysis reveals distinct mRNA transcripts for DUT-N (1.1 kb) and DUT-M (1.4 kb). (wikipedia.org)
  • promotes
  • D) Model showing that NF1 loss through Ras activation promotes ERK activation and AP-1, thereby suppressing MAF expression. (nih.gov)
  • chromosome
  • DUTP pyrophosphatase, also known as DUT, is an enzyme which in humans is encoded by the DUT gene on chromosome 15. (wikipedia.org)
  • ING1 is located near the following genes on Chromosome 13 CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function) COL4A2: A2 Subunit of type IV collagen RAB20: Potential regulator of Connexin 43 trafficking. (wikipedia.org)
  • By copying and replacing the altered area with a very similar area on the sister homolog chromosome, the gene can be replicated as if nothing was ever wrong on the chromosome. (wikipedia.org)
  • Phenotype
  • hTERT expression includes phenotype-specific RNA maturation and correlates with TA but not with TL. (ac.be)
  • A wide ratio of TA to hTERT expression between leukemia subtypes suggests phenotype-specific hTERT post-transcriptional deregulations. (ac.be)
  • Genetic
  • Genetic and epigenetic changes can occur at many levels, from gain or loss of entire chromosomes, to a mutation affecting a single DNA nucleotide, or to silencing or activating a microRNA that controls expression of 100 to 500 genes. (wikipedia.org)
  • Tumor suppressor genes are often disabled by cancer-promoting genetic changes. (wikipedia.org)
  • promoters
  • The isoforms are produced from alternative splicing at different 5' exons, with the first exon of DUT-N occurring 767 base pairs downstream of the first exon in DUT-M. Regulation at different promoters has been proposed to account for the differential expression of these isoforms. (wikipedia.org)
  • effects
  • Thus the re-establishment of gene control by PRH is in part responsible for the therapeutic effects of dasatinib. (biomedsearch.com)