• metabolism
  • Our results suggest that increasing 5-HT production during the transition from pregnancy to lactation increases mRNA expression of enzymes involved in energy metabolism in the liver, and mRNA abundance and distribution of glucose transporters within the mammary gland. (nih.gov)
  • In the presence of toluene, menadione reduced TodS activity whereas toluene did not stimulate activity in the presence of menadione.The opposing effects of menadione on glucose and toluene metabolism may be partially responsible for the interwoven regulation of both catabolic pathways.This work provides mechanistic detail on how complex sensor kinases integrate different types of signal molecules. (nih.gov)
  • Glucose
  • Serotonin (5-HT) affects expression of liver metabolic enzymes and mammary gland glucose transporters during the transition from pregnancy to lactation. (nih.gov)
  • Feeding 5-HTP resulted in increased mRNA expression of key gluconeogenic and glycolytic enzymes in liver and glucose transporters 1 and 8 (GLUT-1, -8) in the mammary gland. (nih.gov)
  • Mice
  • Examination of beta-galactosidase expression in heart, lung, kidney, liver, spleen, and brain of adult mice demonstrated robust signal in large and medium-sized blood vessels. (biomedsearch.com)
  • Western blotting of microdissected kidney nephron segments confirmed that expression of the thiazide-sensitive NCC (Na⁺-Cl⁻ co-transporter) was increased, as expected, in the distal convoluted tubule when transgenic mice were induced with doxycycline. (biomedsearch.com)
  • This inducible model shows, for the first time, that in vivo expression of a mutant WNK4 protein is sufficient to cause the rapid and reversible appearance of a PHAII disease phenotype in mice. (biomedsearch.com)
  • Plant
  • Expression patterns of various stress responsive genes were enhanced, and the activities of anti-oxidative enzymes were elevated in transgenic plants, suggesting a possible involvement of AtIpk2beta in plant stress responses. (nih.gov)
  • Expression of AtIpk2β in the transgenic plant was controlled by the Cauliflower Mosaic Virus (CaMV) 35S promoter. (nih.gov)
  • Constitutive expression of AtIpk2β did not affect overall plant morphology although the transgenic plants grew slightly faster than wild type plants under normal growth condition. (nih.gov)
  • fetal
  • Therefore, we assessed p-RNAPII S2 at the promoter and exonic region of fetal cardiac genes and of GATA-4 in neonatal rat cardiomyocytes transfected with control siRNA (siCT) or siRNA against 14-3-3 (si14-3-3) after stimulation with the hypertrophic agonist phenylephrine (Figure 6B). (nih.gov)
  • effects
  • Finally, "in vivo" effects of S6K suppression were analyzed in the permanent middle cerebral artery occlusion model of ischemia , in which absence of S6K expression increased mortality and infarct volume. (curehunter.com)
  • major
  • The amount of RBCS synthesized was tightly correlated with rbcL mRNA level among genotypes but not associated with changes in mRNA levels of other major chloroplast-encoded photosynthetic genes. (biomedsearch.com)
  • transgenic
  • These transgenic eNOS promoter-reporter lines will be a valuable resource for ongoing studies addressing the regulated expression of eNOS in vivo in both health and disease. (biomedsearch.com)
  • Several PHAII inducible transgenic mouse lines were created, each with differing TG (transgene) copy numbers and displaying varying degrees of TG expression (low, medium and high). (biomedsearch.com)
  • enzyme
  • Alternatively, the enzyme is recruited in response to the stimulus of gene activation (Adelman et al. (nih.gov)
  • Enzyme inhibition can refer to the inhibition of the expression of the enzyme by another molecule interference at the enzyme-level, basically with how the enzyme works. (wikipedia.org)
  • activity
  • The activity and expression of NTPDase is altered in lymphocytes of multiple sclerosis patients. (biomedsearch.com)
  • We evaluated the activity and expression of NTPDase and adenosine deaminase (ADA) activity in lymphocytes from patients with the relapsing-remitting form of MS (RRMS). (biomedsearch.com)
  • OGD-induced apoptosis was increased by the combined deletion of S6K1 and S6K2 genes, as well as by treatment with rapamycin that inhibits S6K1 activity by acting on the upstream regulator mTOR (mammalian target of rapamycin ). (curehunter.com)
  • Expression of AtIpk2beta rescued the salt-, osmotic- and temperature-sensitive growth defects of a yeast mutant strain (arg82Delta) that lacks inositol polyphosphate multikinase activity encoded by the ARG82/IPK2 gene. (nih.gov)
  • levels
  • CONCLUSIONS: The regulation of ATP and adenosine levels by NTPDase and ADA activities may be important to preserve cellular integrity and to modulate the immune response in MS. (biomedsearch.com)
  • Rescue of either S6K1 or S6K2 expression by adenoviral infection revealed that protective functions were specifically mediated by S6K1, because this isoform selectively promoted resistance to OGD and reduction of ROS levels. (curehunter.com)
  • p-RNAPII S2 increased at ANP, β-MHC and GATA-4 exonic regions in cells with normal expression of 14-3-3, but not in cells with reduced 14-3-3 levels (Figure 6C). (nih.gov)
  • Role
  • The aim of the current investigation was to delineate the role of kallikrein in the regulation of fibrosis, by 'knocking down' its expression using specific small interfering RNAs (siRNA). (biomedsearch.com)
  • plants
  • In higher plants genes encoding inositol polyphosphate kinases have been identified previously, but their physiological functions have not been fully resolved. (nih.gov)