• protein-codin
  • In contrast to conventional protein-coding genes, the sequences, transcriptional start sites, exon structures, and lengths for these non-coding genes are all highly variable. (biomedcentral.com)
  • It is estimated that 1 to 5% of all mammalian genes encode for miRNA, which regulate the expression of approximately 30% of all of the protein-coding genes [ 4 , 5 ], and that each miRNA on average regulates 200 target genes through an interaction between the seed sequence and the complementary target sites [ 6 ]. (ijbs.com)
  • brain
  • We identify some of the first lncRNA orthologs present in birds (chicken), marsupial (opossum), and eutherian mammals (mouse), and investigate whether they exhibit conservation of brain expression. (biomedcentral.com)
  • Instead, their preservation across diverse amniotes, their apparent conservation in exon structure, and similarities in their pattern of brain expression during embryonic and early postnatal stages together indicate that these are functional RNA molecules, of which some have roles in vertebrate brain development. (biomedcentral.com)