• biological
  • Current challenges can be expected to remain as RNA sequencing matures, and they will thus motivate ongoing research efforts into noise reduction and identification of robust, translationally relevant biological signals in expression data from FFPE tissues. (duhnnae.com)
  • These genes were involved in variable important biological processes including ion transport, cysteine metabolic process, apoptosis, DNA damage repair, etc. (duhnnae.com)
  • profiles
  • We tested reproducibility by comparing the expression profiles provided by U133 Plus 2.0 GeneChipsĀ® for 3 independently amplified RNA samples: a high degree of correlation between the replicates was obtained. (unimi.it)
  • Chip
  • Current cancer research makes use primarily of DNA microarrays in which an arrayed series of microscopic spots of pre-defined DNA oligonucleotides known as probes are covalently attached to a solid surface such as glass, forming what is known as a gene chip. (wikipedia.org)
  • DNA labeled with fluorophores (target) is prepared from a sample such as a tumor biopsy and is hybridized to the complementary DNA (cDNA) sequences on the gene chip. (wikipedia.org)
  • studies
  • ResultsThe Emerging Technologies for Translational Bioinformatics symposium on gene expression profiling for archival tissues featured presentations of two large-scale FFPE expression profiling studies each involving over 1,000 samples, overviews of several smaller studies, and representatives from three leading companies in the field Illumina, Affymetrix, and NuGEN. (duhnnae.com)
  • patients
  • A total of 142 genes were differentially expressed (115 genes were upregulated and 27 downregulated) between the patients with any stage of ROP compared to the no-ROP premature controls. (arvojournals.org)