Gene expression sperm sex chromatin. Medical search. Frequent questions

Cells are normally diploid - this means that they have a pair - two sets of homologous chromosomes, and hence two copies of each gene or genetic locus. (topperone.com)
Haploid: only has one set of chromosomes - i.e. in a sperm or oocyte. (topperone.com)
Chromosomes, Genes and DNA Chromosomes are made up of DNA (deoxyribonucleic acid), the hereditary material in humans and most of other organisms. (newpathworksheets.com)
There are about about 100000 genes found on human chromosomes. (newpathworksheets.com)

Last week I finally matched my list of enriched GOterms with gene IDs and methylation difference information. (github.io)
I searched for each of the gene products in publicly available DML lists from the four other ocean acidification and methylation in oyster studies: Downey-Wall et al. (github.io)
Changes in methylation of this gene could impact progression of gametogenesis or embryogenesis. (github.io)
Potential methylation regulation of chromatin structure. (github.io)
Increased expression of this gene in Artemia sinica can suppress cell division and macromolecule synthesis (Jiang 2011), so methylation may be regulating gonad development. (github.io)
In a pilot study, our group recently demonstrated that cannabis use in humans, and exposure to delta-9-tetrahydrocannabinol (THC, the main psychoactive component of cannabis) in rats, is associated with significantly altered levels of DNA methylation in sperm. (duke.edu)
The hypothesis of this research was that cannabis exposure is associated with heritable, but reversible, changes in DNA methylation in sperm at genes important for early life development. (duke.edu)
Broadly, the main objectives of this thesis research were to generate meaningful data to contribute to the gaps in knowledge of how cannabis can impact sperm DNA methylation. (duke.edu)
An initial pilot study from our group used reduced representation bisulfite sequencing (RRBS) to analyze methylation changes in sperm between cannabis users and controls. (duke.edu)
Use of human fetal brain tissues demonstrated that there is a significant, sex-specific, inverse relationship between DNA methylation and gene expression at this locus. (duke.edu)
Bisulfite pyrosequencing identified significant changes in rat sperm DNA methylation at Dlgap2, as well as significant losses of methylation at the same locus in F1 nucleus accumbens (NAc) tissues. (duke.edu)
Having demonstrated that autism candidate gene DLGAP2 shows functional changes in DNA methylation, the next question addressed was whether different routes of THC exposure, and exposure to different drugs, could similarly impact DNA methylation at a select group of neuroactive genes. (duke.edu)
Bisulfite pyrosequencing of sperm DNA from rats exposed to injected THC or vehicle control was performed to examine methylation at regions identified by RRBS. (duke.edu)
In the sperm of rats injected with THC and those nicotine-exposed, significant differential methylation at five of seven neurodevelopmentally active genes that were initially identified as significantly altered by oral gavage was identified. (duke.edu)
As such, they can include but are not exclusive to DNA methylation , histone modifications , non-coding RNA , and the structure of chromatin . (whatisepigenetics.com)
They specifically focused on differentially methylated regions (DMRs) where DNA methylation , which is associated with gene silencing, differed between the control and HFD mice. (whatisepigenetics.com)
Sperm DNA methylation is predominantly stable in mice offspring bornafter transplantation of long-term cultured spermatogonial stem cells. (diagenode.com)

Gametic epigenetic changes - the collection of molecular modifications made to DNA and histone proteins that play a role in regulating gene activity - provide one potential explanation. (duke.edu)
Lastly, two publicly available datasets were investigated to determine significant overlap between a known list of autism candidate genes and a list of genes with bivalent chromatin, a unique epigenetic feature. (duke.edu)
Sex differences at the genetic/epigenetic level in early development. (ubc.ca)
This effect is accompanied by epigenetic changes involving histone post-translational modifications at the mineralocorticoid receptor (MR) gene and decreased MR expression in the hippocampus. (nature.com)
These findings highlight the beneficial impact that early adverse experiences can have in adulthood, and the implication of epigenetic modes of gene regulation. (nature.com)
This is accompanied by epigenetic changes at the mineralocorticoid receptor (MR) gene and decreased MR expression, that can be mimicked in vivo by pharmacological blockade of MR. These findings highlight the potential adaptive benefit of adverse experiences in early life, and implicate a stress hormone receptor and its epigenetic regulation. (nature.com)
The term epigenetic here refers to marks that are involved in potentially altering heritable gene activity states that are not dependent on changes in DNA sequence 2 . (whatisepigenetics.com)
They investigated the transmission of hedonic behaviors, metabolic phenotypes, and the sperm DNA methylome in subsequent generations of mice exposed to a HFD - producing interesting results for the transgenerational epigenetic field and influencing what direction it will go in the future. (whatisepigenetics.com)
27, 2022 - Researchers have discovered a gene responsible for prenatal death when critical epigenetic instructions are missing from egg cells. (lesvilains.com)
Abstract Early mouse development is characterized by structural and epigenetic changes at the chromatin level while cells progress towards differentiation. (sciencegate.app)

Polycomb group (PcG) proteins maintain the repressed state of lineage-inappropriate genes and are therefore essential for embryonic development and adult tissue homeostasis. (bvsalud.org)
2020). Higher expression of dynein proteins over the course of spermatogeneisis in C. gigas (Dheilly et al. (github.io)
Both Gre proteins encoded in the eno gene encoding a subunit of cytochrome bd. (itwontfailbecauseofme.com)
When analyzing P2 (sperm offense), we additionally included mating number and its two-way interactions with experimental removal of natural lipids Lipids were extracted from the TCDB database, we clustered archaeal proteins within a core archaeal-type membrane chemistry. (itwontfailbecauseofme.com)
All living organisms package their DNA with chromatin proteins. (biologists.com)
The initial domains of homeotic gene repression are set by the segmentation proteins, which also divide the embryo into segments. (nih.gov)
Sperm competition risk drives plasticity in seminal fluid proteins that enhance post-copulatory fertilization order yasmin online success. (eviematilda.art)
In eukaryotic cells, chromatin comprises a complex consisting of DNA, RNA, and proteins where covalent modifications correlate with regulation of gene expression [ 1 ]. (biomedcentral.com)
It possesses DNA, which directs the formation of proteins and enzymes in the cell, it controls the gene expression and regulates other functions performed by the cell. (topperone.com)
I'm talking about genes, DNA, genetic recombination and all that we know about meiosis and mitosis, spermatogenesis and oogenesis, genomics and epigenetics, mitochondrial DNA, ribosomes, mRNA, proteins and the like, none of which I'm particularly knowledgeable about - but surely even what I know about it all would make Darwin's head explode. (ussromantics.com)

Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3. (ens-lyon.fr)
These results emphasize that the regulation of chromatin structure by CBX2 at a specific stage of spermatogenesis is critical, which distinguishes this from a mechanism that is reliant on histone modification. (bvsalud.org)
Helicase domino: Exchanges phosphorylated histone for acetylated form, with chromatin remodeling impacting gene expression. (github.io)
Structure of histone-based chromatin in Archaea. (itwontfailbecauseofme.com)
We propose that GLP-1/Notch promotes reprograming by activating specific genes, silenced by the Polycomb repressive complex 2 (PRC2), and identify the conserved histone demethylase UTX-1 as a crucial GLP-1/Notch target facilitating reprograming. (scite.ai)
Diet-induced obesity led to altered acetylation of lysine 27 on histone H3 (H3K27ac) and to altered monomethylation of lysine 4 on histone H3 (H3K4me1) at numerous loci, with concomitant changes in the expression of genes that were functionally relevant to intestinal cancers. (biomedcentral.com)
2021) Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression. (oeaw.ac.at)

The Hsf1(-/-) male mice displayed regions of seminiferous tubules containing only spermatogonia and increased morphological abnormalities in sperm heads. (abo.fi)
The primordial germ cells differentiate in the testis, in these seminiferous tubules… But let me first fast forward to the end of the process and describe a complete, mature sperm cell or spermatozoon. (ussromantics.com)
Immotile sperm flow from the lumen of the seminiferous tubules into the epididymis via the rete testis. (jci.org)

Dynein heavy chain 5, axonemal: Associated with sperm (flagellar and cillar) motility). (github.io)
2012). Dynein does not have strict functions relating to sperm motility. (github.io)
Overall, most human studies associate marijuana use with a deleterious impact on male fertility status, mainly because of the correlation with lower sperm concentrations, morphologic abnormalities, and reduced motility and viability ( 6 - 9 ). (frontiersin.org)
During their passage through the epididymis to the vas deferens, sperm acquire their motility. (jci.org)

The Drosophila chromosomal protein Mst77F is processed to generate an essential component of mature sperm chromatin. (ens-lyon.fr)
Disruption of Hsf1, together with another HSF family member, Hsf2, causes male sterility and complete lack of mature sperm in mice, but the specific role of HSF1 in spermatogenesis has remained unclear. (abo.fi)

We therefore compared the expression of irradiation responsive genes can you get high on ventolin in macrophages. (itwontfailbecauseofme.com)
Expression of order yasmin online irradiation responsive genes independently (Table 2). (eviematilda.art)

Overall, genes are mainly involved in developmental progression and regulation. (github.io)
Control of gene expression at transcription and translation level: Regulation of phages, viruses, prokaryotic and eukaryotic gene expression, role of chromatin in regulating gene expression and gene silencing. (pathfinderacademy.in)

The use of three different mouse models (Brdt knock-out mice, mice expressing a non-functional Brdt and mice expressing a mutated Brdt lacking its first bromodomain) showed that Brdt drives a meiotic and post-meiotic gene expression program. (wikipedia.org)
The mechanism of action of JQ1 could be explained by considering Brdt's functions as a driver of testis-specific gene expression and post-meiotic chromatin reorganization. (wikipedia.org)
Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system. (ens-lyon.fr)
Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive. (ens-lyon.fr)
In mice, previous studies revealed that MEIOC, alongside binding partners YTHDC2 and RBM46, represses mitotic genes and promotes robust meiotic gene expression in spermatogenic cells that have already initiated meiosis. (bvsalud.org)
This confers on spermatogenic cells the molecular competence to, in response to retinoic acid, fully activate the STRA8-MEIOSIN transcriptional regulator, which is required for the meiotic G1/S cell cycle transition and meiotic gene expression. (bvsalud.org)
In addition, our results show that HSF1 localizes to the sex body prior to the meiotic divisions and to the sex chromocenter after completed meiosis. (abo.fi)

When not physically linked, the elements interact with elements on the homologous chromosome and cause derepression of its wild-type Scr gene. (nih.gov)
how- felter syndrome is characterized by X chromosome polys- ever, successful sperm recovery from men with Kline- omy with X disomy being the most common variant felter syndrome indicating that adolescents with Kline- (47,XXY). (health-abstracts.com)
Each chromosome is made up of many genes. (newpathworksheets.com)

Epigenetics Chromatin, 11(1):19. (ens-lyon.fr)

CBX2 forms condensates (similar to previously described Polycomb bodies) that colocalize with target genes bound by CBX2 in differentiating spermatogonia. (bvsalud.org)
In search for HSF1 target genes, we identified 742 putative promoters in mouse testis. (abo.fi)
The genes encode homeodomain-containing transcription factors that control cell fates by regulating the transcription of downstream target genes. (nih.gov)

One gene identified as being significantly differentially methylated was an autism candidate gene, Discs-Large Associated Protein 2 (DLGAP2). (duke.edu)
Enrichment of both autism candidate genes and genes possessing bivalent chromatin was identified in the human RRBS dataset of genes significantly differentially methylated in sperm of cannabis users. (duke.edu)

Such results suggest that there may be differential sex-specific phenotypes of F3 generation mice whose lineages/ancestors were exposed to a HFD. (whatisepigenetics.com)
Differential expression analyses were performed between TBLCs and multi-embryonic cell stages to identify differentially expressed genes. (sciencegate.app)

Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain. (ens-lyon.fr)
Long before the identification of its molecular nature, it was recognized that chromatin exists in two main states: the densely stained heterochromatin contrasting with euchromatin ( Heitz, 1928 ). (biologists.com)

BET inhibitors such as JQ1 block the region of BRDT responsible for chromatin binding, and cause a reversible reduction of sperm production, sperm quality, and size of the testis in mice. (wikipedia.org)
Here, we have generated an Actl7b-null allele in mice to unravel the role of ACTL7B in sperm formation. (bvsalud.org)
However, it was unclear if such expression was specific to male or female mice in the data presented. (whatisepigenetics.com)
Here, we profile the gut microbiome and chromatin characteristics in colon epithelium from mice fed either an obesogenic or control diet, followed by an analysis of the resultant changes in gene expression. (biomedcentral.com)

Unlocking sperm chromatin at fertilization requires a dedicated egg thioredoxin in Drosophila. (ens-lyon.fr)
However, despite its smaller size, most developmental genes and at least half of the disease- and cancer-causing genes in humans are conserved in Drosophila , making Drosophila an excellent model system for the study of human development and disease. (nih.gov)
In Drosophila , the homeotic genes specify cell identities at both embryonic and adult stages. (nih.gov)
Assays in transgenes in Drosophila previously identified cis -acting transcriptional regulatory elements from homeotic genes. (nih.gov)

Chakraborty S, Liu L, Henard CA, Bourret TJ, Song M, Kim JS, Liu L,. We then show can you get high on ventolin that these had key differences in survival costs of sperm cell aging. (itwontfailbecauseofme.com)
Sex differences in the metabolism of synthetic and natural steroid hormones. (eviematilda.art)
Sex Differences in gut microbiota composition correlates with diet and microbiome and aging remains sparse, some initial observations highlight the potential for manipulating the microbiome contributes to aging and age-associated diseases. (eviematilda.art)

Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm production. (jci.org)

It was further discovered that autism candidate genes are significantly enriched for genes containing bivalent chromatin. (duke.edu)
Through a combination of genetics, tissue-specific transcriptome analysis, and functional studies of candidate genes, we uncovered a possible explanation for this unexpected role of GLP-1/Notch. (scite.ai)

Sex- and age-related phenotypes. (itwontfailbecauseofme.com)
The researchers noted, "Recent studies have reported a mechanistic link between altered sperm sncRNAs and the transmission of metabolic and behavioral phenotypes in the progeny following parental stress15 or HFD exposure. (whatisepigenetics.com)
It will therefore be of great interest to examine in future studies the role of sperm sncRNAs in transgenerational transmission of altered metabolic and addictive-like phenotypes in transgenerational models of maternal HFD insult. (whatisepigenetics.com)

Among them, the sex chromosomal multicopy genes that are expressed in postmeiotic cells were occupied by HSF1. (abo.fi)
We used a large number of existing chromosomal aberrations in the Scr homeotic gene to investigate the functions of the cis -acting elements within the endogenous gene. (nih.gov)
Characterization of the chromosomal rearrangements shown in Figure 1 also revealed that two genetic elements (proximal and distal MES [maintenance elements for silencing]), about 70 kb apart in the Scr gene, must be in cis to maintain proper repression. (nih.gov)

The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin features and, ultimately, gene expression. (biomedcentral.com)

In sir-2.1(0) males, the hypercontraction of the spicule-associated muscles pinch the vas deferens opening, thus blocking sperm release. (elifesciences.org)

Given that the sex chromatin mostly is repressed during and after meiosis, it is remarkable that HSF1 directly regulates the transcription of sex-linked multicopy genes during postmeiotic repression. (abo.fi)

2022). Possible stochastic sex determination in Bursaphelenchus nematodes. (caltech.edu)
5, 2022 - Researchers have revealed how an 'accordion effect' is critical to switching off genes, in a study that transforms the fundamentals of what we know about gene silencing. (lesvilains.com)

In the C. elegans germline, reprograming germ cells into somatic cells requires chromatin perturbation. (scite.ai)
Spermatogonia are undifferentiated male germ cells, or sperm cells. (ussromantics.com)

The study reported here aims to evaluate the effects of marijuana, within other conditions (obesity, sedentary lifestyle, smoking, alcohol consumption), on the spermatozoa function and sex hormone levels in reproductive failure situations in patients attending an andrology setting. (frontiersin.org)
That's an active, motile sperm - plural spermatozoa, or just plain sperm. (ussromantics.com)

the variety of heritable characteristics (genes) in a population of interbreeding individuals. (edrawmind.com)

2009). These effects include changes in the concentration and ratios of sex steroid hormones (Landry et al. (researchgate.net)

Canonical Polycomb repressive complex 1 (cPRC1), particularly its component CBX2, can compact chromatin and phase-separate in vitro. (bvsalud.org)

C, E) Gene enrichment analysis revealed that SNSs in transcripts encoding metabolic functions in Salmonella can you get high on ventolin Pathogenesis. (itwontfailbecauseofme.com)

Chronic medical illnesses may directly suppress sex hormone production and sperm production, leading to end-organ failure. (medscape.com)

MEIOC thereby derepresses E2F6- and MGA-repressed genes, including Meiosin and other meiosis-associated genes. (bvsalud.org)
To the best of our knowledge, HSF1 is the first known transcription factor found at the repressed sex chromatin during meiosis. (abo.fi)

Given the important roles of the gut microbiome in regulating host physiology and gene expression, a better understanding of the relationship between the host and the symbiont microbiota should provide new insights into human health and disease risk. (biomedcentral.com)

Bromodomain testis-specific protein is a protein that in humans is encoded by the BRDT gene. (wikipedia.org)
Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
Higher expression of serine/threonine-protein kinases in mature female gonads (Dheilly et al. (github.io)
2021). Examination of the C. gigas kinome found several serine/threonine-protein kinases in eggs and embryos, with some gene expression changes in response to abiotic stress (Epelboin et al. (github.io)
Male worms in which the gene for this protein has been 'knocked out' have a normal lifespan, but show signs of aging earlier than normal males. (elifesciences.org)

Complete semen analyses, sperm functional tests, SHBG, and hormonal levels, testosterone-to-estradiol ratio (T/E 2 ), and testis volume were evaluated. (frontiersin.org)
Our genetic, pharmacological, and behavioral analyses suggest that in sir-2.1(0) and older wild-type males, enhanced catabolic enzymes expression, coupled with the reduced expression of ROS-scavengers contribute to the behavioral decline. (elifesciences.org)

It contains all of our genetic information and only genes that are necessary for skin cells are expressed.Thus, producing the unique cell type needed for the epidermis. (topperone.com)

ASF1 is required to load histones on the HIRA complex in preparation of paternal chromatin assembly at fertilization. (ens-lyon.fr)

2012), especially during sex determination processes (Broquard et al. (github.io)
The homeotic genes are expressed in precise spatial patterns that are crucial for the proper determination of cell fate. (nih.gov)

There remains an urgent need to investigate the effects of cannabis on the sperm epigenome as use increases across the globe. (duke.edu)

Microbiome researchers would do well to control for or otherwise account for age, sex, and other areas of biology. (eviematilda.art)

Our gene expression in the activation of key determinants associated with diversity and profiles of human germline mutation. (itwontfailbecauseofme.com)

Homozygous mutant males were sub-fertile and both sexes had a decreased number of lumbar and sacral vertebrae. (wikipedia.org)

2012). The paramyosin homologue is highly expressed in females over males, with declining expression as gametes mature (Broquard et al. (github.io)
To avoid a double dose of X-linked genes in females, one of the Xs is silenced early in the developmental process. (lesvilains.com)

Both unilateral and bilateral cryptorchidism are associated with a decrease in sperm production and semen quality, regardless of the timing of orchidopexy. (medscape.com)

During dynamic developmental events, such as sexual reproduction, we propose that dramatic and rapid reconfiguration of source-sink relationships modifies chromatin states. (biologists.com)
One of the important groups of conserved developmental genes are the homeotic genes. (nih.gov)

Furthermore, the CES-2-like basic region leucine-zipper (bZip) transcription factor ATF-2, an upstream modulator of the core apoptotic cell death pathway, is able to directly regulate the expression of at least two key autophagy-related genes, bec-1/ATG6 and lgg-1/ATG8. (scite.ai)

Remarkably, a subpopulation within the TBLCs population expressed a high level of the totipotent-related genes Zscan4s and displayed transcriptomic features similar to mouse two-cell stage embryonic cells. (sciencegate.app)

Both loss of expression and ectopic expression in the wrong tissues lead to changes in cell fate. (nih.gov)
To better understand the role of nm23 genes in cell migration, we investigated the function of NDK-1, the sole Caenorhabditis elegans homolog of group I NDPKs in distal tip cell (DTC) migration. (scite.ai)
Lyons VG, Payne NL, McCoy CE (2018) Optimization techniques for miRNA expression in low frequency immune cell populations. (hudson.org.au)
Each gene provides the cell with different information. (newpathworksheets.com)

One critical function of PcG complexes is modulating chromatin structure. (bvsalud.org)
While these transgenic assays have been important in defining the structure of the cis -regulatory elements and identifying trans -acting factors that bind to them, their functions within the context of the endogenous genes remain poorly understood. (nih.gov)

Methyalation of this gene could promote homeostasis by regulating gonad development processes. (github.io)
Further, it is critical to investigate these effects on genes that are uniquely positioned to contribute to early development. (duke.edu)
However in recent years with the development of epigenesis, genomic imprinting and the horizontal transferences of the genes, Lamarck's ideas have resurfaced. (intechopen.com)
In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)
These chromatin changes may be associated with those seen during colon cancer development. (biomedcentral.com)

As in centenarians, the causal role of the specific bacterial species, genes, and metabolites in promoting healthy aging remain unclear. (eviematilda.art)

Anatomy3

Chemicals and Drugs1

Phenomena and Processes3

Chromosomes4

Methylation17

Epigenetic10

Proteins10

Histone7

Seminiferous Tubules3

Motility4

Mature sperm2

Irradiation responsive genes2

Regulation2

Meiotic7

Chromosome3

Epigenetics1

Target genes3

Differentially methylated2

Differential2

Heterochromatin2

Mice4

Drosophila4

Differences3

Spermatogenesis1

Candidate genes2

Phenotypes3

Chromosomal3

Eukaryotic1

Deferens1

Regulates1

20222

Germ cells2

Spermatozoa2

Heritable1

Steroid hormones1

Repressive complex1

Enrichment1

Suppress1

Meiosis2

Microbiota1

Protein5

Analyses2

Genetic1

Paternal1

Determination2

Epigenome1

Microbiome1

Germline1

Homozygous1

Females2

Semen1

Developmental2

Transcription factor1

Embryonic1

Cell4

Structure2

Development5

Role1