• antibody
  • The invention provides an antibody specific to the ANGPTL4 protein capable of neutralizing proliferation and methods of making and using the same. (patentsencyclopedia.com)
  • The antibody of the invention is further directed to the C terminal region of the protein and may be capable of neutralizing cell proliferation and treating cancer. (patentsencyclopedia.com)
  • 30. An antagonist to angiopoietin like 4 protein (ANGPTL4) that reduces cell proliferation and reduces a level of Reactive Oxygen Species in a cell, wherein the antagonist comprises an interfering RNA sequence or an antibody specific to angiopoietin like 4 protein (ANGPTL4). (patentsencyclopedia.com)
  • 34. A method of treating a patient to reduce cell proliferation and reduce a level of Reactive Oxygen Species in a cell, which comprises the step of: (a) contacting proliferating cell with an antagonist to angiopoietin like 4 protein (ANGPTL4) wherein the antagonist comprises an interfering RNA sequence or an antibody specific to angiopoietin like 4 protein (ANGPTL4). (patentsencyclopedia.com)
  • Western Blot: MxA/Mx1 Antibody [H00004599-B01P] - Analysis of MX1 expression in Jurkat. (novusbio.com)
  • Western Blot: MxA/Mx1 Antibody [H00004599-B01P] - Analysis of MX1 expression in transfected 293T cell line by MX1 polyclonal antibody. (novusbio.com)
  • monocytes
  • Methods In a cohort of 35 pSS patients, myxovirus-resistance protein A (MxA) was assessed as a potential biomarker for type I IFN activity, using an enzyme immunoassay (EIA) on whole-blood and flow cytometric analyses (fluorescence-activated cell sorting, FACS) of isolated CD14 monocytes. (bmj.com)
  • The IFNscore, a measure for total type I IFN bioactivity, was calculated using expression values of the IFN type I signature genes-IFI44, IFI44L, IFIT3, LY6E and MX1-in CD14 monocytes, determined by real-time quantitative PCR. (bmj.com)
  • Previously, we described the systemic upregulation of IFN type I-inducible genes (IFIGs) in CD14 monocytes of pSS patients, the so-called IFN type I signature. (bmj.com)
  • Genes on the left represent the total set of genes probed for with the kit, and the genes on the right represent those genes induced following HCMV infection of monocytes. (jimmunol.org)
  • Targets
  • also known as Fbw7, SEL-10, hCdc4, and hAgo) targets for degradation proteins with wide-ranging functions, and uncovering its in vivo role has been difficult, because Fbxw7 -/- embryos die in utero. (pubmedcentralcanada.ca)
  • regulate
  • Furthermore, our study confirms a deregulation of the vitamin D system: among the transcription factors that potentially regulate the deregulated genes, we find TCF3 and SP1 that are both involved in vitamin D3-induced p27Kip1 expression. (pubmedcentralcanada.ca)
  • GTPases
  • The GSK class (Irga6, Irgb6, and Irgd) are considered the canonical grouping of GTPases, whereas a second grouping of GMS proteins, which have a lysine to methionine mutation in the active site, function to prevent premature activation by associating with the nucleotide binding motif in a manner similar to Guanosine nucleotide dissociation inhibitors (GDI's). (wikipedia.org)
  • sequence
  • The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)
  • Arya A., Murakami Y., Mizuguchi K., "Integrating sequence and gene expression information predicts genome-wide DNA-binding proteins and suggests a cooperative mechanism. (mizuguchilab.org)
  • determination
  • Host response pattern determination by expression analysis of a predefined set of genes is a novel strategy in the diagnosis of virus infections. (asmscience.org)
  • Another strategy in differentiating viral and bacterial infections from each other could be the determination of a single marker, such as myxovirus resistance protein A (MxA), which is generally induced by viruses but not by bacteria. (asmscience.org)
  • for determination of NAbs, BAbs, gene expression of MxA and protein concentrations of MMP-9, TIMP-1, sTRAIL, CXCL-10 and CCL-2. (forskningsdatabasen.dk)
  • Squares represent individual genes, and the "line of best fit" on each graph was used to calculate the coefficients of determination ( R 2 ). (jimmunol.org)
  • viruses
  • The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. (genecards.org)
  • transcription
  • Interestingly, MS networks show a reduced connectivity relative to the healthy condition, and the treatment activates the transcription of genes and increases their connectivity in MS patients. (pubmedcentralcanada.ca)
  • human
  • Genes located within the Human Leukocyte Antigen (HLA) region are the most important MS susceptibility loci [ 2 , 3 ], but several international genome-wide association studies (GWAS) studies have led to the identification of other candidates for the disease susceptibility [ 4 , 5 , 6 ]. (pubmedcentralcanada.ca)
  • MX1 (NP_002453.1, 1 a.a. - 662 a.a.) full-length human protein. (novusbio.com)
  • analysis
  • Importantly, the analysis of changes in gene connectivity in MS patients provides new evidence of association for genes already implicated in MS by single-nucleotide polymorphism studies and that do not show differential expression. (pubmedcentralcanada.ca)
  • Interactive Toxicogenomics: Gene set discovery, clustering and analysis in Toxygates. (mizuguchilab.org)
  • An integrative data analysis platform for gene set analysis and knowledge discovery in a data warehouse framework. (mizuguchilab.org)
  • RT-PCR analysis confirmed that HCMV induced the expression of ICAM-1, integrin β 8 , integrin α 1 , IL-1β, TNF-α, and CCL2. (jimmunol.org)
  • mice
  • Studies in mice have characterized the importance of the type 2 effector molecule IFNγ in various cell types and gone on to determine the importance of these proteins in intracellular pathogen resistance. (wikipedia.org)
  • Cell
  • Freshly isolated cells were characterized by expression of IL-7Rα (CD127) among CD4 T-cell maturation subsets by flow cytometry and sorted CD3 T cells were assessed for expression of IFN-α and interferon stimulated genes (2′-5′-oligoadenylate synthetase-1 and myxovirus resistance A protein) by quantitative real-time PCR. (physiciansweekly.com)
  • However, it is now known to be mediated mainly by proteins that exist in the cell throughout its life ( 1 ). (jimmunol.org)
  • Moreover, some of these proteins display, in addition to their death-oriented function, activities that contribute to the functioning of the living cell. (jimmunol.org)
  • Clarification of the dual nature of these proteins is central to our understanding of the mechanisms of programmed cell death and its physiological significance. (jimmunol.org)
  • type
  • This signature is currently assessed via laborious expression profiles of multiple IFN type I-inducible genes. (bmj.com)
  • E3 ubiquitin ligase complexes of the SCF type consist of ring-box 1 (Rbx1), cullin 1 (Cul1), S-phase kinase-associated protein 1 (Skp1), and a member of the F-box family of proteins. (pubmedcentralcanada.ca)
  • functions
  • In this study, we report the establishment of conditional knockout of the caspase-8 gene using the Cre/ loxP recombination system, and its use for exploring these other functions. (jimmunol.org)
  • single
  • This database is built by NCBI, and, provides only a single record for each gene/transcript. (origene.com)
  • However
  • However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)
  • multiple
  • There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. (genecards.org)
  • Multiple IRG genes have been identified in canines and zebrafish but few in the model organism Tetraodontidae (the pufferfish). (wikipedia.org)
  • significant
  • To be considered statistically significant, genes had to have a present call in at least four of six HCMV-infected samples and a 1.5-fold or greater change in at least four of six HCMV samples (see supplemental data S1 for complete list of genes). (jimmunol.org)
  • The significant genes from mock-infected vs mock-infected, HCMV-infected vs HCMV-infected, and mock-infected vs HCMV-infected samples were then plotted on the basis of signal. (jimmunol.org)
  • total
  • Total genes up-regulated and down-regulated in each grouping are represented within the bar. (jimmunol.org)
  • The total numbers of genes analyzed in each ontology category are shown within parentheses. (jimmunol.org)
  • target
  • Ubiquitylation of target proteins is mediated by the sequential action of 3 enzymes: a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin ligase (E3). (pubmedcentralcanada.ca)