AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth Care
AzacitidineMethylationAntimetabolites, AntineoplasticMyelodysplastic SyndromesDNA MethylationGene Expression ProfilingGene ExpressionGene Expression RegulationLeukemia, Myelomonocytic, ChronicCpG IslandsPromoter Regions, GeneticEpigenesis, GeneticOligonucleotide Array Sequence AnalysisDNA Modification MethylasesChromatography, Supercritical FluidRNA, MessengerEpigenomicsBase SequenceCompassionate Use TrialsDNA (Cytosine-5-)-MethyltransferaseLeukemia, Myeloid, AcuteGene Expression Regulation, NeoplasticTranscription, GeneticMolecular Sequence DataInjections, SubcutaneousGene SilencingGene Expression Regulation, DevelopmentalAnemia, RefractorySulfitesHistonesConsolidation ChemotherapyReverse Transcriptase Polymerase Chain ReactionTranscription FactorsAnemia, Refractory, with Excess of BlastsInduction ChemotherapyCytosineCell Line, TumorMethyltransferasesDrug ApprovalGene Expression Regulation, PlantGene Expression Regulation, EnzymologicGenomic ImprintingTreatment OutcomeHistone-Lysine N-MethyltransferaseDNA-Binding Proteins5-MethylcytosineCell LinePolymerase Chain ReactionDNASurvivalGene Expression Regulation, BacterialLong Interspersed Nucleotide ElementsDNA-Cytosine MethylasesMutationCells, CulturedProtein MethyltransferasesGene Expression Regulation, ViralInternational AgenciesCluster AnalysisSequence Analysis, DNANuclear ProteinsS-AdenosylmethionineChromatinThalidomideDrug Administration ScheduleDNA PrimersSignal TransductionUnited States Food and Drug AdministrationLysineRepressor ProteinsTranscriptomeProtein-Arginine N-MethyltransferasesDinucleoside PhosphatesGenes, ReporterGene Expression Regulation, FungalDNA, NeoplasmMicroarray AnalysisAntimetabolitesLeukemia, MyeloidCell DifferentiationPhenotypeEnzyme InhibitorsDown-RegulationModels, GeneticRemission InductionChromatin ImmunoprecipitationTransfectionBiological AvailabilityRNARNA, Long NoncodingTetrazolium SaltsAmino Acid SequenceGenome, HumanAcetylationUp-RegulationAntineoplastic Combined Chemotherapy ProtocolsTranscriptional ActivationCytarabineMice, Inbred C57BLTumor Cells, Cultured
DecitabineEpigeneticsRegulationInhibitorsAberrantPolymerase Chain ReProteinsGenome-wideApoptosisInhibitorOral azacitidineTumor suppHistone modificationMRNAModificationsProliferationCancersMutations in genesMalignanciesProtein expressionOncogenesTherapeutic targetsInhibitionONUREGChromosomeMutationUpregulationAlterationsProgressionRegulatorVariantsDemethylation drugEnzymesHypermethylation2018TumorigenesisDifferentiationCancerAbnormal expressionMesenchymalDysregulationDifferential gene expressionAcute leukemiaRegulate2019Single geneCells2022Diseases
Decitabine3
  • Significant advances have been achieved in recent years in the study of methylated drugs, such as demethylation drugs Decitabine and Azacitidine and histone deacetylase inhibitor Sedamine, which provides additional strategies for treatment of clinical diseases [ 2 , 3 ]. (biomedcentral.com)
  • Two nucleoside inhibitors of DNA methylation, azacitidine and decitabine, are now standard of care for the treatment of the myelodysplastic syndrome, a deadly form of leukemia. (aacrjournals.org)
  • Some inhibitors have been already approved by FDA, such as Azacitidine and Decitabine as DNA methyltransferase inhibitors for the treatment of myelodysplastic syndrome 8 and Vorinostat and Romidepsin as inhibitors of histone deacetylase for the treatment of peripheral T-cell lymphoma 9 . (nature.com)
Epigenetics10
  • Epigenetics indicates the alterations of gene expression levels mediated by nongene sequence changes. (hindawi.com)
  • Although the full scope of epigenetics has not yet been determined, it is generally defined as chemical modification that mainly includes DNA and RNA methylation, histone modification, noncoding RNA modification and chromatin rearrangement. (biomedcentral.com)
  • 26 CONST ENCIO V,NUNES SP,MOREIRA-BARBOSA C,et al.Early detection of the major male cancer types in blood-based liquid biopsies using a DNA methylation panel J .Clin Epigenetics,2019,11(1):175. (xdzlyx.com)
  • Epigenetics encompasses heritable changes in the pattern of gene expression mediated by mechanisms other than alterations in primary nucleotide sequence. (touchoncology.com)
  • With the recent and better knowledge on how gene regulation occurs and after intense debate in the academic community 1 , epigenetics has been commonly defined as "the study of changes in gene function that are mitotically and/or meiotically heritable and that do not entail a change in DNA sequence" 2 . (nature.com)
  • Over the past years, epigenetics has been shown to play a central role in many different key functions at the cellular level, including differentiation, replication, and gene transcription 3 . (nature.com)
  • Epigenetics is the study of changes in gene expression that are not caused by alterations in the DNA sequence. (cardiodiagnosticsinc.com)
  • Epigenetics is the study of the non-coding changes to the DNA that can alter gene expression. (cardiodiagnosticsinc.com)
  • This review aims to present an overview of current pharmacogenomic biomarkers and future perspectives of pharmacogenomics in CRC, in an evolving scenario moving from a single drug-gene interactions approach to a more comprehensive genome-wide approach, comprising genomics and epigenetics. (oaepublish.com)
  • DNA methylation is one of the best known epigenetic mechanisms in cancer epigenetics. (biomedcentral.com)
Regulation12
  • This study provides novel evidence for widespread alterations in DNA methylation during postnatal heart maturation and suggests that cardiomyocyte cell cycle arrest during the neonatal period is subject to regulation by DNA methylation. (nih.gov)
  • Structural genes encode proteins that are not involved in gene regulation. (p450inhibitors.com)
  • In addition to DNA and histone methylation, another level of epigenetic regulation, namely, RNA methylation, has become a hot topic in biosciences over the past decade. (biomedcentral.com)
  • Be it for development, differentiation, stemness, or sex chromosome dosage compensation, stable, cell specific regulation of gene expression is essential for normal function ( 1 ). (aacrjournals.org)
  • Multiple mechanisms have evolved to perform these essential functions: DNA methylation, a bewildering array of histone modifications, RNA-based regulation, etc. (aacrjournals.org)
  • 5 LIU Q,LIU G,MARTIN DT,et al.Genome-wide association analysis reveals regulation of at-risk loci by DNA methylation in prostate cancer J .Asian J Androl,2021,23(5):472-478. (xdzlyx.com)
  • 10 YANG X,WANG S,REHEMAN A.Regulation of RUNX3 expression by DNA methylation in prostate cancer J .Cancer Manag Res,2020,12:6411-6420. (xdzlyx.com)
  • To study the regulation of DNA methylation in living cells, we developed a trapping assay using transiently expressed fluorescent DNA methyltransferase 1 (Dnmt1) fusions and mechanism-based inhibitors 5-azacytidine (5-aza-C) or 5-aza-2′-deoxycytidine (5-aza-dC). (mdc-berlin.de)
  • On the other hand, we clarified the upstream mechanism regulating miR-124-3p expression in ESCC, which involves in the hypermethylation-silencing regulation mediated by DNA methyltransferase 1(DNMT1), which is of high expression in ESCC tissues and cell lines in the present study. (biomedcentral.com)
  • DNA methylation involves in the addition of a methyl (CH3) group to DNA with DNA methyltransferases (DNMTs), thereby often modifying gene function through regulation of gene expression [ 7 ]. (biomedcentral.com)
  • A microRNA is a small non-coding RNA molecule, which functions in the post-transcriptional regulation of gene expression by partially complementing with the 3′-untranslated regions (3'UTR) of specific mRNAs [ 14 ]. (biomedcentral.com)
  • However, the molecular mechanisms of MEG3 methylation in the regulation of multiple myeloma (MM) are unknown. (spandidos-publications.com)
Inhibitors6
  • Sleeping Elegance is far more susceptible to more than expression inhibition than piggyBac and Tol2, the cargo capacity of Sleeping Attractiveness is constrained, and contrary to Tol2 and piggyBac that Inhibitors,Modulators,Libraries are lively in all mamma lian cell kinds tested, Sleeping Elegance display cell form dependent exercise. (p450inhibitors.com)
  • The epigenetic potential of DNA methylation inhibitors may be limited by other epigenetic mechanisms that are also worth exploring as therapeutic targets. (aacrjournals.org)
  • Increased class 1 HDAC expression has been linked in solid tumours with more locally advanced, de-differentiated and proliferative tumours, and with poor prognosis in MM. HDAC inhibitors, panobinostat and ricolinostat, have been demonstrated to be effective in combination with bortezomib and dexamethasone in newly diagnosed patients with MM and in heavily pre-treated patients with advanced MM. HDAC inhibitor-monoclonal antibody combinations are also being explored. (touchoncology.com)
  • For example, the identification of mutations in genes encoding enzymes involved in DNA methylation led to the development of DNA methyltransferase inhibitors for the treatment of cancer. (cardiodiagnosticsinc.com)
  • In this study, multiple leiomyosarcoma cell lines, SK-UT1, SK-LMS1, and MES-SA were treated with varying doses of the DNA Methyltransferase Inhibitors (DNMTi) 5-azacitidine (Aza), 5-aza-2-deoxycytidine (DAC), and guadecitabine (SGI-110). (oncotarget.com)
  • These two drugs are mere examples of the principal two classes of epidrugs to obtain FDA approval: DNA methyltransferase inhibitors for treatment of MDS (azacitidine, in 2004) and histone deacetyltransferase inhibitors for T cell lymphoma (Vorinostat, in 2006). (biomedcentral.com)
Aberrant9
  • We used quantitative real-time polymerase chain reaction (qRT-PCR) for detecting the aberrant expression level of GRHL2 in 60 patients with acute leukemia and 60 normal controls. (hindawi.com)
  • Indeed, early cancer research focused on the fact that neoplastic cells have aberrant gene expression and differentiation states, pointing to shared mechanisms between normal development and cancer ( 2 ). (aacrjournals.org)
  • Peripheral T-cell lymphomas (PTCL) with T-follicular helper phenotype (PTCL-TFH) has recurrent mutations affecting epigenetic regulators, which may contribute to aberrant DNA methylation and chemoresistance. (bvsalud.org)
  • Frequent mutations in epigenetic modifiers suggest that aberrant DNA methylation contributes to AITL oncogenesis. (biomedcentral.com)
  • Additionally, aberrant DNA methylation was recently shown to potentiate inappropriate costimulation in a subset of AITL cases. (biomedcentral.com)
  • This commentary summarizes the main findings on aberrant DNA methylation and inappropriate costimulation in AITL and proposes several already approved drugs for AITL treatment. (biomedcentral.com)
  • Frequent mutations in epigenetic modifiers suggest aberrant DNA methylation is involved in AITL oncogenesis. (biomedcentral.com)
  • Because all these genes encode epigenetic modifiers, it is suspected that aberrant DNA methylation somehow contributes to AITL oncogenesis. (biomedcentral.com)
  • Furthermore, 5‑Aza‑CdR decreased aberrant hypermethylation of the MEG3 promoter and increased the expression of MEG3. (spandidos-publications.com)
Polymerase Chain Re1
Proteins7
  • Western blots of retinal proteins showed a significant increase in BMP4 expression in diabetic humans and mice compared to the control groups (p (bvsalud.org)
  • At the same time, arsenide trioxide and 5-azacitidine are associated with the inhibition of cellular proliferation of acute leukemia cells and also promote the elevated expression of TGF- β signaling pathway-linked proteins, including TGF- β , Smad2, Smad3, and Smad4. (hindawi.com)
  • Similar to DNA and histone methylation, m 6 A modifications are dynamic and reversible and exert biological effects that are mainly mediated by 'writers', 'erasers' and 'reader' proteins (Fig. 2 ). (biomedcentral.com)
  • The epigenome is an inheritable record of changes to the DNA and histone proteins, such as methylation and nucleosome remodelling that directs which genes are to be silenced or expressed. (touchoncology.com)
  • This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. (cancerindex.org)
  • The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)
  • The SLC6 family is among the largest SLC families, containing 20 genes that encode a group of highly similar transporter proteins. (epiphanyasd.com)
Genome-wide3
  • Gene expression profiling (RNA-seq) and genome-wide sequencing of methylated DNA (MBD-seq) identified dynamic changes in the cardiac methylome during postnatal development [2545 differentially methylated regions (DMRs) from P1 to P14 in the mouse]. (nih.gov)
  • 1 Mutations in regulators of the epigenome have been identified in cancer that have roles such as 'writers', 'readers', 'erasers' or 'editors' and have the potential to deregulate the expression of hundreds of genes genome-wide. (touchoncology.com)
  • Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. (cancerindex.org)
Apoptosis5
Inhibitor2
  • Here, we summarize the different types of epigenetic enzymes which target corresponding protein domains, emphasize DNA methylation , histone modifications, and microRNA-mediated cooperation with epigenetic modification, and highlight recent achievements in developing targets for epigenetic inhibitor therapy. (frontiersin.org)
  • The first epigenetic drug to be approved was azacitidine, a DNA methyltransferase inhibitor used to treat myelodysplastic syndromes. (cardiodiagnosticsinc.com)
Oral azacitidine1
  • This phase 2 study evaluated oral azacitidine (CC-486) plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) as initial treatment for PTCL. (bvsalud.org)
Tumor supp5
  • A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. (wikipedia.org)
  • When a tumor suppressor gene is mutated, it results in a loss or reduction in its function. (wikipedia.org)
  • This initial hypothesis eventually lead to the discovery of the first classic tumor suppressor gene by Alfred Knudson, known as the Rb gene, which codes for the retinoblastoma tumor suppressor protein. (wikipedia.org)
  • This deletion caused increased tumor growth in retinoblastoma, suggesting that loss or inactivation of a tumor suppressor gene can increase tumorigenicity. (wikipedia.org)
  • The role of DNA methylation in the mediation of multiple tumor suppressor gene and microRNA silencing has been implicated in the development and progression of MM ( 7 ). (spandidos-publications.com)
Histone modification2
MRNA3
  • Then we investigated the demethylating effect of arsenic trioxide and 5-azacitidine on the mRNA and protein expression levels of GRHL2 in cell lines of acute leukemia. (hindawi.com)
  • The methylation level of the GRHL2 promoter region in acute leukemia patients and cell lines was significantly higher than the normal control group, and we found the elevated mRNA and protein levels of GRHL2 in acute leukemia cell lines after the use of the demethylation drug arsenic trioxide and 5-azacitidine. (hindawi.com)
  • Furthermore, miR-124-3p directly targets mRNA 3'UTR region of BCAT1, which results in upregulation of BCAT1 expression as observed in ESCC tissues and cell lines. (biomedcentral.com)
Modifications5
Proliferation7
  • Lastly landscaper genes regulate growth by contributing to the surrounding environment, when mutated can cause an environment that promotes unregulated proliferation. (wikipedia.org)
  • The discovery of oncogenes and their ability to deregulate cellular processes related to cell proliferation and development appeared first in the literature as opposed to the idea of tumor suppressor genes. (wikipedia.org)
  • Postnatal inhibition of DNA methylation with 5-aza-2'-deoxycytidine induced a marked increase (~3-fold) in cardiomyocyte proliferation and ~50% reduction in the percentage of binucleated cardiomyocytes compared with saline-treated controls. (nih.gov)
  • As the disease progresses and converts into leukemia, further gene mutation occurs, and a proliferation of leukemic cells overwhelms the healthy marrow. (medscape.com)
  • Finally, we studied the effects of arsenide trioxide and 5-azacitidine on the proliferation of leukemia cells and the TGF- β signaling pathway. (hindawi.com)
  • We show downregulation of miR-124-3p expression in ESCC tissues, which is highly correlated with proliferation and migration of ESCC cell lines KYSE-150 and Eca109. (biomedcentral.com)
  • With the study of loss-of-function and gain-of-function in DNMT/miR-124/BCAT1, we showed that downregulation of hsa-miR-124-3p in ESCC tissues and cells contributed to the upregulation of BCAT1 expression, which enhanced the proliferation and invasion of ESCC. (biomedcentral.com)
Cancers5
  • The loss of function for these genes may be even more significant in the development of human cancers, compared to the activation of oncogenes. (wikipedia.org)
  • This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. (cancerindex.org)
  • This article reviews recent studies on methylation modification of m 6 A in gastrointestinal tract cancers. (biomedcentral.com)
  • They showed that eating turmeric in your food modified a specific gene (SLC6A15) associated with certain cancers, asthma/eczema and depression. (epiphanyasd.com)
  • Among of these genes, miR-124 caught our attention in view of the finding that large number of microRNAs(MiRNAs) have been shown important roles in the development of different cancers [ 11 ]. (biomedcentral.com)
Mutations in genes1
  • More than 90% of cases of MDS harbor detectable drive mutations including: DNMT3A, EZH2, RUNX 1, TET 2, IDH 1, IDH 2, TP53, ASXL1, and mutations in genes in coding components involved in the three prime RNA splicing. (standardofcare.com)
Malignancies4
  • DNA methylation is common in hematological malignancies. (hindawi.com)
  • however, human malignancies are characterized by the gain of methylation at promoter associated CpG islands ( 6 ). (spandidos-publications.com)
  • Furthermore, lncRNA MEG3 expression has been reported to be induced following epigenetic modification of DNA methylation in diverse malignancies, including gliomas ( 19 ), ovarian cancer ( 20 ) and leukemia ( 21 , 22 ). (spandidos-publications.com)
  • Table S5: Regions covered by institutional next-generation sequencing (NGS) interrogating the entire exonic or hotspot regions of 81-genes frequently mutated in myeloid malignancies. (ox.ac.uk)
Protein expression3
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Western blots to the right of the charts show corresponding protein expression in the individual cell clones included in RNA-sequencing analysis. (jci.org)
  • Human GC tissue array was used to analyse patient survival based on BCL6B and CD3 protein expression. (biomedcentral.com)
Oncogenes2
  • Unlike oncogenes, tumor suppressor genes generally follow the two-hit hypothesis, which states both alleles that code for a particular protein must be affected before an effect is manifested. (wikipedia.org)
  • The tumor suppressor genes are inactivated, and the oncogenes are dominant during the formation of the tumor [ 9 ]. (hindawi.com)
Therapeutic targets1
  • In this review, we focus on the relationship between RNA m 6 A methylation and gastrointestinal cancer, especially their role, mechanism and potential clinical application as biomarkers and therapeutic targets for gastrointestinal cancer. (biomedcentral.com)
Inhibition2
  • In addition, DNMT1 knockdown or inhibition of DNMT1 function contributes to downregulation of miR-124-3p and BCAT1 expression. (biomedcentral.com)
  • Inhibition of IRAK4-L abrogates leukaemic growth, particularly in AML cells with higher expression of the IRAK4-L isoform. (cancer-genetics.org)
ONUREG2
  • Do not substitute ONUREG for intravenous or subcutaneous azacitidine. (nih.gov)
  • The indications and dosing regimen for ONUREG differ from that of intravenous or subcutaneous azacitidine ( 2.1 , 5.1 ). (nih.gov)
Chromosome4
  • In order to verify that the loss of function of tumor suppressor genes causes increased tumorigenicity, interstitial deletion experiments on chromosome 13q14 were conducted to observe the effect of deleting the loci for the Rb gene. (wikipedia.org)
  • 21 YAO L,REN S,ZHANG M,et al.Identification of specific DNA methylation sites on the Y-chromosome as biomarker in prostate cancer J .Oncotarget,2015,6(38):40611-40621. (xdzlyx.com)
  • a process which can be reversed by 5-Aza-2'-deoxycytidine (5-Aza-CdR), suggesting a potential therapeutic agent for MM. The maternally expressed 3 (MEG3) imprinted gene is located on chromosome 14q32, which produces a non-coding RNA transcript ( 11 ). (spandidos-publications.com)
  • For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer . (cancer-genetics.org)
Mutation4
  • However, the idea of genetic mutation leading to increased tumor growth gave way to another possible genetic idea of genes playing a role in decreasing cellular growth and development of cells. (wikipedia.org)
  • This unique development pattern allowed Knudson and several other scientific groups in 1971 to correctly hypothesize that the early development of retinoblastoma was caused by inheritance of one loss of function mutation to an RB germ-line gene followed by a later de novo mutation on its functional Rb gene allele. (wikipedia.org)
  • He recognized that this was consistent with a recessive mutation involving a single gene, but requiring bi-allelic mutation. (wikipedia.org)
  • Mutation-driver genes cause clonal outgrowth and propagation of myelodysplastic hematopoiesis. (standardofcare.com)
Upregulation2
  • One of the concerns is the relatively wide effect of epigenetic modulating mechanisms: next to the intended upregulation of, for example, tumor suppressor genes in cancer, metastasis genes might also become upregulated as an unwanted side effect. (biomedcentral.com)
  • In the present study, MEG3 upregulation was negatively associated with the International Staging System (ISS) status of the bone marrow samples of 39 patients with MM. MEG3 overexpression in an MM cell line resulted in elevated p53 expression. (spandidos-publications.com)
Alterations1
  • Various distinct genetic abnormalities have been reported in both MM and MGUS including epigenetic alterations such as DNA and histone methylation, and are known to contribute to the pathogenesis of the disease. (touchoncology.com)
Progression3
  • DBC1 functions as a coactivator for AR-V7 and is required for the expression of AR-V7 target genes including CDH2, a mesenchymal marker linked to CRPC progression. (cancerindex.org)
  • However, it is lack of evidence that these genes are essentially associated with ESCC progression. (biomedcentral.com)
  • In order to investigate the role of Bcl6b in gastric tumourigenesis, we assessed Bcl6b expression and the degree of inflammation during the progression of Benzo[a]pyrene (BaP)-induced gastric carcinogenesis in mice. (biomedcentral.com)
Regulator2
  • Given the role of TET2 as a regulator of genomic methylation, we hypothesized that mutant TET2 allele dosage affects response to 5′-Aza. (jci.org)
  • Methylation is a fundamental regulator of gene transcription. (spandidos-publications.com)
Variants5
  • Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. (cancerindex.org)
  • Outlier Expression of Isoforms by Targeted or Total RNA Sequencing Identifies Clinically Significant Genomic Variants in Hematolymphoid Tumors. (cdc.gov)
  • Prevalence and significance of DDX41 gene variants in the general population. (cdc.gov)
  • Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer. (cancercluster-salzburg.at)
  • Table S6: Variants identified using targeted 81-gene myeloid NGS panel Table S7: CyTOF antibodies utilized. (ox.ac.uk)
Demethylation drug1
  • 5-Aza-2′-deoxycytidine (5-Aza), the demethylation drug, was intraperitoneally injected to restore Bcl6b expression. (biomedcentral.com)
Enzymes2
  • A new class of DNA artificial binders that directly block the methyllysine reading functions of reader enzymes in charge of conveying the methylation signal downstream has recently arisen as promising epigenetic drugs 10 . (nature.com)
  • This process is mediated by various enzymes modifying chromatin structures to achieve the diversity of epigenetic space and the intricacy in gene expression files. (frontiersin.org)
Hypermethylation2
  • Our data are the first to show loss of LDHB expression in prostate cancer, the mechanism of which appears to involve promoter hypermethylation. (ox.ac.uk)
  • 22 LI Y,MENG L,SHI T,et al.Diagnosis and prognosis potential of four gene promoter hypermethylation in prostate cancer J .Cell Biol Int,2021,45(1):117-126. (xdzlyx.com)
20181
  • 9 PELLACANI D,DROOP AP,FRAME FM,et al.Phenotype-independent DNA methylation changes in prostate cancer J .Br J Cancer,2018,119(9):1133-1143. (xdzlyx.com)
Tumorigenesis1
Differentiation1
  • Also, our data indicates that BCAT1 high expression is strongly linked to the disease-free survival, tumor size, pathologic stage, T classification and differentiation grade. (biomedcentral.com)
Cancer13
  • Alfred Knudson, a pediatrician and cancer geneticist, proposed that in order to develop retinoblastoma, two allelic mutations are required to lose functional copies of both the Rb genes to lead to tumorigenicity. (wikipedia.org)
  • the expression level of ZNF326 was inversely associated with advanced pTNM stage (P = 0.002), positive lymph node metastasis (P = 0.004), poor prognosis in patients with breast cancer (P = 0.0097), and ER/PR/Her2 status (P = 0.013). (cancerindex.org)
  • Diverse repetitive element RNA expression defines epigenetic and immunologic features of colon cancer. (umassmed.edu)
  • High-density array analysis of DNA methylation in Tamoxifen-resistant breast cancer cell lines. (umassmed.edu)
  • Absent LDHB expression was also seen in 7/7 (100%) cases of metastatic cancer in bone. (ox.ac.uk)
  • But the idea of stably changing gene expression in vivo has transformative potential in cancer therapy and beyond. (aacrjournals.org)
  • 7 ZHAO SG,CHEN WS,LI H,et al.The DNA methylation landscape of advanced prostate cancer J .Nat Genet,2020,52(8):778-789. (xdzlyx.com)
  • 14 LENG X,LIU M,TAO D,et al.Epigenetic modification-dependent androgen receptor occupancy facilitates the ectopic TSPY1 expression in prostate cancer cells J .Cancer Sci,2021,112(2):691-702. (xdzlyx.com)
  • 15 MAZZU YZ,YOSHIKAWA Y,NANDAKUMAR S,et al.Methylation-associated miR-193b silencing activates master drivers of aggressive prostate cancer J .Mol Oncol,2019,13(9):1944-1958. (xdzlyx.com)
  • 20 TOLKACH Y,ZARBL R,BAUER S,et al.DNA promoter methylation and ERG regulate the expression of CD24 in prostate cancer J .Am J Pathol,2021,191(4):618-630. (xdzlyx.com)
  • 23 LAN T,YIN L,ZHANG H,et al.Diagnostic value of DACT-2 methylation in serum of prostate cancer patients J .Ann Palliat Med,2021,10(3):2421-2428. (xdzlyx.com)
  • 24 BRAIT M,BANERJEE M,MALDONADO L,et al.Promoter methylation of MCAM,ER and ER in serum of early stage prostate cancer patients J .Oncotarget,2017,8(9):15431-15440. (xdzlyx.com)
  • DNA Methylation Signatures Predicting Bevacizumab Efficacy in Metastatic Breast Cancer. (cancercluster-salzburg.at)
Abnormal expression1
  • Our present research is aimed at studying the abnormal expression of GRHL2 and the association of methylation in patients with acute leukemia and its relationship with prognosis. (hindawi.com)
Mesenchymal1
  • Abnormal DNA methylation modifies HOX genes expression in bone marrow mesenchymal stromal cells of myelodysplasias and de novo acute myeloid leukemias. (lnox-team.org)
Dysregulation1
  • The underlying rationale of such counterintuitively contradictory approaches is based on differential gene expression dysregulation associated within any given diseases: some genes are aberrantly overexpressed while others are repressed. (biomedcentral.com)
Differential gene expression1
Acute leukemia6
  • We analyzed the significant correlation between the expression level of GRHL2 with clinicopathological features and patients' prognosis in acute leukemia using the corresponding statistical methods. (hindawi.com)
  • We found a lower level of GRHL2 expression not only in acute leukemia patients but also in cell lines when compared with normal controls. (hindawi.com)
  • At the same time, the expression level of GRHL2 in patients with acute leukemia was significantly correlated with leukocyte count, platelet count, and cytogenetic risk grouping. (hindawi.com)
  • In addition, the lower GRHL2 expression group showed a significantly lower overall survival rate in acute leukemia patients than that of patients with a higher GRHL2 expression group. (hindawi.com)
  • Univariate and multivariate analyses revealed that the expression of GRHL2 is an independent risk factor in acute leukemia patients. (hindawi.com)
  • Increased expression and methylation level of GRHL2 are closely associated with the prognosis and malignant phenotype of acute leukemia patients and play an irreplaceable role in the occurrence and development of patients with acute leukemia. (hindawi.com)
Regulate1
  • Solute carrier 6 (SLC6) is a gene family of ion-coupled plasma membrane cotransporters, including transporters of neurotransmitters, amino acids, and osmolytes that mediate the movement of their substrates into cells to facilitate or regulate synaptic transmission, neurotransmitter recycling, metabolic function, and fluid homeostasis. (epiphanyasd.com)
20191
  • 6 XU N,WU YP,KE ZB,et al.Identification of key DNA methylation-driven genes in prostate adenocarcinoma:an integrative analysis of TCGA methylation data J .J Transl Med,2019,17(1):311. (xdzlyx.com)
Single gene1
  • research shows that about 90% of the blood system of malignant tumors with at least the height of single gene methylation is closely related since this is a reversible process of genetic modification can be through to handle to restore the normal expression of gene methylation, to achieve the purpose of prevention and treatment of tumor [ 10 ]. (hindawi.com)
Cells5
  • The suppression of tumorigenicity in these hybrid cells prompted researchers to hypothesize that genes within the normal somatic cell had inhibitory actions to stop tumor growth. (wikipedia.org)
  • SFRP1 promoter methylation and expression in human trabecular meshwork cells. (umassmed.edu)
  • Application of 14 M cyclopamine for 24 hrs to andro gen independent LNCaP C4 2B cells resulted in decreased expression of PTCH and GLI1, steady with cyclopamine inhibiting SMO and Hedgehog signalling action. (hdac-inhibitors.com)
  • Treatment of LNCaP-LN3 cells with 5'-azacytidine caused re-expression of LDHB transcripts. (ox.ac.uk)
  • Cells have built in machinery to turn off and on gene expression permanently. (aacrjournals.org)
20221
  • A 2022 study explains how one of the more common gene mutations in MDS can lead to severe forms of anemia. (healthline.com)
Diseases2