• In mouse models, deregulated expression of chromosome 21-encoded genes is implicated in leukaemic transformation, but does not recapitulate the effects of trisomy 21 in a human context. (ox.ac.uk)
  • Elastin gene on chromosome 7q11.2 encodes ELN. (elisakits.co.uk)
  • Williams Syndrome (WS) is a rare neurodevelopmental disorder caused by heterozygous deletions in a chromosome 7q11.23 region typically encompassing 26-28 genes. (aging-research.group)
  • Deletions or duplications of genetic material can affect all or part of the FLNA gene, and may also include nearby genes on the X chromosome. (medlineplus.gov)
  • The BTK gene defect has been mapped to the long arm of the X chromosome at band Xq21.3 to Xq22, spanning 37.5kb with 19 exons forming 659 amino acids to complete the BTK cytosolic tyrosine kinase. (medscape.com)
  • Because these genes are located on the X chromosome, hemophilia affects males almost exclusively. (msdmanuals.com)
  • Time-series single-cell RNA sequencing paired with single-cell resolution spatial revealed human embryonic development signatures such as extraembryonic placenta, yolk sac hematopoiesis neural crest, blood vessels, and cardiac mesoderm. (newswise.com)
  • Lead can cross the placenta and enter the developing fetal brain. (cdc.gov)
  • Zonary Placenta: The placenta takes the form of a complete or incomplete band of tissue surrounding the fetus. (ge-shi.net)
  • In this type of placenta the chorionic villi looses their epithelium and mesenchymal layers to such a degree that the endothelial wall of the foetal blood vessels remain in contact with the maternal blood. (ge-shi.net)
  • 4. Type of Placenta Maternal Layers Retained Examples Endometrial Epithelium Connective Tissue Uterine Endothelium Epitheliochorial Horses, swine, ruminants Endotheliochorial Dogs, cats Hemochorial Humans, rodents In humans, fetal chorionic epithelium is bathed in maternal blood because chorionic villi have eroded through maternal endothelium. (ge-shi.net)
  • 8 DEVELOPMENT OF PLACENTA The villous chorion ( increase in number, enlarge and branch ) will form the fetal part of the placenta. (ge-shi.net)
  • Functions of Placenta: Histologically the placenta consists of barriers that prevent the blending of blood of the foetus and mother. (ge-shi.net)
  • Note that the lower edge of the placenta is about 0.9 cm from the cervical internal os Placental Types Mouse placenta Discoid in humans, mouse, insectivores, rabbit, rat, and monkeys. (ge-shi.net)
  • Recently, the placenta, a tissue with a unique hypomethylated methylome, has been shown to possess great inter-individual variability, which we highlight as a promising target tissue for studying MEs and mixed environmental exposures. (frontiersin.org)
  • Placenta-associated pregnancy complications, such as preeclampsia and intrauterine growth restriction, are all associated with aberrant patterns of DNA methylation and expression which are only now being linked to disease risk later in life. (frontiersin.org)
  • Human exposure to perchlorates is expected to occur primarily through the ingestion of food and water containing perchlorate. (cdc.gov)
  • We show here that in vitro exposure to SARS-CoV-2 activates the expression of the human endogenous retrovirus (HERV) HERV-W proinflammatory envelope protein (ENV) in peripheral blood mononuclear cells from a subset of healthy donors, in ACE2 receptor and infection-independent manner. (unmc.edu)
  • In particular, in vitro exposure to interleukin-2/Phytohaemagglutinin or valproic acid induces the expression of several HERVs and cytokines while Efavirenz inhibits them. (biomedcentral.com)
  • In this context, we aimed to determine whether cannabis exposure has the potential to directly impact the human fetal testis. (biomedcentral.com)
  • Depending on the molecules and testis age, highly deleterious effects of phytocannabinoid exposure were observed on testis tissue after 14 days, including Sertoli and germ cell death. (biomedcentral.com)
  • In the USA, while fetal exposure to tobacco decreases, cannabis use during pregnancy rises along with the enhanced perception that there are no risks with cannabis consumption during pregnancy [ 2 ]. (biomedcentral.com)
  • Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAEL) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
  • Estimates of exposure levels posing minimal risk to humans (Minimal Risk Levels or MRLs) have been made for di-n-butyl phthalate. (cdc.gov)
  • An MRL is defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse effects (noncarcinogenic) over a specified duration of exposure. (cdc.gov)
  • As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)
  • In humans, low protein intake by women in late but intrauterine exposure was (20). (cdc.gov)
  • Retrospective studies of the survivors of famines, such as those exposed to the Dutch Hunger Winter of 1944-45, have linked exposures around conception to later disease outcomes, some of which correlate with DNA methylation changes at certain genes. (frontiersin.org)
  • Amy Radunz, a nutritionist from the department of animal sciences at the University of Wisconsin in River Falls, has partnered with molecular biologist Hasan Khatib, an associate professor at University of Wisconsin-Madison, to ask how differences in maternal diet during pregnancy induce gene expression and DNA methylation changes in fetal tissues in sheep. (genengnews.com)
  • Single-cell level characterization of embryonic development is a major benchmark of human developmental biology. (newswise.com)
  • Here, we defined the single-cell spatiotemporal gene expression landscape of human embryonic development with stem-cell-derived organoids. (newswise.com)
  • We established the human embryonic organoid (HEMO) from expanded potential stem cells and achieved both embryonic and extraembryonic tissues in the same organoid. (newswise.com)
  • Overall, our study advances the spatiotemporal analysis of human embryonic development in stem-cell-derived organoids. (newswise.com)
  • The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. (nih.gov)
  • Recent work using primary human foetal liver and bone marrow cells, human embryonic stem cells and iPS cells shows that prior to acquisition of GATA1 mutations, trisomy 21 itself alters human foetal haematopoietic stem cell and progenitor cell biology causing multiple abnormalities in myelopoiesis and B-lymphopoiesis. (ox.ac.uk)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • Immunohisto- have been used for positive selection of NSCs from em- chemistry on human embryonic central nervous system bryonic mice (Nagato et al. (lu.se)
  • Mutations in this gene may be associated with sporadic cases of neural tube defects. (wikipedia.org)
  • Mutations in this gene have been associated with adult i blood group phenotype. (nih.gov)
  • N-terminal truncating mutations in the key haematopoietic transcription factor GATA1 are acquired during foetal life in virtually every case. (ox.ac.uk)
  • Mutations in the ELN-gene are associated with Williams syndrome characterized by tissue abnormalities, cardiovascular defects well as intellectual disability. (elisakits.co.uk)
  • Variants (also known as mutations) in the FLNA gene have been identified in people with frontometaphyseal dysplasia. (medlineplus.gov)
  • X-linked agammaglobulinemia (XLA), or Bruton agammaglobulinemia, is an inherited immunodeficiency disease caused by mutations in the gene coding for Bruton tyrosine kinase (BTK). (medscape.com)
  • Hemophilia is an inherited disorder that results from mutations, deletions, or inversions affecting the factor VIII or factor IX gene. (msdmanuals.com)
  • A new mutation has been reported, making a total of 15 different mutations that can cause premature stop codons in the alpha-L-iduronidase gene ( IDUA ), and the biochemistry of these mutations has been investigated. (medscape.com)
  • These authors demonstrated monoclonal antibody FB5 reactivity in a significant proportion of tumor blood vessels, including those of sarcoma, while ostensibly being absent from normal tissues. (hindawi.com)
  • It is now accepted that the formation of solid tumors requires the proliferation of stromal cells to support cancer cell growth, invasion, and metastasis [ 5 ] and that the stromal cell compartment comprises a heterogeneous mix of cell types responsible for the formation of blood vessels as well as supporting a microenvironment commensurate with tumor growth and proliferation. (hindawi.com)
  • Mechanical forces have an important role in regeneration of tissues, such as bone, cartilage, blood vessels, and myocardium. (hairloss-research.org)
  • Elastin (ELN) is a protein found in the matrix, for providing elasticity and resilience to various tissues like the skin, lungs, and blood vessels. (elisakits.co.uk)
  • These numerous functions involving filamin A have been found to play roles in regulating skeletal and brain development, the formation of heart tissue and blood vessels, blood clotting, skin elasticity, the maintenance of lung tissue, and the function of the digestive system. (medlineplus.gov)
  • Загальні відомості про порушення згортання крові Abnormal bleeding can result from disorders of the coagulation system, of platelets, or of blood vessels. (msdmanuals.com)
  • Currently more than 300 environmental chemicals or their metabolites are measured in human samples (urine, blood, serum, stool, breast milk, and meconium). (susansmithjones.com)
  • Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2. (nih.gov)
  • Human elastin ELISA kit can measure concentrations of ELN (elastin) present is plasma, serum, biological fluids or tissue homogenate samples. (elisakits.co.uk)
  • We tested various specimens (blood, cerebrospinal fluid, intraocular fluid, serum, and tissues) from the organ donor and recipients by serology, RT-PCR, immunohistochemistry, metagenomic next-generation sequencing, and host gene expression, and conducted a traceback of blood transfusions received by the organ donor. (cdc.gov)
  • This gene encodes the enzyme responsible for formation of the blood group I antigen. (nih.gov)
  • Endosialin, also known as Tumor Endothelial Marker-1 (TEM-1) or CD248, was first described as a vascular endothelial cell surface antigen in human fetal fibroblasts [ 1 ]. (hindawi.com)
  • SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells. (nih.gov)
  • Hemoglobin is an iron-containing respiratory protein in red blood cells that binds oxygen and then transports and releases it to cells that need oxygen. (icr.org)
  • 4 The worms have an amazing extracellular multi-hemoglobin system with one in the coelomic cavity (a fluid-filled body cavity) and two in the vascular (blood system) compartment. (icr.org)
  • In a study on vertebrate globins, Jay Storz and his colleagues wrote, "The retention of the proto- Hb and Mb genes in the ancestor of jawed vertebrates permitted a physiological division of labor between the oxygen-carrier function of Hb [hemoglobin] and the oxygen-storage function of Mb [myoglobin]. (icr.org)
  • Representation of a human hemoglobin protein molecule. (icr.org)
  • Hemoglobin is an iron-containing oxygen-transport protein found in red blood cells. (icr.org)
  • There are over 300 alleles (one of two or more forms of a gene that produce variations in a given trait) for the hemoglobin gene, part of the globin gene superfamily. (icr.org)
  • Hemoglobin is an iron-containing protein in red blood cells that transports oxygen to tissues throughout the body. (cshlpress.com)
  • Contributors examine the structure, expression, and evolution of the globin genes, the assembly of globin subunits into functional forms of hemoglobin, and the numerous variants that result from genetic alterations. (cshlpress.com)
  • This book includes discussions of management and treatment strategies for hemoglobin disorders, such as transfusions, iron-chelating agents, gene therapy, and stem cell transplantation. (cshlpress.com)
  • The unadulterated mutation encourages hemoglobin to clump and deform red blood cells, leading to anemia, increased hemolysis, and vascular occlusions that affect multiple organs. (nih.gov)
  • Decades before Jimi was born, chemist Linus Pauling discovered the root of the problem in sickle cell disease: an atypical form of the oxygen-carrying hemoglobin protein inside red blood cells. (investorvillage.com)
  • Atypical hemoglobin is the result of a misspelling in one gene - a T where there should be an A. People with just one copy of the altered gene have "sickle cell trait. (investorvillage.com)
  • It regulates differentiation and migration of neural crest cells along with other genes (e.g. (wikipedia.org)
  • Cells Tissues Organs. (wikipedia.org)
  • Cell-cell communication network analysis demonstrated that trophoblast-like tissues supplied WNT signaling in neural crest cells to facilitate maturation and migration. (newswise.com)
  • Mesenchymal stem cells (MSC) are multipotent cells which can be obtained from several adult and fetal tissues including human umbilical cord units. (escholarship.org)
  • Genes related to systems development, osteogenesis and immune system were expressed at higher levels in UCB, whereas genes related to cell adhesion, morphogenesis, secretion, angiogenesis and neurogenesis were more expressed in UC cells. (escholarship.org)
  • Endosialin (CD248, TEM-1) is expressed in pericytes, tumor vasculature, tumor fibroblasts, and some tumor cells, including sarcomas, with limited normal tissue expression, and appears to play a key role in tumor-stromal interactions, including angiogenesis. (hindawi.com)
  • Liver sinusoidal endothelial cells (LSECs) are directly exposed to translocated gut microbiota in portal vein blood. (bvsalud.org)
  • The high frequency of a unique neonatal preleukaemic syndrome, transient abnormal myelopoiesis (TAM), and subsequent acute myeloid leukaemia in early childhood in patients with trisomy 21 (Down syndrome) points to a specific role for trisomy 21 in transforming foetal haematopoietic cells. (ox.ac.uk)
  • At that point they develop from adult precursor cells, so-called monocytes, which are found in the blood. (eurekalert.org)
  • We discovered that fetal precursor cells divide faster than the adult precursor cells," says the study's first author Elza Evren, doctoral student in Tim Willinger's research group. (eurekalert.org)
  • The fetal precursor cells therefore populate the lungs faster, which is important early on in life to quickly remove microorganisms and other inhaled particles. (eurekalert.org)
  • Thereafter, the cells were harvested and their gene expression was analyzed using cDNA microarray methods. (hairloss-research.org)
  • Mesenchymal cells derived from the dermomyotome condense within connective tissue (mesenchymal) scaffolds to form 2 common muscle masses. (medscape.com)
  • Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
  • Conversion of Peripheral Blood NK Cells to a Decidual NK-like Phenotype by a Cocktail of Defined Factors The Journal of Immunology, 190:3939-3948 (2013). (bioind.com)
  • We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)
  • The transferred, expanded natural killer cells proliferated in vivo in an interleukin-2 dose-dependent fashion, persisted up to 4 weeks, were readily detectable in the human bone, inhibited myeloma growth and protected bone from myeloma-induced osteolysis. (haematologica.org)
  • Conclusions These studies provide the rationale for testing expanded natural killer cells in humans. (haematologica.org)
  • We recently demonstrated that autistic children and their mothers share high expression levels of some HERVs and cytokines in peripheral blood mononuclear cells (PBMCs) ex vivo, suggesting a close mother-child association in Autism Spectrum Disorder (ASD). (biomedcentral.com)
  • Since rodent models cannot recapitulate many of the human disease features, human induced pluripotent stem cells derived from Parkinson's patients have been used to generate brain organoids, greatly contributing to our understanding of the disease pathophysiology. (nature.com)
  • Similarly, co-treatment of PM and THP-1 cells with the COX-2 selective inhibitor NS-398 resulted in a significant decrease in PGE2, suggesting that MEHP-stimulated PGE2 is dependent specifically on increased COX-2 expression. (biomedcentral.com)
  • Western blot analysis revealed a significant increase in COX-2 expression in PM and THP-1 cells treated with 180 micromolar MEHP, and no changes in COX-1 expression, supporting the role of COX-2 in MEHP-stimulated PGE2 synthesis. (biomedcentral.com)
  • Recent data collected by our laboratory suggest that MEHP stimulates expression in human trophoblast cells of PTGS2, the gene for COX-2 [ 18 ], an enzyme that is critical for synthesis of uterotonic prostaglandins, prostaglandin E 2 (PGE 2 ) and prostaglandin F 2α (PGF 2α ). (biomedcentral.com)
  • High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells. (thermofisher.com)
  • Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor. (thermofisher.com)
  • The Cellular and Molecular Therapeutics Laboratory, led by Dr. John F. Tisdale, is working on multiple strategies both in the laboratory and in the clinic to cure sickle cell disease by repairing or replacing the precursor bone marrow cells that give rise to sickled red blood cells. (nih.gov)
  • In addition, strategies to correct the underlying mutation which causes sickle cell disease are being pursued utilizing newly developed gene editing tools, and work in the laboratory to develop methods for efficient editing of hematopoietic stem cells is underway. (nih.gov)
  • Dr. Tisdale has an active research program in trying to characterize tolerance and create conditions in which patients will more easily tolerate donor cells and tissues without the need for destroying the immune system or perpetual use of immunosuppressant drugs. (nih.gov)
  • After extracting and isolating precursor CD34+ cells from patients, they use viral transduction to insert a correct copy of the β-globin gene before returning the cells to the patient's bone marrow. (nih.gov)
  • The laboratory has focused on optimizing the conditions for viral transduction, including selecting and modifying viral strains for study in animal models, optimizing growth conditions for transduced hematopoietic cells, and designing gene vectors to ensure appropriate placement and expression of the inserted gene. (nih.gov)
  • Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
  • Inside Jimi, normally pliable, disc-shaped red blood cells deformed into rigid crescents. (investorvillage.com)
  • We also use human stem cells as a test-tube model to study the process of heart formation and to create new human heart tissues and organs from these stem cells. (stanford.edu)
  • We subsequently became interested in developing a developing heart expression atlas in order to identify the cell type, developmental stage, and anatomical location of each single cardiac cells during mouse heart development using a random forest-based computational algorithm that we termed ATLAS-seq. (stanford.edu)
  • 1. Development of a ML/AI pipeline for the prediction of subtypes and differentiation stage of developing mouse cardiac cells from mesoderm to birth and from in vitro differentiation of human induced pluripotent stem cells (hiPSCs). (stanford.edu)
  • Recent Accomplishments - Starting in 2013, we incorporated Fluidigm-based multiplex single cell PCR equipment HD Biomark to analyze the differentiation of single cardiac progenitor cells in vitro and found that Nkx2.5 expression marks a subpopulation of committed endocardial precursor cells in the mouse heart (Li et al, Development 2015). (stanford.edu)
  • Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells. (lww.com)
  • 2 Despite having high metabolic activity, human CECs (hCECs) do not proliferate in vivo because these cells arrest in the G1 phase of the cell cycle. (lww.com)
  • The FLNA gene provides instructions for producing the protein filamin A, which helps build cells' extensive internal network of protein filaments called the cytoskeleton. (medlineplus.gov)
  • Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
  • In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
  • Human CMV grows only in human cells and replicates best in human fibroblasts. (medscape.com)
  • The large proteoglycan molecules made up of protein cores, and GAG branches are secreted by cells and constitute a significant fraction of the extracellular matrix of connective tissue. (medscape.com)
  • The enzyme deficiencies lead to the accumulation of mucopolysaccharides in the lysosomes of the cells in the connective tissue and to an increase in their excretion in the urine. (medscape.com)
  • 2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
  • Maternal obesity alters placental tissue function and morphology with a corresponding increase in local inflammation. (aging-research.group)
  • Widely expressed in human tissues, SLUG is most notably absent in peripheral blood leukocytes, adult liver, and both fetal and adult brain tissues. (wikipedia.org)
  • Tissue content of monoamines, volumetric brain abnormalities, dendritic spine density in the hippocampus, and various domains of the mouse behavior repertoire were evaluated in adult male mice. (researchgate.net)
  • We believe that by understanding the mechanisms regulating the formation of the heart during fetal development we can then apply these principles to understand the causes of adult heart diseases such as heart attack and heart failure. (stanford.edu)
  • In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)
  • 2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)
  • Cell-free RNA (cfRNA) transcripts known to be expressed by the fetal brain are detectable by quantitative reverse transcription PCR (RT-qPCR) in amniotic fluid and represent potential biomarkers of neurodevelopment. (biomedcentral.com)
  • A novel approach would be to examine the genetic transcripts found in the amniotic fluid that encode genes responsible for neurodevelopment. (biomedcentral.com)
  • Amniotic fluid (AF) cell-free RNA (cfRNA) has previously been shown to be a novel source of information about multiple organ systems including the fetal brain [ 1 - 3 ]. (biomedcentral.com)
  • Design and Methods OPM2 and high-risk primary myeloma tumors were grown in human fetal bone implanted into non-obese diabetic severe combined immunodeficiency mice with a deficient interleukin-2 receptor gamma chain. (haematologica.org)
  • Studies have identified pericytes and reactive fibroblasts, two essential cell types required for tumor survival and growth, as the major sites of expression of endosialin. (hindawi.com)
  • Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
  • This gene encodes a member of the Snail superfamily of C2H2-type zinc finger transcription factors. (wikipedia.org)
  • This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. (nih.gov)
  • DNA methylation is the most commonly studied epigenetic mark in humans, as it is well recognised as a stable, heritable mark that can affect genome function and influence gene expression. (frontiersin.org)
  • The majority of the gene expression studies on AF utilizing cfRNA have been performed with whole genome microarrays, with fewer data from RT-qPCR, which has a greater dynamic range. (biomedcentral.com)
  • Scott Weiss is the Scientific Director of Partners HealthCare Personalized Medicine where he supervises a faculty of 6 and a staff of over 100 who are dedicated to translating the results of human genome research into clinical medical practice. (partners.org)
  • Scientists armed with whole genome sequence data can now ask questions about genome structure and organization that impact gene expression. (genengnews.com)
  • explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)
  • CfRNA transcripts that are (1) highly expressed by fetal brain, (2) detectable in AF and (3) exhibit brain-specific expression patterns, represent candidate biomarkers of neurodevelopment that could be measured using RT-PCR. (biomedcentral.com)
  • Functional analysis of cfRNA suggests that is more promising than amniocyte RNA as a source of potential biomarkers of fetal neurodevelopment [ 3 ]. (biomedcentral.com)
  • gse98564] Gene expression biomarkers for neurobehavioral impairment from tot. (aging-research.group)
  • 2020) Pathological processes in the uterine wall decidua in preeclampsia and fetal growth restriction. (ntnu.edu)
  • The upregulated genes included hair growth genes such as VEGF, WNT, BMP, and PDGF, and the downregulated genes included hair-removing genes such as IL-6 and TNF. (hairloss-research.org)
  • An optimal stretching/stimulation force applied for a suitably long period can up-regulate hair growth genes and down-regulate hair removal genes in HDPCs. (hairloss-research.org)
  • This simple movement applies a repeated stretching force to the scalp and will in so doing, according to the above study, up-regulate hair growth genes and down regulate genes involved in hair miniaturization. (hairloss-research.org)
  • The working hypothesis going into the experiment was that the primary impact on the fetal growth in previous studies was the result of the amount of glucose in the maternal diet. (genengnews.com)
  • expression of mhDISC1, endogenous DISC1, lissencephaly type 1, nuclear distribution protein nudE-like 1, glycoprotein 130, growth factor receptor-bound protein 2, and glycogen synthase kinase-3beta were assessed in cortical samples of newborn mice. (researchgate.net)
  • Cannabis consumption by pregnant women continues to increase worldwide, raising concerns about adverse effects on fetal growth and deleterious impacts on the newborn, in connection with evidence of placental transfer of cannabis compound. (biomedcentral.com)
  • Prenatal interaction modulated secretion of inflammatory cytokines in fetal brains, levels of mhDISC1, endogenous mouse DISC1, and glycogen synthase kinase-3beta. (researchgate.net)
  • Plasma and/or sera of 221 COVID-19 patients from different cohorts, infected with successive SARS-CoV-2 variants including the Omicron, had detectable HERV-W ENV, which correlated with ENV expression in T lymphocytes and peaked with the disease severity. (unmc.edu)
  • Polymorphisms in the human tropoelastin gene modify in vitro self-assembly and mechanical properties of elastin-like polypeptides. (elisakits.co.uk)
  • The results show that HERVs and cytokines expression can be modulated in vitro by different stimuli in PBMCs from autistic children and their mothers, while no significant changes were found in PBMCs ASD fathers or in controls individuals. (biomedcentral.com)
  • To date, our methods of antenatal prediction of long term neurodevelopmental outcome has been confined to only a few modalities-imaging with ultrasound and MRI, and maternal blood analysis for markers of aneuploidy or neural tube defects. (biomedcentral.com)
  • The fetal testis, whose endocrine function orchestrates the masculinization of many distant organs, is particularly sensitive to disruption by xenobiotics. (biomedcentral.com)
  • In the blood, absorbed lead is bound to erythrocytes and then is distributed initially to multiple soft tissues and eventually into bone. (cdc.gov)
  • Bone marrow transplants from healthy donors are used successfully to treat certain blood cancers for which the course of the disease is so severe that the destruction of the patient's own immune system through high-dose chemotherapy and radiation seems an effective compromise. (nih.gov)
  • Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. (wjgnet.com)
  • Putative pathogenic effects mediated by human endogenous retroviruses (HERVs) in neurological and psychiatric disorders in humans have been extensively described. (biomedcentral.com)
  • OBJECTIVE- To examine the longitudinal association of fat mass-and obesity-associated ( FTO ) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse. (diabetesjournals.org)
  • 1 ) identified a common variant in fat mass-and obesity-associated ( FTO ) gene (rs9939609) that was related to higher BMI in both children and adults. (diabetesjournals.org)
  • Alison's previous wet-lab research interests lie in adipose tissue regulation, obesity and developmental origins of health and disease. (nottingham.ac.uk)
  • Animal and human epidemiological studies have established that sub-optimal maternal diet throughout pregnancy results in offspring that are at increased risk of later metabolic disease including diabetes and obesity. (nottingham.ac.uk)
  • gse97554] Primate fetal hepatic response to maternal obesity: epigenetic sig. (aging-research.group)
  • 11), altered liver structure and function (12), altered naire data from 8,765 children aged 5 to 7 years, smoking gene expression (13), and possibly type 2 diabetes mel- after pregnancy was not associated with childhood obesity litus (10). (cdc.gov)
  • Of the 287 chemicals detected in the umbilical cord blood, (lots more below) 180 cause cancers in humans, 217 are toxic to the brain and nervous system, and 208 cause birth defects or abnormal development. (susansmithjones.com)
  • In 2005, the Environmental Working Group 2 tested umbilical cord blood from 10 children and found 287 chemicals: 180 of them were carcinogenic, 217 were neurotoxic, and 208 caused birth defects or abnormal development in animal tests. (ndnr.com)
  • However, with the help of a model, researchers at Karolinska Institutet have now been able to directly study the development of human macrophages in a living lung. (eurekalert.org)
  • The expression of elastin and the formation of fibers reach their peak during fetal development and early postnatal development. (elisakits.co.uk)
  • She then spent 2 years at Imperial College London as a post-doctoral scientist, followed by 2 years as a University of Nottingham Senior Research Fellow in the School of Human Development. (nottingham.ac.uk)
  • Altogether, these results demonstrate that SARS-CoV-2 could induce HERV-W envelope protein expression and suggest its involvement in the immunopathogenesis of certain COVID-19-associated syndromes and thereby its relevance in the development of personalized treatment of patients. (unmc.edu)
  • The loss of NF-1 is relevant to the development of the disease in human patients. (genengnews.com)
  • HERVs may alter the development of the brain by means of several mechanisms, including modulation of gene expression, alteration of DNA stability, and activation of immune system. (biomedcentral.com)
  • Our study is the first to evidence the presence of the ECS in the human fetal testis and to highlight the potential adverse effect of cannabis consumption by pregnant women onto the development of the male gonad. (biomedcentral.com)
  • Genes required for B cell development. (medscape.com)
  • This was the first study to suggest that smoking tension and vascular defects (8,9), altered fetal pancreatic during pregnancy is linked to adverse changes in the lipo- development and structure (10), altered glucose tolerance protein levels of children (19). (cdc.gov)
  • RT qPCR was performed for the reference gene GAPDH , and three genes associated with neurodevelopment ( NRXN3, NTRK3 , and ZBTB18 ). (biomedcentral.com)
  • Adhesion of MSCs to DLT molded in silicone and particularly in collagen initiates polygonal morphology and monolayer formation and enhances not only transcription of CEC typical genes such as ZO-1, Na/K-ATPase, PITX2, and COL-8 but also expression of the corresponding proteins. (lww.com)
  • CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages", Elza Evren, Emma Ringqvist, Jean-Marc Doisne, Anna Thaller, Natalie Sleiers, Richard A. Flavell, James P. Di Santo, Tim Willinger. (eurekalert.org)
  • On day 130 of pregnancy, nonsurvival surgery was performed on the ewes to enable the measure of uterine blood flow to monitor nutrient supply to the fetus and to collect tissue samples from four fetal tissues. (genengnews.com)
  • Then, midway through Amanda's pregnancy, the couple read an article about Victoria Gray, a woman whose genes had been experimentally edited to treat her sickle cell disease. (investorvillage.com)
  • Pregnancy is characterized by physiologic changes in mineral metabolism, to allow calcium accretion in the fetal skeleton [ 1-3] . (who.int)
  • The patterns of intronic ncRNA expression in MSC from UC and UCB paired units were highly similar, indicative of their common donor origin. (escholarship.org)
  • Hierarchical clustering based on protein-coding expression similarities grouped MSC according to their tissue location rather than original donor. (escholarship.org)
  • The current view is that the relative amount of different amino acids (arginine, methionine, and cysteine) may play a more significant role given that these amino acids contain methyl donor groups that can impact the activity of maternally and paternally imprinted genes. (genengnews.com)
  • 3 days before organ procurement, the organ donor received a blood transfusion from a donor who had received a yellow fever vaccine 6 days before blood donation. (cdc.gov)
  • The diagnosis is confirmed by abnormally low or absent numbers of mature B lymphocytes, as well as low or absent expression of the µ heavy chain on the surface of the lymphocyte. (medscape.com)
  • Remarkably, the antiretroviral drug Efavirenz restores the expression of specific HERV families to values similar to those of the controls, also reducing the expression of proinflammatory cytokines but keeping the regulatory ones high. (biomedcentral.com)
  • Here the chorion possesses finger-like vascular processes, the villi, which grows out into the adjacent maternal tissue. (ge-shi.net)
  • 16q24.3 (Morquio syndrome): The deficiency of enzymes in Morquio syndrome type A or type B leads to the accumulation of keratan sulfate and chondroitin-6-sulfate in the connective tissue, the skeletal system, and the teeth. (medscape.com)
  • HERV-W ENV was also found in postmortem tissues of lungs, heart, gastrointestinal tract, brain olfactory bulb, and nasal mucosa from COVID-19 patients. (unmc.edu)
  • gse45642] Circadian patterns of gene expression in the human brain and disru. (aging-research.group)
  • Recent infection with yellow fever virus was confirmed in all four organ recipients by identification of yellow fever virus RNA consistent with the 17D vaccine strain in brain tissue from one recipient and seroconversion after transplantation in three recipients. (cdc.gov)
  • Cannabis action is mediated by the endocannabinoid system (ECS), which expression is well established in the brain but unknown in the developing testis. (biomedcentral.com)
  • The ECS, which is sensitive to phytocannabinoids, plays a fundamental physiological role in the brain and peripheral tissues, as well as in many pathological conditions [ 14 ]. (biomedcentral.com)
  • It receives blood from a vein in the nasal cavity, runs backwards, and gradually increases in size as blood drains from veins of the brain and the DURA MATER. (bvsalud.org)
  • Expression of FTO was tested in adipocytes from db / db mice and mouse macrophages. (diabetesjournals.org)
  • FTO gene was universally expressed in human and mice tissues, including adipocytes. (diabetesjournals.org)
  • In an ancillary study of adipocytes from db / db mice, FTO expression was ∼50% lower than in those from wild-type mice. (diabetesjournals.org)
  • In addition, the expression of FTO gene was reduced in adipocytes from db / db mice. (diabetesjournals.org)
  • Hematopoietic tissues eventually predominated HEMO with erythropoiesis, mekagaryopiesis, and myelopoiesis. (newswise.com)
  • In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. (thermofisher.com)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • Elastin is abundant in tissues that require elasticity for functions including large arteries, lungs, skin, and ligaments. (elisakits.co.uk)
  • IL-17A enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. (thermofisher.com)
  • Prolia (denosumab) is a human IgG2 monoclonal antibody with affinity and specificity for human RANKL (receptor activator of nuclear factor kappa-B ligand). (rxlist.com)
  • Imposed upon this gross morphological description is the modern understanding of gene expression and protein elucidation, which bring about these developmental processes. (medscape.com)
  • Improved access to bioinformatics tools enables scientists to process, manage, and store raw data, annotate sequences to define genes, and quantitate RNA sequence data to get insight into gene expression patterns. (genengnews.com)
  • gse89595] Signiture microRNA expression patterns identified in Williams synd. (aging-research.group)
  • states'' or gene expression patterns. (lu.se)
  • Although people carry many variations in the gene for this enzyme, this woman had an unusual difference: she expressed multiple copies of the gene. (the-scientist.com)
  • Gene-environment interactions (GEI) are involved in the pathogenesis of mental diseases. (researchgate.net)
  • Lung macrophages begin to develop in humans from birth when the lungs are first inflated with inhaled air. (eurekalert.org)
  • Changes in these additional genes may account for some of the other signs and symptoms, such as neurological abnormalities and unusual facial features, that occur in some affected individuals. (medlineplus.gov)