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  • apoptosis
  • Many of these are members of fundamental cancer-related pathways, including those related to DNA and metal binding, and regulation of apoptosis and also but include genes implicated in chronic heart and lung diseases. (beds.ac.uk)
  • Differing from day 7, the majority of cluster gene categories modified by nanoparticles in kidney 30 days after dosing were genes implicated in cell regulation and apoptosis. (springer.com)
  • Morphine increases apoptosis in human microglial cells, and animal studies demonstrate long-term changes in behavior, brain function, and spatial recognition memory following morphine exposure. (mdpi.com)
  • candidate genes
  • Results from numerous studies have identified several genomic regions known to be subject to imprinting, candidate genes, and gene-environment interactions. (wikipedia.org)
  • See Table 1) Table 1 Table 1- Modified from Schanen (2006) Genes on 15q11-13 can be classified into three main categories: GABAA receptor genes: Members of the GABA receptor family, especially GABRB3, are attractive candidate genes for Autism because of their function in the nervous system. (wikipedia.org)
  • Upregulation
  • Several gene families are involved in the processes of hyperaccumulation including upregulation of absorption and sequestration of heavy metal metals. (wikipedia.org)
  • Although experiments have shown that the hyperaccumulation is partially dependent on environmental exposure (i.e. only plants exposed to a metal are observed with high concentrations of that metal), hyperaccumulation is ultimately dependent on the presence and upregulation of genes involved with that process. (wikipedia.org)
  • FMR1
  • An expansion of the CGG trinucleotide repeat in the promoter of the gene FMR1 in boys causes fragile X syndrome, and at least 20% of boys with this mutation have behaviors consistent with autism spectrum disorder. (wikipedia.org)
  • mutations
  • Wilson disease is a rare autosomal recessive disorder of the copper metabolism caused by homozygous or compound heterozygous mutations in the ATP-ase Cu(2+) transporting polypeptide (ATP7B) gene. (thisisms.com)
  • We describe a child with clinical zinc deficiency as presenting symptom of Wilson disease, which was confirmed by 2 mutations within the ATP7B gene and an increased copper excretion. (thisisms.com)
  • ALL emerges when a single lymphoblast gains many mutations to genes that affect blood cell development and proliferation. (wikipedia.org)
  • These genes, in turn, increase the risk that more mutations will occur in developing lymphoid cells. (wikipedia.org)
  • Environmental risk factors are also needed to help create enough genetic mutations to cause disease. (wikipedia.org)
  • First, individuals with autism have significantly reduced fecundity, they are 20 times less likely to have children than average, thus curtailing the persistence of mutations in ASD genes over multiple generations in a family. (wikipedia.org)
  • The first genes to be definitively shown to contribute to risk for autism were found in the early 1990s by researchers looking at gender-specific forms of autism caused by mutations on the X chromosome. (wikipedia.org)
  • genetic
  • This sensitivity is thought to be genetic, although no gene has yet been implicated. (harpers.co.uk)
  • Klump KL, Miller K, Keel P, McGue M, Iacono W. Genetic and environmental influences on anorexia nervosa syndromes in a population-based twin sample. (springer.com)
  • Anorexia nervosa and major depression: shared genetic and environmental risk factors. (springer.com)
  • Mitchell K, Neale M, Bulik C, Aggen S, Kendler K, Mazzeo S. Binge eating disorder: a symptom-level investigation of genetic and environmental influences on liability. (springer.com)
  • However, individuals can develop asthma without any apparent genetic predisposition, and exposures other than allergens can lead to the development of asthma. (aappublications.org)
  • Although genetic factors play an important role in the development of asthma, recurrent airway inflammation, presumably mediated by environmental exposures, may result in persistent airway hyperresponsiveness and the development of chronic airway disease. (aappublications.org)
  • Because current research approaches to asthma cannot sufficiently describe the relationship and individual relevance of genetic and environmental factors in the development of airway disease in children, a holistic research approach that incorporates new genomic technologies with better exposure data is necessary to elucidate the pathogenesis of asthma. (aappublications.org)
  • This suggests that overexpression of ZIP family genes that encode cation transporters is a characteristic genetic feature of hyperaccumulation. (wikipedia.org)
  • instead, non-genetic factors cause the organism's genes to behave (or "express themselves") differently. (wikipedia.org)
  • metabolism
  • Anthropometric measurements and venous blood were collected and analyzed for gene expression in SSAM (sex steroid activity and metabolism) from the offspring. (rti.org)
  • Early life experiences, even when generations removed, can cause permanent epigenetic modifications of DNA resulting in changes in gene expression, endocrine function and metabolism. (wikipedia.org)
  • During bacterial starvation the USP genes upregulated will often arrest cell growth and promote its metabolism to adapt to sparse nutrients. (wikipedia.org)
  • induce
  • The primary function of this superfamily is to protect the organism from environmental stress such as exposure to UV light, which may induce genes containing the USP domain in order to protect the DNA and more generally the cell from further damage. (wikipedia.org)
  • renal
  • While nephrotoxicity of cadmium is well documented, very limited information exists on renal effects of exposure to cadmium-containing nanomaterials. (springer.com)
  • Renal gene expression changes were also observed in the kidney of CdCl 2 -treated rats with a total of 253 and 70 probes modulated at 7 and 30 days, respectively. (springer.com)
  • Modest renal gene expression changes were observed at day 30 in rats treated with CdCl 2 . (springer.com)
  • Cadmium exposure has been linked to lung, prostate and renal cancer. (wikipedia.org)
  • stressors
  • The mechanism by which heat-shock (or other environmental stressors) activates the heat shock factor has been determined in bacteria. (wikipedia.org)
  • UspA is especially implicated in the resistance of a huge number of stressors most notably tetracycline exposure and high temperatures, with the exception of not forming a response to cold shock. (wikipedia.org)
  • mediate
  • When this gene cluster is activated, these enzymes mediate the production of gliotoxin from serine and phenylalanine residues. (wikipedia.org)
  • immune
  • Changes in how genes in the immune system function may result in age-related macular degeneration (AMD), the leading cause of visual impairment in older adults, based on preliminary research conducted by National Institutes of Health (NIH) investigators. (nih.gov)
  • pollution
  • These genes included many that have been implicated in ischemic heart disease, chronic obstructive pulmonary disease (COPD), lung cancer, and other pollution-related illnesses. (beds.ac.uk)
  • These data provide a molecular link between the associations of air pollution exposures with health effects. (beds.ac.uk)
  • Human studies of global changes in gene expression following controlled exposures [ 7 ], or using in vitro models [ 8 , 9 ] have provided some insights in this regard, yet few studies have rigorously assessed the impact of air pollution on gene expression in real-life settings. (beds.ac.uk)
  • In this study, we characterized the cellular response induced by traffic-related air pollution exposures in a population of non-smoking US trucking industry employees. (beds.ac.uk)
  • Anthropogenic pollution has been the focus of extensive research for some time and a variety of programs for the monitoring and assessment of environmental pollution have been developed. (diva-portal.org)
  • A simple fractionation procedure in combination with liquid chromatography and 2-DE provided samples from mussels residing in different regions of a pollution gradient around the harbor of Gothenburg, as well as from mussels exposed to two types of fuel oil similar to that of the Prestige that were suitable for environmental proteomics. (diva-portal.org)
  • occur
  • KMT2A (formerly MLL) gene rearrangements are most common and occur in the embryo or fetus before birth. (wikipedia.org)
  • chromatin
  • NCoR), resulting in an altered chromatin structure and inactive genes. (diabetesjournals.org)
  • Chromatin remodeling in rodent offspring and altered gene expression within the limbic brain regions that may contribute to depression, stress, and anxiety-related disorders in future generations. (wikipedia.org)
  • chromosome
  • Also, genes on the X chromosome may play an important role, as in Rett Syndrome. (wikipedia.org)
  • The commonly duplicated region of chromosome 15 also includes paternally imprinted genes that can be considered candidates for ASD. (wikipedia.org)
  • Furthermore
  • Furthermore, we show that active exposure to tobacco smoke is associated with a biologically relevant mRNA expression signature. (aacrjournals.org)
  • Application of two-dimensional electrophoresis (2-DE) provided protein expression signatures (PES) for exposure to these different pollutants.Furthermore, several individual protein components of these PES could be putatively identified. (diva-portal.org)
  • occupational
  • We integrate these data with micro-environmental measures of occupational exposure to three pollutants -particulate matter ≤ 2.5 microns in aerodynamic diameter (PM 2.5 ), elemental carbon (EC), and organic carbon (OC) in PM 1.0 (particulate matter with a diameter of ≤1.0 μm). (beds.ac.uk)
  • office workers with no occupational traffic related exposures, and combination workers, who performed the job duties of a P&D driver or a dock worker, as needed. (beds.ac.uk)
  • humans
  • 15q11-13 in humans contains a cluster of genetically imprinted genes important for normal neurodevelopment. (wikipedia.org)
  • cluster
  • In Aspergillus fumigatus, the enzymes needed for gliotoxin biosynthesis are encoded in 13 genes within the gli gene cluster. (wikipedia.org)
  • interactions
  • Rett syndrome and Fragile X syndrome (FXS) are single gene disorders related to ASD with overlapping symptoms that include deficient neurological development, impaired language and communication, difficulties in social interactions, and stereotyped hand gestures. (wikipedia.org)
  • suggests
  • A comparison of urban and rural children suggests that the pathogenesis of airway disease is multifactorial and unique exposures may contribute to the development of disease in both settings. (aappublications.org)
  • A growing body of evidence suggests long-term harm associated with neonatal opioid exposure. (mdpi.com)
  • species
  • In diurnal (day-active) species, exposure to light soon after wakening advances the circadian rhythm, whereas exposure before sleeping delays the rhythm. (wikipedia.org)
  • These hyperaccumulation genes (HA genes) are found in over 450 plant species, including the model organisms Arabidopsis and Brassicaceae. (wikipedia.org)
  • The expression of such genes is used to determine whether a species is capable of hyperaccumulation. (wikipedia.org)
  • As there is wide variety among hyperaccumulating species that span across different plant families, it is likely that HA genes were ecotypically selected for. (wikipedia.org)
  • Environmental Exposure Exposure to fungal species that secrete gliotoxin is common because airborne Aspergillus fungal spores are ubiquitous in many environments. (wikipedia.org)
  • risks
  • Infectivity data are important for assessing public health risks from exposure to human pathogenic viruses in the environment. (environmental-expert.com)
  • Ramboll Environ provides assistance in assessing and mitigating potential environmental risks so that companies can operate more efficiently, address legal and regulatory challenges and reduce or eliminate future liabilities. (wikipedia.org)
  • The firm provides assistance so that industrial facilities are regulatory compliant, manage potential liabilities, and can assess environmental, health, and safety risks when making an acquisition. (wikipedia.org)
  • It carries high risks of environmental contamination. (wikipedia.org)
  • phenotypes
  • Table 1) Like other genetically imprinted genes, the parent of origin determines the phenotypes associated with 15q11-13 duplications. (wikipedia.org)
  • pollutants
  • At the request of the Hong Kong Environmental Protection Department the company developed a comprehensive air quality model system to address air quality concerns, including ozone, particulate matter, and other pollutants due to local sources, as well as transport from China and other areas in Asia. (wikipedia.org)
  • promoter
  • Influence of Cyclooxygenase-2 (COX-2) gene promoter-1195 and allograft inflammatory factor-1 (AIF-1) polymorphisms on allograft outcome in Hispanic kidney transplant recipients. (semanticscholar.org)
  • It is not a strong mutagen, but acts as a promoter through mitogenic effects on gene expression. (wikipedia.org)
  • phenotype
  • 290. Mitra S., Ghantasala S., Sameer Kumar GS, Lakshmi BJ, Thakur SS, Kumar S. Absence of Wdr13 gene predisposes mice to mild social isolation - chronic stress, leading to depression-like phenotype associated with differential expression of synaptic proteins. (gov.pl)
  • Although senescent cells can no longer replicate, they remain metabolically active and commonly adopt an immunogenic phenotype consisting of a pro-inflammatory secretome, the up-regulation of immune ligands, a pro-survival response, promiscuous gene expression (pGE) and stain positive for senescence-associated β-galactosidase activity. (wikipedia.org)
  • Evocative Environments respond to individuals based on the genes they express (phenotype). (wikipedia.org)
  • clock
  • In contrast to the pacemaker neurons, in which the circadian oscillations of clock gene expression what time should you take spironolactone self-sustained for many days in DD, oscillations in the peripheral clocks decline after several cycles in DD. (luxbar-starway.ru)
  • interact
  • In 1983, psychology professors Sandra Scarr and Kathleen McCartney proposed that genes affect the environments individuals choose to interact with, and that phenotypes influence individuals' exchanges with people, places, and situations. (wikipedia.org)
  • alcohol
  • Many cancers can be prevented by not smoking, maintaining a healthy weight, not drinking too much alcohol, eating plenty of vegetables, fruits and whole grains, vaccination against certain infectious diseases, not eating too much processed and red meat, and avoiding too much sunlight exposure. (wikipedia.org)
  • liver
  • Many people who have fatty liver are obese, but the condition can also result from injury to the liver caused by alcoholism, exposure to industrial chemicals, viral hepatitis, iron overload disease, or malnutrition. (turmericsgold.com)
  • Usually there has to be some kind of 1-2 punch to trigger inflammation in the liver, such as taking one of the aforementioned medications and drinking too much, or exposure to heavy metals. (turmericsgold.com)
  • levels
  • Inattentive mothering has led to increased levels of gene methyl marks, compared to attentive mothers. (wikipedia.org)
  • For example, brain cytokine levels increase following stress exposure, while treatments designed to alleviate stress reverse this effect. (wikipedia.org)
  • specific
  • This new study is leading to the discovery of environmental stressors that dictate initiation of specific neurological disorders and specific disease biomarkers. (wikipedia.org)
  • The specific DNA sequence in the MCM6 gene helps control whether the LCT gene is turned on or off. (wikipedia.org)
  • stress
  • As rodent offspring are fostered mono-parentally and have no direct exposure with their fathers, offspring born of stressed male rodents provide a good model for transgenerational stress inheritance. (wikipedia.org)
  • Early
  • Cytokines and chemokines regulate neurotrophins and other molecules critical to neurodevelopmental processes, and exposure to certain neuroimmune challenges early in life affects brain development. (wikipedia.org)
  • patients
  • Advances in cognitive behavioral therapy methods, such as Exposure therapy have improved our ability to treat patients with these conditions. (wikipedia.org)
  • brain
  • These irregularities, damage, or other cerebral anomalies observed in the brain are attributed to an individual's pathophysiology and their environmental surroundings. (wikipedia.org)
  • provides
  • While none of these ground-based analogs provides a perfect simulation of human microgravity exposure during spaceflight, each is useful for study of particular aspects of muscle unloading as well as for investigation of sensorimotor alterations. (wikipedia.org)
  • The LCT gene provides the instructions for making lactase. (wikipedia.org)
  • shown
  • has shown that birds were able to successfully imitate their tutor's song after relatively short exposure (40 playbacks of the motifs lasting 30 seconds total) over the duration of their sensitive learning period. (wikipedia.org)
  • Health
  • Changing down at 2017, we think a free History of the French Language enabled by environmental allergic causes, fucking the understanding noise album, stopping dress manuscripts, posting good pro-eugenics, the soldier of entitled vigour data, and reporting j to appraisal and health. (southwayinc.com)