• The molecular components of key Ca2+ signalling pathways have been identified. (hstalks.com)
  • Consequently our understanding of Ca2+ signalling is now advancing rapidly through experimental approaches that involve the controlled expression, inhibition of expression and use of naturally occurring or engineered mutations of channels, pumps, effectors and other proteins related to Ca2+ signalling pathways. (hstalks.com)
  • These findings reveal a central role for HDAC4 in CaMKII signaling pathways and have implications for the control of gene expression by calcium signaling in a variety of cell types. (jci.org)
  • Altered hair root gene expression profiles highlight calcium signaling and lipid metabolism pathways to be associated with curly hair initiation and maintenance in Mangalitza pigs. (mpg.de)
  • [ 34 , 35 ] were found to be associated with bipolar disorder in multiple samples, and expression analysis in rodents following administration of lithium or valproate indicated a role for FAT in neurodevelopment signaling pathways. (medscape.com)
  • Neuronal control of behavior arises from the activity of underlying neural circuits, which in turn are specified by the interaction of various signaling pathways. (jneurosci.org)
  • Early steps in this transition are complex, with at least 2 signaling pathways identified: 1 stops yeast growth and another, with a heat shock protein 70-type profile, initiates the assembly of proteins necessary for mycelial growth. (cdc.gov)
  • Yeast-form-specific genes identified in Histoplasma capsulatum function in calcium/calmodulin signaling pathways and sulphur metabolism. (cdc.gov)
  • Calcium-dependent signaling pathways and heat shock protein expression regulate dimorphism in Paracoccidioides brasiliensis and have broad implications for other pathogens. (cdc.gov)
  • In addition, gene set enrichment analysis shows 6 pathways that differ between high- and low-risk group. (techscience.com)
  • Finally, these signaling pathways induce expression of the nuclear factor of activated T cells c1 (NFATc1), which is a key transcription factor for osteoclastogenesis. (molcells.org)
  • Plants are immobile and, to overcome harsh environmental conditions such as drought, salt, and cold, they have evolved complex signaling pathways. (mdpi.com)
  • Effects of the carcinogenic metal cadmium on the regulation of mammalian gene expression are reviewed and discussed in the light of observations on interference with cellular signal transduction pathways. (nih.gov)
  • Nongenotoxic mechanisms upregulating intracellular signalling pathways leading to increased mitogenesis are discussed as major mechanisms for the interpretation of the carcinogenic activity by chronic cadmium exposure. (nih.gov)
  • In considering the available evidence, the carcinogenic properties of cadmium are interpreted using a multifactorial approach involving indirect genotoxicity (interference with DNA repair) and the upregulation of mitogenic signalling pathways. (nih.gov)
  • Elimination of BCR/ABL-dependent intracellular signals triggers apoptosis, but it is unclear whether this activates additional cell survival and/or death pathways. (lu.se)
  • The non-specific lethal complex regulates genes and pathways genetically linked to Parkinson's disease. (medscape.com)
  • median, 1.5), signaling pathways are far from fully understood. (lu.se)
  • Calcium plays an important role in this communication, because it exerts regulatory effects on many cellular proteins and cellular processes. (uib.no)
  • Lastly, we used RNA knockdown methods to diminish the expression of connexin proteins, which generate so-called "gap junctions" between cells - channels of communication which calcium and other molecules can traverse. (uib.no)
  • Na/K-ATPase beta1 subunit expression is required for blastocyst formation and normal assembly of trophectoderm tight junction-associated proteins. (nih.gov)
  • Free Ca 2+ is then rapidly sequestered by the action of calcium pumps and exchangers and also with buffering by cytosolic calcium binding proteins. (jneurosci.org)
  • We found that if you interfere with the calcium-signaling proteins located at these unusual clusters, you basically eliminate excitation-transcription coupling, which is critical for learning, memory, and other forms of neuronal plasticity. (sciencealert.com)
  • These effects of choline are correlated with modifications in histone and DNA methylation in brain, and with alterations in the expression of genes that encode proteins important for learning and memory processing, suggesting a possible epigenomic mechanism of action. (mdpi.com)
  • It stimulates the expression of immediate early genes (c-fos, c-jun, and c-myc), of the tumor suppressor gene p53, and of genes coding for the syntheses of protective molecules, including metallothioneins, glutathione, and stress (heat shock) proteins. (nih.gov)
  • Its activation is tightly controlled by numerous other signaling proteins including protein kinase C (PKC), Sab/SH3BP, and caveolin-1. (medscape.com)
  • There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)
  • Progesterone regulation of Na/K-ATPase β1 subunit expression in the mouse uterus during the peri-implantation period. (nih.gov)
  • Under the guidance of pharmacology chair and University Distinguished Professor Mark Nelson, Ph.D., his research focused on calcium signaling in vascular smooth muscle, which plays a crucial role in blood vessel regulation. (uvm.edu)
  • The Yokomori laboratory investigates the mechanisms of chromosome structural organization and how they affect DNA repair and gene regulation in human health and disease. (uci.edu)
  • In response to low temperature, many biochemical and physiological processes change in plants through regulation of cold responsive (COR) gene expression as well as through posttranslational protein modifications. (biomedcentral.com)
  • The ICE1-CBF-COR transcriptional cascade (inducer of CBF expression 1 and C-repeat binding factor transcriptional cascade) is the best characterized pathway for gene regulation under cold conditions in many species [ 8 ]. (biomedcentral.com)
  • Taken together, these findings provide the first evidence of ST5 involvement in positive regulation of osteoclastogenesis via Src/Syk/calcium signaling. (molcells.org)
  • Activation of Btk results in a cascade of signaling events resulting in calcium mobilization and fluxes, cytoskeletal rearrangements, and transcriptional regulation involving nuclear factor-kappaB (NF-kappaB) and nuclear factor of activated T cells (NFAT). (medscape.com)
  • Experiments using phytohormone priming and phytohormone inhibitors showed that resistance resulted from activation of JA-ET signaling pathway. (nature.com)
  • MiRNA-451 Inhibits Glioma Cell Proliferation and Invasion Through the mTOR/HIF-1α/VEGF Signaling Pathway by Targeting CAB39. (nih.gov)
  • To increase our understanding of these differentially expressed unigenes, we performed Gene ontology and KEGG pathway enrichment analyses. (biomedcentral.com)
  • An elevation of the intracellular calcium level, which is mediated by N-methyl-D-aspartate receptors and L-type Ca2+ channels both, activates the mitogen-activated protein (MAP) kinase signaling pathway involved in synaptic modification. (asahq.org)
  • Because the effects of local anesthetics on cellular signal transduction in neuronal cells are not well-known, the authors investigated whether they affect the MAP kinase signaling pathway using PC12 cells. (asahq.org)
  • We evaluated the expression and activation of Notch pathway genes in the adult human and murine corneal epithelium during proliferation. (molvis.org)
  • The expression of Notch pathway genes in the limbal and central human corneal epithelium was compared by reverse transcription polymerase chain reaction (RT-PCR). (molvis.org)
  • The Notch signaling pathway plays a key role in the proliferation and differentiation of many tissues. (molvis.org)
  • In the most well characterized "canonical" pathway in mammalian cells, the Notch intracellular domain (NotchIC) translocates to the nucleus where it mostly associates with the recombination signal binding protein for the immunoglobulin kappa J region (RBPJκ). (molvis.org)
  • In this recently published study , we dynamically imaged changes in intracellular calcium concentration in the early embryos of Oikopleura dioica using the genetically encoded calcium indicator GCaMP6. (uib.no)
  • The Ca 2+ signal is characterized by a rapid increase in the concentration of free cytosolic calcium ([Ca 2+ ] i ) attributable to the opening of calcium channels located in the plasma membrane and in the membranes of intracellular calcium stores. (jneurosci.org)
  • The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. (wikipedia.org)
  • This gene encodes an integral membrane protein that comprises a subunit of an ATP-metabolizing enzyme responsible for transporting sodium and potassium ions across the plasma membrane. (nih.gov)
  • Anatomical profiling of G protein-coupled receptor expression. (guidetopharmacology.org)
  • MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39. (nih.gov)
  • MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy. (nih.gov)
  • Our results suggest that cold temperature significantly affects genes related to protein translation and cellular metabolism in this chilling sensitive species. (biomedcentral.com)
  • It has recently been reported that mitogen-activated protein (MAP) kinase (also known as extracellular signal reactive kinase [Erk]) might play an important role in linking membrane depolarization to gene expression in the postsynaptic neurons. (asahq.org)
  • Trimmer and his colleagues had already detected multiple channels through these protein clusters, some that allow only potassium ions through a cell's membrane, while others are only for calcium ions. (sciencealert.com)
  • Through experiments on rodent neurons, the team uncoupled the potassium and calcium channels, which have protein bits that bind to each other. (sciencealert.com)
  • The protein diversity of mammalian cells is determined by arrays of isoforms from genes. (elifesciences.org)
  • Accurate Long-read transcriptome sequencing at single-cell level is required to decipher the spectrum of protein expressions in mammalian organisms. (elifesciences.org)
  • While protein expression is dictated by the level of gene expression, the structure and function of the protein is largely determined by the isoforms of the mRNA of a given gene and are impacted by mutations or other structural alterations to the amino acids ( Faustino and Cooper, 2003 ). (elifesciences.org)
  • The mechanisms underlying the modulation of gene activity by cadmium are discussed in terms of interference with cellular signalling at the levels of cell surface receptors, cellular calcium and zinc homeostases, protein phosphorylation, and modification of transcription factors. (nih.gov)
  • This gene provides instructions for making a protein called calcium/calmodulin-dependent serine protein kinase (CASK). (medlineplus.gov)
  • The CASK protein is primarily found in nerve cells (neurons) in the brain, where it helps control the activity (expression) of other genes that are involved in brain development. (medlineplus.gov)
  • Research suggests that the CASK protein may also interact with the protein produced from another gene, FRMD7 , to promote development of the nerves that control eye movement (the oculomotor neural network). (medlineplus.gov)
  • Mutations in the CASK gene affect the role of the CASK protein in brain development and function, resulting in the signs and symptoms of CASK -related intellectual disability. (medlineplus.gov)
  • Affected individuals with nystagmus may have CASK gene mutations that disrupt the interaction between the CASK protein and the protein produced from the FRMD7 gene, leading to problems with the development of the oculomotor neural network and resulting in abnormal eye movements. (medlineplus.gov)
  • This mechanism may underlie ascorbate release, signalling phenomena, apoplastic redox reactions, iron acquisition, and control the ionic and electrical equilibrium (together with K+ efflux via GORK channels). (deepdyve.com)
  • There, he has been mostly devoted to the study of Ca2+ and redox modulation/signalling impact on cancer cell motility. (cienciavitae.pt)
  • This enzyme regulates the electrochemical gradient of these ions in cells, and plays a central role in osmoregulation and signal transmission in nerves and muscles, among other biological processes. (nih.gov)
  • His work shed light on how calcium regulates gene expression in vascular smooth muscle cells, contributing to our understanding of this field. (uvm.edu)
  • ABA signaling component that regulates the ABA-responsive gene expression via ABF4. (or.jp)
  • Ca2+ signals are attenuated by sequestration of Ca2+ into intracellular organelles that function as Ca2+ stores or by the expulsion of Ca2+ back across the plasma membrane. (hstalks.com)
  • Cadmium ions are taken up through calcium channels of the plasma membrane of various cell types, and cadmium is accumulated intracellularly due to its binding to cytoplasmic and nuclear material. (nih.gov)
  • In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
  • miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity. (nih.gov)
  • Specifically, we use various DNA damaging methods, including laser microirradiation to study nucleus-wide epigenetic responses to complex DNA damage through PARP signaling and metabolic alteration. (uci.edu)
  • These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
  • Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)
  • Maps also chart the connectivity between these molecules, elucidating the circuits and signaling processes that give rise to function. (stanford.edu)
  • Immune escape is mainly caused by histocompatibility complex (MHC) class I, abnormal antigen signaling mechanism, immunosuppressive components (such as HLA-G), Fas and its ligands to activate apoptosis and overexpression of other immunosuppressive molecules, such as lymphocyte activation gene 3 (LAG-3), T cell immunoglobulin and mucin domain 3 (TIM-3) ( Steven and Seliger, 2018 ). (techscience.com)
  • CASK -related intellectual disability, as its name suggests, is caused by mutations in the CASK gene. (medlineplus.gov)
  • Mutations can occur in any area of the gene. (medscape.com)
  • Murine gene mutations in human counterparts may be associated with a clinical illness different from the illness seen in mice. (medscape.com)
  • Human genetic studies have identified mutations in the sodium channel SCN5A gene causing tachyarrhythmia disorders, as well as progressive cardiac conduction system diseases, or overlapping syndromes. (medscape.com)
  • In order to eliminate harmful pathogens, while allowing beneficial microbes to persist, inflammatory signalling in the intestine needs to be carefully regulated. (doria.fi)
  • In an infection-induced colitis model, knockout mice were more prone to tissue damage and inflammatory cytokine expression. (guidetopharmacology.org)
  • The volumetric analysis of cellular expression patterns provides evidence for molecular mechanisms regulating the development of pre-implantation mouse embryos. (zeiss.com)
  • CONCLUSIONS: Carbanilides, including TCC, enhanced hormone-dependent induction of ER- and AR-dependent gene expression but had little agonist activity, suggesting a new mechanism of action of endocrine-disrupting compounds. (cdc.gov)
  • The fungal cell cyle is considered with respect to the mechanism of sequential gene expression in Candida albicans, since little is known about the cell cycle in pathogenic molds. (cdc.gov)
  • The aim of the PhD thesis, for which this is a pre-synopsis submission talk, is to investigate the precise mechanism by which contact-mediated signaling affects specific developmental phenomena. (imsc.res.in)
  • This is followed by showing that the same inter-cellular communication mechanism can change the collective behavior of oscillatory gene expression (involving so-called ``clock genes'') thereby reproducing all the empirically observed dynamical transitions in somitogenesis, a fundamental developmental process in all vertebrates. (imsc.res.in)
  • It is shown that the changing geometry of cellular packing over the course of development results in altering the intensity of the contact-induced signal, a mechanism that when impaired can lead to developmental pathologies including cancer. (imsc.res.in)
  • These findings identify IFN-gamma as a modulator of monocytic CD38 expression and indicate that CD38 plays a specific role in the activation and adhesion processes performed by monocytes. (nih.gov)
  • . pilosum and a de novo assembled transcriptome, which can be used to characterize genes related to diverse biological processes. (biomedcentral.com)
  • While the role of morphogens has received enormous attention in developmental contexts, it is now becoming clear that juxtacrine signaling, which occurs between cells in physical proximity, can also play a key role in shaping the outcomes of such processes. (imsc.res.in)
  • Preventing calcium entry during the repeated PEMF exposure with the co-administration of EGTA or TRP channel antagonists precluded the inhibition of differentiation. (nature.com)
  • The inverse correlation between Notch signaling and the proliferative status of the corneal epithelium is consistent with the idea that Notch plays a role in corneal epithelial differentiation. (molvis.org)
  • In a microarray approach, we found the suppression of tumorigenicity 5 (ST5) gene is upregulated by receptor activator of nuclear factor-κB ligand (RANKL), the OC differentiation factor. (molcells.org)
  • Prognostic models based on immune-related genes help to improve the prognosis prediction and clinical treatment of breast cancer patients. (techscience.com)
  • In the study, we used weighted gene co-expression network analysis to construct a co-expression network to screen out highly prognostic immune-related genes. (techscience.com)
  • Subsequently, the prognostic immune-related gene signature was successfully constructed from highly immune-related genes through COX regression and LASSO COX analysis. (techscience.com)
  • The immune-related gene signature effectively predicts the survival and immune infiltration of breast cancer patients and is expected to provide more effective immunotherapy targets for the prognosis prediction of breast cancer. (techscience.com)
  • Interestingly, the heart showed relatively few differentially expressed genes when compared to other tissues (e.g. skeletal muscle and white adipose). (wku.edu)
  • It has recently been suggested that MAP kinase plays a role in coupling the synaptic excitation to gene expression in the nucleus of postsynaptic neurons. (asahq.org)
  • Exchanges of these ions are one of the main ways cells like neurons communicate to each other - passing on a signal like a touch, or the patterns of thought, from one group of cells to another so we can process them consciously. (sciencealert.com)
  • They flooded the neurons with decoy potassium channel fragments that the calcium channels latched on to before falling away from the cell membrane clusters. (sciencealert.com)
  • Calcium signaling is well studied in dendrites , the extended bits of neurons that manage messages between the cells, but before now there hasn't been much research into how calcium signaling might work inside the actual neuron cell body. (sciencealert.com)
  • and of charged atoms (ions), which are necessary for signaling between neurons. (medlineplus.gov)
  • By introducing GCaMP6 into the unfertilized egg, after which the indicator is transmitted to all the cells in the embryo, we were able to track calcium signals with a camera by filming the accompanying changes in GCaMP6 fluorescence. (uib.no)
  • Once the egg is fertilized, and the egg starts to divide, the signals continue with the same regularity, but are initiated in particular cells (those that eventually give rise to the muscle cells of the body) before propagating through other cells in a stereotyped wave-like pattern. (uib.no)
  • read more keep the cytoplasmic calcium ([Ca2+]c) low and then allow selective increases in [Ca2+]c by stimulating either Ca2+ release from the cells' internal Ca2+ stores or the influx of Ca2+ from the extracellular environment. (hstalks.com)
  • In some cells the Ca2+ signals are very brief, taking only milliseconds, whilst in other cells they can persist over several hours. (hstalks.com)
  • Embryotrophic factor-3 from human oviductal cells enhances proliferation, suppresses apoptosis and stimulates the expression of the beta1 subunit of sodium-potassium ATPase in mouse embryos. (nih.gov)
  • Description: Agonist activity determined in vitro, measuring calcium response in CHO-K1 cells expressing hGPR15 and Aequorin. (guidetopharmacology.org)
  • The detection of GPR15 in the colon suggests it may be important for transmission of HIV and SIV, and the authors speculate that the high expression in the colon suggests it may be present in non-lymphoid cells [ 11 ]. (guidetopharmacology.org)
  • Gene expression signatures within memory B cells suggest qualitative differences in the antibody responses in aged patients with severe disease. (medrxiv.org)
  • Single cell RNA sequencing revealed augmented signatures of activation, exhaustion, cytotoxicity, and type-I interferon signaling in memory T cells and NK cells. (medrxiv.org)
  • These CBFs can bind to and activate downstream COR genes, such as COR15 , COR47 , COR78 , and KIN1 , to protect plant cells from freezing damage. (biomedcentral.com)
  • Dibucaine and tetracaine at clinical concentrations were found to inhibit the activation of MAP kinase and the expression of c-Fos mediated by L-type Ca2+ channels in PC12 cells. (asahq.org)
  • SIGNALS initiated by neurotransmitter release are transferred to the nuclei of the postsynaptic cells to activate specific programs of gene expression, thus influencing synaptic functions. (asahq.org)
  • In cultured keratinocytes, CWO stimulated calcium signaling, resulting in calcineurin-dependent activation of nuclear factor of activated T cells (NFAT). (biorxiv.org)
  • Expression of Notch1 , Jagged1 , and Hes1 was found predominantly in the basal and immediate suprabasal cells. (molvis.org)
  • In vitro, the expression of Hes1 was higher in confluent cells maintained under high calcium conditions. (molvis.org)
  • The combination of gene expressions, fusion gene transcripts, and mutation gene expressions significantly improved the classification of liver cancer cells versus benign hepatocytes. (elifesciences.org)
  • The results showed evolutionary patterns of single molecule mutational gene expression from benign hepatocytes to liver cancer cells. (elifesciences.org)
  • We further demonstrated that suppression of autophagy using either pharmacological inhibitors or RNA interference of essential autophagy genes enhanced cell death induced by IM in cell lines and primary CML cells. (lu.se)
  • In contrast to nonpacemaker cells, SA and AV nodal cells predominantly use calcium channels for the initial upstroke in phase 0 (Fig. 1) and lack sodium ion channels for the rapid initial upstroke in phase 1 of their action potentials. (medscape.com)
  • BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
  • Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)
  • Genetic influences and gene-age interactions are also incomplete explanations, in light of the sudden increase in and other known causes of chronic diseases. (cdc.gov)
  • Less ROS accumulation, upregulation of ROS signaling genes and higher antioxidant enzyme activities post BNS resulted in resistance. (nature.com)
  • There was greater accumulation of secondary metabolites and upregulation of secondary metabolite-related genes after BNS. (nature.com)
  • Human CD38, a surface molecule expressed by immature and activated T and B lymphocytes, has been characterized as a molecule transducing activation and proliferation signals, and intervening in adhesion to endothelium via its ligand CD31. (nih.gov)
  • On the counter side plants adopt timely activation of suitable phytohormone signaling depending on the pathogen's lifestyle so as to restrict the infection process 12 . (nature.com)
  • RESULTS: Some carbanilide compounds, including TCC (1-10 muM), enhanced estradiol (E(2))-dependent or testosterone-dependent activation of ER- and AR-responsive gene expression up to 2.5-fold but exhibited little or no agonistic activity alone. (cdc.gov)
  • Calcium signaling is known to play a role in NFATc1 activation by promoting its nuclear translocation. (molcells.org)
  • Notch signaling is initiated by the interaction between the ligand on one cell and the receptor on a neighboring cell. (molvis.org)
  • Thus, we can now propose that intricately choreographed calcium signaling through gap junctions plays a pivotal role in steering the early development of the embryo. (uib.no)
  • Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA. (uci.edu)
  • By altering intracellular Ca 2+ and InsP 3 levels through genetic means, we now show that signaling through the InsP 3 R is required at multiple steps for generating the neural circuit required in air puff-stimulated Drosophila flight. (jneurosci.org)
  • Mutants in the gene encoding the InsP 3 R ( itpr ) in Drosophila exhibit a range of defects including altered wing posture, increased spontaneous firing, and loss of rhythmic flight patterns in response to an air puff stimulus. (jneurosci.org)
  • We investigated the effects of monocyte-activating stimuli (IFN-gamma, IL-2, LPS, TNF-alpha, and GM-CSF) on the expression and function of CD38, starting from the observation that human monocytes and the derived lines U937, THP-1, and Mono-Mac-6 bear the molecule on their surface. (nih.gov)
  • We then tested the effects of various calcium channel blockers to try to better characterize how the signals are generated. (uib.no)
  • Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)
  • The synthesis and secretion of prostaglandins I 2 and E 2 and the normal function of the stretch receptors are dependent on the intracellular ionized calcium concentration. (medscape.com)
  • By contrast, repeated exposures diminished chondrogenic outcome and could be attributed to calcium entry after the initial induction. (nature.com)
  • A total of twenty genes functioning in different aspects of plant defense that were monitored over a time course during the changing infection phases showed a coordinated response. (nature.com)
  • Phytohormone signaling involving JA, ET or SA is an integral component of multilayered host-defense system against plethora of fungal pathogens. (nature.com)
  • Calcium (Ca2+) plays a major role in controlling cell function. (hstalks.com)
  • The functional properties and localization of the channels as well as the pumps, exchangers, and buffers are thought to play a crucial role in generating a range of calcium signals that vary from a brief local increase to repetitive calcium spikes and waves spreading over a larger region. (jneurosci.org)
  • We are only at the beginning of understanding the significance of this signaling, but these new results may provide information that could shape new research into its role in brain function, and perhaps eventually into the development of new classes of therapeutics," says Trimmer . (sciencealert.com)
  • To understand the role of each cell in an organism, broad spectrum mRNA isoform and mutational gene expression analyses at the single-cell level is necessary. (elifesciences.org)
  • OBJECTIVES: In this study, we assessed the activity of TCC, its analogs, and TCS in in vitro nuclear-receptor-responsive and calcium signaling bioassays. (cdc.gov)
  • Phosphorylation of HDAC4 by CaMKII promotes nuclear export and prevents nuclear import of HDAC4, with consequent derepression of HDAC target genes. (jci.org)
  • In cardiomyocytes, CaMKII phosphorylation of HDAC4 results in hypertrophic growth, which can be blocked by a signal-resistant HDAC4 mutant. (jci.org)
  • The application of molecular biology to Ca2+ signalling research has also opened new avenues of investigation. (hstalks.com)
  • One important strategy for studying these dynamic but highly regulated host defenses is to observe gene expression patterns in the host 5 . (nature.com)
  • genes in peripheral blood of at-risk, new-onset and long-term type 1 DM , and healthy controls. (indexindex.com)
  • To examine the changes in gene expression during this transition, both live and fixed samples are imaged at different timepoints using spinning disk confocal microscopy. (zeiss.com)
  • There are a lot of different calcium channels, but the particular type of calcium channel found at these clusters is necessary for converting changes in electrical activity to changes in gene expression," says Trimmer . (sciencealert.com)
  • 5 MAP kinase has been shown to be activated by calcium influx through both N -methyl-D-aspartate (NMDA) receptors and L-type Ca 2+ channels. (asahq.org)
  • The BTK gene is large and consists of 19 exons that encode the 659 amino acids that form the Btk cytosolic tyrosine kinase. (medscape.com)
  • This was shown to break the link between electrical neural cell signaling and gene expression, a critical process in a properly functioning brain called the excitation-transcription coupling. (sciencealert.com)
  • Electroporation-mediated in vivo gene delivery of the Na+/K+-ATPase pump reduced lung injury in a mouse model of lung contusion. (nih.gov)
  • För att upprätthålla liv använder cellerna i en organism intrikata signaleringsräckor för regleringen av fysiologiska processer inom enskilda celler och mellan olika celler och vävnaderna som utgör en organism. (doria.fi)