• The telomeres shorten with progressive cell division, and eventually senescence or apoptosis takes place. (nih.gov)
  • Three alternatively spliced variants of mTid-1 were isolated, two of which correspond to the recently identified hTid-1(L) and hTid-1(S) forms of the human TID1 gene that exhibit opposing effects on apoptosis. (embl.de)
  • Apoptosis is a morphologically and biochemically distinctive form of cell death, critical in the maintenance of tissue homeostasis. (researchgate.net)
  • Furthermore, compared with treatment with each agent alone, cotreatment with DZNep and the pan-histone deacetylase inhibitor panobinostat caused more depletion of EZH2, induced more apoptosis of AML, but not normal CD34 + bone marrow progenitor cells, and significantly improved survival of nonobese diabetic/ severe combined immunodeficiency mice with HL-60 leukemia. (elsevierpure.com)
  • In the present study, we investigated the molecular mechanisms underlying the pro-apoptotic effects of quercetin (Qu) by evaluating the effect of Qu treatment on DNA methylation and posttranslational histone modifications of genes related to the apoptosis pathway. (cancerindex.org)
  • In summary, our results showed that enhanced apoptosis, induced by Qu, might be caused in part by its DNA demethylating activity, by HDAC inhibition, and by the enrichment of H3ac and H4ac in the promoter regions of genes involved in the apoptosis pathway, leading to their transcription activation. (cancerindex.org)
  • Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. (tamu.edu)
  • Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. (wikipathways.org)
  • 7. Tumor promoter induces high mobility group HMG-Y protein expression in transformation-sensitive but not -resistant cells. (nih.gov)
  • A cell-permeable compound that is shown (at 1 µM concentrations) to inhibit EZH2-mediated trimethylation of K27 on histone H3 and induces the expression of cell-cycle regulatory genes, p21 and p27, as well as the cell death regulator, FBXO32, in OCI-AML3 and HL-60 cells, whereby treatment with inhibitor increases p16 levels in the former, but not the latter of the two cultures. (sigmaaldrich.com)
  • This induces trimethylation of lysine 27 on histone H3, regulates the expression of HOX genes, and promotes proliferation and aggressiveness of neoplastic cells. (elsevierpure.com)
  • The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes. (cancerindex.org)
  • In the Kcne2 potassium channel ancillary subunit knockout model, disruption of this gene induces achlorhydria and is related to reduced parietal cell protein secretion and abnormal parietal cell morphology. (medscape.com)
  • [ 58 ] Corroborating these findings, lipoprotein or glycolipid components of A. phagocytophilum membranes stimulate innate immune cell proliferation. (medscape.com)
  • Telomerase-containing human telomerase reverse transcriptase (hTERT) can extend telomeres of chromosomes, delay senescence, and promote cell proliferation leading to tumorigenesis. (nih.gov)
  • The Ras family of GTPases is a collection of molecular switches that link receptors on the plasma membrane to signaling pathways that regulate cell proliferation and differentiation. (embl.de)
  • YTHDF2 positively and negatively correlates with miR-126 and miR-126's downstream target genes, respectively, in AML patients, and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis, indicating that miR-126 is a functionally important target of YTHDF2 in AML. (bvsalud.org)
  • 3 Hence, the new World Health Organisation classification has grouped "diffuse proliferation of large neoplastic B lymphoid cells with nuclear size equal to or exceeding normal macrophage nuclei" under the umbrella term of DLBCL. (bmj.com)
  • Also, gene expression signatures of phenoxbenzamine were consistent with several agents in each case that were known to suppress tumor proliferation, notably, protein kinase C inhibitors, Heat Shock Protein inhibitors, epidermal growth factor receptor inhibitors, and glycogen synthase kinase inhibitors. (fortuneonline.org)
  • Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway. (tamu.edu)
  • Telomerase is an enzyme responsible for the production of telomeres, which play an important role in the regulation of normal cell division. (uclahealth.org)
  • After identified the candidate mediators can be regulated by MDI-exposure, we investigated the roles of miR-mediated calcineurin signaling in regulation of these candidate mediators' expressions in relation to the exposure to MDI. (cdc.gov)
  • Expression profiling of miR-142-deficient Treg cells revealed an up-regulation of multiple genes in the interferon gamma (IFNγ) signaling network. (bvsalud.org)
  • This suggested a functional change in the cell following migration that may have been attributable to TRPC5, for example, channel up-regulation. (researchgate.net)
  • Recent studies indicate that one such inhibitor, Survivin, may have dual functions that are specific to its cellular location, including suppression of apoptotis (cytosolic) and regulation of cell division (nuclear). (researchgate.net)
  • Qu treatment almost eliminates DNMT1 and DNMT3a expression, and this regulation was in part STAT-3 dependent. (cancerindex.org)
  • the molecular mechanisms underlying the transcriptional regulation of this gene have yet to be elucidated. (aspetjournals.org)
  • Gene expression regulation by retinoic acid. (wikipathways.org)
  • E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation. (tamu.edu)
  • Developmental regulation of DNA replication: replication fork barriers and programmed gene amplification in Tetrahymena thermophila. (tamu.edu)
  • The identity of differentially expressed genes suggested that more resilient, stably surviving DA neurons were enriched in samples from advanced stages of disease, either as a consequence of positive selection of a less vulnerable long-term surviving mDA neuron subtype or due to up-regulation of neuroprotective gene products. (frontiersin.org)
  • MicroRNAs modulate the chemosensitivity of tumor cells. (nih.gov)
  • Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBP expression and contributes to transformation of breast tumor cells. (tamu.edu)
  • A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. (musc.edu)
  • Deoxyribonuclease II, lysosomal is a protein that in humans is encoded by the DNASE2 gene. (wikipedia.org)
  • 1. Increased expression of high mobility group protein I(Y) in high grade prostatic cancer determined by in situ hybridization. (nih.gov)
  • 11. High mobility group protein HMGI(Y) enhances tumor cell growth, invasion, and matrix metalloproteinase-2 expression in prostate cancer cells. (nih.gov)
  • 17. Reduction of QM protein expression correlates with tumor grade in prostatic adenocarcinoma. (nih.gov)
  • [ 52 ] IL-18 produced by the inflammasome, a protein scaffold associated with the inflammatory process, also regulates CD4 + T-cell responses. (medscape.com)
  • Previous research has shown that a protein called p16INK4a, which slows cell division, is produced at higher levels by cells as a person ages. (eurekalert.org)
  • The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein. (embl.de)
  • Here we report the cloning and characterization of a novel GAP-binding protein, mTid-1, a DnaJ chaperone protein that represents the murine homolog of the Drosophila tumor suppressor l(2)tid gene. (embl.de)
  • TRPC5 is a member of this protein family which combines with TRPC1 to form non-selective cation channels in human saphenous vein cells, a type of smooth muscle cell. (researchgate.net)
  • Finally, it was demonstrated that CAPE promoted the ATRA-mediated nuclear transcription activation of RARalpha assessed by EMSA assay and enhanced the expression of target genes including RARalpha, C/EBPepsilon, and p21 protein resulting in the differentiation development of leukemia," wrote H.C. Kuo and colleagues, Chung-Shan Medical University, Institute of Biochemistry and Biotechnology. (blogspot.com)
  • 10 The translocation to the IgH promoter deregulates the bcl2 gene, causing overexpression of the protein. (bmj.com)
  • 11 However, translocation of the bcl2 gene does not correlate significantly with overexpression of the BCL2 protein in DLBCL. (bmj.com)
  • This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. (cancerindex.org)
  • These studies examined the influence of DEX treatment on transport protein expression and function in sandwich-cultured (SC) rat hepatocytes. (aspetjournals.org)
  • The expression of sinusoidal [(organic anion transporting polypeptide 1a1 (Oatp1a1), Oatp1a4, multidrug resistance-associated protein 3 (Mrp3), and Na + -dependent taurocholate cotransporting polypeptide (Ntcp)] and canalicular [bile salt export pump (Bsep), multidrug resistance protein 1a/b (Mdr1a/b), and Mrp2] transport proteins was determined by Western blot analysis. (aspetjournals.org)
  • Modest alterations in hepatic transport protein function were consistent with changes in protein expression. (aspetjournals.org)
  • Huss and Kasper, 2000 ) and a common medium supplement, on hepatic transport protein expression and function have not been investigated in SC rat hepatocytes. (aspetjournals.org)
  • Protein tyrosine phosphatase-PEST and 8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells. (tamu.edu)
  • The LHRH-producing cell line GT1-1 also contains EP1-R mRNA and, to a lesser extent, the three alternatively spliced forms of EP3-R mRNA (α, β, and γ) that encode receptors linked to inhibition and stimulation of cAMP formation. (jneurosci.org)
  • Tumor cell intrinsic RON signaling suppresses innate immune responses in breast cancer through inhibition of IRAK4 signaling. (uc.edu)
  • Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models. (uc.edu)
  • Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling. (musc.edu)
  • Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. (tamu.edu)
  • At concentrations between 200 nm and 2000 nM, this compound is found to dose-dependently deplete the expression of polycomb group proteins EZH2, SUZ12, and EED in cultured and primary AML cell extracts. (sigmaaldrich.com)
  • Cancer Res (2000) 60 (13): 3612-3622. (aacrjournals.org)
  • Formation of the active form of vitamin D3 and its influence on nearly 2000 genes within cells throughout the body. (thepaleodiet.com)
  • The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. (tmu.edu.tw)
  • Investigators publish new data in the report "Enhancement of caffeic acid phenethyl ester on all-trans retinoic acid-induced differentiation in human leukemia HL-60 cells. (blogspot.com)
  • Kuo and colleagues published their study in Toxicology and Applied Pharmacology (Enhancement of caffeic acid phenethyl ester on all-trans retinoic acid-induced differentiation in human leukemia HL-60 cells. (blogspot.com)
  • The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines. (musc.edu)
  • In this study, we demonstrate that treatment with the S-adenosylhomocysteine hydrolase inhibitor 3-deazaneplanocin A (DZNep) depletes EZH2 levels, and inhibits trimethylation of lysine 27 on histone H3 in the cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells. (elsevierpure.com)
  • This study was performed in vivo in two human xenograft acute myeloid leukemia (AML) models and in vitro using HL60 and U937 cell lines. (cancerindex.org)
  • [ 54 ] Expression of Toll-like receptors or myd88 remains unaltered during A. phagocytophilum infection of neutrophils, [ 55 ] and JNK2 inhibits production of IFN-γ by NK T cells upon A. phagocytophilum challenge in mice. (medscape.com)
  • Injection of α-galactosylceramide, a strong NK T-cell agonist, also increased IFN-γ release and protected mice from A. phagocytophilum . (medscape.com)
  • DZNep (1mg/kg, twice per week, i.p.) and PS significantly prolong the survival of mice implanted with HL-60 cells compared to treatment with either compound alone. (sigmaaldrich.com)
  • cells were described to induce tumors in athymic mice and to synthesize lecithin. (maayanlab.cloud)
  • Leukemic stem cells (LSCs) from miR-142-/-BCR-ABL mice recapitulate the BC phenotype in congenic recipients, supporting LSC transformation by miR-142 deficit. (bvsalud.org)
  • Here, we report that mice with Treg cell-specific ablation of miR-142 (hereafter Foxp3CremiR-142fl/fl mice) developed a fatal systemic autoimmune disorder due to a breakdown in peripheral T-cell tolerance. (bvsalud.org)
  • Foxp3CremiR-142fl/fl mice displayed a significant decrease in the abundance and suppressive capacity of Treg cells. (bvsalud.org)
  • Ifng ablation rescued the Treg cell homeostatic defect and alleviated development of autoimmunity in Foxp3CremiR-142fl/fl mice. (bvsalud.org)
  • The goal of this study was to investigate the effects of As on hTERT mRNA expression in humans and in vitro . (nih.gov)
  • Human epidermal keratinocytes were treated with arsenite to assess effects on cell viability and hTERT expression in vitro . (nih.gov)
  • The in vitro results also showed a dose-response relationship between arsenite concentrations and hTERT expression and reached the peak at 1 μM. (nih.gov)
  • hTERT expression was associated with As exposure in vivo and in vitro . (nih.gov)
  • Induction of phase I metabolic enzymes in SC rat hepatocytes to levels representative of in vivo expression and function may extend the utility of this in vitro model to facilitate the prediction of hepatobiliary disposition of metabolically labile substrates. (aspetjournals.org)
  • The accessory GTPase-activating proteins (GAPs) negatively regulate the cell signaling by increasing the slow intrinsic GTP to GDP hydrolysis rate of Ras. (embl.de)
  • In addition to its association with Ras, GAP has been shown to bind to several tyrosine-phosphorylated proteins in cells stimulated by growth factors or expressing transforming tyrosine kinase variants. (embl.de)
  • Despite the diverse underlying genetic defects that likely affect the function of various subcellular compartments in neutrophil precursors, such as ER or mitochondria, the proteins encoded by these genes may share (a) signaling pathway(s). (oaepublish.com)
  • HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. (musc.edu)
  • Treatment of SC rat hepatocytes with DEX resulted in alterations in the expression of CYP3A1/2 and some hepatic transport proteins. (aspetjournals.org)
  • The increased hTERT expression may be a cellular response to genomic insults by As and may also indicate that As may function as a tumor promoter in carcinogenesis in humans. (nih.gov)
  • Virtually all of the laboratory evidence in animals and humans and most of the mechanistic work done in cells fail to support a causal relationship between exposure to ELF-EMF at environmental levels and changes in biological function or disease status. (nih.gov)
  • A sun-rich environment supposedly characterized the ecological niches of most of our hunter-gatherer ancestors 32 until about 40 to 60 thousand years ago when a significant number of humans migrated to higher latitudes 33 (although extreme latitudes appear to have only been systematically occupied more recently. (thepaleodiet.com)
  • catenin dependent metabolic pathways and a gene signature that stratifies breast cancer patient survival. (uc.edu)
  • Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National CancerInstitute Anticancer Drug Screen. (nih.gov)
  • Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. (tamu.edu)
  • Decreased bone marrow function and changes in hematopoietic progenitor and peripheral blood cells in the spleen have been described in acute infection with A. phagocytophilum . (medscape.com)
  • Higher expression of p16INK4a in peripheral blood lymphocytes has been described in older adults following chemotherapy, but prior to this study, not in young adult survivors," said Dr. Smitherman. (eurekalert.org)
  • The five-year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY-1 to affect telomerase activity in cancer cells lines, including one known as HL-60, as well as normal peripheral blood mononuclear and hematopoietic stem cells. (uclahealth.org)
  • When co-treated with panobinostat (PS), 200 nM to 1000nM DZNep is shown to decrease cell viability in OCI-AML3 and HL-60 cultures more effectively than DZNep alone, in a dose-dependent manner. (sigmaaldrich.com)
  • Genetic ablation of a Na+/H+ exchanger (NHE2), which is expressed in the stomach at high levels, leads to a decrease in gastric acid secretion, along with decreased viability of parietal cells, severe metaplasia, and hyperplasia of the gastric mucosa. (medscape.com)
  • 2020), Transposon Insertion Sequencing, a Global Measure of Gene Function. (nih.gov)
  • UCLA researchers have found that a Chinese herbal regimen called TSY-1 (Tianshengyuan-1) increased telomerase activity in normal blood cells but decreased it in cancer cells. (uclahealth.org)
  • The ability to increase or decrease telomerase activity has important implications for treating cancers in which insufficient numbers of blood cells are produced. (uclahealth.org)
  • Rao's team used various approaches, including assays of telomerase activity, measurement of cell growth, and gene expression profiling of TSY-1 treated cells, to determine how it acts. (uclahealth.org)
  • Nonradioactive and Radioactive Telomerase Assays for Detecting Diminished Telomerase Activity in Cancer Cells after Treatment with Retinoid. (musc.edu)
  • [ 60 ] However, these innate immune molecules seem important for host-derived immunopathology. (medscape.com)
  • This class of radiation can result in the development of squamous cell or basal cell carcinoma. (fortuneonline.org)
  • and cell carcinomas because they begin in squamous cells - the cells cancers of the pancreas, liver and intrahepatic bile duct, thyroid, that line the mouth and throat. (cancer.org)
  • This gene encodes a member of the DNase family. (wikipedia.org)
  • While congenital neutropenia can result from mutations in approximately 30 genes, its leading cause is gain-of-function mutations in the ELANE gene, which encodes the neutrophil granule serine protease, neutrophil elastase. (oaepublish.com)
  • Mutations of ELANE , the gene that encodes neutrophil elastase (NE), are the most frequent cause of the inherited forms of neutropenia. (oaepublish.com)
  • Characterization of rco-1 of Neurospora crassa, a pleiotropic gene affecting growth and development that encodes a homolog of Tup1 of Saccharomyces cerevisiae. (tamu.edu)
  • Furthermore, neutrophils do not seem to play a major role in A. phagocytophilum immunity, as these cells are not efficient in clearing A. phagocytophilum infection, have their signaling pathways modulated by A. phagocytophilum , and are significantly decreased during infection. (medscape.com)
  • hTERT expression was significantly correlated with OGG1 and ERCC1 expression. (nih.gov)
  • In addition, Qu treatment significantly increased the mRNA levels of all these genes, when compared to cells treated with vehicle only (control cells) (*p (cancerindex.org)
  • CD95 counts in the 3 types of white blood cells were significantly higher in PEM infants and showed improvement after nutritional rehabilitation yet not reaching the control values. (who.int)
  • To experimentally validate NeoLoopFinder, we deleted the hijacked enhancers in prostate adenocarcinoma cells using CRISPR-Cas9, which significantly reduced expression of the target oncogene. (nature.com)
  • An extensive comparison of PBZ with suberanilohydroxamic acid (SAHA) and trichostatin A (TSA) demonstrated gene expression enrichment scores (connectivity) for PBZ that compared equal to or greater than those for SAHA and TSA for several gene expression signatures in MSigDB that are associated with histone modifications [1]. (fortuneonline.org)
  • As the most common internal modification of mRNA, N6-methyladenosine (m6A) and its regulators modulate gene expression and play critical roles in various biological and pathological processes including tumorigenesis. (bvsalud.org)
  • In this paper, we use ribonucleic acid interference to deplete Hax1 in the neutrophil-like cell line PLB-985 and identify Hax1 as a negative regulator of integrin-mediated adhesion and chemotaxis. (nih.gov)
  • Neutrophil differentiation was prepared using HL-60 cells cultured in complete RPMI-1640 media containing 1.5% DMSO for 7 days. (cdc.gov)
  • thus, it is not necessarily always an autonomous neutrophil cell phenomenon [ 9 ] . (oaepublish.com)
  • However, cell-intrinsic neutrophil maturation arrest, as a primary cause of neutropenia, has been reported for at least some neutropenia genes [ 3 ] . (oaepublish.com)
  • Coexpedia is a database of context-associated co-expression networks inferred from individual series of microarray samples for human and mouse of GEO. (coexpedia.org)
  • Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity. (nih.gov)
  • Following recent advances in microarray technology, two subgroups-the germinal centre (GC) B cell-like and the activated B cell-like-gene expression signatures have been identified. (bmj.com)
  • Massive amount of array-based transcriptomics data have been deposited in several public depositories such as Gene Expression Omnibus (GEO) and ArrayExpress. (coexpedia.org)
  • UPLC-ESI-TOFMS-Based Metabolomics and Gene Expression Dynamics Inspector Self-Organizing Metabolomic Maps as Tools for Understanding the Cellular Response to Ionizing Radiation. (nih.gov)
  • In addition, cytokine secretion varies according to the type of cell investigated, the sensitivity of the technique adopted during experimentation, and the approach used during pathogen infection. (medscape.com)
  • In the early phase of infection, IL-12/23p40 regulates CD4 + T cells, while IL-12/23p40-independent mechanisms contribute to pathogen elimination from the host. (medscape.com)
  • Hepatic histopathology upon infection was dependent on IFN-γ produced by NK, and to a lesser extent, NK T cells. (medscape.com)
  • Chronic inflammatory changes related to gastric Helicobacter pylori infection can also induce parietal cell changes. (medscape.com)
  • TaqMan gene expression assays were obtained from ThermoFisher Scientific. (cdc.gov)
  • State-transition and mutual information analyses of "bulk" and single cell RNA-seq data, metabolomic profiling and functional metabolic assays identify enhanced fatty acid ß-oxidation, oxidative phosphorylation and mitochondrial fusion in LSCs as key steps in miR-142-driven BC evolution. (bvsalud.org)
  • Here we review the current knowledge and emerging questions regarding how ELANE mutations contribute to a shortage of, and/or dysfunction in neutrophils, and discuss possible strategies that target NE in the context of neutropenia, focusing on ELANE gene editing and NE inhibitors. (oaepublish.com)
  • Additional analysis of TCGA-data was performed to assess the general alteration of DR6 in cancer and influence of IDH-mutation on DR6 expression in gliomas. (cancerindex.org)
  • Posttranscriptional control of gene expression by microRNA (miRNA) has recently emerged as an essential genetic element for Treg cell function. (bvsalud.org)
  • Redundancy of the two dicer genes in transgene-induced posttranscriptional gene silencing in Neurospora crassa. (tamu.edu)
  • 1] There are emerging data to suggest that the deletion of this gene may lead to early-onset nonalcoholic fatty liver disease. (medscape.com)
  • Fig. 5: Deletion of hijacked enhancers reduced oncogene expression in prostate adenocarcinoma. (nature.com)
  • Disruption of these pathways at different stages, by defective products of neutropenia-causative genes, would then have similar hematopoietic manifestations [ 3 ] . (oaepublish.com)
  • Analyses of gene expression in cells affected by neurodegenerative disease can provide important insights into disease mechanisms and relevant stress response pathways. (frontiersin.org)
  • The goal of our search was to identify publications describing the role of specific genes, gene signatures, or molecular pathways and their effects in response to environmental exposures. (cdc.gov)
  • The binding of 1α,25(OH)2D3 (either from the kidneys or derived from local production) to the VDR will affect the expression of approximately 2,000 genes and regulate many cellular processes. (thepaleodiet.com)
  • Much recent research has focused on the role of semaphorins in the development and adult activity of hormone systems and, reciprocally, how circulating reproductive hormones regulate their expression and function. (karger.com)
  • 85% for both cell lines. (sigmaaldrich.com)
  • CellMiner: a relational database and query tool for the NCI-60 cancer cell lines. (nih.gov)
  • Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines. (nih.gov)
  • Utilizing the Harvard/Massachusetts Institute of Technology Broad Institute genomic database, CLUE, the present study suggests that the gene expression signature of phenoxybenzamine in malignant cell lines is consistent with anti-inflammatory/immunomodulatory activity and suppression of tumor expansion by several possible mechanisms of action. (fortuneonline.org)
  • Furthermore, treatment of the cell lines with the proteasome inhibitor, MG132, together with Qu prevented degradation of class I HDACs compared to cells treated with Qu alone, indicating increased proteasome degradation of class I HDACS by Qu. (cancerindex.org)
  • Moreover, Qu (50 μmol/L) treatment of cell lines for 48 h caused accumulation of acetylated histone 3 and histone 4, resulting in three- to ten fold increases in the promoter region of DAPK1, BCL2L11, BAX, APAF1, BNIP3, and BNIP3L. (cancerindex.org)
  • A range of suspension cell lines and differentiated and undifferentiated macrophages have been tested using HiPerFect Reagent for siRNA transfection. (qiagen.com)
  • Many lines were successfully transfected with excellent knockdown of target gene expression (see Table 1). (qiagen.com)
  • Some cell lines were not amenable to transfection using HiPerFect Reagent (see Table 2). (qiagen.com)
  • We applied NeoLoopFinder in Hi-C data from 50 cancer cell lines and primary tumors and identified tens of recurrent genes associated with enhancer hijacking. (nature.com)
  • Fig. 2: Detection of neoloops in 50 cancer cell lines or patient samples. (nature.com)
  • The expression of DR6 is elevated in different kinds of tumors including ovarian, breast cancer and adult sarcoma. (cancerindex.org)
  • 4. Expression profile of prostate-specific antigen messenger RNA assessed by in situ hybridization is a novel prognostic marker for patients with untreated prostate cancer. (nih.gov)
  • In OCI-AML3 cultures, 1000 nM of treatment demonstrates a significant increase in the accumulation of cells in the G 0 /G 1 phase (58.5%) with a concomitant decrease in the number of cells in S phase (35.2%) and G 2 /M phases (6.3%) of the cell cycle. (sigmaaldrich.com)
  • A previous study gave evidence that phenoxybenzamine had anti-proliferative activity in suppression of growth in several human tumor cell cultures. (fortuneonline.org)
  • 6. Prostate stem cell antigen (PSCA) expression in human prostate cancer tissues: implications for prostate carcinogenesis and progression of prostate cancer. (nih.gov)
  • Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness. (uc.edu)
  • MST1R (RON) expression is a novel prognostic biomarker for metastatic progression in breast cancer patients. (uc.edu)
  • Using expression of the gene that codes for p16INK4a as a marker of age, Andrew Smitherman, MD, MSc, of the University of North Carolina at Chapel Hill's Lineberger Comprehensive Cancer Center, and his colleagues examined immune cells circulating in the blood of young adult survivors of childhood cancers and of children and adolescents newly diagnosed with cancer. (eurekalert.org)
  • Alveolar macrophages are the most abundant immune cell type in the lung, and these cells serve as one of the first immune responders against inhaled pathogens, particles, stimuli, and chemical allergens such as dNCOs. (cdc.gov)
  • However, both the levels of these asthma-associated, macrophage-secreted inflammatory/immune mediators in MDI-OA patients' airways and how expression of these mediators change in response to MDI exposure in alveolar macrophages are largely undetermined. (cdc.gov)
  • Regulatory T (Treg) cells are critical in preventing aberrant immune responses. (bvsalud.org)
  • The aim of this study was to test the hypothesis that diverting the cytoplasmic subcellular localization of the anti-apoptotic form of Survivin to the nucleus would sensitize cancer cells to chemotherapeutics. (researchgate.net)
  • Qu induced demethylation of the pro-apoptotic BCL2L11, DAPK1 genes, in a dose- and time-dependent manner. (cancerindex.org)
  • 16. Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells. (nih.gov)
  • Histone Methyltransferase EZH2 Inhibitor, DZNep, CAS 120964-45-6, is a cell-permeable inhibitor of EZH2-mediated trimethylation of K27 on histone H3. (sigmaaldrich.com)
  • Isolated mDA neurons were subjected to genome-wide gene expression analysis by mRNA sequencing. (frontiersin.org)
  • More than half (23 of 39) of the articles represent epidemiologic studies including candidate gene and genome-wide association studies (GWAS) examining genetic effect modification on disease risk. (cdc.gov)
  • Results showed that mostly non-overlapping genes were differentially expressed in ILBD, subjects who were early after diagnosis (less than five years) and those autopsied at more advanced stages of disease (over five years since diagnosis). (frontiersin.org)
  • However, many compounds are substrates for more than one transport system, and this adds to the complexity of studying hepatobiliary transport in the whole cell and intact organ. (aspetjournals.org)