• 2001
  • These viral GPCRs (vGPCRs) show considerable homology to chemokine receptors, which are essential in the development of the hematopoietic system and regulation of cellular homeostasis ( Mackay, 2001 ). (aspetjournals.org)
  • murine
  • This targeting vector was designed so that the entire coding sequences of the murine CCR8 gene was replaced with the neomycin (neo) gene (see Fig. 1 A). This targeting vector was linearized with NotI restriction digestion and electroporated into embryonic stem (ES) cells. (rupress.org)
  • cytokine
  • Using a real-time PCR array, we identified leukemia inhibitory factor as a chemokine/cytokine undergoing a rapid increase in the hypothalamus of obesity-resistant and a rapid decrease in the hypothalamus of obesity-prone mice fed a high-fat diet for 1 day. (biomedcentral.com)
  • homology
  • Finally, the two plausible predicted transcriptional regulatory proteins display no homology at all to those in the alpha-, beta-, or gammaherpesvirus subfamilies. (asm.org)
  • A 1.2-kb BglII DNA fragment of the mCCR8 gene containing the 5′ region of homology, and a 6.5-kb BglII-HindIII fragment containing the 3′ region of homology were sequentially cloned into pOS Dupdel plasmid (a gift of Dr. O. Smithies, University of North Carolina at Chapel Hill, Chapel Hill, NC). (rupress.org)
  • The EBV-encoded BILF1 receptor presents limited homology to chemokine receptors, with highest homology to CXCR4. (aspetjournals.org)
  • tumors
  • The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. (wikipedia.org)
  • inflammation
  • Global gene expression profiling showed simultaneous upregulation of genes related to bone changes and inflammation in week 0 to 2 after onset of clinical disease. (biomedcentral.com)
  • Expression of all three receptors was substantially reduced during clinical remission, coinciding with diminished inflammation and demyelination in the spinal cord. (biomedcentral.com)
  • The objective of this study was to identify chemokine-related transcripts that could be involved in the early stages of diet-induced hypothalamic inflammation. (biomedcentral.com)
  • As in other chronic inflammatory processes [ 6 - 8 ], it is expected that in the hypothalamus, a network of chemokines and cytokines orchestrate the installation and perpetuation of inflammation that occur in response to the consumption of dietary fats. (biomedcentral.com)
  • chemotactic
  • Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. (wikipedia.org)
  • Although the primary function of chemokines is considered to be chemotactic, many studies suggest that they have complex regulatory functions that extend beyond leukocyte trafficking ( 2 )( 3 )( 4 )( 5 ). (rupress.org)
  • expression
  • To clarify the physiologic functions of chemokines, recent efforts have focused on defining the cellular expression and distribution of their G protein-coupled receptors. (rupress.org)
  • To date, several of these receptors have been characterized and evidence suggests differential expression by leukocyte subpopulations ( 6 )( 7 ). (rupress.org)
  • In particular, lymphocyte subpopulations are reported to display restricted expression of chemokine receptors, raising the possibility of receptor-based immune manipulation ( 8 ). (rupress.org)
  • Intriguingly, this differential receptor expression includes both human and mouse type 1 (Th1) and type 2 (Th2) Th cells. (rupress.org)
  • A histological and gene expression profiling time-course study on bone remodelling in CIA was linked to onset of clinical symptoms. (biomedcentral.com)
  • Global gene expression was studied with a gene chip array system. (biomedcentral.com)
  • Furthermore, we observed time-dependent expression of genes involved in early and late osteoblast differentiation and function, which mirrored the histopathological bone changes. (biomedcentral.com)
  • Comparison to human genome-wide association studies (GWAS) revealed differential expression of several genes associated with human arthritis. (biomedcentral.com)
  • dendritic
  • This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. (wikipedia.org)
  • cellular
  • Furthermore, cross-talk or heterodimerization with endogenous chemokine receptors represent other ways for vGPCRs to modify intracellular signaling and cellular functions. (aspetjournals.org)
  • The physiological role of GPCR activation ranges from gene transcription to cellular migration and proliferation. (aspetjournals.org)
  • In addition, chemokine receptors play a prominent role in cancer development (e.g., by inducing cellular proliferation or by modifying cellular migration patterns), resulting in cancer metastasis ( Balkwill, 2004 ). (aspetjournals.org)
  • peptide
  • Synthetic peptide: TEDYDTTTEFDYGDATPC, corresponding to amino acids 7 - 24 of Human CCR1. (genetex.com)