Loading...
  • CCR8
  • To assess the role of CCR8 in vivo, we examined multiple immune and inflammatory parameters in mice with a targeted deletion of the CCR8 gene. (rupress.org)
  • This targeting vector was designed so that the entire coding sequences of the murine CCR8 gene was replaced with the neomycin (neo) gene (see Fig. 1 A). This targeting vector was linearized with NotI restriction digestion and electroporated into embryonic stem (ES) cells. (rupress.org)
  • function of chemokines
  • By definition leukocyte chemoattraction is the hallmark function of chemokines, however chemokines also induce cellular responses that are unrelated to leukocyte migration such as cell differentiation and activation ( 1 ), apoptosis ( 2 ), development ( 3 ), angiogenesis ( 4 ), or tumor growth and metastasis ( 5 , 6 ). (frontiersin.org)
  • 1997
  • Its receptor has remained elusive since its cloning in 1997, although it has been reported to induce migration of breast cancer cells by signaling through PITPNM3, but we show that this receptor is not expressed on lymphocytes. (frontiersin.org)
  • RANTES
  • The [3-variant form of RANTES was subsequently found to also inhibit HIV to the same degree but to lack the same binding affinity to the CCR1 receptor. (thefreedictionary.com)
  • It has been suggested that platelets play a dual role participating in parasite clearance by activation of the hosts' innate immune system and releasing platelet-specific chemokines such as CXCL4/PF4 and RANTES and by activating an exaggerated innate immune response. (symbiosisonlinepublishing.com)
  • RANTES was first identified in a search for genes expressed "late" (3-5 days) after T cell activation. (wikipedia.org)
  • RANTES, along with the related chemokines MIP-1alpha and MIP-1beta, has been identified as a natural HIV-suppressive factor secreted by activated CD8+ T cells and other immune cells. (wikipedia.org)
  • Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit). (wikipedia.org)
  • tumors
  • The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. (wikipedia.org)
  • Molecular
  • With the aim to understand the molecular mechanisms linking inflammation with new bone formation, the present study was initiated to histologically characterise bone remodelling in the CIA model throughout the disease course, and to relate this to gene expression. (biomedcentral.com)
  • leukocyte
  • To date, several of these receptors have been characterized and evidence suggests differential expression by leukocyte subpopulations ( 6 )( 7 ). (rupress.org)
  • expression
  • In particular, lymphocyte subpopulations are reported to display restricted expression of chemokine receptors, raising the possibility of receptor-based immune manipulation ( 8 ). (rupress.org)
  • Intriguingly, this differential receptor expression includes both human and mouse type 1 (Th1) and type 2 (Th2) Th cells. (rupress.org)
  • A histological and gene expression profiling time-course study on bone remodelling in CIA was linked to onset of clinical symptoms. (biomedcentral.com)
  • Global gene expression was studied with a gene chip array system. (biomedcentral.com)
  • Global gene expression profiling showed simultaneous upregulation of genes related to bone changes and inflammation in week 0 to 2 after onset of clinical disease. (biomedcentral.com)
  • Furthermore, we observed time-dependent expression of genes involved in early and late osteoblast differentiation and function, which mirrored the histopathological bone changes. (biomedcentral.com)
  • Comparison to human genome-wide association studies (GWAS) revealed differential expression of several genes associated with human arthritis. (biomedcentral.com)
  • pathway
  • If the G-protein coupled receptor is not naturally coupled to a calcium signalling pathway, a universal coupling effector is coexpressed in order to redirect the coupling towards intracellular calcium release. (bio-medicine.org)
  • The differentially expressed genes belong to the bone morphogenetic pathway (BMP) and, in addition, include the osteoblast markers integrin-binding sialoprotein ( Ibsp ), bone gamma-carboxyglutamate protein ( Bglap1 ), and secreted phosphoprotein 1 ( Spp1 ). (biomedcentral.com)
  • interactions
  • This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. (githubusercontent.com)
  • The aims of the study were to compile a catalog of human genes involved in response to TBEV infection and to rank genes from the catalog based on the number of neighbors in the network of pairwise interactions involving these genes and TBEV RNA or proteins. (biomedcentral.com)
  • We reconstructed a network formed by pairwise interactions between TBEV virion itself, viral RNA and viral proteins and 140 genes/proteins from TBEVHostDB. (biomedcentral.com)
  • Genes were ranked according to the number of interactions in the network. (biomedcentral.com)
  • inflammatory
  • Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. (genecards.org)
  • This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. (wikipedia.org)
  • Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. (wikipedia.org)
  • Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. (wikipedia.org)
  • Signaling
  • We identified a group of transcription factors responsible for overexpression of psoriasis genes and a number of previously unknown signaling pathways that may play a role in this process. (springer.com)
  • Enrichment analysis (EA) showed that these genes encode proteins involved in regeneration, hyperkeratosis, metabolic function, immune response, and inflammation and revealed a number of modulating signaling pathways. (springer.com)
  • human
  • An integrin alpha with A domain that is a translation product of the human ITGA2 gene or a 1:1 ortholog thereof. (githubusercontent.com)
  • Based on manual review and curation of scientific publications a catalog comprising 140 human genes involved in response to TBEV infection was developed. (biomedcentral.com)
  • A database comprising 140 human genes involved in response to TBEV infection was compiled and the TBEVHostDB web resource, providing access to all genes was created. (biomedcentral.com)
  • Human ACKR2 genome location and ACKR2 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • It was subsequently determined to be a CC chemokine and expressed in more than 100 human diseases. (wikipedia.org)