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  • kinase
  • This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. (wikipedia.org)
  • Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. (wikipedia.org)
  • NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ) is a protein that in humans is encoded by the IKBKG gene. (wikipedia.org)
  • NEMO is a subunit of the IκB kinase complex that activates NF-κB. (wikipedia.org)
  • NEMO (IKK-γ) is the regulatory subunit of the inhibitor of IκB kinase (IKK) complex, which activates NF-κB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. (wikipedia.org)
  • Binding of IKK-γ to IKK-α and IKK-β subunits activates the IKK complex leading to phosphorylation of IκB kinase, IκBα, and release of NF-κB dimers p105 and RELA to translocate to the nucleus and activate transcription of NF-κB responsive genes. (wikipedia.org)
  • IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene. (wikipedia.org)
  • IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. (wikipedia.org)
  • In response to DNA damage, ribosomal subunit kinase-1 (RSK1) also has the ability to phosphorylate RELA at serine 536 in a p53-dependent manner. (wikipedia.org)
  • induces
  • 2008. IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17. (springer.com)
  • The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. (wikipedia.org)
  • extracellular
  • It is composed of two extracellular Ig-like domains, and is a member of both the immunoglobulin superfamily and the multi-chain immune recognition receptor (MIRR) family. (wikipedia.org)
  • With one Ig-like domain in its extracellular portion, this Fc receptor is also a member of the immunoglobulin superfamily. (wikipedia.org)
  • approximately 10
  • Plaques of psoriasis A person's arm covered with plaque psoriasis Psoriasis of the palms Additional types of psoriasis comprise approximately 10% of cases. (wikipedia.org)
  • The following approximately 10 days help the patient to recover between treatments. (wikipedia.org)
  • monocytes and macrophages
  • Scheibenbogen C, Keilholz U, Richter M, Andreesen R, Hunstein W: The interleukin-2 receptor in human monocytes and macrophages: regulation of expression and release of the alpha and beta chains (p55 and p75). (exbio.cz)
  • For instance, IKK2 is found to be mainly responsible for phosphorylating serine 536 in monocytes and macrophages, or in CD40 receptor binding in hepatic stellate cells. (wikipedia.org)
  • lymphocyte
  • The turning point was the sharp division of bronchial asthma into two large groups based on the expression of the type 2 helper T lymphocyte (T H 2) genes underlying the disease, namely, T H 2-high and T H 2-low asthma ( 2 ). (frontiersin.org)
  • high affinity
  • Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. (exbio.cz)
  • Two types of FcεR are known: the high-affinity receptor FcεRI is a member of the immunoglobulin superfamily (it has two Ig-like domains). (wikipedia.org)
  • regulate
  • A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. (wikipedia.org)
  • Once activated, NF-κB transcription factors regulate genes that are implicated in many important cellular processes, including immune response, inflammation, cell death, and cell proliferation. (wikipedia.org)
  • Furthermore, 14-3-3ζ may regulate glucose receptor trafficking in response to insulin levels through its interaction with IRS1. (wikipedia.org)
  • pathway
  • IL-10 may autoregulate its expression via a negative feed-back loop involving autocrine stimulation of the IL-10 receptor and inhibition of the p38 signaling pathway. (wikipedia.org)
  • IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. (wikipedia.org)
  • Phosphorylated IκB is degraded via the ubiquitination pathway, freeing NF-κB, and allowing its entry into the nucleus of the cell where it activates various genes involved in inflammation and other immune responses. (wikipedia.org)
  • This gene is similar to the sem-5 gene of Caenorhabditis elegans, which is involved in the signal transduction pathway. (wikipedia.org)
  • human
  • IL9R also denotes its human gene. (wikipedia.org)
  • Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. (cancerindex.org)
  • Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. (drugbank.ca)
  • The reagent is designed for Flow Cytometry analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)
  • Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
  • expression
  • Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes (2, 5). (rndsystems.com)
  • The expression of IL-10 is minimal in unstimulated tissues and seems to require triggering by commensal or pathogenic flora. (wikipedia.org)
  • IL-10 expression is tightly regulated at the transcriptional and post-transcriptional level. (wikipedia.org)
  • Additionally, IL-10 expression is extensively regulated at the post-transcriptional level, which may involve control of mRNA stability via AU-rich elements and by microRNAs such as let-7 or miR-106. (wikipedia.org)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Gene expression regulation for IL-2 can be on multiple levels or by different ways. (wikipedia.org)
  • Its localization to both the cytoplasm and nucleus also suggests a role in gene expression, possibly through regulation of transcription factor activity. (wikipedia.org)
  • complex
  • This protein forms a receptor complex with interleukin 10 receptor, beta (IL10RB). (wikipedia.org)
  • IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. (wikipedia.org)
  • Inflammatory bowel disease 28 (IBD28): A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. (nih.gov)
  • NBD is a peptide that acts by binding to regulatory subunit NEMO (IKK-γ) thereby preventing it from binding subunits IKK-α and IKK-β and activating the IKK complex. (wikipedia.org)
  • In the absence of regulatory subunit IKK-γ the IKK complex is inactive, preventing the downstream signal transduction cascade leading to NF-κB activation. (wikipedia.org)
  • In the presence of the NBD peptide, the IKK complex remains inactive and IκBα sequesters NF-κB dimers in the cytoplasm inhibiting transcription of NF-κB responsive genes. (wikipedia.org)
  • This property allows FcγRI to bind a sole IgG molecule (or monomer), but all Fcγ receptors must bind multiple IgG molecules within an immune complex to be activated. (wikipedia.org)