• chromosomal
  • Both IL-1 receptors (CD121a/IL1R1, CD121b/IL1R2) appear to be well conserved in evolution, and map to the same chromosomal location. (wikipedia.org)
  • In 1989 a virally encoded portion of the chromosomal mouse Cbl gene was the first member of the Cbl family to be discovered and was named v-Cbl to distinguish it from normal mouse c-Cbl. (wikipedia.org)
  • ligand
  • The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. (genecards.org)
  • CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). (exbio.cz)
  • Scatchard analysis of radio ligand binding data from 125I-OSM binding to a variety of OSM responsive cell lines produced curvilinear graphs which the authors interpreted as the presence of two receptor species, a high affinity form with an approximate dissociation constant Kd of 1-10 pM, and a low affinity form of 0.4-1 nM. (wikipedia.org)
  • This data hinted to the existence of an additional ligand specific receptor chain which led to the cloning of OSMR. (wikipedia.org)
  • The IL-2 Receptor (IL-2R) α subunit has low affinity for its ligand but has the ability (when bound to the β and ϒ subunit) to increase the IL-2R affinity 100-fold. (wikipedia.org)
  • Four alpha-helices (αC, αE, αG, and αI) form an amphipathic groove that serves as the ligand binding site, which can recognize three types of consensus binding motifs: RXX(pS/pT)XP, RXXX(pS/pT)XP, and (pS/pT)X1-2-COOH (where pS/pT represents phosphorylated serine/threonine). (wikipedia.org)
  • IKK1 functions as the major kinase phosphorylating serine 536 under different stimuli, such as the ligand activation of the lymphotoxin-β receptor (LTβR). (wikipedia.org)
  • affinity
  • Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. (exbio.cz)
  • Subsequently it was shown that the presence of gp130 alone was sufficient to reproduce the low affinity form of the receptor, and co-transfection of COS-7 cells with LIFR and gp130 produced a high affinity receptor. (wikipedia.org)
  • it is one of four identified EP receptors, the others being EP1, EP2, and EP3, all of which bind with and mediate cellular responses to PGE2 and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). (wikipedia.org)
  • expression
  • Western blot analysis of IL-22 receptor expression in human HepG2 cell lysate with IL-22 receptor antibody at 1 μg /ml. (genetex.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • These results highlight the fact that gemfibrozil regulates microglial activation by inhibiting inflammatory gene expression in a PPAR-β dependent pathway and further reinforce its therapeutic application in several neuroinflammatory and neurodegenerative diseases. (springer.com)
  • Asayama K, Sandhir R, Sheikh FG, Hayashibe H, Nakane T, Singh I (1999) Increased peroxisomal fatty acid beta-oxidation and enhanced expression of peroxisome proliferator-activated receptor-alpha in diabetic rat liver. (springer.com)
  • The expression of IL-10 is minimal in unstimulated tissues and seems to require triggering by commensal or pathogenic flora. (wikipedia.org)
  • IL-10 expression is tightly regulated at the transcriptional and post-transcriptional level. (wikipedia.org)
  • IL-10 may autoregulate its expression via a negative feed-back loop involving autocrine stimulation of the IL-10 receptor and inhibition of the p38 signaling pathway. (wikipedia.org)
  • Expression of IL-10 from transfected tumor cell lines. (wikipedia.org)
  • Gene expression regulation for IL-2 can be on multiple levels or by different ways. (wikipedia.org)
  • Its localization to both the cytoplasm and nucleus also suggests a role in gene expression, possibly through regulation of transcription factor activity. (wikipedia.org)
  • Activation of ERK induces expression of EGR1, a transcription factor which controls transcription of genes involved in cellular differentiation and mitogenesis. (wikipedia.org)
  • mice
  • Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice. (wikipedia.org)
  • Research indicates that mice with a genetic deletion of the type I IL-1 receptor display markedly impaired hippocampal-dependent memory functioning and Long-term potentiation, although memories that do not depend on the integrity of the hippocampus seem to be spared. (wikipedia.org)
  • in IL-10 transgenic mice. (wikipedia.org)
  • A study in mice has shown that IL-10 is also produced by mast cells, counteracting the inflammatory effect that these cells have at the site of an allergic reaction. (wikipedia.org)
  • Lack of IL-10 has been shown to cause COX activation and resultant Thromboxane receptor activation to cause vascular endothelial and cardiac dysfunctions in mice. (wikipedia.org)
  • It is thus not surprising that targeted gene disruption of Grb2 in mice is lethal at an early embryonic stage. (wikipedia.org)
  • The virus used in the experiment was a retrovirus known as Cas-Br-M, and was found to have excised approximately a third of the original c-Cbl gene from mice it was injected into. (wikipedia.org)
  • lambda
  • Immunocytochemistry/ Immunofluorescence: IL-28 R alpha/IFN-lambda R1 Antibody [NBP1-- Staining of human cell line U-251 MG shows localization to cytosol. (novusbio.com)
  • Immunohistochemistry-Paraffin: IL-28 R alpha/IFN-lambda R1 Antibody [NBP1-- Staining of human duodenum shows strong cytoplasmic positivity in glandular cells. (novusbio.com)
  • Recombinant Human
  • More specifically, PEGylated recombinant human IL-10 (PEG-rHuIL-10) has been shown to enhance CD8+ T cell secretion of the cytotoxic molecules Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion. (wikipedia.org)
  • glycoprotein
  • The 196 residue OSM is the predominant form isolated form a variety of cell lines and corresponds to a glycoprotein of 28 KDa, although the larger 227 residue pro-OSM can be isolated from over transfected cells. (wikipedia.org)
  • extracellular
  • Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and different pharmacological characteristics have been cloned from mouse and human cell lines: these have been termed type I and type II receptors. (wikipedia.org)
  • inflammatory
  • Inflammatory gene polymorphisms may be associated with glioma risk. (cancerindex.org)
  • The purpose of this study was to analyze effects of certain inflammatory gene and some clinical factors on patient survival.The clinical information of 269 glioma patients conceived operation from September 2010 to May 2014 to decide the 1-, 3-year survival rates according to follow-up results and analyze age, gender, the WHO classification, extent of surgical resection, radiotherapy and chemotherapy factors effects on prognosis. (cancerindex.org)
  • Delerive P, De Bosscher K, Besnard S et al (1999) Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. (springer.com)
  • Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. (wikipedia.org)
  • myeloid
  • Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia. (wikipedia.org)
  • mediates
  • The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. (genecards.org)
  • The promoter of the UBC gene contains putative heat shock elements (HSEs), which mediates UBC induction upon stress. (wikipedia.org)