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  • chromosomal
  • Both IL-1 receptors (CD121a/IL1R1, CD121b/IL1R2) appear to be well conserved in evolution, and map to the same chromosomal location. (wikipedia.org)
  • In 1989 a virally encoded portion of the chromosomal mouse Cbl gene was the first member of the Cbl family to be discovered and was named v-Cbl to distinguish it from normal mouse c-Cbl. (wikipedia.org)
  • cell receptor
  • Carballido JM, Faith A, Carballido-Perrig N, Blaser K: The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells. (springer.com)
  • More specifically, PEGylated recombinant human IL-10 (PEG-rHuIL-10) has been shown to enhance CD8+ T cell secretion of the cytotoxic molecules Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion. (wikipedia.org)
  • affinity
  • Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. (exbio.cz)
  • Subsequently it was shown that the presence of gp130 alone was sufficient to reproduce the low affinity form of the receptor, and co-transfection of COS-7 cells with LIFR and gp130 produced a high affinity receptor. (wikipedia.org)
  • it is one of four identified EP receptors, the others being EP1, EP2, and EP3, all of which bind with and mediate cellular responses to PGE2 and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). (wikipedia.org)
  • expression
  • Western blot analysis of IL-22 receptor expression in human HepG2 cell lysate with IL-22 receptor antibody at 1 μg /ml. (genetex.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • These results highlight the fact that gemfibrozil regulates microglial activation by inhibiting inflammatory gene expression in a PPAR-β dependent pathway and further reinforce its therapeutic application in several neuroinflammatory and neurodegenerative diseases. (springer.com)
  • Asayama K, Sandhir R, Sheikh FG, Hayashibe H, Nakane T, Singh I (1999) Increased peroxisomal fatty acid beta-oxidation and enhanced expression of peroxisome proliferator-activated receptor-alpha in diabetic rat liver. (springer.com)
  • Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. (wikipedia.org)
  • The expression of IL-10 is minimal in unstimulated tissues and seems to require triggering by commensal or pathogenic flora. (wikipedia.org)
  • IL-10 expression is tightly regulated at the transcriptional and post-transcriptional level. (wikipedia.org)
  • Additionally, IL-10 expression is extensively regulated at the post-transcriptional level, which may involve control of mRNA stability via AU-rich elements and by microRNAs such as let-7 or miR-106. (wikipedia.org)
  • Expression of IL-10 from transfected tumor cell lines. (wikipedia.org)
  • Gene expression regulation for IL-2 can be on multiple levels or by different ways. (wikipedia.org)
  • Its localization to both the cytoplasm and nucleus also suggests a role in gene expression, possibly through regulation of transcription factor activity. (wikipedia.org)
  • Activation of ERK induces expression of EGR1, a transcription factor which controls transcription of genes involved in cellular differentiation and mitogenesis. (wikipedia.org)
  • mice
  • Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice. (wikipedia.org)
  • Research indicates that mice with a genetic deletion of the type I IL-1 receptor display markedly impaired hippocampal-dependent memory functioning and Long-term potentiation, although memories that do not depend on the integrity of the hippocampus seem to be spared. (wikipedia.org)
  • However, when mice with this genetic deletion have wild-type neural precursor cells injected into their hippocampus and these cells are allowed to mature into astrocytes containing the interleukin-1 receptors, the mice exhibit normal hippocampal-dependent memory function, and partial restoration of long-term potentiation. (wikipedia.org)
  • in IL-10 transgenic mice. (wikipedia.org)
  • A study in mice has shown that IL-10 is also produced by mast cells, counteracting the inflammatory effect that these cells have at the site of an allergic reaction. (wikipedia.org)
  • Lack of IL-10 has been shown to cause COX activation and resultant Thromboxane receptor activation to cause vascular endothelial and cardiac dysfunctions in mice. (wikipedia.org)
  • Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age. (wikipedia.org)
  • It is thus not surprising that targeted gene disruption of Grb2 in mice is lethal at an early embryonic stage. (wikipedia.org)
  • The virus used in the experiment was a retrovirus known as Cas-Br-M, and was found to have excised approximately a third of the original c-Cbl gene from mice it was injected into. (wikipedia.org)
  • glycoprotein
  • The 196 residue OSM is the predominant form isolated form a variety of cell lines and corresponds to a glycoprotein of 28 KDa, although the larger 227 residue pro-OSM can be isolated from over transfected cells. (wikipedia.org)
  • extracellular
  • Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and different pharmacological characteristics have been cloned from mouse and human cell lines: these have been termed type I and type II receptors. (wikipedia.org)
  • endothelial
  • In general cells derived from endothelial and tumour origins express high levels of OSM receptors, whereas cells of Haematopoietic origin tend to express lower numbers. (wikipedia.org)
  • tumor
  • or dosing with IL-10 leads to control of primary tumor growth and decreased metastatic burden. (wikipedia.org)
  • More recently, PEGylated recombinant murine IL-10 (PEG-rMuIL-10) has been shown to induce IFNγ and CD8+ T cell dependent anti-tumor immunity. (wikipedia.org)
  • Differentiation
  • T he current literature on the role of interleukin (IL)-2 in memory CD8 + T-cell differentiation indicates a significant contribution of IL-2 during primary and also secondary expansion of CD8 + T cells. (springer.com)
  • The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. (cancerindex.org)
  • The name "interleukin" was chosen in 1979, to replace the various different names used by different research groups to designate interleukin 1 (lymphocyte activating factor, mitogenic protein, T-cell replacing factor III, B-cell activating factor, B-cell differentiation factor, and "Heidikine") and interleukin 2 (TSF, etc. (wikipedia.org)
  • immune
  • Lymphokines and the immune response: the central role of interleukin-2. (springer.com)
  • This review outlines the pathogenic mechanisms utilized by the immune system to mediate destruction of the pancreatic beta-cells. (soc-bdr.org)
  • Phosphorylated IκB is degraded via the ubiquitination pathway, freeing NF-κB, and allowing its entry into the nucleus of the cell where it activates various genes involved in inflammation and other immune responses. (wikipedia.org)
  • The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. (wikipedia.org)
  • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. (wikipedia.org)