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  • electrophysiologic
  • In contrast, ectopic activation of Wnt signaling was sufficient to induce formation of ectopic AV junction-like tissue as assessed by morphology, gene expression, and electrophysiologic criteria. (ahajournals.org)
  • The ECG may show any of the following: Inappropriate sinus bradycardia Sinus arrest Sinoatrial block Tachy-Brady Syndrome Atrial fibrillation with slow ventricular response A prolonged asystolic period after a period of tachycardias Atrial flutter Ectopic atrial tachycardia Sinus node reentrant tachycardia Wolff-Parkinson-White syndrome Electrophysiologic tests are no longer used for diagnostic purposes because of their low specificity and sensitivity. (wikipedia.org)
  • abnormalities
  • Current trends in research emphasize next-generation gene-based therapy that utilizes nonviral or viral gene delivery vectors to correct genetic abnormalities, via enzyme replacement or gene silencing (depending upon whether the source of the given condition is due to an overabundance or a deficiency). (raredr.com)
  • protein
  • It is of note that only a small proportion of the transcribed RNAs are translated into protein with the remainder performing a host of functions, affecting those sequences (genes) that encode for protein. (onlinejacc.org)
  • We report a mutation in the myosin-binding protein-C (MyBP-C) gene, its clinical consequences in a large family, and myocardial tissue findings that may provide insight into the mechanism of disease. (ahajournals.org)
  • The authors found that the gene encoding the gamma2 subunit of AMP-activated protein kinase (AMPK) strongly correlated with Zaire Ebolavirus transduction in the tumor cell panel. (nih.gov)
  • Association study of five tagging single-nucleotide polymorphisms (tSNPs) in the 5′-AMP-activated protein kinase α2 subunit gene PRKAA2 in 2777 normal Caucasian women (mean (SD) age 47.4 (12.5) years). (bmj.com)
  • Danon disease involves a genetic defect (mutation) in a gene called LAMP2, which results in a change to the normal protein structure. (wikipedia.org)
  • While the function of the LAMP2 gene is not well understood, it is known that LAMP2 protein is primarily located in small structures within cells called lysosomes. (wikipedia.org)
  • Diagnosis
  • Something called the "horse versus zebra syndrome" may sound like the beginning of a comedy routine, but it actually represents a major diagnosis challenge about which cardiologists joke only wryly. (raredr.com)
  • lethal
  • Transmission of lethal genes such as associated with Huntington's disease can, through in vitro fertilization, avoid passing it on to one's offspring. (onlinejacc.org)
  • genetic
  • Genetic ablation is another term for gene silencing, in which gene expression is abolished through the alteration or deletion of genetic sequence information. (wikipedia.org)
  • clinical
  • Because of the size of the family (27 gene carriers), the clinical consequences associated with the altered splicing of exon 25 could be reliably assessed as incomplete penetrance, late onset of disease, and low cardiac mortality. (ahajournals.org)
  • patients
  • Patients with AF, WPW syndrome, and rapid ventricular response who are hemodynamically compromised should receive prompt direct-current cardioversion. (medscape.com)
  • Administration of intravenous amiodarone, adenosine, digoxin (oral or intravenous), or nondihydropyridine calcium channel antagonists (oral or intravenous) in patients with WPW syndrome who have preexcited AF is potentially harmful because these drugs accelerate the ventricular rate. (medscape.com)
  • An individual displaying MERRFs syndrome will manifest not only a single symptom, but regularly patients display more than one affected body part at a time. (wikipedia.org)
  • It has been observed that patients with MERRF syndrome will primarily display Myoclonus as a first symptom, along with it they can also manifest seizures, cerebellar ataxia and myopathy. (wikipedia.org)
  • disorders
  • Rapid DNA sequencing is being embraced for single gene disorders, particularly for sporadic cases and those from small families. (onlinejacc.org)
  • disease
  • The disease phenotype in this family was characterized in detail: only 10 of 27 gene carriers fulfilled diagnostic criteria. (ahajournals.org)
  • Tachycardia-bradycardia syndrome is often associated with ischemic heart disease and heart valve disease. (wikipedia.org)
  • Coronary artery disease, high blood pressure, and aortic and mitral valve diseases may be associated with sick sinus syndrome, although this association may only be incidental. (wikipedia.org)
  • MERRF syndrome (or myoclonic epilepsy with ragged red fibers) is a mitochondrial disease. (wikipedia.org)
  • atrial
  • About 10 to 30 percent of people with WPW syndrome occasionally experience a type of irregular heartbeat known as atrial fibrillation. (mayoclinic.org)
  • treatment
  • Artificial pacemakers have been used in the treatment of sick sinus syndrome. (wikipedia.org)
  • Restless legs syndrome can be treated using clonazepam as a third-line treatment option as the use of clonazepam is still investigational. (wikipedia.org)
  • Alcohol withdrawal syndrome Benzodiazepines, such as clonazepam, are sometimes used for the treatment of mania or acute psychosis-induced aggression. (wikipedia.org)
  • expression
  • The [FA] citation in the expression in adult fly column indicates data summarized from FlyAtlas (individual genes do not have unique URLs). (upenn.edu)