• Scientists from the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim (UMM) successfully tested a new form of cellular immunotherapy against brain tumors in mice for the first time. (dkfz.de)
  • Glioblastomas are the most aggressive of all brain tumors. (dkfz.de)
  • We are interested in how gene expression is regulated in the brain and how this process influence neurodegenerative diseases, psychiatric disorders and brain tumors. (lu.se)
  • Our lab is interested in transposable elements and how these viral-like sequences influence human brain evolution, neurodegenerative diseases, brain tumors and ageing. (lu.se)
  • Meningiomas account for approximately 13-19% of all brain tumors. (medscape.com)
  • Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
  • Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
  • The present study revealed that E2F1 gene expression correlates with TS and Survivin gene expressions and tumor proliferation. (aacrjournals.org)
  • During the progression of NSCLC, E2F1 overexpression could produce more aggressive tumors with a high proliferation rate and chemoresistance. (aacrjournals.org)
  • Cancer-preventing strategies of these beneficial bacteria such as binding to carcinogens and degrading them, stimulating anti-cancer enzymes, and preventing the conversion of procarcinogens to carcinogens, production of beneficial compounds that act as signaling molecules affecting the immune system, cell death, and proliferation, and interference with cell signaling pathways are reported [ 16 - 19 ]. (hindawi.com)
  • The activation of the PDGF receptor tyrosine kinase triggers the proliferation of DFSP tumor cells. (medscape.com)
  • Tight control of the cell cycle in eukaryotic cells exists to control proliferation, differentiation or apoptosis. (benthamscience.com)
  • However, the underlying mechanisms involved in the induction of genomic instability, genotoxicity, mutations and consequent increased cell proliferation are still a matter of intense research. (benthamscience.com)
  • Although these tumors are considered to be non-malignant, they have a high rate of proliferation and can reach large sizes before being diagnosed. (frontiersin.org)
  • The c-MYC transcription factor controls the activity of a large number of genes involved in cell division, and its over-expression leads to excessive cell proliferation. (medicalxpress.com)
  • In the present study, we demonstrate that Triphala significantly inhibit the proliferation of Capan-2 and BxPC-3 human pancreatic cancer cells. (biomedcentral.com)
  • 6/7 primary cultures tested reduced proliferation, irrespective of prior RA signaling levels. (uni-wuerzburg.de)
  • In vitro testing of primary tumor cultures provided clear evidence of a potential utility of retinoids in Wilms tumor treatment based on the analysis of gene expression, proliferation, differentiation and apoptosis. (uni-wuerzburg.de)
  • While all these entities are characterized by proliferation of highly atypical, anaplastic CD30+ T cells, the expression of T-cell specific antigens in the tumor cells is not consistently detectable. (uni-wuerzburg.de)
  • Now, we are investigating how MESH1 removal leads to proliferation of arrests and anti-tumor phenotypes. (duke.edu)
  • This data suggests that the INGAP gene is a novel pancreatic gene expressed during islet neogenesis whose protein product is a constituent of Ilotropin and is capable of initiating duct cell proliferation, a prerequisite for islet neogenesis. (jci.org)
  • However, it was still necessary to identify the proliferation and cell invasion genes that were inhibited by the molecule. (fapesp.br)
  • or physiological or as a description of key events and processes starting toxic effects that affect cell proliferation. (cdc.gov)
  • In making the overall evaluation, the Working Group considered the following evidence: (i) although the hypothesis linking the formation of mouse liver tumors with peroxisome proliferation is plausible, trichloroethylene also induced tumors at other sites in mice and rats. (who.int)
  • When higher than normal levels of p53 tumor suppressor exist, there is enough p53 to bind to many regulatory sites in the cell's genome to activate the production of other proteins that will halt cell division if the DNA damage can be repaired. (news-medical.net)
  • In the presence of Wnt signals, the Wnt proteins bind to (frizzled) frizzled receptors ( FZDs ) and low-density lipoprotein receptor-related protein ( LRP ) receptors, leading to the stabilization of β-catenin , its transfer to the nucleus, and the activation of target genes. (hindawi.com)
  • Whole cell lysates were probed for NF-κB and IκB family proteins by immunoblot. (biomedcentral.com)
  • The three genes encoding these proteins were inserted individually into vaccinia virus GLV-1h68 genome under the control of an identical promoter. (uni-wuerzburg.de)
  • The functional consequences of identified mutations were evaluated after the mutant proteins were expressed in cultured cells. (nih.gov)
  • In vivo studies further confirmed the inhibitory effect of celastrol on the expression of HIF-1α proteins, leading to a decreased growth of Hep3B cells in a xenograft tumor model. (spandidos-publications.com)
  • IFN-α 2A enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T cells. (sigmaaldrich.com)
  • The initial finding that Abcc10, a member of a ubiquitous family of proteins called ATP-binding cassette transporters, thwarts taxanes' anti-tumor activity was something of a surprise, says Hopper-Borge, because none of the other family members seem to have that ability. (news-medical.net)
  • They bind to messenger RNAs expressed by genes and break them down or prevent them from being translated into proteins. (fapesp.br)
  • Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. (lookformedical.com)
  • Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. (lookformedical.com)
  • Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm. (lookformedical.com)
  • We found that the three Id proteins expressed in neuroblastoma cells (Id1, Id2, and Id3) were down-regulated during induced differentiation, indicating that Id proteins help keep the tumor cells in an undifferentiated state. (lu.se)
  • The ability of Id proteins to affect HES-1 activity is of particular interest in neuronal cells, where regulation of HES-1 is essential for the timing of neuronal differentiation. (lu.se)
  • The reprogrammed cancer cells thereby lose their ability to become tumors, and instead activate the immune system to respond to mutated proteins in the tumor. (lu.se)
  • In particular, he aims to understand non-oncogene addiction mechanism that cooperates with the Ras oncogene to support tumor initiation, progression and metastasis. (cancer.gov)
  • Hermeking and his colleagues had previously demonstrated that AP4 promotes the metastasis of colon tumors. (medicalxpress.com)
  • this association is primarily based on the HIF-1-mediated regulation of genes that play pivotal roles in the central features of cancer pathogenesis such as angiogenesis, invasion, metastasis and anti-apoptosis. (spandidos-publications.com)
  • In vitro and in vivo trials performed at CTC as part of the PhD research of Bruna Muys , who is supported by a scholarship from FAPESP, showed that when miR-450a was overexpressed, it not only reduced the tumor but also blocked the process of metastasis. (fapesp.br)
  • It also dysregulated genes involved in the epithelial-to-mesenchymal transition pathway - essential for cell migration, invasion and resistance to apoptosis (programmed cell death) - thereby inhibiting the process of metastasis. (fapesp.br)
  • The possibility of disease-free survival increases after resection of primary tumor and isolated metastasis excision. (medscape.com)
  • The study also revealed increased risk of death due to renal cell carcinoma in patients who did not undergo surgical resection of metastasis. (medscape.com)
  • We searched for mutations in the EGFR gene in primary tumors from patients with non-small-cell lung cancer who had a response to gefitinib, those who did not have a response, and those who had not been exposed to gefitinib. (nih.gov)
  • We found that four CpG's, located approximately 700 bp upstream of the transcriptional start site are methylated in the majority of breast cancer cell lines and primary tumors but not in DNA from normal breast epithelia or matched lymphocytes from cancer patients. (duke.edu)
  • It is within the cell-autonomous context that ST6GAL1 involvement in cancer progression has been interpreted. (nature.com)
  • Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
  • These findings suggest that CMTM2 protein suppresses the development and/or progression of hepatocellular carcinoma and therefore that the CMTM2 gene acts as a tumor suppressor in this cancer. (wikipedia.org)
  • A multitude of pathways control cyclin-dependent kinase activities as the major event for cell cycle progression. (benthamscience.com)
  • Hypoxia is an important micro-environmental factor in promoting tumor progression. (spandidos-publications.com)
  • Formation of a tumor and its progression is seemingly linked to myeloid cells though they are an essential part of the immune system. (healthjockey.com)
  • Although for years most studies have focused on tumor cells, allowing the discovery of numerous key (epi)-genetic aberrations and oncogenic pathways, it is now widely accepted that ecosystem integration is also critical for the understanding of cancer progression. (haematologica.org)
  • Administration of supernatant and whole-cell culture of L. rhamnosus expressively reduced tumor growth compared to the control group. (hindawi.com)
  • Reduced tumor-growth in Triphala fed mice was due to increased apoptosis in the tumors cells, which was associated with increased activation of p53 and ERK. (biomedcentral.com)
  • An in vivo investigation in nude mice was done to assess the anti-tumor activity of L. rhamnosus supernatant and whole-cell culture. (hindawi.com)
  • We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
  • Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
  • IPA analysis of the 280 significantly differentially expressed genes in the whole blood was suggestive of increased hematopoiesis and cell development, activation of cancer/tumor development pathways, and atopy. (cdc.gov)
  • If p53 is inactivated, as it is in over half of all human cancers, checks and balances on cell growth fail to operate, and body cells start to accumulate mutations, which ultimately may lead to cancer. (news-medical.net)
  • Many chemotherapeutical drugs used to treat cancer exert their biological effects on tumor cells through activation of the p53 pathway. (news-medical.net)
  • Unless promptly and properly repaired, these DNA breaks can let cell division spiral out of control, ultimately causing cancer. (news-medical.net)
  • Dormant cancer cells: programmed quiescence, senescence, or both? (nature.com)
  • Cancer Cell 18 , 485-498 (2010). (nature.com)
  • We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase ( TS ) and Survivin , in case of non-small-cell lung cancer (NSCLC). (aacrjournals.org)
  • Lung cancer is a major cause of cancer-related deaths, and non-small-cell lung cancer (NSCLC) comprises ∼75% of all lung cancers ( 1 ). (aacrjournals.org)
  • In this study, the cytotoxicity effects of L. rhamnosus supernatant and whole-cell culture on a cancer cell line (Kyse30) compared to 5fu were evaluated by the MTT assay. (hindawi.com)
  • This study is the first report that assessed the potential impact of L. rhamnosus , especially its supernatant on esophageal cancer and Wnt signaling pathway genes. (hindawi.com)
  • This cancer is divided into two types: (1) squamous cell carcinoma, which appears in the middle or top of the esophagus and (2) adenocarcinoma, seen in the glandular cells of the esophagus [ 1 ]. (hindawi.com)
  • The study, published in the current issue of Molecular Cell , also reveals how those interconnections could potentially be exploited to treat GBM using a class of cancer drugs whose members are currently being evaluated in clinical trials. (sciencedaily.com)
  • Lukas Bunse, a scientist at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and a physician at the University Medical Center Mannheim, relies on the comparatively new concept of "T cell receptor transgenic cells" in his current study: To this end, brain tumor patients were first inoculated with an antigenic fragment of the protein NLGN4X (Neuroligin4X). (dkfz.de)
  • In this way, they succeeded in producing large numbers of T cells with identical specificity, all of which recognize the cancer antigen NLGN4X. (dkfz.de)
  • In melanoma, the malignant black skin cancer, such T-cell receptor transgenic T cells have already been shown to prolong the lives of some patients. (dkfz.de)
  • According to the scientist, it is also conceivable to generate T cell receptor transgenic cell therapies against patient-individual cancer antigens. (dkfz.de)
  • Research from his laboratory has identified multiple stress-response pathways that are critical for the survival of cancer cells. (cancer.gov)
  • We use genetic, molecular, pharmacological tools to study how the KRAS oncogene maintain the tumorigenic state in lung, colorectal and pancreatic cancer cells. (cancer.gov)
  • We were among the first to carry out synthetic lethal screens to identify non-oncogene addiction in KRAS mutant cancer cells. (cancer.gov)
  • Although 2-dimensional cell culture has traditionally been a useful method to study cancer cell behavior, this model does not capture the anchorage-independent nature of cancer cell growth. (cancer.gov)
  • We are developing scalable 3-dimensional (3D) culture models of tumor spheroid and lung organoid as an alternative and better approach to model KRAS mutant cancer in vitro . (cancer.gov)
  • We are using CRISPR gene editing and chemical biology approaches in these 3D models to discover non-oncogene addiction mechanism that are critically required for the anchorage-independent growth of cancer cells. (cancer.gov)
  • Differentiation and apoptosis have cell cycle withdraw in common, while cancer and degenerative processes both show altered control of the cell cycle. (benthamscience.com)
  • Both 2D monolayer and 3D neurospheres were successfully cultured and characterized for proliferative potential, intrinsic plasticity, presence of cancer stem cells and the expression of stem cell markers. (frontiersin.org)
  • Enrichment of cancer stem cells was observed in neurospheres by FACS using CD133 antibody and RT-PCR. (frontiersin.org)
  • A new study carried out by a team led by Professor Heiko Hermeking at the Institute of Pathology at LMU (and German Cancer Consortium) now shows that c-MYC induces the production of a transcription factor that increases the numbers of stem cells in the intestinal epithelium, and thereby contributes to the formation of adenomas in the colon. (medicalxpress.com)
  • In this ApcMin strain of mice, which is particularly prone to developing colon cancer, the team deleted the Ap4 gene specifically in the colon epithelium. (medicalxpress.com)
  • Can a vitamin transform natural killer cells into a cancer therapy? (medicalxpress.com)
  • Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). (nih.gov)
  • Similar mutations were detected in tumors from 2 of 25 patients with primary non-small-cell lung cancer who had not been exposed to gefitinib (8 percent). (nih.gov)
  • A subgroup of patients with non-small-cell lung cancer have specific mutations in the EGFR gene, which correlate with clinical responsiveness to the tyrosine kinase inhibitor gefitinib. (nih.gov)
  • Celastrol showed a potent inhibitory activity against HIF-1 activation induced by hypoxia in various human cancer cell lines. (spandidos-publications.com)
  • Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. (elifesciences.org)
  • PD-L1 CAR haNKs reduced levels of macrophages and other myeloid cells endogenously expressing high PD-L1 in peripheral blood from patients with head and neck cancer. (elifesciences.org)
  • Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)
  • The effect of CIK cells on re-sensitizing lung cancer cells to the chemotherapy drug was partially dependent on the secretion of IFN-γ. (jcancer.org)
  • This reprogramming process has also been reported in intestinal cancer cells. (genengnews.com)
  • SUZHOU, China , Nov. 20, 2023 /PRNewswire/ -- On November 20 , 2023, Porton Advanced announced a strategic partnership with Ascle Therapeutics to jointly develop and produce NK cells, assist in the development and innovation in gene and cell therapy, and accelerate the application of NK cells in cancer prevention, beauty, and anti-aging. (wtnh.com)
  • According to the agreement, Porton Advanced will provide services of development, production, and declaration in China for Ascle Therapeutics' NK cell project, supporting the application of NK cells in cancer prevention, anti-aging, and beauty. (wtnh.com)
  • Dr. Li Huashun, founder and chairman of Ascle Therapeutics, stated, "CAR-NK cell therapy has a significant effect on cancer treatment. (wtnh.com)
  • I believe that with its rich experience and professional technology, Porton Advanced can provide important support for Ascle Therapeutics to promote the application of NK cells in anti-aging, beauty, and cancer prevention. (wtnh.com)
  • Through Porton Advanced's CDMO platform, we can swiftly support Ascle Therapeutics in making new progress in NK cell anti-aging, beauty, and cancer prevention. (wtnh.com)
  • Similarly, Triphala induced apoptosis in another pancreatic cancer cell line BxPC-3 by activating ERK. (biomedcentral.com)
  • Our preclinical studies demonstrate that Triphala is effective in inhibiting the growth of human pancreatic cancer cells in both cellular and in vivo model. (biomedcentral.com)
  • Cancerous tumours are individual, as they contain several types of cancer cells. (helsinki.fi)
  • Scholars@Duke publication: Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer. (duke.edu)
  • Treatment of the breast cancer cell line, MDAMB468 with the DNA methylation inhibitor, 5-azacytidine (5-AzaC) results in growth arrest, whereas the growth of the normal breast epithelial line DU99 (telomerase immortalized) is relatively unaffected. (duke.edu)
  • Comparing gene expression profiles of these two lines after 5-AzaC treatment, we identified 36 genes that had relatively low basal levels in MDAMB468 cells compared to the DU99 line and were induced in the cancer cell line but not in the normal breast epithelial line. (duke.edu)
  • Of these genes, 33 have associated CpG islands greater than 300 bp in length but only three have been previously described as targets for aberrant methylation in human cancer. (duke.edu)
  • Further analysis of one of these genes, GADD45a, showed that 5-AzaC induced expression in five additional breast cancer cell lines with little or no induction in three additional lines derived from normal breast epithelial cells. (duke.edu)
  • Therefore, this simple method of dynamic transcriptional profiling yielded a series of novel methylation-sensitive genes in breast cancer including the BRCA1 and p53 responsive gene, GADD45a. (duke.edu)
  • We are using functional genomic approaches to investigate the nutrient signaling and stress adaptations of cancer cells when exposed to various nutrient deprivations and microenvironmental stress conditions. (duke.edu)
  • Previously, we have identified the profound cystine addiction of renal cell carcinoma (1), breast cancer cells (2, 3), and ovarian cancer cells (4). (duke.edu)
  • The study, from a team in the Department of Surgery and Cancer and published in Cell Reports Medicine, including NIHR Imperial BRC Surgery and Cancer Theme lead Professor Iain McNeish, sought to understand and characterise how these differences or variabilities arise in a patient's tumours and what it can tell us about the patient and their cancer. (nihr.ac.uk)
  • The study found variations in different key genes related to ovarian cancer in different tumours within each patient. (nihr.ac.uk)
  • Lead author Dr Paula Cunnea, said: "Our study further highlights the complex and variable nature of ovarian cancer tumour biology, and how it changes as it progresses. (nihr.ac.uk)
  • Nowell, a tumor biologist in the pathology department at the University of Pennsylvania School of Medicine, was interested in the relationship between cancer and alterations in genes (although he had no proof there was one). (laskerfoundation.org)
  • At a time when the idea that cancer had a genetic basis was widely disbelieved, Nowell's results provided the first clear evidence that a particular genetic defect in a single chromosome can lead to a population or clone of identical cells that accumulate in numbers to form a deadly malignancy. (laskerfoundation.org)
  • The tiny Philadelphia chromosome became a clear and consistent marker of CML, a cancer of the myeloid or bone marrow cells, with broad implications for diagnosis and prognosis of disease. (laskerfoundation.org)
  • Rowley had identified the first "translocation" in cancer, providing clear evidence that the cause of CML could be related to the fact that by moving from one chromosome to another, the aberrant segment of chromosome 22 was no longer sitting next to genes that controlled its behavior. (laskerfoundation.org)
  • The molecule miR-450a is usually underexpressed in tumors, but experiments in cultured cells and mice showed that when overexpressed, it can have positive effects on the treatment of cancer by silencing genes involved in cell migration and tumor energy metabolism. (fapesp.br)
  • In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (lookformedical.com)
  • Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. (lookformedical.com)
  • Mutations in this gene predispose humans to breast and ovarian cancer. (lookformedical.com)
  • Tumors or cancer of the human BREAST. (lookformedical.com)
  • Tumors or cancer of the OVARY. (lookformedical.com)
  • Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance. (lookformedical.com)
  • arations verified the presence of cancer cells in all samples. (lu.se)
  • In cancer patients dendritic cells may become dysfunctional or excluded from tumors. (lu.se)
  • In the next step, he used the same molecules to reprogram cancer cells into dendritic cells. (lu.se)
  • In other words, using the molecules as a trojan horse to "force" cancer cells to develop into immune cells. (lu.se)
  • Our findings are paving the way for the development of a gene therapy for cancer where the three molecules are delivered directly into tumors in patients eliciting a response independently of the tumor type. (lu.se)
  • Gefitinib and erlotinib would be effective for tumors with epidermal growth factor receptor (EGFR) mutations or increased EGFR gene copy numbers ( 6 ). (aacrjournals.org)
  • It is believed that mutations in the deoxyribonucleic acid (DNA) signal the cells related to the esophagus to multiply abnormally [ 4 , 5 ]. (hindawi.com)
  • Molecular characterization of these benign yet rapidly proliferating tumors has been limited to evaluating a few mutations in few genes. (frontiersin.org)
  • Mutation analysis indicated the presence of germline mutations in three genes and somatic mutations in two other genes. (frontiersin.org)
  • In cases where multiple other mutations, in genes such as TP53, ATRX, and others, recurrence of the tumor is a possibility. (frontiersin.org)
  • It is unknown, however, whether normal variants (independent of mutations) in the fragile X gene family (FMR1, FXR1, FXR2) and in FMR2 modulate autistic features. (uni-wuerzburg.de)
  • Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not. (lookformedical.com)
  • CMTM2 protein is expressed in the bone marrow and various circulating blood cells. (wikipedia.org)
  • It is also highly expressed in testicular tissues: The CMTM2 gene and CMTM2 protein, it is suggested, may play an important role in testicular development. (wikipedia.org)
  • Finally, the forced overexpression of CMTM2 protein in cultured hepatocellular tumor cells inhibited their invasiveness and migration. (wikipedia.org)
  • AZM and MDM attenuated PMA-induced MUC5AC and MUC2 gene and protein expression in NCI-H292 cells. (karger.com)
  • Until now, scientists had assumed, based on studies in cultured cells, that p53 had to be modified by attaching chemical groups to specific sites on the protein to function normally in the body. (news-medical.net)
  • Under normal conditions, the p53 protein is very unstable and found only at very low levels in the cell. (news-medical.net)
  • But when the cell senses that its DNA has been damaged, it slows down the degradation of p53, so that p53 protein levels can rise and initiate protective measures. (news-medical.net)
  • Or, if the damage is too severe for the breaks to be repaired, critical backup protection, also governed by the p53 tumor suppressor protein, kicks in. (news-medical.net)
  • Since the p53 protein is able to trigger such drastic action as cellular suicide, the cells of the body must ensure that the p53 protein is only activated when damage is sensed and that the protein is quickly degraded when it is not needed. (news-medical.net)
  • Previous tissue culture studies by several labs around the world indicated that tinkering with the tail end prevented the protein from being flagged for degradation or activation. (news-medical.net)
  • Instead of accumulating in mouse cells and halting cell division in the genetically engineered mice, the altered p53 protein performed flawlessly: it was unstable when no DNA damage was present and was stable and fully functional when needed to halt the cycle cell to repair DNA damage or to induce apoptosis. (news-medical.net)
  • One of those genes turns out to be a protein named BRD4. (sciencedaily.com)
  • This protein controls the expression and activity of yet another transcription factor, cMyc, which plays a central role in driving the aberrant metabolism and growth of GBM cells. (sciencedaily.com)
  • The fusion protein is then processed into functional PDGF-B and subsequently interacts with the PDGF receptor on the cell surface of DFSP tumor cells. (medscape.com)
  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
  • The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • Our work has demonstrated that KRAS mutant cells exhibit non-oncogene addiction to multiple stress-response pathways that maintain chromosome stability, mRNA splicing, protein SUMOylation and autophagy for survival. (cancer.gov)
  • Two biochemical processes, protein phosphorylation/dephosphorylation and ubiquitin-mediated degradation drive cell cycle control. (benthamscience.com)
  • The regulatory protein c-MYC plays an important role in promoting the development of many types of tumors. (medicalxpress.com)
  • It turned out that mice which lacked the Ap4 protein developed significantly fewer tumors and survived for 100 days longer, on average, than did the mice that could still synthesize it," says Hermeking. (medicalxpress.com)
  • T-cell receptor (TCR)-induced IL-2 expression is suppressed at the level of mRNA and protein following chronic culture of T cells with tumour necrosis factor (TNF) at picomolar concentrations, an effect that is reversible upon removal of TNF. (biomedcentral.com)
  • This compound markedly decreased the hypoxia-induced accumulation of HIF-1α protein dose-dependently, whereas it did not affect the expressions of HIF-1β and topoisomerase-I (topo‑I). Furthermore, celastrol prevented hypoxia-induced expression of HIF-1 target genes for vascular endothelial growth factor (VEGF) and erythropoietin (EPO). (spandidos-publications.com)
  • According to the research, postnatal mice apparently seem to use retinal myeloid cells present in their retinas in the developing stage, to regulate blood vessel branching with the help of Wnt protein signaling network. (healthjockey.com)
  • Interferon α 2A (IFN-α 2A) belongs to the type I interferon protein family and is produced by many cell types in response to viral infection. (sigmaaldrich.com)
  • Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. (jci.org)
  • Islet neogenesis associated protein (INGAP) is a product of a novel gene expressed in regenerating hamster pancreas. (jci.org)
  • The researchers found that miR-450a blocked genes associated with vimentin, a protein in the cell invasion pathway. (fapesp.br)
  • Thus, our work demonstrates that APA links genetic variation to variation in gene expression, protein expression, and disease risk, and reveals uncharted modes of genetic regulation. (elifesciences.org)
  • To understand the role of the epigenetic co-repressor protein TRIM28 in the control of transposable elements (TEs) and how TEs control gene regulation in the developing and adult brain. (lu.se)
  • In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
  • In vivo RA styles early intestinal immune system reactions by promoting IL-22 synthesis by T ILC and cells [54]. (mingsheng88.org)
  • Micrograph of an organoids, which were generated from intestinal epithelial cells cultered ex vivo. (medicalxpress.com)
  • Here, we describe the pre-clinical in vitro and in vivo study of irradiated haNK cells engineered to express a second-generation chimeric antigen receptor (CAR) targeting programmed death-ligand 1 (PD-L1). (elifesciences.org)
  • Using ex vivo models of primary MCL cells (n=23), we demonstrated that, through the secretion of IL32β, the tumor was able to polarize monocytes into specific MCL-associated macrophages, which in turn favor tumor survival. (haematologica.org)
  • Metabolic crosstalk between PPAT and PCa cell lines (PC-3 and LNCaP) was studied using ex vivo experiments. (bvsalud.org)
  • The International Journal of Biochemistry & Cell Biology. (wikipedia.org)
  • It is important to design an optimal therapeutic strategy according to tumor biology to improve the treatment of NSCLC ( 2 ). (aacrjournals.org)
  • Using this approach, they created a "mapping" of the tumour of each patient, which would be unique for them and reveal crucial information about the true biology of the tumour, its behaviour and tendency to spread and recur, and how it responds to treatment. (nihr.ac.uk)
  • This demonstrates that a single biopsy approach may not be sufficient to adequately represent the entire spectrum of the patient's tumour biology, potentially resulting in suboptimal decision-making processes. (nihr.ac.uk)
  • BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
  • Microarrays were prepared in tumor biology. (lu.se)
  • Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
  • Biochemical and genetic data suggest a role as a tumor suppressor. (cancerindex.org)
  • Proponents argue that nutrients in food alter gene expression or structure, acting differently on different people according to their genetic makeup. (technologyreview.com)
  • Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
  • To validate the results, they used blood cells from patients with a very rare congenital inflammatory disease in which RNaseT2 cannot be produced due to a genetic defect, and who suffer from severe mental and physical disability as a result. (uni-bonn.de)
  • This therapy modifies NK cells by using genetic engineering to improve their ability to identify and kill tumor cells while reducing damage to normal cells. (wtnh.com)
  • First, we are elucidating the genetic determinants and disease relevance of ferroptosis, a newly recognized form of cell death. (duke.edu)
  • Recently, we have found that the genetic removal of MESH1 in tumor cells triggers extensive transcriptional changes and confers protection against oxidative stress-induced ferroptosis (11). (duke.edu)
  • Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. (lookformedical.com)
  • The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive. (lookformedical.com)
  • To begin addressing this gap, we used 3' Seq to study the impact of genetic variation on alternative polyadenylation (APA) in the nuclear and total mRNA fractions of 52 HapMap Yoruba human lymphoblastoid cell lines. (elifesciences.org)
  • Through the cloning of Dolly, we learned that the cell nucleus contains all the genetic information needed for the cell to develop into any type of cell. (lu.se)
  • Analysis of gene activity in these microstructures enabled the researchers to conclude that Ap4 acts on two crucial signaling pathways that regulate the balance between stem cell maintenance and differentiation, and tips the scales toward stem cells. (medicalxpress.com)
  • ATRA and 9cis-RA induced morphological changes suggestive of differentiation, while fenretinide induced apoptosis in several cultures tested. (uni-wuerzburg.de)
  • Microarray analysis of ATRA treated WT cells revealed differential expression of many genes involved in extracellular matrix formation and osteogenic, neuronal or muscle differentiation. (uni-wuerzburg.de)
  • CD4 + T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. (nature.com)
  • Aggressive B-cell malignancies, such as mantle cell lymphoma (MCL), are microenvironment-dependent tumors and a better understanding of the dialogs occurring in lymphoma-protective ecosystems will provide new perspectives to increase treatment efficiency. (haematologica.org)
  • This integrated analysis led to the discovery of microenvironment-dependent and tumor-specific secretion of interleukin-32 beta (IL32β), whose expression was confirmed in situ within MCL lymph nodes by multiplex immunohistochemistry. (haematologica.org)
  • Finally, we demonstrated the efficacy of selective NIK/alternative-NFkB inhibition to counteract microenvironment-dependent induction of IL32β and BAFF-dependent survival of MCL cells. (haematologica.org)
  • Evidence demonstrating that the tumor ecosystem plays a central role in tumoral expansion and treatment resistance has continued to accumulate since the emergence of the tumor microenvironment concept more than a century ago. (haematologica.org)
  • PPAT lipidomic composition study may allow us to understand the tumor metabolic microenvironment and provide new stratification factors. (bvsalud.org)
  • We have found that, although chronic TNF attenuates TCRζ expression and TCR-proximal signalling, IL-2 expression is suppressed regardless of whether cells are stimulated via the TCR, or with phorbol ester and calcium ionophore to activate the MAPK and NFAT pathways directly. (biomedcentral.com)
  • Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. (elifesciences.org)
  • Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
  • Our aim was to establish a live cell culture to enable the understanding of the cellular processes driving the non-malignant growth of these tumors. (frontiersin.org)
  • Stem cells are thus especially susceptible to malignant transformation," says Hermeking. (medicalxpress.com)
  • Angiogenesis is a process of blood vessel branching that also seems to result in the formation of malignant tumors. (healthjockey.com)
  • To identify novel molecular regulations, we performed a transcriptomic analysis based on the comparison of circulating MCL cells (n=77) versus MCL lymph nodes (n=107) together with RNA sequencing of malignant (n=8) versus normal B-cell (n=6) samples. (haematologica.org)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • Cigana C, Assael BM, Melotti P: Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. (karger.com)
  • Clark JM, Annenkov AE, Panesar M, Isomäki P, Chernajovsky Y, Cope AP: T cell receptor zeta reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor alpha. (biomedcentral.com)
  • β-catenin forms a complex with T-cell factor ( TCF ) /lymphoid enhancer factor ( LEF ) transcription factors and cofactors such as histone acetyltransferase p300 (p300), CBP, BCL9, and pygopus, to transcribe Wnt signaling target genes such as Cyclin D1 , C-Myc , and survivin [ 9 , 12 - 15 ]. (hindawi.com)
  • 5′-GACGTG-3′) on the promoter region in various target genes ( 1 , 2 ). (spandidos-publications.com)
  • This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
  • Brain tumor-bearing mice treated with transgenic NLGN4X-specific human T cells had a greater than 40 percent response to treatment. (dkfz.de)
  • The three resulting recombinant viruses were used to infect tumor cells in cultures and human tumor xenografts in nude mice. (uni-wuerzburg.de)
  • The tumor phenotype in mice takes eight weeks to develop from the H-Ras and shp53 model. (genengnews.com)
  • The tumor phenotype is revealed when mice appear lethargic and have an enlarged head. (genengnews.com)
  • We are investigating their function using culture cells, MESH1 KO mice, and other model organisms. (duke.edu)
  • In the new research, Hopper-Borge and colleagues wanted to further explore, in both cultured cells and mice, the role of Abcc10. (news-medical.net)
  • The researchers isolated cells from the knockout mice and tested the cells' reactions to taxanes and two other anticancer drugs, vincristine and Ara-C. Compared to cells from normal mice that still possessed the gene for Abcc10, the knockout mouse cells were much more sensitive to the drugs. (news-medical.net)
  • Next, the research team studied the effects of one particular taxane, paclitaxel, on mice and found that the knockout mice were more sensitive to the drug, as reflected in body weight, white blood cell count, and ability to survive escalating doses of the drug. (news-medical.net)
  • Our technical expertise include lentiviral vectors, transgenic mice and stem cells cultures. (lu.se)
  • Some aspects of the potential of PCI for site-specific gene delivery in therapeutic situations will also be discussed. (nih.gov)
  • Because tumour dormancy provides a unique therapeutic window to prevent metastatic disease, we discuss on-going clinical trials and weigh the potential for immunotherapy to eradicate dormant disease. (nature.com)
  • Goss, P. E. & Chambers, A. F. Does tumour dormancy offer a therapeutic target? (nature.com)
  • Folkman, J. Tumor angiogenesis: therapeutic implications. (nature.com)
  • To find out if this potentially therapeutic effect might be induced by a drug, the researchers examined the genes whose expression is controlled by SOX9 and FOXG1. (sciencedaily.com)
  • These discoveries could help the development of new therapeutic strategies for the treatment of Ras mutant tumors. (cancer.gov)
  • To search for possible modes of action of retinoids as novel therapeutic options, primary tumor cell cultures were treated in vitro with all-trans-RA (ATRA), 9cis-RA, fenretinide and combinations of retinoids and a histone deacetylase (HDAC) inhibitor. (uni-wuerzburg.de)
  • To develop vector-based strategies of CRISPR/Cas9-mediated gene editing in the brain for experimental and therapeutic purposes. (lu.se)
  • The therapeutic approach to renal cell carcinoma (RCC) is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)
  • Treatment of xenograft tumors resulted in PD-L1-dependent tumor growth inhibition. (elifesciences.org)
  • Further, oral administration of 50 mg/kg or 100 mg/kg Triphala in PBS, 5 days/week significantly suppressed the growth of Capan-2 pancreatic tumor-xenograft. (biomedcentral.com)
  • Analysis of lung tissue RNA using Ingenuity Pathway Analysis (IPA) indicated trends in inflammatory response and connective tissue organization markers, with an emphasis on immune cell trafficking, phagocytosis, and adaptive immune responses. (cdc.gov)
  • Additionally, gene expression changes in the blood were indicative of ER-stress and downregulation of mTOR pathway. (cdc.gov)
  • The real-time PCR method was used to analyse the L. rhamnosus supernatant effect on the expression of Wnt signaling pathway genes. (hindawi.com)
  • The supernatant of this bacterium significantly reduced the expression of Wnt signaling pathway genes. (hindawi.com)
  • HSER in normal and XP-C cell lines, but not CS-A, XP-A, XP-D or XP-G cells, suggests that HS treatment can enhance the repair of UV-damaged DNA through an enhancement of transcription coupled repair (TCR) or a mechanism which involves the TCR pathway. (mcmaster.ca)
  • According to scientists the branching patterns of the retina are guided by myeloid cells stem cells of the immune system which make use of this molecular pathway. (healthjockey.com)
  • We show in the setting of retina that myeloid cells use this pathway to direct vascular traffic. (healthjockey.com)
  • The expression of a certain gene Flt1 was apparently linked to the myeloid cells that utilize the Wnt pathway. (healthjockey.com)
  • These data uncovered the IL32β/BAFF axis as a previously undescribed pathway involved in lymphoma-associated macrophage polarization and tumor survival, which could be counteracted through selective NIK inhibition. (haematologica.org)
  • Reduced RA pathway activity and MYCN overexpression were found in high risk tumors as opposed to tumors with low/ intermediate risk, suggesting a beneficial impact of RA especially on advanced WT. (uni-wuerzburg.de)
  • we have found the Hippo pathway effectors TAZ and YAP are responsible for the cell density-dependent ferroptosis (4, 6, 7). (duke.edu)
  • As gene liberation depends on light, enhancement of gene expression is achieved only at illuminated regions. (nih.gov)
  • We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
  • Whole blood gene expression profiling is a promising approach to identification of novel biomarkers for tissues over traditional, invasive biopsy. (cdc.gov)
  • And, the CMTM2 gene has been found to be more highly expressed in the salivary gland adenoid cystic carcinoma tissues of patients who did not develop tumor recurrences or perineural invasion of their carcinomas compared to the expression of this gene in patients whose adenoid cystic carcinoma tissues went on to develop these complications. (wikipedia.org)
  • 16-membered) on MUC5AC and MUC2 gene expression and secretion from human airway epithelial cells. (karger.com)
  • The MUC5AC and MUC2 gene expression was measured by real-time quantitative RT-PCR. (karger.com)
  • Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
  • Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)
  • Quantitative reverse transcription-PCR was done to evaluate the gene expression of E2F1, TS , and Survivin . (aacrjournals.org)
  • 0.0001), although no correlation was observed between E2F1 gene expression and the apoptotic index. (aacrjournals.org)
  • About 60% of GBM tumors are fueled by the mutation or rampant over-expression of EGFR, most often by the EGFRvIII mutant. (sciencedaily.com)
  • Instead, they boost the expression of their target coding genes. (sciencedaily.com)
  • Most of the enhancers activated by EGFRvIII bore signature DNA sequences that are bound by dozens of transcription factors--regulators of gene expression--expressed at high levels in GBM. (sciencedaily.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis. (cancerindex.org)
  • Hence, susceptibility to infection can be characterized by a construct that involves not only gene expression patterns of the host but also that of the microorganism, both of which continue to adapt in response to external stimuli. (hindawi.com)
  • How does tumour necrosis factor uncouple T-cell receptor-induced IL-2 gene expression in murine T cells? (biomedcentral.com)
  • However, the initial rate of decay was similar in control and TNF-treated cells, suggesting that reduced expression in TNF-treated cells was not due to decreased stability of IL-2 mRNA. (biomedcentral.com)
  • c-Rel, IκBβ and IκBε were regulated differently in control and TNF-treated cells: expression of IκBε was comparatively enhanced, while that of c-Rel and IκBβ was attenuated in TNF-treated cells. (biomedcentral.com)
  • However, altered regulation of NF-κB expression and activity in TNF-treated cells may contribute to poor inducibility of IL-2 through effects on stimulus-induced changes in chromatin conformation across pIL-2. (biomedcentral.com)
  • Isomäki P, Panesar M, Annenkov A, Clark JM, Foxwell BM, Chernajovsky Y, Cope AP: Prolonged exposure of T cells to TNF down-regulates TCR zeta and expression of the TCR/CD3 complex at the cell surface. (biomedcentral.com)
  • For first mechanistic insight, we contrasted microRNA expression in peripheral blood mononuclear cells of selected extreme group subjects with high-versus low-risk constellation regarding the accumulation model. (uni-wuerzburg.de)
  • Conclusion CIK cells can reverse the drug resistance of A549/DDP in a time-dependent manner by reducing GST-π expression to increase the accumulation of DDP. (jcancer.org)
  • Scientists armed with whole genome sequence data can now ask questions about genome structure and organization that impact gene expression. (genengnews.com)
  • Improved access to bioinformatics tools enables scientists to process, manage, and store raw data, annotate sequences to define genes, and quantitate RNA sequence data to get insight into gene expression patterns. (genengnews.com)
  • Amy Radunz, a nutritionist from the department of animal sciences at the University of Wisconsin in River Falls, has partnered with molecular biologist Hasan Khatib, an associate professor at University of Wisconsin-Madison, to ask how differences in maternal diet during pregnancy induce gene expression and DNA methylation changes in fetal tissues in sheep. (genengnews.com)
  • In addition, primary cutaneous CD30+ lymphoproliferative disorders showed such a similar expression pattern to that of systemic anaplastic large cell lymphomas, that none of the markers we investigated can reliably distinguish between these CD30+ T-cell lymphoproliferations. (uni-wuerzburg.de)
  • NCBI Gene Expression Omnibus, GSE138197. (elifesciences.org)
  • Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)
  • Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
  • Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)
  • The challenge is knowing which molecules need to be added to alter gene expression and initiate reprogramming. (lu.se)
  • The cellular cascade of molecular signals that instructs cells with fatally damaged DNA to self-destruct pivots on the p53 tumor suppressor gene. (news-medical.net)
  • Relationship between hematogenous tumor cell dissemination and cellular immunity in DCIS patients. (nature.com)
  • Much more advanced in clinical development than T-cell receptor transgenic cells are cellular therapies using so-called CAR-T (chimeric antigen receptor) cells, which have already been approved for the treatment of various leukemias and lymphomas. (dkfz.de)
  • Since this response was absent in the SV40-transformed fibroblast cell line and 4 of 5 tumour cell lines examined, HSER of beta-gal activity for UV-irradiated Ad5HCMVsp1lacZ also requires some cellular function(s) affected by transformation. (mcmaster.ca)
  • After the characterization stage, we had to find out which cellular migration and invasion genes were regulated by miR-450a," Silva Junior said. (fapesp.br)
  • Our expertise includes human stem cell cultures, viral vectors, gene editing, cellular reprogramming and bioinformatical analysis of transposons. (lu.se)
  • Filipe Pereira has found his niche at the interface of cellular reprogramming and blood cell identity. (lu.se)
  • Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)
  • Objective This study aimed to evaluate the effects of CIK cells on cisplatin (DDP) resistance in the human lung adenocarcinoma cell line A549/DDP. (jcancer.org)
  • The induction of the dedifferentiation occurs only when two hits occur in the same cell: either H-Ras overexpression and loss of p53 or loss of tumor suppressors NF1 and p53. (genengnews.com)
  • Confluent NCI-H292 human mucoepidermoid airways epithelial cells were pretreated with AZM or MDM for 2 h and then stimulated with 200 nmol/l phorbol 12-myristate 13-acetate (PMA) for 8 h. (karger.com)
  • The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
  • Shimizu T, Shimizu S: Azithromycin inhibits mucus hypersecretion from airway epithelial cells. (karger.com)
  • however, mechanisms through which these bioactive compounds act on epithelial cells have not been identified. (biorxiv.org)
  • Surprisingly, the loss of Ap4 had no effect on the division rates of either normal or tumorous epithelial cells in the colon. (medicalxpress.com)
  • These rearrangements fuse the collagen type I alpha 1 ( COL1A1 ) and the PDGF-beta chain ( PDGFB , c-sis proto-oncogene) genes. (medscape.com)
  • We are particularly focused on dissecting mechanism of non-oncogene addiction in KRAS mutant cells that plays a critical role in alleviating oncogenic stress. (cancer.gov)
  • We have developed combinatorial RNAi and CRISPR technologies to systematically interrogate the patterns of oncogene and non-oncogene addiction in KRAS mutant cells. (cancer.gov)
  • The study also looked at the impact of paternally expressed genes: IGF2, PEG1, PEG3, DLK1, and DIO3 for transcriptomic and epigenomic alterations of the imprinted genes in fetal tissues. (genengnews.com)
  • Tumour tissues and blood samples were provided by the Imperial College Healthcare NHS Trust Tissue Bank- a facility partly funded by the NIHR Imperial BRC. (nihr.ac.uk)
  • Tissues and Cells. (lu.se)
  • The only variant culture was derived from mesoblastic nephroma, a distinct childhood kidney neoplasm. (uni-wuerzburg.de)
  • In humans, it is encoded by the CMTM2 gene located in band 22 on the long (i.e. "q") arm of chromosome 16. (wikipedia.org)
  • Routine vaccination with ACAM2000 is recommended for laboratory personnel who directly handle 1) cultures or 2) animals contaminated or infected with replication-competent vaccinia virus, recombinant vaccinia viruses derived from replication-competent vaccinia strains (i.e., those that are capable of causing clinical infection and producing infectious virus in humans), or other orthopoxviruses that infect humans (e.g., monkeypox, cowpox, and variola) (recommendation category: A, evidence type 2). (cdc.gov)
  • Not surprisingly, the regulation of this vital safeguard has been studied in great detail for many years but mainly in tissue culture, or in vitro, models. (news-medical.net)
  • Markus Hafner, a researcher at the Laboratory of Muscle Stem Cells and Gene Regulation, also contributed to the study. (fapesp.br)
  • In differentiating neuroblastoma cells, HASH-1 is down-regulated, and there is coincident up-regulation of the transcriptional repressor HES-1, which is known to bind the HASH-1 promoter. (lu.se)
  • Methods The detect resistance index, drug resistance related-genes and cytokine secretion of A549/DDP co-cultured with CIK cells were assayed in vitro . (jcancer.org)
  • Design and Methods We evaluated biopsies from 19 patients with primary cutaneous CD30+ lymphoproliferative disorders, 38 with ALK- and 33 with ALK+ systemic anaplastic large cell lymphoma. (uni-wuerzburg.de)
  • Motorists, whose modulation evoked etoposide-like gene appearance adjustments (e.g., mTOR), had been cytotoxic both by itself and in conjunction with etoposide. (mingsheng88.org)
  • After these initial studies had yielded such promising results, Lukas Bunse expects that vaccine-induced T-cell receptors targeting brain tumor antigens could be a promising approach to develop new immunotherapies against glioblastoma. (dkfz.de)
  • By switching off other genes, the researchers discovered two important tools of the immune system: RNaseT2 and RNase2. (uni-bonn.de)
  • Pereira's research also involves reprogramming skin cells into dendritic cells, which are the sentinels of the immune system. (lu.se)
  • However, as tumors evade immune system detection many patients or tumor types do not respond. (lu.se)
  • The overall survival rate was significantly lower in patients with high- E2F1 tumors than in those with low- E2F1 tumors ( P = 0.0027), especially among patients with stage II to III NSCLCs ( P = 0.0188). (aacrjournals.org)
  • The interlinked phenomena, the team reports, are reflected in a global database of the genes expressed in GBM cells and seen in tumors expressing EGFRvIII obtained from GBM patients. (sciencedaily.com)
  • They point out that any such drug would also have the advantage of a biomarker--the presence of EGFRvIII in tumors--to determine whether it would be of benefit to patients. (sciencedaily.com)
  • In 10-20% of patients with this tumor, trauma at the site seems to be incriminated. (medscape.com)
  • Annual incidence of Bednar tumor among blacks is 7.5 times higher than that of white patients. (medscape.com)
  • Here, we report an accumulation model of 8 SNPs in these genes, associated with autistic traits in a discovery sample of male patients with schizophrenia (N = 692) and three independent replicate samples: patients with schizophrenia (N = 626), patients with other psychiatric diagnoses (N = 111) and a general population sample (N = 2005). (uni-wuerzburg.de)
  • The primary immune cells from these patients enabled the Bonn researchers to validate the results from the CRISPR-Cas9 model cell lines very well," says Prof. Dr. Jutta Gärtner, Director of the Department of Pediatrics and Adolescent Medicine at the University Medical Center Göttingen, who first described this disease and provided the Bonn researchers with immune cells from these rare patients. (uni-bonn.de)
  • The team also observed variations in the rate of growth between different tumour sites in patients. (nihr.ac.uk)
  • I came to realize that there were many questions about chromosome changes in patients that would be rewarding to study," noted Rowley, and for the next decade she labored over the microscope looking at chromosomes in leukemic cells. (laskerfoundation.org)
  • The treatment of metastatic renal cell carcinoma is problematic, and, whenever possible, patients should be directed to approved and controlled clinical trials. (medscape.com)
  • Reprogramming skin cells to blood stem cells could potentially provide an unlimited source of cells for transplantation to patients with blood disorders. (lu.se)
  • Background Cytokine-induced killer (CIK) cells can potentially enhance the tumor-killing activity of chemotherapy. (jcancer.org)
  • Furthermore, tumour cells grown in culture from different tumour sites displayed variable responses to conventional chemotherapy. (nihr.ac.uk)
  • Administration of miR-450a, with or without chemotherapy, can contribute as neoadjuvant therapy [ to shrink the tumor before surgery ], improving the preoperative response rate. (fapesp.br)
  • The tumor is heterogeneous with meningeal tumor cells, mainly a mixture of fibroblast like cells, and neuroepithelial cells in a background of connective tissue. (frontiersin.org)
  • EGFRIII changes the cell's internal signaling network, its uptake and use of nutrients, key elements of its gene-reading machinery known as transcription factors and its epigenetic landscape--the distribution of chemical tags that determines which parts of its genome are available for reading. (sciencedaily.com)
  • Notably, silencing of the two transcription factors stopped tumor growth, both in cell cultures and in an animal model that mimics GBM. (sciencedaily.com)
  • To conclude, normal variation in these genes contributes to the continuum of autistic phenotypes. (uni-wuerzburg.de)
  • Background: Wilms tumor (WT) is one of the most common malignancies in childhood. (uni-wuerzburg.de)
  • Today's anticancer drugs often work wonders against malignancies, but sometimes tumors become resistant to the effects of such drugs, and treatment fails. (news-medical.net)
  • As a result of the changes in energy metabolism, glutaminolysis decreased and glycolysis increased in cells that overexpressed miR-450a. (fapesp.br)
  • It is found in large quantities in glioblastoma cells, but is virtually undetectable in healthy brain tissue. (dkfz.de)
  • Tumor tissue from a rare non-infantile 8-year-old female DIG patient was dissociated and digested using collagenase to establish live cultures. (frontiersin.org)
  • Cells cultured as 3D were embedded as tissue blocks. (frontiersin.org)
  • Instead, deletion of Ap4 is associated with a reduction in the numbers of adult stem cells present in the tissue. (medicalxpress.com)
  • After seeing the effects on white blood cells, we decided to look at the tissue types that produce white blood cells to see if we could actually see differences there,' says Hopper-Borge. (news-medical.net)
  • They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. (lookformedical.com)
  • 2. Mode of carcinogenic action cell and tissue changes over time. (cdc.gov)
  • DFSP is a locally aggressive tumor with a high recurrence rate. (medscape.com)
  • SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
  • We report a case of chronic Schistosoma haematobium infection with pseudometastatic pulmonary nodules and high-grade squamous cell carcinoma in a 30-year-old man in Mali. (cdc.gov)
  • Schistosomiasis-induced squamous cell carcinoma of the bladder with pseudometastatic pulmonary nodules in a 30-year-old man from Mali. (cdc.gov)
  • Anatomopathology revealed urinary schistosomiasis complicated by a high-grade, well-differentiated, keratinized squamous cell carcinoma (SCC) (Figure, panel B). Within the wall, ovoid structures, sometimes calcified, corresponded to bilharzia eggs. (cdc.gov)
  • Co-culture of tumor cells with fibroblasts in these 3D models enable the characterization of tumor-stroma interaction. (cancer.gov)
  • HS enhanced reactivation (HSER) of the reporter gene was detected in normal cells, HT29 tumour cells and XP-C fibroblasts. (mcmaster.ca)
  • A recombinant nonreplicating human adenovirus type 5, Ad5HCMVsp1lacZ, expressing the lacZ gene under control of the human cytomegalovirus immediate early promoter, was used to assess the effect of heat-shock (HS) on DNA repair of a UV-damaged reporter gene. (mcmaster.ca)
  • Rao S, Procko E, Shannon MF: Chromatin remodeling, measured by a novel real-time polymerase chain reaction assay, across the proximal promoter region of the IL-2 gene. (biomedcentral.com)
  • Rao S, Gerondakis S, Woltring D, Shannon MF: c-Rel is required for chromatin remodeling across the IL-2 gene promoter. (biomedcentral.com)
  • Anatomopathology confirmed complete resection of the tumor reaching the muscle layer and the perivesical fat. (cdc.gov)
  • [ 18 ] A study by Alt et al found that complete resection of multiple renal cell carcinoma metastases may be associated with long-term survival. (medscape.com)
  • The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
  • A research team led by the University of Bonn has now discovered how this sensor plays an important role in defending human cells against intruders. (uni-bonn.de)
  • When bacteria or the pathogens that cause malaria invade living human cells, these cells can be very unwelcoming. (uni-bonn.de)
  • But how does the living human cell recognize if an undesirable guest is even there? (uni-bonn.de)
  • As the research group leader at the Institute for Clinical Chemistry and Clinical Pharmacology at the University Hospital Bonn explains, it was only the advent of the CRISPR-Cas9 gene editing that made it possible to understand the importance of the TLR8 immune sensor in human cells. (uni-bonn.de)
  • The consequence was that human cells were no longer able to recognize RNA from bacteria," says Thomas Ostendorf, lead author from Bartok's research group. (uni-bonn.de)
  • The IFNA2 (interferon alpha 2) gene is mapped to human chromosome 9p21.3. (sigmaaldrich.com)
  • HumanKine IFN-α 2A, expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 16 kDa. (sigmaaldrich.com)
  • Production in human HEK 293 cells offers authentic glycosylation. (sigmaaldrich.com)
  • The activity is determined by the dose-dependent cytotoxicity of the human TF-1 cell line (human erythroleukemic indicator cell line)) ≤ 0.4. (sigmaaldrich.com)
  • A portion of human INGAP gene was cloned and appears to be highly homologous to the hamster gene. (jci.org)
  • A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. (lookformedical.com)
  • A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. (lookformedical.com)
  • To understand the functional analyses of miRNAs and their role in neural stem cells by characterizing and identifiying known and novel RNAs bound to the mouse and human RNA induced Silencing Complex in various cell types of the brain. (lu.se)
  • He has succeeded in converting human skin cells into blood stem cells, which is a first step towards creating fully functional blood stem cells in test tubes. (lu.se)
  • T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
  • Ascle Therapeutics is an innovative biopharmaceutical company engaged in the R&D and production of breakthrough immune cell therapy products, primarily focusing on the field of NK/CAR-NK anti-tumor immunotherapy drugs. (abc4.com)
  • Chronic culture of murine T cells in TNF does not alter the stability of IL-2 mRNA induced via TCR, or by PMA and ionomycin, in those cells. (biomedcentral.com)
  • Porton Advanced is committed to providing end-to-end gene and cell therapy CDMO services, covering fields such as plasmids, cell therapy, gene therapy, and mRNA therapy. (wtnh.com)
  • Ascle Therapeutics has also established a comprehensive immune cell therapy research and production system and it has three major technology platforms: universal CAR-NK, allogeneic NK/CAR-NK, and mRNA-LNP. (wtnh.com)
  • Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)
  • NK cells express germ-line receptors that are either stimulatory or inhibitory, and the summation of these signals determines activation status ( Caligiuri, 2008 ). (elifesciences.org)
  • Cultured DFSP tumor cells have increased growth in response to platelet-derived growth factor (PDGF)-beta. (medscape.com)
  • Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. (elifesciences.org)
  • Furthermore, this observation seemed to test the effect it has on retinal diseases which are mainly linked to abnormality in blood vessel growth or tumor formation. (healthjockey.com)
  • Growth-inhibitory effects of Triphala were evaluated in Capan-2, BxPC-3 and HPDE-6 cells by Sulphoradamine-B assay. (biomedcentral.com)
  • Glycosylation contributes to stability in cell growth media and other applications. (sigmaaldrich.com)
  • These drugs--originally derived from the Pacific yew tree--work by disrupting cell division, thus arresting the growth and spread of tumors. (news-medical.net)
  • The molecule also decreased tumor growth by inhibiting one mitochondrial gene ( MT-ND2 ) and three nuclear genes ( ACO2 , ATP5B and TIMMDC1 ) involved in one of the stages of cell respiration and in energy production (oxidative phosphorylation). (fapesp.br)
  • Results: The association of retinoid signaling and clinical parameters could be validated in a large independent tumor set, but its relevance in primary nephrectomy tumors from very young children may be different. (uni-wuerzburg.de)
  • Partial or radical nephrectomy may be used, depending on tumor and patient characteristics. (medscape.com)
  • Together, these studies identify T cell-mediated tumor regression as the mechanism through which a plant-derived essential oil diminishes established tumor burden. (biorxiv.org)