Gene studies gametogenesis. Medical search. Frequent questions

Conclusions: Our current study illustrated the important contribution of sperm DNA methylation to the genetic architecture underlying male fertility in cattle and demonstrated the usefulness of functional annotations in enhancing the biological interpretation of GWAS results for complex traits and diseases. (usda.gov)
Based on the genetic differences VanKuren and Long now see between Apollo and Artemis in modern flies, they calculate that the original gene duplicated itself, or was copied and pasted as a second version in the genome, around 200,000 years ago. (chicagobiomedicalconsortium.org)
Hence, Instituto Bernabeu has developed a panel of 426 genes that evaluates the main genes involved in spermatogenesis to complete the diagnosis of male infertility from the genetic point of view by personalizing in vitro fertilization (IVF) treatment. (institutobernabeu.com)
Then, a bioinformatic study of the identified genetic mutations is carried out to assess their pathogenicity and to be able to inform about the reproductive prognosis of the patient. (institutobernabeu.com)
In addition, it allows to complement other results of genetic studies of the male such as, for example, karyotype and FISH or seminal TUNEL . (institutobernabeu.com)
Until now, only very few genes could be analysed in order to know the genetic origin of male reproductive failure. (institutobernabeu.com)
Advances in molecular biology and the development of massive sequencing techniques - together with the constant investment of the most avant-garde technology of Instituto Bernabeu - have allowed us to design the most complete genetic study of male fertility, identifying a total of 426 related genes with male gametogenesis. (institutobernabeu.com)
This study investigated whether genetic variations in MMR genes are associated with an increased risk of sperm DNA damage and male infertility. (biomedcentral.com)
Our results provide evidence supporting the involvement of genetic polymorphisms in MMR genes in the aetiology of male infertility. (biomedcentral.com)
The purpose of this work is three-fold: (1) to examine whether MMR gene polymorphisms are associated with increased risk of azoospermia or oligozoospermia, (2) to ascertain whether genetic variants in MMR genes result in sperm DNA damage and, thereby, increase male infertility, and (3) to investigate the biological activity of the significant functional variants. (biomedcentral.com)
Students will also study mutations as the other source of genetic variation. (sctritonscience.com)
The inheritance of genetic disorders will be analyzed to study the relationship between heredity, phenotypes and mutations. (sctritonscience.com)
Our study provides an unprecedented quantification of population genetic forces governing PAR1 biology across extant and extinct hominids. (biomedcentral.com)
Since the evolutionary forces driving genetic changes that cause infertility between species are likely also acting within species, the study of hybrid sterility also promises significant insight into mechanisms underlying infertility within species. (elifesciences.org)
The research interests of the Wolgemuth lab focus on understanding the genetic control of gametogenesis and embryogenesis using mouse models and gene targeting, transgenic, and molecular and cell biological approaches. (columbia.edu)
Finally, the lab is pursuing studies on the role of retinoid signaling during male germ cell differentiation, again in using molecular genetic approaches in the mouse model, and more recently, pharmacologic intervention. (columbia.edu)
Access to human germline cell types for study is limited, and little is known about the underlying genetic regulation of human gametogenesis. (harvard.edu)

Finding gene mutations that cause infertility. (upmc.com)
Either de novo mutations in synaptic genes, congenital abnormalities of epigenetic control (for example, Rett syndrome), or acquired alterations of epigenetic control induced by various environmental factors can lead to synaptic dysfunction and resultin autism. (biomedcentral.com)
B cell translocation gene 4 (BTG4) is a key adaptor of the CCR4-NOT deadenylase complex, which is involved in maternal mRNA decay in mice, but no human diseases caused by mutations in BTG4 have previously been reported. (appliedbioinfo.com)
Whithout mutations we would know very little about inheritance and the existence of genes. (intechopen.com)
In the last 30 years, the discovery of mutations in various parts of the genome in patients with disorders of puberty has made it possible to identify some genes involved in this process. (sciencedaily.com)
It is caused by mutations in the KAL gene. (medscape.com)

We study repeat content and double-strand break hotspot regions in PAR1 and find that they may play roles in ensuring the obligate X-Y recombination event during male meiosis. (biomedcentral.com)

The genome-wide DNA methylation pattern of remaining testis suggested that substantial genes harbored differentially methylated regions (1,139) in gene bodies, which were enriched in process of protein binding and cell adhesion. (animbiosci.org)

Our study detected 16 genes as the most promising candidate genes for male fertility, including SAMD5 and PDE5A. (usda.gov)

We detected genomic regions (including 16 genes as candidate biomarkers), that experienced DNA methylation alterations in sperm, were associated with aging and male fertility in cattle. (usda.gov)
However, due to the lack of accurate male fertility records (i.e., limited mating times), few studies have investigated the comprehensive impacts of sperm DNA methylation on male fertility in mammals. (usda.gov)
Results: Here, we investigated the relationships between sperm DNA methylation and male fertility in cattle by integrating large-scale (n = 27,214) genome-wide association studies (GWAS) of 35 complex traits (including 12 male fertility traits) and sperm DNA methylation. (usda.gov)
Who is the fertigenetic IBgen sperm study recommended for? (institutobernabeu.com)
Studying in-vitro approaches to produce sperm or eggs. (upmc.com)
Students can learn here about the process of gametogenesis (formation of sperm and egg cells) in males and females and menstrual cycle and ovulation in females. (tiwariacademy.com)
This study was conducted to evaluate in vivo and in vitro development of in vitro-matured equine oocytes fertilized by intracytoplasmic sperm injection. (bioone.org)

The mismatch repair (MMR) pathway plays an important role in the maintenance of the genome integrity, meiotic recombination and gametogenesis. (biomedcentral.com)
Studies of gene knockout mice indicate that several members of the MMR family also participate in the meiotic recombination process and are involved in gametogenesis [ 17 , 18 ]. (biomedcentral.com)
Primig, M.: Normal execution of the meiotic ncRNA expression program and the onset of gametogenesis in budding yeast require the conserved exosome subunit Rrp6. (tu-dresden.de)
Moreover, RNA-seq results indicated that 46 differentially expressed genes (DEGs) involved in meiotic cell cycle, synaptonemal complex assembly and spermatogenesis were upregulated in the hemicastration group, while 197 DEGs were downregulated, which were related to arachidonic acid metabolism. (animbiosci.org)
Here, we show that truncation of the KRAB domain of mouse PRDM9 leads to loss of PRDM9 function and altered meiotic prophase and gametogenesis. (springer.com)
In Saccharomyces cerevisiae , meiotic DSBs preferentially occur at nucleosome-depleted regions in gene promoters (Ohta et al. (springer.com)

DNA methylation plays important roles in many processes like gene expression, genomic imprinting, repression of transposable elements, and gametogenesis. (usda.gov)
This phenomenon, termed genomic imprinting, is highlighted by the neighboring Igf2 and H19 genes, which are monoallelically expressed on opposite parental chromosomes. (kb.se)
By means of laser-dissection and bisulfite genomic sequencing, it was observed that de novo methylation of CTCF target sites occurred in BORIS-expressing spermatocytes that exhibit repression of CTCF gene. (kb.se)
Recent progress in genome assembly of the sex chromosomes and the availability of population genomic datasets have now made it possible to study divergence and diversity processes of this important region in detail. (biomedcentral.com)
However in recent years with the development of epigenesis, genomic imprinting and the horizontal transferences of the genes, Lamarck's ideas have resurfaced. (intechopen.com)

My laboratory also studies fertility preservation in male cancer patients. (utsa.edu)
Genomewide discovery and classification of candidate ovarian fertility genes in the mouse. (appliedbioinfo.com)
To systematically discover ovarian fertility genes en masse, we employed a mouse model (Foxo3) in which follicles are assembled normally but then undergo synchronous activation. (appliedbioinfo.com)
Our study reveals how quickly multiple barriers to fertility can arise. (elifesciences.org)

Among these, 17.5% had putative functions in signaling, 14.3% were assigned to cell cycle and gene expression, 8.7% were linked to the cytoskeleton or inner membrane complex, 7.9% were involved in proteostasis and 6.4% in metabolism, 12.7% were cell surface-associated proteins, 11.9% were assigned to other functions, and 20.6% represented genes of unknown function. (biomedcentral.com)
In contrast, the thermally sensitive population exhibited higher basal levels of heat shock proteins and had three times fewer changes in gene expression overall. (frontiersin.org)
In the unicellular algae and mating types are controlled by a complex locus gene in the locus has been shown to be necessary for expression of expression patterns during gametogenesis and on a second gene unique to the locus transcription after nitrogen removal and its sequence similarity to grow RWP-RK proteins involved in nitrogen-responsive processes suggest that Mid conformation/activity may be nitrogen sensitive. (tam-receptor.com)
Previous research from the gene demonstrated it encodes a proteins with five forecasted NXT/S glycosylation sites three forecasted transmembrane regions no homologs in today's data source (Ferris gametes have the ability to type practical zygotes with wild-type gametes where isn't within Roscovitine either cell series (Ferris and Goodenough 1997). (tam-receptor.com)
Further, we constructed protein interaction networks of the genes identified by the feature selection method and gene ontology analysis elucidated the role of the proteins in the progression of the parasite through its life cycle. (fortunepublish.com)
Epigenetics is a mechanism that regulates gene expression independently of the underlying DNA sequence, relying instead on the chemical modification of DNA and histone proteins. (biomedcentral.com)
Therefore, proteins involved in synthesis and acquisition of phospholipids were extensively studied in the past and represent prime targets for malaria therapeutics. (rwth-aachen.de)
This modification of the microRNA expression profile is essential to the inhibition of the expression of transcription factors (proteins that activate or inhibit gene expression) that have a repressive effect on GnRH expression. (sciencedaily.com)

This study caused a major shift in the research orientation of our team, which became focused on investigations of imprinted gene regulation in the endosperm. (sciencewatch.com)
The application of this microarray to the study of mollusk gametogenesis should provide a better understanding of the key factors involved in sex differentiation and the regulation of oyster reproduction. (univ-brest.fr)
The limited changes in gene regulation suggest that individuals have reduced genome plasticity to tolerate thermal fluctuations and consequently may not have enough energy to repair damage and resume cellular homeostasis at extreme temperatures. (frontiersin.org)
Epigenetic gene regulation is essential for normal development, thus defects in epigenetics cause various rare congenital diseases. (biomedcentral.com)
Topics covered will include cell membrane structure and function, metabolism, cell motility and division, genome structure and replication, the regulation of gene expression and protein production, genotype to phenotype relationship, and basic principles of inheritance. (middlebury.edu)
Regulation of gene expression, e.g. expression of the GnRH gene, by microRNAs is therefore considered "epigenetic" regulation. (sciencedaily.com)

A subset of autosomal genes is preferentially or exclusively expressed from one of the parental alleles. (kb.se)
Genes preferentially expressed in bovine oocytes revealed by subtractive and suppressive hybridization. (appliedbioinfo.com)
B-cell translocation gene 4, cullin 1, MCF.2 transforming sequence, a locus similar to snail soma ferritin, and three unidentified genes were, indeed, preferentially expressed in the oocyte, even though most were also highly expressed in testis. (appliedbioinfo.com)

For a subset of 27 genes, transcript changes during gametogenesis were studied in detail by real-time RT-PCR. (biomedcentral.com)
In the meantime, a number of genes related to autism have been identified, which are mutated in a subset of autistic children. (biomedcentral.com)

HOX gene clusters and microRNAs) located in dynamic hypomethylated regions (HMRs) and partially methylated domains (PMDs) were significantly involved in the embryonic development. (usda.gov)
These profiles suggest a role in gametogenesis, fertilization, or early embryonic development. (appliedbioinfo.com)

Principal component analysis and hierarchical clustering showed a significant divergence in gene expression patterns of males and females coinciding with the start of gonial mitosis. (univ-brest.fr)
The presence of a germline did not significantly influence lipid profiles, raising the possibility that germline-dependent changes in metabolic gene expression patterns serve a homeostatic purpose. (usuhs.edu)
Moreover, we profiled the testicular gene expression patterns by RNA sequencing (RNA-seq) to examine whether methylation changes affected gene expression in hemicastrated mice. (animbiosci.org)

The goal of this study was to identify genes that may be involved in sexual maturation in experimentally matured eels. (biomedcentral.com)
The goal of our study was to identify genes connected to female gametophyte development and archegonia production in the dioecious liverwort Pellia endiviifolia species B, which is representative of the most basal lineage of the simple thalloid liverworts. (biomedcentral.com)

The Gamblin laboratory studies the mechanisms that lead to the polymerization of the microtubule-associated protein tau. (utsa.edu)
Since it was recognized that interstitial cells of Cajal express the gene product of c-kit, we performed immunohistochemistry for c-kit protein in ciliary muscle specimens of monkeys' eyes. (scielo.br)
For 40% of the identified genes there has as yet not been any protein evidence. (biomedcentral.com)
For selected genes, a regulated expression during gametogenesis was confirmed on the protein level, using quantitative confocal microscopy. (biomedcentral.com)
The protein encoded by this gene is a member of the BTG/Tob family. (appliedbioinfo.com)
Several well-known oocyte-specific genes were represented, including growth differentiation factor 9, bone morphogenetic protein 15, or the zona pellucida glycoprotein genes. (appliedbioinfo.com)
Interestingly, RNA-seq revealed that G. haimaensis hosts responded to B. pettiboneaei parasitism through significant upregulation of protein and lipid anabolism related genes, and that this parasitism may enhance host mussel nutrient anabolism but inhibit the host's ability to absorb nutrients, thus potentially helping the parasite obtain nutrients from the host. (frontiersin.org)
Integrative analysis revealed that proteasome 26S subunit ATPase 3 interacting protein gene, which encodes a protein crucial for homologous recombination in spermatocytes, exhibited promoter hypomethylation and higher expression level in hemicastrated mice. (animbiosci.org)
One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)

Based on phylogenetic and synteny analyses, this study reveals that nanos1 gene has undergone multiple duplications and gene copies losses in Vertebrates. (nature.com)
The two successive nanos gene duplications may result from the second and third whole genome duplication events at the basis of Vertebrates and Teleosts respectively. (nature.com)
Our study opens new perspectives concerning the complex evolution of nanos1 paralogs and their potential distinct roles in Vertebrates gonads. (nature.com)
In Vertebrates, three Nanos paralogous genes were described. (nature.com)
In Vertebrates, Nanos paralogous genes were associated to partial redundancies and specific functional evolutions. (nature.com)
Since most of the genes examined here have orthologs in other vertebrates, the results of this study will contribute to the body of knowledge concerning reproduction in vertebrates as well as to an improved understanding of eel biology. (biomedcentral.com)
The research concerns the Developmental Biology, particularly gametogenesis and embryogenesis of a team of lower vertebrates such as amphibians, fish and reptiles, recently invertebrates. (batcenter.it)
We will study the phylogeny, anatomy, physiology, and ecology of the major extinct and extant taxa of vertebrates and discuss how each group solves the problems of finding food, finding mates, and avoiding predators. (middlebury.edu)

We are testing the hypothesis that specific transcription factors form regulatory networks to execute gene expression programs important for SSC fate decisions (self-renewal and differentiation), and ultimately, spermatogenesis. (utsa.edu)

Research is focused on studying the molecular mechanisms involved in the pathogenesis of Vibrio cholerae , the bacterium that causes cholera, and Francisella tularensis , the bacterium that causes tularemia. (utsa.edu)
This study shows that the brains of eels undergo major changes at the molecular level at sexual maturity that may include re-organization at the cellular level. (biomedcentral.com)
Here, we have defined a set of genes that help to understand the molecular mechanisms controlling reproduction in eels. (biomedcentral.com)
The human-to-mosquito transmission triggers important molecular changes in the gametocytes, which initiate gametogenesis and prepare the parasite for life-cycle progression in the insect vector. (biomedcentral.com)
In the basal lineage of land plants, bryophytes, moss Physcomitrella patens has emerged as a model organism for molecular studies to learn about the mechanisms controlling the key moments during the transition from vegetative to reproductive phase of its life cycle. (biomedcentral.com)
Triplicate datasets have been generated for gametogenesis and the results were presented on a poster by PDRA Holly Matthews at the annual Molecular Parasitology Meeting (MPM) in the USA in Sept 2018 (~1.3 years into the project). (europa.eu)
However, it involves complex molecular processes with many genes and networks acting synergistically or antagonistically. (biomedcentral.com)

Long-term efforts of this project will involve developing RAR-alpha selective antagonists, identifying the target genes of RAR-alpha, and determining their function in germ cell-Sertoli cell interactions. (columbia.edu)
In terms of diagnosis, the study carried out by Vincent Prévot's team in Lille shows the interest of analysing DNA segments from which microRNAs are transcribed, as well as the genome segments that encode their binding sites on the target genes. (sciencedaily.com)

Ferris mating buildings (Ferris and Goodenough 1997) they cannot fuse with gametes because of the insufficient locus and encoding a glycoprotein necessary for fusion (Ferris mutants is certainly designated phenotype could be rescued by changing mutants with (Ferris provides been proven to be engaged in the activation/repression Roscovitine of the next genes: (locus but simply beyond your R area encodes the agglutinin. (tam-receptor.com)

One of the broader directions of the field will be to identify new imprinted genes in Arabidopsis in order to draw general conclusions. (sciencewatch.com)

The set of up-regulated genes includes genes involved in neuroendocrine processes, cell-cell signaling, neurogenesis and development. (biomedcentral.com)
In flowering plants such as Arabidopsis thaliana , the transition from the sporophytic phase to the gametophytic phase consists of two sequential processes, sporogenesis and gametogenesis. (biomedcentral.com)

FSH and LH bind to receptors in the testis and ovary and regulate gonadal function by promoting sex steroid production and gametogenesis. (medscape.com)

Both DNA and histone methylation are also essential for imprinting of genes in mammals and our results pointed to a convergent evolution of imprinting mechanisms. (sciencewatch.com)
Gametogenesis in mammals entails profound re-patterning of the epigenome. (biomedcentral.com)

The expression of 434 genes could be localized in either germ cells or somatic cells of the gonad by comparing the transcriptome of female gonads to the transcriptome of stripped oocytes and somatic tissues. (univ-brest.fr)
Comparative profiling of other tissues, including microdissected oocytes and somatic cells, revealed distinct gene classes and provided new insights into oogenesis and ovarian function, demonstrating the utility of our approach for tissue-specific gene discovery. (appliedbioinfo.com)

This takes place during male and female gametogenesis, and we have recently shown that the Retinoblastoma pathway plays an essential role in maternal activation of DNA methylation dependent imprinting genes (Jullien PE, et al . (sciencewatch.com)
Two years ago, in parallel with the identification of imprinting of FIS2 , we showed that maternally expressed imprinted genes could be also controlled by a different silencing mechanism dependent on histone methylation by Polycomb group activity (Jullien PE, et al . (sciencewatch.com)
Work in our team and in the teams of T. Kinoshita and R. Fischer has shown that epigenetic marks establishment during gametogenesis is critical for imprint establishment for genes regulated by DNA methylation. (sciencewatch.com)
The same principle probably holds true for imprinting genes dependent on histone methylation, and the mechanisms involved in the dynamics of these epigenetic marks now needs to be addressed. (sciencewatch.com)
Although more highly transcribed genes acquire methylation earlier, the major transitions in the oocyte transcriptome occur well before the de novo methylation phase, indicating that transcription is generally not rate limiting in conferring permissiveness to DNA methylation. (biomedcentral.com)
Thus, investigating methylation at intermediate stages would be informative, but genome-wide studies have not yet been done. (biomedcentral.com)
The methylation plasticity of the H19 ICR was nevertheless tolerated without affecting the imprinted status of either Igf2 or H19 genes. (kb.se)
Global profiling of DNA methylation and gene expression demonstrated that hemicastration-induced compensatory response maintained normal growth and testicular morphological structure in mice. (animbiosci.org)

The contribution of the identified genes may be crucial for successful liverwort sexual reproduction. (biomedcentral.com)
A number of genes have been identified in several angiosperm species which play crucial functions in many different steps of the male and female gametophytes formation [ 2 , 3 ]. (biomedcentral.com)
This gene encodes a transcriptional regulator that plays a crucial role in forming many organs [ 11 ]. (biomedcentral.com)

This study also demonstrated that functional annotations can help to explain GWAS results for complex traits and diseases. (usda.gov)
The genes that control these competing traits, say for feather size and color, are said to be subject to sexual conflict, or selection in opposite directions by males and females. (chicagobiomedicalconsortium.org)

On the basis of whole-transcriptome analyses, we identify many genes that are expressed in a sex- or life stage-specific manner and characterize the transcriptional landscape of a morphological region with unique biological adaptations, namely, bacillary band and stichosome, found only in whipworms and related parasites. (nature.com)
Of these, 22 genes were expressed in gametocytes, and for 15 genes transcript expression in gametocytes was increased compared to asexual blood stage parasites. (biomedcentral.com)
Timecourses have been conducted to quantify the number and type of replicating nuclei, together with other cell-biological features, in P. falciparum parasites across the course of both erythrocytic schizogony and gametogenesis. (europa.eu)
PNPLA1-deficient parasites showed normal asexual replication, gametocyte development and gametogenesis. (rwth-aachen.de)
The loss of PNPLA1 function also led to a transcriptional deregulation of genes related to game to cytogenesis, including the gene encoding the key regulator of sexual commitment, the transcription factor AP2-G. Comparative lipidodomic analysis of asexual PNPLA1-deficient parasites revealed overall increased levels of major phospholipids, in particular phosphatidylcholine (PC), which is the main component of plasmodial membranes. (rwth-aachen.de)

Transcript levels of seven genes were particularly high in activated gametocytes, pointing at functions downstream of gametocyte transmission to the mosquito. (biomedcentral.com)

M.: The PGM3 gene encodes the major phosphoribomutase in the yeast Saccharomyces cerevisiae. (tu-dresden.de)

The authors show that in Drosophila, a single gene duplicated and the two copies subsequently evolved to carry opposite sex-specifying functions contributing to the developmental and functional differences between males and females. (chicagobiomedicalconsortium.org)

The pituitary gland secretes follicle-stimulating hormone (FSH) and luteinizing hormone (LH) which are gonadotropins that act on the gonads to induce sex steroid synthesis and promote gametogenesis. (biomedcentral.com)

METHODOLOGY/PRINCIPAL FINDINGS: Gene expression was studied in gonads of oysters cultured over a yearly reproductive cycle. (univ-brest.fr)
Together, our findings provide new insights into the effects of parasite scale worms on changes in symbiotic bacteria and gene expression in deep sea mussel hosts. (frontiersin.org)
In addition, these findings provide further support for models in which conflicts between different genes in genomes can drive the process of speciation. (elifesciences.org)

More importantly, our study clearly showed that the maintenance DNA methyltransferase MET1 is responsible for silencing of the paternal allele of FIS2 during the vegetative life cycle, male gametogenesis, and development of the endosperm, the extra-embryonic tissues where imprinting takes place in plants. (sciencewatch.com)
In flowering plants a number of genes have been identified which control the transition from a vegetative to generative phase of life cycle. (biomedcentral.com)
Moreover we observed ten-fold increased transcripts level for all three genes in the archegonial tissue in comparison to the vegetative parts of the same female thalli grown in natural habitat suggesting their connection to archegonia development. (biomedcentral.com)

To isolate bovine oocyte marker genes, we performed suppressive and subtractive hybridization between oocytes and somatic tissues (i.e., intestine, lung, muscle, and cumulus cells). (appliedbioinfo.com)
Gametogenesis (the production of spermatozoa and oocytes) and the secretion of hormones by the ovaries and testes are heavily dependent on the hypophysis, a small gland located below the brain, to which it is connected by a capillary network. (sciencedaily.com)

Thus, schizogony challenges some basic paradigms about DNA replication control, while gametogenesis demands a speed of DNA replication and cell division that is unprecedented in eukaryotic gametogenesis. (europa.eu)
Aim 1: detailed characterisation, at the whole-cell level, of the asynchronous genome replication that occurs in schizogony and gametogenesis. (europa.eu)

Background: D. melanogaster is increasingly used as a lipid metabolism model, but the D. melanogaster metabolome is not well studied. (usuhs.edu)
A number of studies strongly suggest that lipid metabolism is linked to sexual behavior and gametogenesis. (usuhs.edu)

We further propose that an locus is usually operant during gametogenesis. (tam-receptor.com)

This study will thus facilitate comprehensive analyses of follicle development, ovarian function, and female infertility. (appliedbioinfo.com)

The really unexpected result from this study is that despite being so young, these genes rapidly evolved, not only in a way to mitigate the sexual conflict but also to develop essential, sex-specific functions. (chicagobiomedicalconsortium.org)
This is one of the first studies to provide data showing that gene duplication can resolve sexual conflict, and that separate functions can evolve much more rapidly than classical evolutionary theories predict. (chicagobiomedicalconsortium.org)
While VanKuren and Long don't yet know the function of the ancestral gene that preceded Apollo and Artemis, they suspect it must have been subject to extremely strong sexual conflict to still see residual effects. (chicagobiomedicalconsortium.org)
Interestingly, while genes involved in immune system function were down-regulated in the brains of mature males, changes in the expression levels of several receptors and channels were observed suggesting that some rewiring is occurring in the brain at sexual maturity. (biomedcentral.com)

Recent advances in single cell RNA-sequencing (sc-RNA) techniques paved new ways to characterize gene expression changes during the development stages of the plasmodium life cycle [4,5]. (fortunepublish.com)
Final stages of gametogenesis. (proprofs.com)

We also present that knockdown of by RNA disturbance (RNAi) compromises or prevents gametogenesis indicating an important function for in this technique. (tam-receptor.com)

We found that the more thermally tolerant population had greater plasticity of gene expression and had significantly more downregulated genes, which may provide more energy to repair damage associated with thermal stress and to maintain basic functions at these extreme temperatures. (frontiersin.org)
Chromatin immunoprecipitation (ChIP) experiments revealed that the active chromatin mark trimethylation of lysine 4 of histone 3 (H3K4me3), was significantly enriched in areas associated with interferon-stimulated genes in STAT1 GOF cells in comparison to cells from healthy donors. (kb.se)

We will learn here that the role of genes and DNA in inheritance. (tiwariacademy.com)

Polycomb group complexes self-regulate imprinting of the polycomb group gene MEDEA in Arabidopsis ," Current Biology 16[5]: 486-92, 7 March 2006). (sciencewatch.com)
They can bind to the 3′ untranslated region (3′UTR) of target messenger RNAs (mRNAs) in order to regulate gene expression post-transcriptionally with no sequence specificity but by potential electrostatic interactions with the phosphate backbone of RNA 2 , 3 . (nature.com)

The obtained transcriptome data demonstrate the regulations of gene expression immediately following malaria parasite transmission to the mosquito. (biomedcentral.com)

The two copies, called Apollo and Artemis, began as essentially the same gene when D. melanogaster first evolved as a separate species 1.5 million years ago. (chicagobiomedicalconsortium.org)
Chondrichthyan species display two nanos1 genes (named nanos1A / 1B ), which were both retrieved in some Osteichthyes at basal positions in Sarcopterygii and Actinopterygii lineages. (nature.com)
Analysis of the GnRH gene in humans shows that analogous phenomena might occur in our own species. (sciencedaily.com)

Duplicate copies of a gene shared by male and female fruit flies have evolved to resolve competing demands between the sexes. (chicagobiomedicalconsortium.org)
METHODS: Eight eyes from four adult male new world monkeys (Cebus apella) were studied. (scielo.br)
A role of this gene in Germinal Stem Cells maintenance may be evolutionarily conserved as Nanos2 is specifically expressed both in oogonia and in spermatogonia of adult medaka 11 and in a subpopulation of undifferentiated A spermatogonia in juvenile and spermiating male trout 12 . (nature.com)
Based on their important physiological functions, these five MMR genes are good candidate genes for explaining male infertility. (biomedcentral.com)
A total of 1,657 infertile patients, diagnosed with unexplained male factor infertility, were drawn from the Centre of Clinical Reproductive Medicine between April 2005 and March 2009 (NJMU Infertile Study). (biomedcentral.com)

Our original main research interest was to study endosperm development. (sciencewatch.com)
To better understand gene regulations during the initial phase of malaria parasite transmission, we focused on the transcriptome changes that occur within the first half hour of parasite development in the mosquito. (biomedcentral.com)
Also the PpFIE gene ( FERTILIZATION INDEPENDENT ENDOSPREM ) has been implicated in the gametophyte development. (biomedcentral.com)
The X chromosome carries genes that have a role in many organ systems, playing a part, for example, in testes function, brain development, and growth. (medscape.com)

Graduates with high academic achievement may go on to postgraduate studies in research, or professional programs in the biological, veterinary, medical, and health sciences fields. (mcgill.ca)

Even though males and females share nearly all of their genomes, they each have to deal with very distinct selective pressures," said Nicholas VanKuren , a graduate student at UChicago and co-author of the study, published this week in Nature Ecology & Evolution . (chicagobiomedicalconsortium.org)

All three genes are exclusively expressed in the female individuals, regardless of whether they were cultured in vitro or were collected from a natural habitat. (biomedcentral.com)

Previous studies have revealed that the microbiota plays an important role in host adaptability. (frontiersin.org)

Here, we compared gill-microbiota, gene expression and host-microorganism interactions in a group of deep sea mussels ( Gigantidas haimaensis ) parasitized by scale worm (PA group) and a no parasitic control group (NPA group). (frontiersin.org)

We resolve chromosomal sequences and infer sex chromosome-specific parasite genes and new potential drug targets. (nature.com)

We want to understand how two alleles with identical DNA sequences can be differentially marked by epigenetic modification, which, in turn, results in imprinted gene expression. (sciencewatch.com)

Another area of interest is the study of pathogenic mechanisms of Francisella tularensis , a potential bioweapon, with particular interest in determining how this bacterium evades killing within host macrophages. (utsa.edu)

Anatomy12

Organisms6

Diseases4

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Psychiatry and Psychology1

Phenomena and Processes36

Disciplines and Occupations1

Information Science3

Named Groups1

Health Care2

Genetic17

Mutations6

Meiosis1

Differentially methylated regions1

Candidate genes for male1

Sperm7

Meiotic6

Genomic5

Fertility4

Proteins8

Regulation6

Preferentially3

Subset2

Embryonic development2

Expression patterns3

Identify genes2

Protein9

Vertebrates8

Differentiation1

Molecular7

Target genes2

Repression1

Conclusions1

Processes2

Gonadal1

Mammals2

Somatic cells2

Methylation8

Crucial3

Traits2

Parasites5

Gametocyte1

Encodes1

Functional1

Steroid1

FINDINGS3

Vegetative3

Oocytes2

Replication2

Lipid2

Locus1

Analyses1

Sexual4

Stages2

Knockdown1

Significantly2

Inheritance1

Regulate2

Transcriptome data1

Species3

Male5

Development4

Biological1

Males and females1

Exclusively expressed1

Role1

Interactions1

Chromosomal1

Sequences1

Mechanisms1