• Glucocorticoid is dependent on Glucocorticoid plasma concentration, cellular glucocorticoid receptor expression and the pre-receptor hormone metabolism that is catalyzed by 11β-HSD. (wikipedia.org)
  • This demonstrates that there is likely a relationship between hyperlipidemia and cortisol metabolism. (wikipedia.org)
  • The significant module (royal blue) identified was associated with TC, TG and non-HDL-C. GO and KEGG enrichment analyses revealed that the genes in the royal blue module were associated with carbon metabolism, steroid biosynthesis, fatty acid metabolism and biosynthesis pathways of unsaturated fatty acids. (biomedcentral.com)
  • Common single nucleotide polymorphisms (SNPs) in genes involved in lipid metabolism are potentially important genetic markers in affecting normal variation in the plasma or serum lipid profiles and thus determining susceptibility or resistance to CHD in the general population. (biomedcentral.com)
  • Gene therapy displacement of endogenous MCUb with a dominant-negative MCUb transgene (MCUb W246R/V251E ) in vivo rescued T2D cardiomyocytes from metabolic inflexibility and stimulated cardiac contractile function and adrenergic responsiveness by enhancing phospholamban phosphorylation via protein kinase A. We conclude that MCUb represents one newly discovered molecular effector at the interface of metabolism and cardiac function, and its repression improves the outcome of the chronically stressed diabetic heart. (diabetesjournals.org)
  • 1 In 1938, Müller linked xanthomas, elevated cholesterol, and coronary heart disease to an in-born error of metabolism from a single gene defect. (acc.org)
  • In adipocyte Senp2-de﫿ciency mice, accumulation of the SUMOylated Setdb1 suppressed the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes, which would decrease the ability of lipid storage in adipocytes. (deepdyve.com)
  • Variations in genes regulating fatty acid metabolism must be considered in the search for factors affecting the lipid phenotypic expression of FCHL. (univaq.it)
  • While most people suffer from HeFH, in rare cases, the mutations in both copies of genes related to cholesterol metabolism give rise to the lethal form of familial hypercholesterolemia, i.e. (delveinsight.com)
  • Expression of cardiac PPARγ coactivator 1-α (PGC1α), which promotes mitochondrial biogenesis, had the most profound reduction among various fatty acid metabolism genes. (jci.org)
  • Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. (wikipedia.org)
  • One of our groundbreaking discoveries was the identification of founder mutations in the DYRK1B gene, underlying atherosclerosis, metabolic syndrome, and fatty liver disease. (yale.edu)
  • One of our recent groundbreaking discoveries was the identification of novel loss of function mutations in a gene encoding the pancreatic exocrine elastase Cela2a in patients with diabetes, CAD and MetS traits, including obesity, hypertension, hypertriglyceridemia, NAFLD (OMIM: AOMS4). (yale.edu)
  • One of the most common types of hyperlipidemias occurs due to mutations in the LDL receptor gene (low density lipoprotein), familial hypercholesterolemia (FH). (diploidegenetics.com)
  • In addition to the well-known consequences of absolute leptin deficiency, subjects with heterozygous leptin gene mutations have low circulating leptin levels and increased body adiposity. (diabetesjournals.org)
  • 4 And in 1983, Russell and colleagues cloned the LDLR gene, which allowed for molecular-level analysis of receptor mutations. (acc.org)
  • 6 There are also rare forms of FH that result from mutations in genes for apolipoprotein B-100 (ApoB), proprotein convertase subtilisin/kexin type 9 (PCSK9), 8 and the low-density lipoprotein receptor adaptor protein 1 (LDLRAP1), which causes a rare form of autosomal recessive FH. (acc.org)
  • Mutations in four major genes have been identified to cause HoFH, including Low-density lipoprotein receptor (LDLR), Apolipoprotein B (APOB), Proprotein convertase subtilisin/kexin type 9 (PCSK9), and Low-Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1). (delveinsight.com)
  • The diagnostic journey of HoFH involves the examination of family history for clues, assessing physical manifestations like xanthomas, and delving into sophisticated genetic analyses to detect the significant mutations in LDL receptor genes. (delveinsight.com)
  • In pregnancy as mentioned earlier the lipid concentration in blood increases, if the concentration of the lipids in the blood is not controlled it results in the increase in the concentration of the lipid in the perinatals and may be leads obesity and/or hyperlipidemia [ 25 - 31 ]. (omicsonline.org)
  • Metabolic syndrome is defined as a cluster of metabolic abnormalities including obesity, hyperlipidemia, hyperglycemia, insulin resistance, and hypertension [ 3 ]. (hindawi.com)
  • Previous studies have reported the therapeutic properties of A. iwayomogi on obesity, hyperlipidemia, and liver fibrosis [ 7 , 8 ]. (hindawi.com)
  • Therefore, we evaluated the effect of ACE on major manifestations of metabolic syndrome including obesity, hyperlipidemia, and fatty liver using a high-fat diet mouse model. (hindawi.com)
  • These hormones, the pathways controlling their production, and their receptors are promising targets for managing obesity, hyperlipidemia, and insulin resistance. (diabetesjournals.org)
  • GS is a 63-year-old patient with a history of hypertension, hyperlipidemia, and obesity. (aafp.org)
  • Cortisol levels consequently rise, and cortisol binding to the mineralocorticoid receptor produces clinical signs and symptoms of hypokalemia, alkalosis and hypertension (i.e., mineralocorticoid excess). (wikipedia.org)
  • Despite equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had less severe renal histological abnormalities and a reduced intrarenal advanced glycation and oxidative stress. (hindawi.com)
  • The genesis of diabetic nephropathy (DN) in type 2 diabetes mellitus is clearly multifactorial, involving hypertension, hyperglycemia, hyperinsulinemia, and hyperlipidemia [ 1 - 6 ]. (hindawi.com)
  • Despite the equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had a significantly lower proteinuria and less severe renal histological abnormalities. (hindawi.com)
  • In some women, further investigations may be needed to identify contributing factors and comorbidities such as polycystic ovary syndrome, diabetes, hypertension, and hyperlipidaemia. (tressless.com)
  • It occurs more often in people who have vascular risk factors (eg, hypertension, diabetes mellitus, hyperlipidemia, smoking) and in those who have had several strokes. (msdmanuals.com)
  • Gene association studies identified candidate genes and epigenetic silencing of the androgen receptor gene on the occipital scalp, explaining the inheritance and pattern of androgenetic alopecia. (tressless.com)
  • Relationship between the CAG repeat polymorphism in the androgen receptor gene and acne in the Han ethnic group. (vestnikdv.ru)
  • Zitzmann M, Nieschlag E. The CAG repeat polymorphism within the androgen receptor gene and maleness. (vestnikdv.ru)
  • The microarray dataset of GSE66676 obtained from patients with hyperlipidaemia was downloaded. (biomedcentral.com)
  • and peroxisome proliferator-activated receptor alpha, PPAR α ). (hindawi.com)
  • Adiponectin production is stimulated by thiazolidinedione agonists of peroxisome proliferator-activated receptor-γ and may contribute to increased insulin sensitivity. (diabetesjournals.org)
  • HLHG) along with the increased extent of ERS, oxidized lipids, and decreased expression of liver X receptors beta (LXRβ) in the small intestine, peroxisome proliferator‐activated receptor‐γ (PPARγ) in the liver, and of the glucose transporter 4 in the myocardium. (zendy.io)
  • Using a recombinant endonuclease-deficient Cas9-based gene promoter pulldown approach coupled with mass spectrometry, we found that MCUb is upregulated in the T2D heart due to loss of glucose homeostasis regulator nuclear receptor corepressor 2 repression, and chromatin immunoprecipitation assays identified peroxisome proliferator-activated receptor α as a mediator of MCUb gene expression in T2D cardiomyocytes. (diabetesjournals.org)
  • In recent posts we have looked at PPARα ( Peroxisome proliferator-activated receptor alpha) and PEA ( Palmitoylethanolamide) , which activates it. (epiphanyasd.com)
  • This rat strain has the same hypertensive background as SHR but also a genetic mutation in the leptin receptor gene, which leads to hyperphagia with an attendant wide range of metabolic abnormalities, that is, high body weight, hyperglycemia, hyperlipidemia, and hyperinsulinemia. (hindawi.com)
  • Dual PPARα/γ agonists that were developed to target hyperlipidemia and hyperglycemia in patients with type 2 diabetes caused cardiac dysfunction or other adverse effects. (jci.org)
  • Significant relationships were discovered between increased VDR expression with heart disease, peripheral vascular disease (PVD), and hypercholesterolemia/hyperlipidemia. (iupui.edu)
  • Decreased activity of LDL-receptors' resulting in decreased receptor-mediated catabolism of LDL and IDL is the main cause of the hypercholesterolemia observed in hypothyroidism 13-15 . (hormones.gr)
  • Heterozygous familial hypercholesterolemia individuals inherit one mutated copy of the LDL receptor gene from one parent and one normal copy from the other parent. (delveinsight.com)
  • Several common genetic polymorphisms in the low density lipoprotein receptor (LDL-R) gene have associated with modifications of serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels, but the results are not consistent in different populations. (biomedcentral.com)
  • This phenotype results from a point mutation in the gene specifying the very low density lipoprotein receptor (VLDLR), whose protein product normally mediates the massive oocytic uptake of egg yolk precursors from the circulation. (psu.edu)
  • 3 Building on this work in 1973, Goldstein and Brown characterized the low-density lipoprotein receptor (LDLR) and related the phenotype of FH to defects in the LDLR. (acc.org)
  • Primary hyperlipidemia , also sometimes called familial hyperlipidemia, is hereditary and is transmitted genetically from either your mother or father. (cardiology-doctors.com)
  • Secondary hyperlipidemia , also called acquired hyperlipidemia, is usually caused by an underlying health condition like diabetes and hypothyroidism, but is also associated with poor diet and other negative external factors such as alcohol consumption and smoking. (cardiology-doctors.com)
  • Insuf﫿cient adipose lipid storage is asso- ciated with many pathological conditions including hyperlipidemia, insulin resistance, and type 2 diabetes. (deepdyve.com)
  • Tocotrienols (T3) are well-known for their antioxidant properties besides showing therapeutic potential in clinical complications such as hyperlipidemia induced by diabetes. (iium.edu.my)
  • Given that her C-peptide level was not too low and considering her negative diabetes-related antibodies and high TG level, targeted gene panel sequencing was performed on the genes associated with diabetes and HTG. (e-apem.org)
  • Leptin treatment dramatically improves metabolic abnormalities (insulin resistance and hyperlipidemia) in patients with relative leptin deficiency due to lipoatrophy. (diabetesjournals.org)
  • adqcKO Mechanistically, adipocyte Senp2 de﫿ciency caused the downregula- Senp2 mice exhibit an ectopic lipid accumulation and tion of Pparg and Cebpa as well as their downstream target genes insulin resistance related to lipid storage. (deepdyve.com)
  • the action of the thyroid hormone axis is via an active metabolite that enters target cells and signals a nuclear receptor to stimulate both proliferation and maturation of the growth plate. (orthobullets.com)
  • HSD-11βs co-localizes with intracellular adrenal steroid receptors. (wikipedia.org)
  • G protein-coupled receptors (GPCR) have recently been implicated in intracellular crosstalk pathways with IR. (mdpi.com)
  • Our work involves population and family-based genetic studies, high throughput sequencing to identify disease genes, with a focus on coronary artery disease (CAD) and metabolic syndrome (MetS). (yale.edu)
  • Since the LDL-R gene plays an important role in cholesterol homeostasis [ 28 ], it is also possible that genetic variations in this gene may exist that have only a small effect on the function of the receptor. (biomedcentral.com)
  • This is to say, the high cholesterol associated with primary hyperlipidemia is not caused by poor habits but is caused by a genetic disorder (specifically, a mutated gene which is passed on from a parent which causes a missing or malfunctioning LDL receptor, causing LDL to accumulate in the blood to a dangerous amount). (cardiology-doctors.com)
  • We support it with complete and rapid genetic diagnoses of hereditary vascular diseases that cover most of the associated genes. (diploidegenetics.com)
  • Conversely, genetic variants in the IRS-1, FABP-2, and the beta(3)-AR gene appear not to have a major role as modifier genes in FCHL. (univaq.it)
  • Univariate and multivariable linear regression and within-gene haplotype trend regression were used to test for genetic associations assuming an additive mode of inheritance for each of the three major race/ethnic groups in the United States (non-Hispanic white, non-Hispanic black, and Mexican American). (cdc.gov)
  • We studied the mechanisms that underlie the cardiotoxic effects of a dual PPARα/γ agonist, tesaglitazar, in wild-type and diabetic (leptin receptor-deficient, db/db) mice. (jci.org)
  • Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice. (tohoku.ac.jp)
  • 10-d hyperlipidemia increases the HSD-11β Type 1 expression in visceral and subcutaneous adipose tissues. (wikipedia.org)
  • Hyperlipidemia decreases HSD-11β Type 2 expression in the liver and adipose tissue. (wikipedia.org)
  • In the peripheral tissues, particularly adipose and muscle tissue, VLDL is cleaved by lipoprotein lipase (LPL), extracting most of the triglycerides and forming an IDL that contains apoproteins B-100 and E. IDL can be taken up by the liver through the LDL receptor, or it can be converted to the cholesterol-rich LDL that contains apoprotein B-100. (medscape.com)
  • To prevent over-stimulation of the mineralocorticoid receptor by cortisol, HSD-11βs convert the biologically active cortisol to the inactive cortisone, which can no longer bind the mineralocorticoid receptor. (wikipedia.org)
  • HSD-11β Type 2 is expressed by aldosterone-selective tissues and protects the mineralocorticoid receptor from the activation by cortisol by converting it to cortisone using the enzyme 11-Oxoreductase. (wikipedia.org)
  • In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. (wikipedia.org)
  • It is the first nonsteroidal mineralocorticoid receptor (MR) antagonist to be approved for this purpose. (medscape.com)
  • Upon photostimulation, restricted ovulator (RO) female chickens exhibit endogenous hyperlipidemia, develop atherosclerotic lesions, and generally fail to lay eggs. (psu.edu)
  • Just lately, it was reported that adeno-associated-virus-8 (AAV8)-mediated overexpression of PCSK9 (AAV8-PCSK9) quickly induced hyperlipidemia. (aabioetica.org)
  • LDL is removed from the circulation primarily by the liver through the LDL receptor. (medscape.com)
  • By inhibiting the production of LDL and VLDL the risk factors for the hyperlipidemia can be controlled, Bile acid sequestrants like Cholestyramine, Colestipol and Colesevelam are used to regulate high serum levels by binding the bile acid which is secreting from liver to metabolize the triglycerides [ 20 - 24 ]. (omicsonline.org)
  • However, other gene variants also contribute to the prevalence of FH. (acc.org)
  • Therefore, we have evaluated the association of the common variants in the lipoprotein lipase (LPL) (D9N, N291S, and S447X), insulin receptor substrate-1 (IRS-1) (G972R), fatty acid binding protein-2 (FABP-2) (A54T), and beta(3)-adrenergic receptor beta(3)-AR) (W64R) genes with lipid and lipoprotein levels in 30 Italian FCHL families (195 individuals). (univaq.it)
  • The frequencies of variants in the IRS-1, FABP-2, and beta(3)-AR genes were not significantly different between affected and nonaffected FCHL family members and normolipemic controls. (univaq.it)
  • The TDT did not demonstrate any significant association of these gene variants with the FCHL trait. (univaq.it)
  • Conversely, the variants in the IRS-1, FABP2, and beta(3)-AR genes did not show any major influence on lipid and lipoprotein levels in FCHL family members. (univaq.it)
  • Cells may acquire cholesterol via an LDL receptor on the cell membrane. (medscape.com)
  • SQLE and SCD are related to hyperlipidaemia, and SQLE/SCD may be new targets for cholesterol-lowering or triglyceride-lowering therapy, respectively. (biomedcentral.com)
  • Hyperlipidemia, also called hyperlipoproteinemia, is characterized by high levels of lipids (fats, cholesterol and triglycerides) or lipoproteins in the blood. (cardiology-doctors.com)
  • The hallmark sign of hyperlipidemia is high cholesterol (with yellowish fatty growths around the eyes or the joints). (cardiology-doctors.com)
  • The receptor defect alters the catabolism of LDL, and the resulting elevation in plasma LDL cholesterol promotes the deposition of cholesterol in the skin, tendons and coronary arteries (atherosclerosis) 7. (diploidegenetics.com)
  • Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)
  • Other hyperlipidemia symptoms could include high triglycerides and other fats in your arteries, and more serious health issues such as blood clots, heart attack and stroke, which may be precipitated by hyperlipidemia. (cardiology-doctors.com)
  • Nevertheless, variations in genes affecting the removal rate of triglycerides (TG) from plasma, such as the LPL gene, significantly influence the lipid phenotypic expression of FCHL. (univaq.it)
  • The expression levels of Gα subunits influence the biased profiling of β-agonists and antagonists in that they determine both their activity and efficacy by affecting different membrane distribution of receptor-G protein populations. (mdpi.com)
  • In the naïve state, the level of Gα expression influences the partitioning of not only Gα but also the co-expressed receptor in different membrane domains. (mdpi.com)
  • Our goal was to explore possible associations between outcomes of chronic wounds, healing status, genotype, gene expression, and the role of social demographics. (iupui.edu)
  • Quantification of gene expression was performed via RT-qPCR. (iupui.edu)
  • TT genotype of rs1544410 present in vitamin D receptor (VDR) gene was associated with increased VDR expression as compared to CT genotype. (iupui.edu)
  • Furthermore, increased methylenetetrahydrofolate reductase (MTHFR) gene expression was associated with PVD. (iupui.edu)
  • This study is one of the first known to investigate the impact of environmental factors and demographics on gene expression in patients with chronic wounds. (iupui.edu)
  • Our results indicate social environment and genotype can play a significant role in patient gene expression and wound outcome. (iupui.edu)
  • Future studies with larger sample sizes are warranted to investigate additional demographic data and expression of other genes involved in wound healing. (iupui.edu)
  • We extracted gene expression profiles from mouse macrophages from the GEO dataset, GSE152795 using the GEO2R webtool. (degruyter.com)
  • An assay measuring the expression of lacZ shows the tissue where the gene is expressed. (mousephenotype.org)
  • Weighted gene co-expression network (WGCNA) analysis was used to analyse the gene expression profile, and the royal blue module was considered to have the highest correlation. (biomedcentral.com)
  • Gene co-expression network-based methods have been widely used in processing microarray data and have especially been used to identify meaningful functional modules [ 18 , 19 ]. (biomedcentral.com)
  • Weighted gene co-expression network analysis (WGCNA) is one of the most effective methods of gene co-expression network analysis. (biomedcentral.com)
  • the promoter of the LDL receptor gene contains a thyroid hormone responsive element (TRE) which allows the triiodothyronine (T3) to upregulate the gene expression of the LDL receptor 8 . (hormones.gr)
  • This increases low-density lipoprotein (LDL-C) receptor recycling and expression on the hepatocyte cell surface, which increases LDL-C uptake and lowers LDL-C levels in the circulation. (medscape.com)
  • In the present study, the effect of MSG on cell viability and its effect on expression of APC , BECN1 , and TP53 genes in SW620 and SW480 colon cancer cell lines were studied. (scielo.br)
  • Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice. (tohoku.ac.jp)
  • Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese Ay mice. (tohoku.ac.jp)
  • Familial combined hyperlipidemia (FCHL) is a common, atherogenic lipid disorder characterized by a variable phenotypic expression of hyperlipidemia. (univaq.it)
  • The effects of PTE on osteoclast differentiation and the expression of osteoclast-specific genes and proteins were determined. (researchgate.net)
  • Additionally, PTE efficaciously suppressed the expression of key osteoclast-specific genes and proteins. (researchgate.net)
  • The aim of this study was to determine the effects of δ-T3, γ-T3, and α-T3 on insulin secretion-associated genes expression of rat pancreatic islets in a dynamic culture. (iium.edu.my)
  • The cells were collected for total RNA extraction and reverse-transcribed, followed by measurement of insulin secretion-associated genes expression using quantitative real-time polymerase chain reaction. (iium.edu.my)
  • These proteins also serve as ligands to specific receptors, they facilitate transmembrane transport, and they regulate enzymatic activity. (medscape.com)
  • Sleep disorders are treated using anti-insomnia drugs that target ionotropic and G protein-coupled receptors (GPCRs), including g -aminobutyric acid (GABA) agonists, melatonin agonists, and orexin receptor antagonists. (vdocuments.mx)
  • The present study was undertaken to detect the association of LDL-R gene Ava ║ polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. (biomedcentral.com)
  • Genotyping of the LDL-R gene Ava ║ polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. (biomedcentral.com)
  • The association of LDL-R gene Ava ║ polymorphism and serum lipid levels is different between the Bai Ku Yao and Han populations. (biomedcentral.com)
  • The discrepancy might partly result from different LDL-R gene Ava ║ polymorphism or LDL-R gene-enviromental interactions. (biomedcentral.com)
  • This allows cortisol to outcompete aldosterone and bind to mineralocorticoid receptors, resulting in the activation of several pathways that increase blood pressure. (wikipedia.org)
  • Subsequent molecular and physiological studies in human mutation carriers and animal models have allowed us to unravel novel functions of the identified genes, to delineate their cognate pathways and to discover new targets for pharmaceutical intervention. (yale.edu)
  • Many genes involved in metabolic pathways have been found to contribute to lipid level variability [ 14 , 26 , 27 ]. (cdc.gov)
  • Finding out the position of a selected gene in atherosclerosis usually requires a time-consuming and sometimes tough means of producing double knockouts or transgenics on ApoE-/- or LDL receptor (LDLR)-/- background. (aabioetica.org)
  • 22 The majority had a common mutant allele, a 3-base pair deletion in exon 4 of the LDLR gene 23 called FH-Piscataway. (acc.org)
  • More than 90% of HoFH cases result from a mutation in the LDLR gene . (delveinsight.com)
  • iPLEX® and MassARRAY® systems were used to genotype ten SNPs of seven genes involved in wound healing. (iupui.edu)
  • Finally, the CC genotype of rs2274976 present in MTHFR gene was associated with better wound outcome than the CT genotype. (iupui.edu)
  • [ 15-20 ] This is not surprising, because GLP-1 receptors are abundantly expressed in the vascular endothelium. (medscape.com)
  • The integration of GPCR and receptor tyrosine kinase (RTK) signaling, including IR upon ligand stimulation, is eloquently reviewed. (mdpi.com)
  • We further found that SET domain bifurcated 1 (Setdb1) was a SUMOylated protein and that SUMOylation promoted Setdb1 occupancy on the promoter locus of Pparg and Cebpa genes to suppress their expressions by H3K9me3. (deepdyve.com)
  • Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene. (tohoku.ac.jp)
  • FCHL individuals carrying the LPL N291S gene showed higher plasma lipids and apolipoprotein B (apoB) levels compared with affected noncarriers. (univaq.it)
  • In conclusion, these results confirmed that none of the investigated genes were major loci for FCHL. (univaq.it)
  • We leverage modern techniques of functional genomics, epigenetics, transcriptomics, proteomics, gene editing and model-driven experimentation to understand the underlying causes of atherosclerosis and metabolic syndrome and discover therapeutic targets. (yale.edu)
  • Identified genes, miRNAs, and TFs can be possible drug targets that may be used for the therapeutics. (degruyter.com)
  • The purpose of this study was to explore the potential molecular targets of hyperlipidaemia and the related molecular mechanisms. (biomedcentral.com)
  • In various epidemiological studies, a rate of 13% for hyperlipidaemia. (who.int)
  • The tumor suppressor TP53 (also called p53) has been among the most extensively studied genes since its discovery in 1979 [ 1 , 2 ]. (nature.com)
  • TP53 is a tumor suppressor gene that functions in modifying DNA errors and/or inducing apoptosis of damaged cells, and both APC and BECN1 genes are involved in CRC and are of importance in cellular growth and metastasis. (scielo.br)
  • TP53 é um gene supressor de tumor que atua modificando erros de DNA e/ou induzindo apoptose de células danificadas, estando os genes APC e BECN1 envolvidos no CRC e sendo importantes no crescimento celular e metástase. (scielo.br)
  • The contribution of serotonin 5-HT2C and melanocortin-4 receptors to the satiety signaling of glucagon-like peptide 1 and liragultide, a glucagon-like peptide 1 receptor agonist, in mice. (tohoku.ac.jp)
  • Scope We aimed at investigating the mechanisms linking hyperlipidemia (HL) with dysfunctional HDL and its main antioxidant enzyme, paraoxonase1 (PON1). (zendy.io)
  • However, because of its molecular similarity to aldosterone it also binds the mineralcorticoid receptor at higher concentrations. (wikipedia.org)
  • Molecular docking experiments were performed to gain insights on how the T3 bind to the receptors. (iium.edu.my)
  • A family history of the hyperlipidemia may be your biggest tipoff to a future diagnosis. (cardiology-doctors.com)
  • 11β-Hydroxysteroid dehydrogenase (HSD-11β or 11β-HSD) enzymes catalyze the conversion of inert 11 keto-products (cortisone) to active cortisol, or vice versa, thus regulating the access of glucocorticoids to the steroid receptors. (wikipedia.org)
  • Conversely, Curcuma longa ( C. longa ) has been used to treat the pathological condition of blood stasis and reportedly exerts a beneficial effect on hyperlipidemia [ 9 , 10 ]. (hindawi.com)
  • Most recently, we have established techniques of high throughput gene editing and multiple parallel reporter assays in my laboratory and have successfully mapped the regulatory landscape of a number of GWAS disease genes. (yale.edu)
  • In response, we developed a diagnostic panel consisting of 3 real-time reverse transcription PCR assays targeting the nucleocapsid gene and evaluated use of these assays for detecting SARS-CoV-2 infection. (cdc.gov)
  • Short-term exposure of δ- and γ-T3 to pancreatic β cells in a stimulant glucose condition (16.7 mM) significantly regulated preproinsulin mRNA levels and insulin gene transcription. (iium.edu.my)