• Biol
  • 301. Osband M., McCaffrey R. Solubilization, separation and partial characterization of histamine Ht and H2 receptors from calf thymocyte membranes, J. Biol. (bio-cat.ru)
  • ligands
  • The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). (wikipedia.org)
  • This suggests that FPR3 rapidly internalizes after binding its ligands and thereby may serve as a "decoy" receptor to reduce the binding of its ligands to FRP1 and FRP2 receptors. (wikipedia.org)
  • Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices. (wikipedia.org)
  • The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. (wikipedia.org)
  • chemotactic factor
  • Since these oligopeptides were produced by bacteria or synthetic analogs of such products, it was suggested that the N-formyl oligopeptides are important chemotatic factors and their receptors are important chemotactic factor receptors that act respectively as signaling and signal-recognizing elements to initiate Inflammation responses in order to defend against bacterial invasion. (wikipedia.org)
  • 309. Left-Brown M. A., Boetchr N. A., Leonard E. J. Chemotactic response of normal human basophils to C5a and to lymphocyte-derived chemotactic factor, J. Immunol. (bio-cat.ru)
  • expression
  • Bio-Rad collaborated with Biogazelle, leaders in real-time PCR research, to design and experimentally validate PCR primers for gene expression assays across the human and mouse transcriptomes. (bio-rad.com)
  • The selected pathways were used to design panels of real-time PCR primers tailored for the top-ranked genes for differential gene expression analysis. (bio-rad.com)
  • Each gene target within a pathway was assigned a score based on the frequency of differential expression and its research significance. (bio-rad.com)
  • Reference genes are used in relative gene expression analysis to normalize for variation in the amount of input messenger RNA (mRNA) among samples. (bio-rad.com)
  • To ensure accurate quantitation, it is important to include one or more reference genes exhibiting constant expression levels under the experimental conditions. (bio-rad.com)
  • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. (wikipedia.org)
  • Differential expression of key genes was confirmed by RT-PCR and results were compared to in vitro data obtained by our group to identify candidate genes. (biomedcentral.com)
  • This would be reflected by differential expression of, among others, atherosclerosis related genes. (biomedcentral.com)
  • 303. Polmar S. H., Birch R. E. Regulation of Fc receptor expression on T-lymphocyte subsets mediated by adenosine and histamine receptors. (bio-cat.ru)
  • amino acid seq
  • Two receptors where thereafter discovered and named FPR2 and FPR3 based on the similarity of their genes' predicted amino acid sequence to that of FPR1 rather than on any ability to bind or be activated by the formyl oligopeptides. (wikipedia.org)
  • All of the active mouse FPR receptors have ≥50% amino acid sequence identity with each other as well as with the three human FPR receptors. (wikipedia.org)
  • proteins
  • This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. (wikipedia.org)
  • Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. (wikipedia.org)
  • Click on genes, proteins and metabolites below to link to respective articles. (wikipedia.org)
  • Rhodopsin-like receptors are a family of proteins that comprise the largest group of G protein-coupled receptors. (wikipedia.org)
  • The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormones, neurotransmitters, and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. (wikipedia.org)
  • Over 30 proteins and protein fragments make up the complement system, including serum proteins, and cell membrane receptors. (wikipedia.org)
  • Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. (wikipedia.org)
  • Sequence
  • The exact size of the GPCR superfamily is unknown, but nearly 800 different human genes (or ~ 4% of the entire protein-coding genome) have been predicted to code for them from genome sequence analysis. (wikipedia.org)
  • mammalian
  • FPR receptors are widely distributed throughout mammalian species with the FPR1, FPR2, and FPR3 paralogs, based on phylogenetic analysis, originating from a common ancestor and early duplication of FPR1 and FPR2/FPR3 splitting with FPR3 originating from the latest duplication event near the origin of primates. (wikipedia.org)
  • Inflammation
  • We recently demonstrated that gene-targeted disruption of the C5a anaphylatoxin receptor prevented lung injury in immune complex-mediated inflammation. (nih.gov)
  • These results suggest that C5a enhances IL-6 secretion mainly in the earlier phase of immune complex-induced inflammation in the peritoneum. (nih.gov)
  • In vivo endotoxin exposure of healthy individuals resulted in the identification of several candidate gene s through which systemic inflammation links to atherosclerosis. (biomedcentral.com)
  • atherosclerosis
  • We aimed to identify these atherosclerosis related genes as candidates for further investigation. (biomedcentral.com)
  • This suggests that inhibiting C5a might provide a therapeutic tool in the prevention or treatment of atherosclerosis, as well as other diseases with immune system participation such as arthritis. (healthcanal.com)
  • But now, this study shows that C5a, a product of an activated complement system may be responsible for the devastating effects of atherosclerosis. (healthcanal.com)
  • regulation
  • It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. (wikipedia.org)
  • Creative Biogene provides kits, reagents, and services that help researchers explore questions about gene discovery, regulation, and function. (creative-biogene.com)
  • adenosine
  • The product of this gene, P2Y14 belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. (wikipedia.org)
  • 304. Birch R. E., Polmar S. H. Induction of Fey receptors on a subpopulation of human T lymphocytes by adenosine and impromide, an H,-histamine agonist, Cell. (bio-cat.ru)
  • immunologic
  • Up to now, anaphylatoxin C5a has been mainly implicated in immunologic diseases such as asthma, rheumatoid arthritis or lupus," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal . (healthcanal.com)
  • and (iii) with receptors on cells and tissues to bring about various immunologic responses. (springer.com)
  • monocytes
  • Such differentially expressed genes in circulating monocytes would be strong candidates for further investigation in disease association studies. (biomedcentral.com)
  • antibody
  • C3a works with C5a to activate mast cells, recruit antibody, complement and phagocytic cells and increase fluid in the tissue, all of which contribute to the initiation of the adaptive immune response. (wikipedia.org)
  • C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. (abcam.com)