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  • Biol
  • 301. Osband M., McCaffrey R. Solubilization, separation and partial characterization of histamine Ht and H2 receptors from calf thymocyte membranes, J. Biol. (bio-cat.ru)
  • chemotactic factor
  • Since these oligopeptides were produced by bacteria or synthetic analogs of such products, it was suggested that the N-formyl oligopeptides are important chemotatic factors and their receptors are important chemotactic factor receptors that act respectively as signaling and signal-recognizing elements to initiate Inflammation responses in order to defend against bacterial invasion. (wikipedia.org)
  • 309. Left-Brown M. A., Boetchr N. A., Leonard E. J. Chemotactic response of normal human basophils to C5a and to lymphocyte-derived chemotactic factor, J. Immunol. (bio-cat.ru)
  • immune
  • We recently demonstrated that gene-targeted disruption of the C5a anaphylatoxin receptor prevented lung injury in immune complex-mediated inflammation. (nih.gov)
  • These results suggest that C5a enhances IL-6 secretion mainly in the earlier phase of immune complex-induced inflammation in the peritoneum. (nih.gov)
  • It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. (wikipedia.org)
  • C3a works with C5a to activate mast cells, recruit antibody, complement and phagocytic cells and increase fluid in the tissue, all of which contribute to the initiation of the adaptive immune response. (wikipedia.org)
  • Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. (wikipedia.org)
  • 294. Rocklin R. E. Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes, J. Clin. (bio-cat.ru)
  • According to this theory, the immune system consists of cells that have specific receptors on their surface to recognize antigens. (wikipedia.org)
  • extracellular
  • The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormones, neurotransmitters, and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. (wikipedia.org)
  • amino acid seq
  • Two receptors where thereafter discovered and named FPR2 and FPR3 based on the similarity of their genes' predicted amino acid sequence to that of FPR1 rather than on any ability to bind or be activated by the formyl oligopeptides. (wikipedia.org)
  • All of the active mouse FPR receptors have ≥50% amino acid sequence identity with each other as well as with the three human FPR receptors. (wikipedia.org)
  • Inflammation
  • In vivo endotoxin exposure of healthy individuals resulted in the identification of several candidate gene s through which systemic inflammation links to atherosclerosis. (biomedcentral.com)
  • Nrf2 regulates gene-environment interactions in an animal model of intrauterine inflammation: Implications for preterm birth and prematurity. (jhu.edu)
  • potent
  • An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a C5-convertase. (wikipedia.org)
  • C3a receptor modulates immunity, arthritis, diet-induced obesity and cancers Potent and selective agonists and antagonists for C3aR have been discovered. (wikipedia.org)
  • mammalian
  • FPR receptors are widely distributed throughout mammalian species with the FPR1, FPR2, and FPR3 paralogs, based on phylogenetic analysis, originating from a common ancestor and early duplication of FPR1 and FPR2/FPR3 splitting with FPR3 originating from the latest duplication event near the origin of primates. (wikipedia.org)
  • Sequence
  • The exact size of the GPCR superfamily is unknown, but nearly 800 different human genes (or ~ 4% of the entire protein-coding genome) have been predicted to code for them from genome sequence analysis. (wikipedia.org)
  • intracellular
  • Compared to FPR1 and FPR2, FPR3 is highly phosphorylated (a signal for receptor inactivation and internalization) and more localized to small intracellular vesicles. (wikipedia.org)
  • enzyme release
  • 298. Sosman J., Busse W. Histamine inhibition of neutrophil lysosomal enzyme release: An H2 histamine receptor source, Science, 194, 737 738 (1976). (bio-cat.ru)