• expression
  • Nur77 −/− BMM exhibit changed expression of M2-specific markers and an inflammatory M1-phenotype with enhanced expression of interleukin-12, IFNγ, and SDF-1α and increased NO synthesis in (non)-stimulated Nur77 −/− BMM cells. (ahajournals.org)
  • SDF-1α expression in nonstimulated Nur77 −/− BMM is repressed by Nur77 and the chemoattractive activity of Nur77 −/− BMM is abolished by SDF-1α inhibiting antibodies. (ahajournals.org)
  • SDF-1α expression is higher in lesions of Nur77 −/− -transplanted mice, which may explain the observed aggravation of lesion formation. (ahajournals.org)
  • In conclusion, in bone marrow-derived cells the nuclear receptor Nur77 has an anti-inflammatory function, represses SDF-1α expression and inhibits atherosclerosis. (ahajournals.org)
  • response
  • Reversible histone acetylation and deacetylation are highly regulated processes that are crucial for chromatin reorganization and the regulation of gene transcription in response to extracellular conditions. (biologists.org)
  • Nur77 and Nurr1 can also form homodimers and heterodimers with retinoid X receptor and bind a DR-5 response element. (ahajournals.org)
  • shown
  • Histone acetylation is one of the best-studied gene modifications and has been shown to be involved in numerous important biological processes. (biologists.org)
  • 1 We and others have shown that Nur77 is expressed in human atherosclerotic lesions in macrophages, endothelial cells and smooth muscle cells (SMCs). (ahajournals.org)