• neurons
  • NaV1.8, formerly called the sensory neuron-specific or the peripheral nerve sodium channel type 3 (PN3), is a tetrodotoxin-resistant VGSC α subunit selectively expressed in the dorsal root ganglion (DRG) neurons. (asahq.org)
  • A systematic survey of the effect of drugs commonly used in a clinical setting for treating neuropathic pain on tetrodotoxin-resistant currents flowing through the VGSC in DRG neurons indicated that there are no drugs capable of preferentially blocking these channels over the tetrodotoxin-sensitive channels, 8 although a depolarized membrane potential does increase the sensitivity of the tetrodotoxin-resistant channels to blockade by some drugs. (asahq.org)