• Genes whose proteins are predicted to be secreted but were previously unknown to be significantly expressed in early oogenesis were downregulated in Nobox knockouts and included astacin-like metalloendopeptidase (Astl), Jagged 1 (Jag1), oocyte-secreted protein 1 (Oosp1), fetuin beta (Fetub), and R-spondin 2 (Rspo2). (appliedbioinfo.com)
  • DAVID was used to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). (medscimonit.com)
  • Transcriptome analysis with RNAseq, followed by gene ontology and cluster analyses, were performed on banked tissue samples of the right kidneys (control kidneys) from cats in the control group and of both kidneys from cats in the RI group, in which unilateral (right) RI had been induced 6 months before the cats were euthanized and the ischemic kidneys (IKs) and contralateral nonischemic kidneys (CNIKs) were harvested. (avma.org)
  • The Gene Ontology resource: enriching a GOld mine. (flybase.org)
  • Term Matrix: A novel Gene Ontology annotation quality control system based on ontology term co-annotation patterns. (flybase.org)
  • We have recently mapped a gene for the autosomal recessive form of WMS to chromosome 19p13.3-p13.2, in a 12.4-cM interval. (nih.gov)
  • The PHEX (phosphate-regulating with homologies to endopeptidases on the X chromosome) gene encodes a Zinc-metalloendopeptidase expressed primarily in osteoblasts and odontoblasts. (biomedcentral.com)
  • The gene is part of a cluster of MMP genes on chromosome 11. (cancerindex.org)
  • In humans, the STAT3 gene is located on the q arm of chromosome 17. (thermofisher.com)
  • Here, we report null mutations in a member of the extracellular matrix protease family, the gene encoding ADAMTS10, a disintegrin and metalloprotease with thrombospondin motifs. (nih.gov)
  • Genes associated with the extracellular matrix (eg, TIMP-1 , fibulin-1, secreted phosphoprotein-1, matrix Gla protein, and connective tissue growth factor) were upregulated in tissue samples from both the IKs and CNIKs, compared with tissues from the control kidneys. (avma.org)
  • This gene, specified and the proteins it encodes had been characterized in a variety of dental streptococci strains, including stress found in this research. (careersfromscience.org)
  • The expression and cellular localisation of proteins encoded by selected candidate genes were confirmed by immunohistochemistry. (biomedcentral.com)
  • The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. (nih.gov)
  • Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family. (nih.gov)
  • Neprilysin , also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene. (assaysolution.com)
  • A gene encoding an endopeptidase from FW213 continues to be cloned and proven to possess high series homology to genes encoding mammalian metalloendopeptidases. (careersfromscience.org)
  • Search results: The pahtway p1357 has 351 genes in the original annotation. (uth.edu)
  • Predicted to enable metalloendopeptidase activity. (jax.org)
  • The MME gene encodes neprilysin (NEP), which is well known to be one of the most prominent beta-amyloid (Aß)-degrading enzymes. (bvsalud.org)
  • Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. (flybase.org)
  • We used a transcriptomic approach to define the protease and antiprotease genes specifically expressed in the hen liver in relation to vitellogenesis by comparing sexually mature and pre-laying chickens showing different steroid milieu. (biomedcentral.com)
  • To use RNA sequencing (RNAseq) to characterize renal transcriptional activities of genes associated with proinflammatory and profibrotic pathways in ischemia-induced chronic kidney disease (CKD) in cats. (avma.org)
  • Results for the IKs, CNIKs, and control kidneys were compared to identify potential differentially expressed genes and overrepresented proinflammatory and profibrotic pathways. (avma.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. (thermofisher.cn)
  • FUNCTION: This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. (utsouthwestern.edu)
  • Currently, there are 230 genes in SZGR 2.0 (with evidence in schizophrenia) that are present at this pathway. (uth.edu)
  • METHODS: To efficiently identify novel causative genes for AR-CMT, we analyzed 303 unrelated Japanese patients with CMT using whole-exome sequencing and extracted recessive variants/genes shared among multiple patients. (bvsalud.org)
  • Unilateral ischemic injury differentially altered gene expression in both kidneys, compared with control kidneys. (avma.org)
  • This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). (uth.edu)
  • 912, 2202, and 1227 genes were significantly differentially expressed between cases with self-reported T2D and controls in neurones, astrocytes, and endothelial cells respectively. (biomedcentral.com)
  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). (cancerindex.org)
  • Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp). (cnr.it)
  • We performed mutation screening of the newly identified membrane metalloendopeptidase (MME) gene in 354 additional patients with CMT. (bvsalud.org)
  • This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS). (lookformedical.com)
  • As defined previously, we discovered a gene located 148 nucleotides upstream and divergently transcribed in the operon. (careersfromscience.org)
  • The blast clade genomes contain more secretome and avirulence effector genes, which likely play key roles in the interaction between Pyricularia species and their plant hosts. (nature.com)
  • Protein-binding microarray helped identify nucleotide motifs that NOBOX binds and that several downregulated genes contain within putative promoter regions. (appliedbioinfo.com)
  • MME, also called CD10, is a cell surface zinc metalloendopeptidase expressed in various normal and neoplastic lymphoid and nonlymphoid tissues including melanomas. (cusabio.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Automated generation of gene summaries at the Alliance of Genome Resources. (flybase.org)
  • Isolation and characterization of alternative messenger RNAs coding class I HLA genes. (cnr.it)
  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (appliedbioinfo.com)
  • Role of Otx1 and Otx2 in brain evolution: functional equivalence between the invertebrate Orthodenticle and the murine OTX1 and OTX2 gene products supports a conserved genetic program of brain development between insects and mammals. (cnr.it)
  • OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information. (appliedbioinfo.com)
  • Eight of the top ten over-expressed genes are known components of the egg yolk or perivitelline membrane. (biomedcentral.com)
  • Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
  • The effects of metalloprotease inhibitors could be reversed by either adding exogenous EGF or by expressing an artificial gene for EGF that lacked a membrane-anchoring domain. (nih.gov)
  • Isolation and identification of the structural organization of the human homeobox gene family (HOX Complex). (cnr.it)
  • The UDP-Glycosyltransferase Family in Drosophila melanogaster: Nomenclature Update, Gene Expression and Phylogenetic Analysis. (flybase.org)
  • Systematic search in PubMed for genes co-occurring with SCZ keywords. (uth.edu)
  • Ten DEGs, including 7 hub genes from PPI analysis, were confirmed by real-time PCR. (medscimonit.com)
  • Expression analysis of several Hox genes in human embryos. (cnr.it)
  • Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development. (cnr.it)
  • Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene. (cnr.it)
  • Hub genes identified from Weighted Gene Co-expression Network Analysis were validated in neurones using the NanoString nCounter platform. (biomedcentral.com)
  • Building a pipeline to solicit expert knowledge from the community to aid gene summary curation. (flybase.org)
  • Background: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). (icbinhibitor.com)
  • This gene exhibits elevated expression levels in multiple human cancers. (cancerindex.org)
  • STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. (thermofisher.com)
  • This gene is predominantly expressed in the ovary with lower levels of expression observed in kidney, heart, skeletal muscle, lung and testis. (utsouthwestern.edu)