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Liver RegenerationRegenerationHepatectomyLiverHepatocytesNerve RegenerationLiver DiseasesLiver TransplantationLiver NeoplasmsBone RegenerationLiver CirrhosisFatty LiverHepatocyte Growth FactorCell ProliferationDrug-Induced Liver InjuryCarbon TetrachlorideLiver Function TestsProliferating Cell Nuclear AntigenLiver Failure, AcuteMicrosomes, LiverTime FactorsRats, WistarRats, Inbred F344STAT3 Transcription FactorRNA, MessengerHyptisCarbon Tetrachloride PoisoningOrgan SizeMice, Inbred C57BLRats, Sprague-DawleyGene Expression RegulationGuided Tissue RegenerationMitochondria, Liver2-AcetylaminofluoreneLiver Neoplasms, ExperimentalStem CellsMice, KnockoutModels, AnimalAlanine TransaminaseLiver CirculationSignal TransductionCell DivisionDNACytochrome ReductasesInterleukin-6Kupffer CellsCells, CulturedRats, Inbred StrainsThioacetamideImmunohistochemistryLiver Cirrhosis, ExperimentalCell DifferentiationMitotic IndexDisease Models, Animalalpha-FetoproteinsPlanariansDrug-Induced Liver Injury, ChronicMythologyHepatic Stellate CellsGalactosamineMice, TransgenicBilirubinCarcinoma, HepatocellularPortal VeinPyrrolizidine AlkaloidsCell CycleAxonsLiver ExtractsGene ExpressionSalamandridaeReverse Transcriptase Polymerase Chain ReactionHepatic InsufficiencyBromodeoxyuridineAmbystoma mexicanumAspartate AminotransferasesExtremitiesApoptosisNerve CrushBile DuctsDiethylnitrosamineBlotting, WesternLiver AbscessGrowth SubstancesLiving DonorsProto-Oncogene Proteins c-metAlbuminsLiver Diseases, AlcoholicBlotting, NorthernPortal SystemNotophthalmus viridescensMolecular Sequence DataDimethylnitrosamineKineticsZebrafishCell TransplantationCyclin A2Up-RegulationAnimal FinsBase SequenceTumor Necrosis Factor-alpha
DifferentiallyHepatectomyDonor liversMutationsTransplantationProteinsHepatocytesDiseasesProteinPartialHepatocytePathwaysMiceHepaticEmbryoMechanismsGeneticPatternsCancersDiseaseNormal liverCellProgressionGenomicProcessesChromatinInterestinglyFibrosisWestern BlotComplicationsInduce liverLarvaeStathminIdentifiesKidneyCellsContextResearchersOrganAnalysesOccursProliferationRegenerateImmuneChronicScientistsActivate
Differentially5
  • Comparative analysis of the transcriptomes from the 3 different conditions identifies 45 differentially expressed genes during oval cell regeneration, 27 up-regulated and 18 down-regulated. (uni-goettingen.de)
  • We obtained the rat liver tissue gene datasets (GSE63742) collected following partial hepatectomy (PH) from the Gene Expression Omnibus (GEO) of the National Center for Biotechnology Information (NCBI), from which, this study screened the late stage LR samples (7 days post-PH) using the R/Bioconductor packages for the identification of differentially expressed genes (DEGs). (jomh.org)
  • The key TF were identified by functional enrichment analysis from the list of differentially expressed genes identified in liver samples between 35 pigs fed with 1.5% or 3.0% soybean oil. (nature.com)
  • Hypergeometric analysis was used to identify canonical pathways and curated networks having statistically significant enrichment of differentially expressed genes. (urotoday.com)
  • Among the approximately 1000 differentially responsive genes expressed in both injured groups, there was an intense upregulation of genes related to the inflammatory response (i.e. (cdc.gov)
Hepatectomy6
Donor livers2
  • The only curative treatment for ALF is liver transplantation, but there are many restrictions on the application of liver transplantation because of financial considerations, a shortage of donor livers, and immunosuppression-related complications [ 3 ]. (springer.com)
  • Liver transplants are often an important component to treatment, but unfortunately, there aren't enough donor livers to help every child. (childrenshospital.org)
Mutations8
  • Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. (nih.gov)
  • Mutations of PTCH1 gene in two pedigrees with bifid rib-basal cell nevus-jaw cyst syndrome. (nih.gov)
  • Diagnosis of Mutations in the dystrophin gene can cause Duchenne these disorders is based on clinical presentation, muscular dystrophy or Becker muscular dystrophy. (who.int)
  • 90% of cases, mutations that from mutation in the dystrophin gene (located on short disrupt the reading frame (frame shift) lead to arm of X chromosome, Xp21). (who.int)
  • Better understanding of new mutations and the wide range of possible phenotypes led to the development of a new nomenclature proposal, based on the gene and inheritance pattern. (medscape.com)
  • [ 6 ] However, the gene mutations responsible for the different forms of CMT1 are clearly myelin genes. (medscape.com)
  • Antigenic drift involves small mutations in the genes of influenza viruses that lead to changes in HA and NA that accumulate over time, resulting in the emergence of novel strains that the human immune system may not recognize. (cdc.gov)
  • They are caused by mutations of the dystrophin gene, the largest known human gene, at the Xp21.2 locus. (msdmanuals.com)
Transplantation8
  • The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. (springer.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
  • Conclusions Human spindle-shaped AF-MSCs or HPL cells might be valuable tools to induce liver repair and support liver function by cell transplantation. (bmj.com)
  • His principal research interests are in the transplant-related immune tolerance and genes associated with progression and recurrence of hepatocellular carcinoma in patients undergoing liver transplantation. (wjgnet.com)
  • Dr. Wang holds memberships in the International Liver Transplantation Society (ILTS), European Association for the Study of the Liver (EASL), American Society of Transplantation (AST), and International Society for Infectious Diseases (ISID). (wjgnet.com)
  • His honors include the Young Investigator Awards in the 17th and 22nd Annual International Congress of ILTS, the Travel Award in the 12th Congress of the Asian Society of Transplantation, the Young Innovator Award in the 3rd Annual Scientific Exchange of the American Society of Transplantation, and the Young Innovator Award in the EASL Special Conference on Liver Transplantation 2011. (wjgnet.com)
  • Many patients are not candidates given the advanced stage of their cancer at diagnosis or their degree of liver disease and, ideally, could be cured by liver transplantation. (medscape.com)
Proteins2
  • This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. (nih.gov)
  • Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
Hepatocytes19
Diseases8
  • Factors that increase the probability liver diseases are developed include but are not limited to obesity, type 2 diabetes, tattoos or body piercings, the injection of drugs using shared needles, exposure to other people's blood and body fluids, unprotected sex, and exposure to chemicals and toxins. (wikipedia.org)
  • New mRNA stem cell therapy, akin to COVID-19 vaccine tech, shows potential against chronic and acute liver diseases. (medindia.net)
  • In the early 1970s, researchers discovered that most severe liver diseases caused such findings regardless of etiology, and, in the late 1970s, the biochemical and enzymatic causes of the disease were reported. (medscape.com)
  • To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
  • Diseases, such as hepatitis and liver cancer, can put a child's life at risk. (childrenshospital.org)
  • When functioning normally, the Hippo pathway is important to cell growth, but when malfunctioning, the Hippo pathway can also play a role in diseases such as liver cancer and liver fibrosis. (childrenshospital.org)
  • The Camargo lab has recently identified chemicals that control Hippo signaling, which could be turned into novel treatments for liver cancer and other liver diseases. (childrenshospital.org)
  • More importantly, the factors they release may also play an important role in cell treatment in diseases of the liver. (bmj.com)
Protein6
  • Kinetically down-regulated genes involved in the lipid metabolism are: hydroxyacid oxidase 3, fatty acid CoA ligase long chain 2, and steroyl CoA desaturase 1.The regulation of protein expression of the cell cycle genes CDC42 and cyclin D1 was studied by Western Blot technique, in the oval cell liver regeneration. (uni-goettingen.de)
  • The liver performs vital functions, including chemical detoxification, blood protein production, bile excretion, and regulation of energy metabolism. (medicalxpress.com)
  • Genetic polymorphism in Methylenetetrahydrofolate Reductase chloride transport protein 6 (MTHFR CLCN6) gene is associated with keratinocyte skin cancer in a cohort of renal transplant recipients. (ucsf.edu)
  • Through the protein network analysis, a core protein interaction network composed of 20 hub genes was derived. (bvsalud.org)
  • Shukla V, Cuenin C, Dubey N, Herceg Z. (2011) Loss of histone acetyltransferase cofactor transformation/transcription domain-associated protein impairs liver regeneration after toxic injury. (who.int)
  • Diagnosis is suggested clinically and is confirmed by genetic testing or analysis of the protein product (dystrophin) of the mutated gene. (msdmanuals.com)
Partial3
  • Experimental pathology of liver: restora-tion of liver of white rat following partial surgical removal. (jomh.org)
  • The liver can regenerate after partial surgical removal or chemical injury. (wikipedia.org)
  • Control of a single gene can stimulate partial regeneration after a damaging stroke, in both live mice and cultured human neurons. (extremetech.com)
Hepatocyte1
Pathways5
  • Liver regeneration (LR) is a complex process influenced by various genes and pathways, the majority of the of research on LR focus on the initiation and proliferation phase while studies on termination phase is lacking. (jomh.org)
  • Taken together, the microarray analysis in this study suggests that DEGs such as Ste2 and Btg2 are the hub genes, which are associated with the regulation of termination stage LR, while the molecular mechanisms are possibly related to the MAPK and TGF-β signal transduction pathways. (jomh.org)
  • Transcriptomic analysis of liver biopsies in patients with NASH revealed that NASH progression is associated with rewiring of metabolic pathways, including upregulation of de novo lipid/cholesterol synthesis and fatty acid remodelling. (nih.gov)
  • Characterisation of gene expression patterns in bladder cancer allows the identification of pathways involved in its pathogenesis, and may stimulate the development of novel therapies targeting these pathways. (urotoday.com)
  • Her research employs high throughput genomics, single cell sequencing, live imaging, cell biology, and functional approaches to unravel the pathways that balance stem cell self-renewal with tissue regeneration. (rockefeller.edu)
Mice8
  • The next step is to explore these gene variants in mice or in humans," she says. (newscientist.com)
  • Preclinical studies in mice have shown that gene therapy is a promising approach to treat individuals with Friedreich's ataxia. (curefa.org)
  • Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
  • In the present review, the phenotypes of Met gene‑modified mice are summarized. (spandidos-publications.com)
  • Using genetic engineering techniques, the team induced hepatoblastoma tumors in mice that either did or did not have Myc in their liver cells. (upmcphysicianresources.com)
  • They found that mice lacking Myc in their liver cells generated tumors more slowly and survived longer than expected. (upmcphysicianresources.com)
  • Mice lacking liver Myc still developed tumors, but the tumors grew more slowly, suggesting that tumor growth, but not initiation, is dependent on Myc," explained Dr. Prochownik. (upmcphysicianresources.com)
  • It reveals that all living things - from men to mice, from trees to seeds - are moulded and controlled by 'electrodynamic fields', which can be measured and mapped with standard modern volt-meters. (i-sis.org.uk)
Hepatic5
  • Since the metabolism of galactose is dependent on liver blood flow and hepatic functional mass, further studies are needed. (hindawi.com)
  • The hepatic artery supplies 30% of the blood flow to the normal liver parenchyma but greater than 90% to hepatic tumors, including both HCC and metastatic lesions. (medscape.com)
  • The primary venous drainage of the liver is through three large hepatic veins that enter the inferior vena cava adjacent to the diaphragm. (medscape.com)
  • The biliary anatomy of the liver generally follows hepatic arterial divisions. (medscape.com)
  • The hepatic duct then divides into two or three additional ducts draining the liver. (medscape.com)
Embryo2
  • She combines mRNA injections, whole-embryo live-imaging, single cell sequencing and in situ whole mount hybridization to capture the dynamics and molecular players of development. (uni-goettingen.de)
  • His efforts are focused on the identification of the complete set of biomineralizing effector genes in the pulmonate gastropod Lymnaea stagnalis , and on identifying the gene regulatory and cellular communication events that coordinate the initiation of shell formation in the early snail embryo. (uni-goettingen.de)
Mechanisms5
  • We aimed to identify potential genes and reveal the underlying the molecular mechanisms involved in the precise regulation of liver size during the termination phase of LR. (jomh.org)
  • Liver regeneration-mechanisms and models to clinical application. (jomh.org)
  • Previous studies have proven that rodent and human MSCs can differentiate into HLCs in vitro and in vivo , which is one of the mechanisms of MSCs in the treatment of liver failure. (springer.com)
  • Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration. (uni-ulm.de)
  • Studies in several vertebrate models and Drosophila have uncovered a surprising degree of evolutionary conservation of regulatory mechanisms and genes that control early cardiogenesis. (biologists.com)
Genetic9
  • One jellyfish's regeneration powers seem linked to key genetic changes. (newscientist.com)
  • The new research focuses on one of cancer's key genetic players, a gene called Myc. (upmcphysicianresources.com)
  • Bodies do wear down over time however if we use genetic engineering to activate all the genes responsible for regeneration then we can keep on going indefinitely. (sentientdevelopments.com)
  • I personally prefer manipulating genes to endow us with traits we do not have and screening out genetic impediments. (sentientdevelopments.com)
  • Although the weights of internal organs have not been direct targets for selection in poultry breeding programs, feed intake (commonly targetted for selection) has exhibited positive genetic correlations with heart weight (0.77), liver weight (0.73) and intestine weight (0.92) in a meat-type chicken population [ 8 ]. (biomedcentral.com)
  • Thus, the discovery of genomic regions and positional candidate genes (PCGs) for intestine length or weights and percentages of heart, liver, gizzard or lungs, is a first step for understanding their genetic architecture. (biomedcentral.com)
  • Our loss- and gain-of-function studies, as well as the observed genetic interactions among Dorsocross, tinman and pannier , suggest that co-expression of these three genes in the cardiac mesoderm, which also involves cross-regulation, plays a major role in the specification of cardiac progenitors. (biologists.com)
  • Antigenic shifts are probably due to genetic recombination (an exchange of a gene segment) between influenza A viruses that affect humans and/or animals. (cdc.gov)
  • Х-зчеплений рецесивний Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (msdmanuals.com)
Patterns2
  • Her lab has recently worked with gene expression patterns during sexual reproduction and regeneration of syllids. (uni-goettingen.de)
  • Scoccianti C, Ricceri F, Ferrari P, Cuenin C, Sacerdote C, Polidoro S, Jenab M, Hainaut P, Vineis P, Herceg Z. (2011) Methylation patterns in sentinel genes in peripheral blood cells of heavy smokers: Influence of cruciferous vegetables in an intervention study. (who.int)
Cancers1
  • 2012) Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers. (who.int)
Disease16
  • Scarring in the liver is very dangerous and can lead to further complications and liver disease. (wikipedia.org)
  • Non-alcoholic fatty liver disease (NAFLD) is a silent pandemic associated with obesity and the metabolic syndrome, and also increases cardiovascular- and cirrhosis-related morbidity and mortality. (nih.gov)
  • Postmortem examination revealed that both the liver and the kidney had a highly unusual pattern of nodular cirrhosis, the histopathologic hallmark of the disease. (medscape.com)
  • Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. (springer.com)
  • These findings, reported today in Science , could help scientists answer important questions about liver maintenance, liver damage (such as from fatty liver or alcoholic liver disease), and liver cancer. (medicalxpress.com)
  • In a mouse model of cardiac disease, these doses only corrected cardiac dysfunction partially and transiently and led to adverse findings associated with iron-sulfur cluster deficiency in liver. (curefa.org)
  • LyGenesis recently received U.S. Food and Drug Administration clearance for its Investigational New Drug application to conduct a Phase 2a clinical trial on the safety, tolerability, and efficacy of its lead cell therapy for patients with end-stage liver disease, with study initiation planned for 2021. (businesswire.com)
  • Liver disease is a substantial contributor to the development of end-stage renal disease (ESRD). (hindawi.com)
  • The results provide a better understanding of how inhibition of this gene can be used to combat the disease, and also suggest that doing so may be associated with fewer side effects than originally assumed. (upmcphysicianresources.com)
  • Understanding the gene signatures of different populations of hiPSC-CMs will impact our understanding of how to use such cells to discover drugs, model heart disease and repair a damaged heart," Dr. Churko explained. (azbio.org)
  • Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. (medscape.com)
  • The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC. (medscape.com)
  • Whereas in the past, HCC generally presented at an advanced stage with right-upper-quadrant pain, weight loss, and signs of decompensated liver disease, it is now increasingly recognized at a much earlier stage as a consequence of the routine screening of patients with known cirrhosis, using cross-sectional imaging studies and serum alpha-fetoprotein (AFP) measurements. (medscape.com)
  • There is also a growing problem with cirrhosis, which develops in the setting of nonalcoholic fatty liver disease (NAFLD), or nonalcoholic steatohepatitis (NASH). (medscape.com)
  • 3] Thus, developing effective and efficient care for patients with end-stage liver disease and HCC must become a significant focus. (medscape.com)
  • People with liver disease may need to use lower doses of CBD. (medlineplus.gov)
Normal liver4
Cell14
  • Temporal regulation of these genes in the context of the oval cell regeneration was studied by Real Time PCR. (uni-goettingen.de)
  • From the data of the present study we conclude that the cell cycle genes CDC42 and cyclin D1 could be involved in the mechanism of proliferation of the oval cell in the liver regeneration process. (uni-goettingen.de)
  • This study investigated the link between GM and the intrahepatic T cell receptor (TCR) immune repertoire (IR), and whether GM modulates the intrahepatic immune microenvironment via TCR IR during liver fibrosis. (frontiersin.org)
  • However, more investigation is needed to understand the different cell types in the human liver," says Hao Zhu, M.D., an associate professor at CRI and lead author of the study. (medicalxpress.com)
  • NYSE American: AGE), a biotechnology company developing therapeutics for human aging and cell regeneration, and LyGenesis, Inc. ("LyGenesis"), a privately held biotechnology company developing cell therapies that enable organ regeneration, announced today that they will proceed to negotiate an agreement for a merger of the two companies. (businesswire.com)
  • Researchers at the University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh of UPMC have uncovered how a key cancer gene works to accelerate cell growth in a mouse model of pediatric liver tumors. (upmcphysicianresources.com)
  • A research team led by Jared Churko, PhD, director of the University of Arizona iPSC Core in the UA Sarver Heart Center, used a transcriptomic approach - studying what genes are expressed - to identify gene signatures of cell subpopulations identified as atrial-like or ventricular-like. (azbio.org)
  • In a study published this month in Nature Communications, Jared Churko, PhD, assistant professor of Cellular and Molecular Medicine at the UA College of Medicine - Tucson, used a systems-based approach encompassing single-cell transcriptomics, single-cell proteomics and CRISPR gene-editing to identify different subpopulations of cardiomyocytes. (azbio.org)
  • CRISPR gene editing is a technology for modifying an organism's DNA code at the single-cell level. (azbio.org)
  • Wnt/β-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart. (uni-ulm.de)
  • Gene networks reveal stem-cell state convergence during preneoplasia and progression to malignancy in multistage skin carcinogenesis. (ucsf.edu)
  • Ralf Heinrich is interested in apoptosis and pharmacological intervention with apoptotic processes to support cell survival, functionality and regeneration. (uni-goettingen.de)
  • Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
  • and stem cell regeneration. (lu.se)
Progression1
  • Our study demonstrates that GM, which exhibits cross-talk with the intrahepatic TCR IR, influences the intrahepatic immune microenvironment and liver fibrosis progression. (frontiersin.org)
Genomic2
  • Dr. Miller received a PhD in molecular biology from Princeton University, where he developed functional genomic approaches to study tumor virus control of cellular gene expression. (nih.gov)
  • We used a high density SNP array (600 K, Affymetrix) to estimate genomic heritability, perform genome-wide association analysis, and identify genomic regions and positional candidate genes (PCGs) associated with internal organ traits in an F2 chicken population. (biomedcentral.com)
Processes1
Chromatin1
Interestingly1
Fibrosis5
  • Liver fibrosis-associated imprinting is predicted to be reflected in GM. (frontiersin.org)
  • Fecal microbial transplant (FMT) and TCRβ knockout (Tcrb KO ) mouse models were employed to determine the biological link between GM and TCR IR in liver fibrosis. (frontiersin.org)
  • We found that GM and intrahepatic TCR IR are highly correlated, with both showing reduced diversity and centralized distribution during liver fibrosis. (frontiersin.org)
  • The restoration of normal intestinal microbiota may reshape intrahepatic TCR IR and delay liver fibrosis. (frontiersin.org)
  • HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)
Western Blot1
  • Animal experimentation (Rat PH model) was performed to acquire liver tissues which were then used for western blot analysis to verify our results. (jomh.org)
Complications1
  • Complications increase when the initial cause of the damage to the liver is still present. (wikipedia.org)
Induce liver1
  • Proteome profile analysis of HPL-CM indicated the presence of anti-inflammatory factors such as interleukins IL-10, IL-1ra, IL-13 and IL-27 which may induce liver recovery. (bmj.com)
Larvae1
Stathmin1
Identifies1
  • Our present study identifies the Dorsocross T-box genes as key mediators of combined Dpp and Wg signals during this process. (biologists.com)
Kidney3
  • Investigators inferred that the enzymatic defect might reside in deficiency of fumarylacetoacetase, which mediates production of fumaric acid and acetoacetate in both liver and kidney. (medscape.com)
  • GM, considered a virtual organ, forms axes with various extraintestinal organs, including the brain, liver, and kidney as well as cardiovascular and endocrine systems. (frontiersin.org)
  • The combined company's pipeline would also include thymus, pancreas, and kidney regeneration, in addition to the existing AgeX assets, including UniverCyte™, which uses the HLA-G gene to potentially confer low immune observability to cells to suppress rejection of transplanted cells. (businesswire.com)
Cells14
  • These two types of cells can repair liver tissue even when the normal mechanism of liver regeneration fails. (wikipedia.org)
  • They found the jellies silenced developmental genes to return cells to a primordial state and activated other genes that allow the nascent cells to re-specialise once a new medusa buds off. (newscientist.com)
  • Hoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway .Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassbly, and controlling the equilibrium between tolerance and immunity to non-self antigens. (joplink.net)
  • Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity). (joplink.net)
  • In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
  • The liver is one of the few organs in the body where differentiated adult stem cells can divide to regenerate after an injury. (childrenshospital.org)
  • Studying the Hippo pathway can help scientists develop treatments which encourage a liver to heal itself, allow scientists to grow liver cells in the lab (a therapeutic approach not yet available) or study the development of liver cancer. (childrenshospital.org)
  • Conditioned medium (CM) derived from AF-MSCs or HPL cells was then delivered intrahepatically in order to determine whether the engraftment of the cells or their secreted molecules are the most important agents for liver repair. (bmj.com)
  • While the amazing regenerative power of the liver has been known since ancient times, the cells responsible for maintaining and replenishing the liver have remained a mystery. (medicalxpress.com)
  • Now, research from the Children's Medical Center Research Institute at UT Southwestern (CRI) has identified the cells responsible for liver maintenance and regeneration while also pinpointing where they reside in the liver. (medicalxpress.com)
  • Along with three previously established mouse strains, researchers observed how the labeled cells multiplied or disappeared over time, and which were responsible for liver regeneration after damage. (medicalxpress.com)
  • So it makes sense that cells in zone 2, which are sheltered from toxic injuries affecting either end of the lobule, would be in a prime position to regenerate the liver. (medicalxpress.com)
  • Certain measurements are used to determine the amount of liver cells indirectly by measuring metabolic function or drug clearance as a substitute for quantitative liver function. (hindawi.com)
  • However, because Myc is expressed in normal cells as well as cancerous ones, there have been concerns in the field that inhibiting the gene would produce too many detrimental side effects. (upmcphysicianresources.com)
Context1
  • The meaning of genes and genomes begins to emerge in this wider context. (cam.ac.uk)
Researchers1
  • In the current study, researchers studied the gene's role in a mouse model of hepatoblastoma, a form of liver cancer that occurs in children, typically under the age of 3. (upmcphysicianresources.com)
Organ5
  • The liver is the only visceral organ with the capacity to regenerate. (wikipedia.org)
  • As little as 51% of the original liver mass is required for the organ to regenerate back to full size. (wikipedia.org)
  • During compensatory hyperplasia, the remaining liver tissue becomes larger so that the organ can continue to function. (wikipedia.org)
  • The liver is an organ essential to digestion, energy metabolism and filtration of poisons from the body. (childrenshospital.org)
  • 4, 5] The liver is the largest internal organ, representing 2-3% of the total body weight in an adult. (medscape.com)
Analyses3
  • Analyses based on STRING database and Cytoscape software identified genes like Ste2 and Btg2 as the hub genes in the termination stage LR. (jomh.org)
  • In this respect, he is using a broad range of methods including immunohistochemical analyses, histological staining procedures and ultrastructural investigations as well as gene expression analyses and phylogenomic approaches. (uni-goettingen.de)
  • cRNA samples were prepared and loaded onto Sentrix Rat-Ref12 Beadchips for gene array analyses. (cdc.gov)
Occurs1
  • Fulminant onset of liver failure occurs in the first few months of life. (medscape.com)
Proliferation3
  • Bei Schädigung des Lebergewebes können sie durch ihre Fähigkeit zur Proliferation eine Regeneration der Leber herbeiführenUnter bestimmten Umständen wie z.B. Hepatokarzinogenese oder einer durch Drogen, Viren oder Toxine induzierten chronischen Leberschädigung, wenn die proliferative Fähigkeit der Hepatozyten beeinträchtigt ist, kommt es zur Rekrutierung fakultativer hepatischer Stammzellen den so genannten Ovalzellen die in der Lage sind Hepatozyten und Gallengangszellen zu generieren. (uni-goettingen.de)
  • Es kann daher angenommen werden, dass die Ovalzellen ein zweites Kompartiment sind, dass an der Regeneration der Leber beteiligt ist, wenn diese massiv geschädigt und die Proliferation der Hepatozyten suprimiert ist.Um die Rattenleberregeneration durch Ovalzellen zu untersuchen wurde das Protokoll der 70% igen partiellen Hepatektomie (PH) und einer zusätzlichen Behandlung mit 2-Acetoamidofluoren (2-AAF) verwendet. (uni-goettingen.de)
  • After the regeneration process has completed, TGF-β puts an end to the proliferation by inducing apoptosis. (wikipedia.org)
Regenerate1
Immune2
  • Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
  • Accordingly, 16S rRNA gene sequencing (16S-seq) and bulk immune repertoire sequencing (IR-seq) were performed to characterize GM and intrahepatic TCR IR. (frontiersin.org)
Chronic1
  • This understanding could lead to regenerative therapy discoveries for the millions of people living with damaged heart muscle caused by heart attacks or other chronic heart conditions. (azbio.org)
Scientists1
  • Then, to pinpoint how T. dohrnii reverts into polyp form, the scientists looked at which genes were active during this reverse metamorphosis. (newscientist.com)
Activate1
  • In an early step, the Dorsocross genes act in parallel with tinman to activate the expression of pannier , a cardiogenic gene encoding a Gata factor. (biologists.com)